CN107003325A - 用于诊断和预后肾损伤和肾衰竭的方法和组合物 - Google Patents

用于诊断和预后肾损伤和肾衰竭的方法和组合物 Download PDF

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Publication number
CN107003325A
CN107003325A CN201580065880.3A CN201580065880A CN107003325A CN 107003325 A CN107003325 A CN 107003325A CN 201580065880 A CN201580065880 A CN 201580065880A CN 107003325 A CN107003325 A CN 107003325A
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CN
China
Prior art keywords
subject
hours
likelihood
renal
step comprises
Prior art date
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Pending
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CN201580065880.3A
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English (en)
Chinese (zh)
Inventor
J·安德贝里
P·麦克弗森
J·格雷
K·中村
J·P·坎普夫
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Astute Medical Inc
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Astute Medical Inc
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Publication date
Application filed by Astute Medical Inc filed Critical Astute Medical Inc
Publication of CN107003325A publication Critical patent/CN107003325A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4704—Inhibitors; Supressors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN201580065880.3A 2014-11-11 2015-11-11 用于诊断和预后肾损伤和肾衰竭的方法和组合物 Pending CN107003325A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462078347P 2014-11-11 2014-11-11
US62/078,347 2014-11-11
PCT/US2015/060204 WO2016077484A1 (en) 2014-11-11 2015-11-11 Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Publications (1)

Publication Number Publication Date
CN107003325A true CN107003325A (zh) 2017-08-01

Family

ID=55955000

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580065880.3A Pending CN107003325A (zh) 2014-11-11 2015-11-11 用于诊断和预后肾损伤和肾衰竭的方法和组合物

Country Status (5)

Country Link
US (1) US20170315134A1 (https=)
EP (1) EP3218724A4 (https=)
JP (1) JP2017534874A (https=)
CN (1) CN107003325A (https=)
WO (1) WO2016077484A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11771113B2 (en) 2017-05-31 2023-10-03 Mars, Incorporated Methods of diagnosing and treating chronic kidney disease
WO2019144081A1 (en) * 2018-01-19 2019-07-25 Mars, Incorporated Biomarkers and classification algorithms for chronic kidney disease in cats
EP3821254A1 (en) * 2018-07-14 2021-05-19 Mars Incorporated Biomarkers and test models for chronic kidney disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120156701A1 (en) * 2009-12-20 2012-06-21 Joseph Anderberg Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20140038203A1 (en) * 2012-07-09 2014-02-06 Musc Foundation For Research Development Methods for detecting or predicting kidney disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3761034A3 (en) * 2011-01-26 2021-02-17 University of Pittsburgh - Of the Commonwealth System of Higher Education Urine biomarkers for prediction of recovery after acute kidney injury: proteomics
US20140329334A1 (en) * 2011-09-22 2014-11-06 Universidad de losAndes Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120156701A1 (en) * 2009-12-20 2012-06-21 Joseph Anderberg Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20140038203A1 (en) * 2012-07-09 2014-02-06 Musc Foundation For Research Development Methods for detecting or predicting kidney disease

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHARLESA.DINARELLO ET AL: "Interleukin-18 and IL-18 binding protein", 《FRONTIER IN IMMUNOLOGY》 *
CHIRAG R.PARIKH ET AL: "Urine IL-18 Is an Early Diagnostic Marker for Acute Kidney Injury and Predicts Mortality in the Intensive Care Unit", 《J AM SOC NEPHROL》 *
DONG LIANG，ET AL: "Imbalance of Interleukin 18 and Interleukin 18 Binding Protein in Patients with Lupus Nephritis", 《CELLULAR & MOLECULAR IMMUNOLOGY》 *
G. LONNEMANN ET AL: "lnterleukin-18，interleukin-18 binding protein and impaired production of interferon-y in chronic renal failure", 《CLINICAL NEPHROLOGY》 *
JUN WANG，ET AL: "PROTECTIVE EFFECTS OF EXOGENOUS INTERLEUKIN 18-BINDING PROTEIN IN A RAT MODEL OF ACUTE RENAL ISCHEMIA-REPERFUSION INJURY", 《SHOCK》 *
YAWEI LIU ET AL: "Urinary Interleukin 18 for Detection of Acute Kidney Injury: A Meta-analysis", 《AJKD》 *
ZHIBIN HE，ET AL: "Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury", 《AM J PHYSIOL RENAL PHYSIOL》 *
傅奕 等: "白介素18结合蛋白研究进展", 《生命科学》 *
董孟华 等: "IL-18及其结合蛋白与原发性肾病综合征", 《现代中西医结合杂志》 *

Also Published As

Publication number Publication date
EP3218724A4 (en) 2018-08-22
EP3218724A1 (en) 2017-09-20
JP2017534874A (ja) 2017-11-24
WO2016077484A1 (en) 2016-05-19
US20170315134A1 (en) 2017-11-02

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