CN107001433A - 芋螺毒素肽κ‑CPTx‑btl03、其制备方法及应用 - Google Patents

芋螺毒素肽κ‑CPTx‑btl03、其制备方法及应用 Download PDF

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CN107001433A
CN107001433A CN201480083954.1A CN201480083954A CN107001433A CN 107001433 A CN107001433 A CN 107001433A CN 201480083954 A CN201480083954 A CN 201480083954A CN 107001433 A CN107001433 A CN 107001433A
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cptx
conotoxin peptide
amino acid
replaced
polypeptide
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CN107001433B (zh
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刘杰
林志龙
闻博
童婷
莫芬
彭超
石琼
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Shenzhen Huada Sansheng Garden Technology Co ltd
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07—ORGANIC CHEMISTRY
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

提供了一种芋螺毒素肽κ‑CPTx‑btl03及其衍生多肽，所述芋螺毒素肽的氨基酸序列如SEQ ID NO:1所示。还提供了所述芋螺毒素肽的制备方法及其在治疗钙离子通道相关疾病中的应用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201480083954.1A 2014-12-26 2014-12-26 芋螺毒素肽κ-CPTx-btl03、其制备方法及应用 Active CN107001433B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2014/095197 WO2016101276A1 (zh) 2014-12-26 2014-12-26 芋螺毒素肽κ-CPTx-btl03、其制备方法及应用

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CN107001433A true CN107001433A (zh) 2017-08-01
CN107001433B CN107001433B (zh) 2021-01-15

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US (1) US10556927B2 (zh)
EP (1) EP3252071B1 (zh)
CN (1) CN107001433B (zh)
WO (1) WO2016101276A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016049873A1 (zh) * 2014-09-30 2016-04-07 深圳华大基因科技有限公司 芋螺毒素多肽κ-CPTx-btl03、其制备方法及应用
WO2016169028A1 (zh) * 2015-04-23 2016-10-27 深圳华大基因研究院 三种芋螺毒素肽、其制备方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0680696A (ja) * 1992-09-01 1994-03-22 Mitsubishi Kasei Corp 新規ペプチド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672682A (en) 1996-03-18 1997-09-30 University Of Utah Research Foundation Conotoxin peptide PVIIA
CN1169830C (zh) 1999-04-30 2004-10-06 解放军军事医学科学院生物工程研究所 芋螺毒素肽
US20040203132A1 (en) * 2003-02-28 2004-10-14 Cognetix, Inc. Conus protein disulfide isomerase
WO2015022575A2 (en) * 2013-08-13 2015-02-19 Auro Peptides Ltd A process for the preparation of gc-c agonist
WO2016049873A1 (zh) 2014-09-30 2016-04-07 深圳华大基因科技有限公司 芋螺毒素多肽κ-CPTx-btl03、其制备方法及应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0680696A (ja) * 1992-09-01 1994-03-22 Mitsubishi Kasei Corp 新規ペプチド

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ZHOU M 等: "Characterizing the evolution and functions of the M-superfamily conotoxins", 《TOXICON》 *
刘耕陶: "《当代药理学 第2版》", 31 May 2008, 中国协和医学大学出版社 *

Also Published As

Publication number Publication date
EP3252071A1 (en) 2017-12-06
WO2016101276A1 (zh) 2016-06-30
US20180162909A1 (en) 2018-06-14
EP3252071A4 (en) 2018-05-30
EP3252071B1 (en) 2019-11-20
CN107001433B (zh) 2021-01-15
US10556927B2 (en) 2020-02-11

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