CN106994006A - Bimodal imaging system - Google Patents
Bimodal imaging system Download PDFInfo
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- CN106994006A CN106994006A CN201710359058.9A CN201710359058A CN106994006A CN 106994006 A CN106994006 A CN 106994006A CN 201710359058 A CN201710359058 A CN 201710359058A CN 106994006 A CN106994006 A CN 106994006A
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- Prior art keywords
- light beam
- triangular prism
- angled triangular
- beam splitter
- imaging system
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- 238000003384 imaging method Methods 0.000 title claims abstract description 26
- 230000002902 bimodal effect Effects 0.000 title claims abstract description 13
- 239000000523 sample Substances 0.000 claims abstract description 17
- 230000001788 irregular Effects 0.000 claims abstract description 16
- 238000007654 immersion Methods 0.000 claims abstract description 15
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 6
- 229910052782 aluminium Inorganic materials 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 5
- 230000035945 sensitivity Effects 0.000 claims description 5
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 claims description 2
- 230000005622 photoelectricity Effects 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 108010054147 Hemoglobins Proteins 0.000 description 3
- 102000001554 Hemoglobins Human genes 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001427 coherent effect Effects 0.000 description 2
- SDIXRDNYIMOKSG-UHFFFAOYSA-L disodium methyl arsenate Chemical compound [Na+].[Na+].C[As]([O-])([O-])=O SDIXRDNYIMOKSG-UHFFFAOYSA-L 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 108010002255 deoxyhemoglobin Proteins 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 238000012014 optical coherence tomography Methods 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
Abstract
A kind of bimodal imaging system, including：The irregular right-angled triangular prism of LASER Light Source, light beam splitter, spectrometer, reference arm, microcobjective, a right-angle side provided with sound focusing groove, regular right-angled triangular prism, immersion type high-velocity scanning galvanometer and ultrasonic probe, wherein：LASER Light Source generation light beam sequentially passes through the iris diaphgram being arranged between LASER Light Source and light beam splitter, the first lens, pinhole diaphragm and the second lens and enters light beam splitter, reference arm is incided by a part of light beam after light beam splitter, another part light beam incides microcobjective formation focus on light beam by light beam splitter, the focus on light beam is projected after injecting the right-angle side of irregular right-angled triangular prism by another right-angle side provided with sound focusing groove, present system structure simplifies, increase the stability of a system, while the cost of the system of reduction.
Description
Technical field
The present invention relates to a kind of technology in micro-imaging field, specifically a kind of bimodal imaging system.
Background technology
Optical coherence micro-imaging (Optical coherence Microscopy, OCM) principle and optical coherence tomography
Imaging is similar, is all based on incident photon tissue back scattering light characteristic, detection biological tissue different depth aspect is to incident light
The back-reflection or scattering strength of son, so as to obtain the tissue microstructure information in the range of certain depth, and then pass through transverse direction
Scanning obtains the two dimension or three-dimensional structure information of biological tissue.Light differentiates opto-acoustic microscopic imaging (Optical-Resolution
Photoacoustic Microscopy, OR-PAM) absorber is mainly based upon in biological tissue to light absorbs distribution character, group
Knit and produce ultrasonic signal because absorbing luminous energy, detected by ultrasonic transducer, so as to obtain the morphology and function ginseng of absorber
The trickle change of number and pathological state image.
OCM imaging techniques, utilize the weak coherent interference signal of tissue scatter's photon, detection biological tissue inside different depth
Organize the back-reflection to incident photon or the change of scattering strength, using the teaching of the invention it is possible to provide high longitudinal resolution is imaged with high comparison structure,
But it can not provide the important capilary such as blood oxygen saturation, oxygen metabolism and blood oxygen protein content important functional parameter letter
Breath.OR-PAM it based on light absorbs of the important composition composition oxygen hemoglobin and deoxyhemoglobin in blood to different-waveband
The difference of coefficient, can be achieved effective ad-hoc location functional imaging and quantifies the related hemoglobin concentration of metabolism, SO2And
The crucial neurological progression parameter index in clinical diagnosis such as total hemoglobin concentration is measured.
The content of the invention
The present invention can not realize the living animal high-resolution imaging of a wide range of high speed for prior art, and sub- imaging system is
Optical coherent chromatographic imaging, is imaged to capilary and especially laterally differentiates presence in the capillary detection of tumor development early stage
Wretched insufficiency, proposes a kind of bimodal imaging system.
The present invention is achieved by the following technical solutions：
The present invention includes：LASER Light Source, light beam splitter, spectrometer, reference arm, microcobjective, a right-angle side are provided with sound
Irregular right-angled triangular prism, regular right-angled triangular prism, immersion type high-velocity scanning galvanometer and the ultrasonic probe of groove are focused on, its
In：The inclined-plane of irregular right-angled triangular prism and regular right-angled triangular prism is bonding, irregular right-angled triangular prism and rule
Between two inclined-planes of right-angled triangular prism be provided with aluminum membranous layer, ultrasonic probe with rule the right-angle side of right-angled triangular prism one fit and with
Sound focusing groove is relative, LASER Light Source produce light beam sequentially pass through be arranged between LASER Light Source and light beam splitter can darkening
Door screen, the first lens, pinhole diaphragm and the second lens enter light beam splitter, incident by a part of light beam after light beam splitter
To reference arm, another part light beam incides microcobjective formation focus on light beam by light beam splitter, and the focus on light beam is injected
Projected after the right-angle side of irregular right-angled triangular prism by another right-angle side provided with sound focusing groove and enter immersion type at a high speed
Scanning galvanometer is scanned to object, and the ultrasonic signal that body surface is produced is through immersion type high-velocity scanning galvanometer, sound focusing groove
Collected with after regular right-angled triangular prism by ultrasonic probe, the rear orientation light that body surface is produced is returned with referring to along original optical path
Light beam, which is combined, in arm produces interference signal, and interference signal incides spectrometer through light beam splitter.
The first speculum and photoelectric detector are provided between the second described lens and light beam splitter, the first speculum will
A part after second lens emergent light beam splitting injects photoelectric detector.
Described reference arm includes condenser lens, the first fiber coupler and the second speculum set gradually.
The light beam maximum impulse energy that described LASER Light Source is sent is more than 20 μ J, and repetition rate is more than 5KHz, and pulse is wide
Degree is less than 10ns.
The centre frequency of described ultrasonic probe is more than 30MHz, and -6dB bands are wider than 50%, and sensitivity is more than -220dB,
Delay line is 4.25 μ s.
Described regular right-angled triangular prism and right angle all sides of irregular right-angled triangular prism are more than 15mm, and hypotenuse is all big
In 21.2mm.
A diameter of 9mm of described sound focusing groove, radius of curvature is more than 7.07mm, and central depths are more than 2.2mm.
The working frequency fast axle of described immersion type high-velocity scanning galvanometer is more than 25KHz, and slow axis is more than 2KHz, and its minute surface is straight
Footpath is more than 1mm, and the vibration period is more than 10-11s。
Technique effect
Compared with prior art, present system structure simplifies, and increases the stability of a system, while the cost of the system of reduction,
The use operation of commercialization and user for system is all highly beneficial, effectively reduces the decay during acoustic wave transmission,
System is more integrated, and light has arrived coaxial purpose with sodar, substantially increases signal to noise ratio and the sensitivity of the detection of system, and
The transmission of light and sound, scanning and transmission are combined in a system.
Brief description of the drawings
Fig. 1 is schematic structural view of the invention；
Fig. 2 schemes for imaging contrast；
In figure：(a) it is imaged for common unit；(b) it is present invention imaging；
In figure：1 LASER Light Source, 2 iris diaphgrams, 3 first lens, 4 pinhole diaphragms, 5 second lens, 6 first speculums, 7
Photoelectric detector, 8 light beam splitters, 9 condenser lenses, 10 first fiber couplers, 11 second speculums, the micro- thing in 12 large apertures
Mirror, 13 irregular right-angled triangular prisms, 14 regular right-angled triangular prisms, 15 aluminum membranous layers, 16 immersion type high-velocity scanning galvanometers, 17 sound
Focus on groove, 18 ultrasonic signals, 19 tanks, 20 ultrasonic probes, 21 signal amplifiers, 22 control collection computers, 23 spectrometers, 24
Second fiber coupler, 25 focusing objective lens.
Embodiment
As shown in figure 1, the present embodiment includes：LASER Light Source 1, light beam splitter 8, spectrometer 23, reference arm, large aperture show
The irregular right-angled triangular prism 13 of speck mirror 12, a right-angle side provided with sound focusing groove 17, regular right-angled triangular prism 14, water
Immersion high-velocity scanning galvanometer 16 and ultrasonic probe 20, wherein：Irregular right-angled triangular prism 13 and regular right-angled triangular prism 14
Inclined-plane it is bonding, aluminum membranous layer is provided between two inclined-planes of irregular right-angled triangular prism 13 and regular right-angled triangular prism 14
15, ultrasonic probe 20 is fitted and relative with sound focusing groove 17 with the regular right-angle side of right-angled triangular prism 14 1, and LASER Light Source 1 is produced
Third contact of a total solar or lunar eclipse beam sequentially passes through the iris diaphgram 2 being arranged between LASER Light Source 1 and light beam splitter 8, the first lens 3, pinhole diaphragm 4
Enter light beam splitter 8 with the second lens 5, reference arm, another part are incided by a part of light beam after light beam splitter 8
Light beam sequentially passes through light beam splitter 8 and incides the formation focus on light beam of large aperture microcobjective 12, and the focus on light beam is injected and do not advised
Then projected after the right-angle side of right-angled triangular prism 13 by another right-angle side provided with sound focusing groove 17 and enter immersion type at a high speed
Scanning galvanometer 16 is scanned to object, and the ultrasonic signal 18 that body surface is produced gathers through immersion type high-velocity scanning galvanometer 16, sound
Collected after burnt groove 17 and regular right-angled triangular prism 14 by ultrasonic probe 20, the former light in rear orientation light edge that body surface is produced
Road, which is returned, is combined generation interference signal with light beam in reference arm, and interference signal incides spectrometer 23 through light beam splitter 8.
The first speculum 6 and photoelectric detector 7, the first reflection are provided between the second described lens 5 and light beam splitter 8
Mirror 6 will be partly into photoelectric detector 7 after the emergent light beam splitting of second lens 5.The focusing that reference arm includes setting gradually is saturating
Mirror 9, the first fiber coupler 10 and the second speculum 11.Focusing objective len is sequentially provided between light beam splitter 8 and spectrometer 23
25 and second fiber coupler 24.
Described immersion type high-velocity scanning galvanometer 16, regular right-angled triangular prism 14, the and of irregular right-angled triangular prism 13
Ultrasonic probe 20 is all immersed in tank 19.
The light beam maximum impulse energy that described LASER Light Source 1 is sent is more than 20 μ J, and repetition rate is more than 5KHz, and pulse is wide
Degree is less than 10ns, it is possible to provide wavelength is 500~980nm wide range wave bands.The centre frequency of ultrasonic probe 20 is more than 30MHz, -6dB
Band is wider than 50%, and sensitivity is more than -220dB, and delay line is 4.25 μ s.Regular right-angled triangular prism 14 and irregular right angle three
The right angle of angle prism 13 all sides are more than 15mm, and hypotenuse is both greater than 21.2mm.A diameter of 9mm of sound focusing groove 17, radius of curvature
More than 7.07mm, central depths are more than 2.2mm.The working frequency fast axle of immersion type high-velocity scanning galvanometer 16 is more than 25KHz, slow axis
More than 2KHz, its minute surface diameter is more than 1mm, and the vibration period is more than 10-11S, the optics that can obtain 80 ° sweeps angle.
The ultrasonic signal that described ultrasonic probe 20 is collected is transferred to control collection computer 22, spectrum through signal amplifier 21
The interference signal that instrument 23 is gathered is also communicated to control collection computer 22, and two and three dimensions bimodulus is rebuild in control collection computer 22
State microstructure function image.
As shown in Fig. 2 the present apparatus can realize the shallow superficial disease Angiogenesis imaging of quick live body, imaging is than common dress
It is set to as relatively sharp, letter is pushed away significantly and has entered the technology in pre- clinical Transformation Application process.Water exists as acoustical signal transmission medium
Optoacoustic system is all present, therefore acoustical signal is in theory only through quartz glass and the transmission of aluminium film secondary interface i.e. to probe circle in the design
Face, according to acoustical signal is incident and refraction angle, the acoustic impedance of aluminium film and quartz glass, the transmissivity of sound wave in this design is
97.5%, 95% detection efficient can be still obtained after being transmitted after secondary, sensitivity improves about 12.3%.
Compared with prior art, present apparatus system architecture simplifies, and increases the stability of a system, while the cost of the system of reduction,
The use operation of commercialization and user for system is all highly beneficial, effectively reduces the decay during acoustic wave transmission,
System is more integrated, and light and sodar have arrived the purpose of coaxial concentric, substantially increases the signal to noise ratio of the detection of system and sensitive
Degree, and the transmission, scanning and transmission of light and sound are integrated in a system.
Above-mentioned specific implementation can by those skilled in the art on the premise of without departing substantially from present apparatus principle and objective with difference
Mode local directed complete set is carried out to it, the protection domain of the present apparatus is defined by claims and not by above-mentioned specific implementation institute
Limit, each implementation in the range of it is by the constraint of the present apparatus.
Claims (8)
1. a kind of bimodal imaging system, it is characterised in that including：It is LASER Light Source, light beam splitter, spectrometer, reference arm, aobvious
The irregular right-angled triangular prism of speck mirror, a right-angle side provided with sound focusing groove, regular right-angled triangular prism, immersion type are at a high speed
Scanning galvanometer and ultrasonic probe, wherein：The inclined-plane of irregular right-angled triangular prism and regular right-angled triangular prism is bonding, does not advise
Aluminum membranous layer, ultrasonic probe and regular right angle trigonometry are then provided between two inclined-planes of right-angled triangular prism and regular right-angled triangular prism
The right-angle side of prism one is fitted and relative with sound focusing groove, and LASER Light Source generation light beam, which is sequentially passed through, is arranged at LASER Light Source and light
Iris diaphgram, the first lens, pinhole diaphragm and the second lens between light beam splitter enter light beam splitter, pass through light beam light splitting
A part of light beam after mirror incides reference arm, and another part light beam incides microcobjective formation focusing by light beam splitter
Light beam, the focus on light beam is penetrated after injecting the right-angle side of irregular right-angled triangular prism by another right-angle side provided with sound focusing groove
Go out and enter immersion type high-velocity scanning galvanometer and object is scanned, the ultrasonic signal that body surface is produced is swept at a high speed through immersion type
Collected after retouching galvanometer, sound focusing groove and regular right-angled triangular prism by ultrasonic probe, the rear orientation light that body surface is produced
Returned along original optical path and generation interference signal is combined with light beam in reference arm, interference signal incides spectrometer through light beam splitter.
2. bimodal imaging system according to claim 1, it is characterized in that, the second described lens and light beam splitter it
Between be provided with the first speculum and photoelectric detector, the first speculum by after the second lens emergent light beam splitting a part inject photoelectricity
Detector.
3. bimodal imaging system according to claim 2, it is characterized in that, described reference arm is poly- including what is set gradually
Focus lens, the first fiber coupler and the second speculum.
4. bimodal imaging system according to claim 1, it is characterized in that, the light beam that described LASER Light Source is sent is maximum
Pulse energy is more than 20 μ J, and repetition rate is more than 5KHz, and pulse width is less than 10ns.
5. bimodal imaging system according to claim 1, it is characterized in that, the centre frequency of described ultrasonic probe is more than
30MHz, -6dB band are wider than 50%, and sensitivity is more than -220dB, and delay line is 4.25 μ s.
6. bimodal imaging system according to claim 1, it is characterized in that, described regular right-angled triangular prism and do not advise
Then the right angle of right-angled triangular prism all sides are more than 15mm, and hypotenuse is both greater than 21.2mm.
7. bimodal imaging system according to claim 6, it is characterized in that, a diameter of 9mm of described sound focusing groove,
Radius of curvature is more than 7.07mm, and central depths are more than 2.2mm.
8. bimodal imaging system according to claim 1, it is characterized in that, the work of described immersion type high-velocity scanning galvanometer
Working frequency fast axle is more than 25KHz, and slow axis is more than 2KHz, and its minute surface diameter is more than 1mm, and the vibration period is more than 10-11s。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710359058.9A CN106994006A (en) | 2017-05-19 | 2017-05-19 | Bimodal imaging system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710359058.9A CN106994006A (en) | 2017-05-19 | 2017-05-19 | Bimodal imaging system |
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| Publication Number | Publication Date |
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| CN106994006A true CN106994006A (en) | 2017-08-01 |
Family
ID=59434832
Family Applications (1)
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|---|---|---|---|
| CN201710359058.9A Pending CN106994006A (en) | 2017-05-19 | 2017-05-19 | Bimodal imaging system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107677621A (en) * | 2017-10-11 | 2018-02-09 | 厦门大学 | The temperature measuring equipment of multispectral optical technology fusion |
| CN110367941A (en) * | 2019-08-20 | 2019-10-25 | 东北大学秦皇岛分校 | A kind of detection light fusion Noncontact optoacoustic-optical coherence tomography double-mode imaging system |
| CN110857908A (en) * | 2018-08-23 | 2020-03-03 | 天津大学 | Biological sample analysis and test system based on off-axis digital holographic microscopy and spectral analysis method |
| CN113552071A (en) * | 2021-08-26 | 2021-10-26 | 天津大学 | Photoacoustic imaging system |
| CN113686552A (en) * | 2021-08-26 | 2021-11-23 | 复旦大学 | Integrated measurement method and device for optical function of micro-lens array |
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| CN105769112A (en) * | 2016-03-30 | 2016-07-20 | 中国科学院上海光学精密机械研究所 | Optical probe for endoscopic imaging |
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| US5408093A (en) * | 1992-08-31 | 1995-04-18 | Hitachi, Ltd. | Optical computed tomography equipment having image inverting optical device |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107677621A (en) * | 2017-10-11 | 2018-02-09 | 厦门大学 | The temperature measuring equipment of multispectral optical technology fusion |
| CN110857908A (en) * | 2018-08-23 | 2020-03-03 | 天津大学 | Biological sample analysis and test system based on off-axis digital holographic microscopy and spectral analysis method |
| CN110367941A (en) * | 2019-08-20 | 2019-10-25 | 东北大学秦皇岛分校 | A kind of detection light fusion Noncontact optoacoustic-optical coherence tomography double-mode imaging system |
| CN110367941B (en) * | 2019-08-20 | 2022-01-28 | 东北大学秦皇岛分校 | Detection light fusion non-contact photoacoustic-optical coherence tomography dual-mode imaging system |
| CN113552071A (en) * | 2021-08-26 | 2021-10-26 | 天津大学 | Photoacoustic imaging system |
| CN113686552A (en) * | 2021-08-26 | 2021-11-23 | 复旦大学 | Integrated measurement method and device for optical function of micro-lens array |
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