CN106983523A - A kind of preparation method of dentistry implant and its alkalescent Nanosurface - Google Patents
A kind of preparation method of dentistry implant and its alkalescent Nanosurface Download PDFInfo
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- CN106983523A CN106983523A CN201710151956.5A CN201710151956A CN106983523A CN 106983523 A CN106983523 A CN 106983523A CN 201710151956 A CN201710151956 A CN 201710151956A CN 106983523 A CN106983523 A CN 106983523A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C13/00—Dental prostheses; Making same
- A61C13/0003—Making bridge-work, inlays, implants or the like
- A61C13/0006—Production methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C2201/00—Material properties
Abstract
The present invention relates to the preparation method of a kind of dentistry implant and its alkalescent Nanosurface, the dentistry implant is using medical titanium or titanium alloy as base material, nanotube pattern and uniform coated magnesium oxide film layer are prepared on its surface, a kind of dentistry implant of the weakly alkaline nano-structure bioactive composite surface of slow degraded release is obtained.The present invention aoxidizes to form uniform discrete nanotube-shaped oxide layer in titanium-based material surface in situ, to improve the hydrophily on surface, and by steps such as immersion, sintering, to the uniform coated magnesium oxide film layer of nanotube walls.The dentistry implant be implanted into oral cavity after by the slow degraded of magnesia film layer, obtain weakly alkaline local environment, can strengthen Gegenbaur's cell implant surface propagation, sprawl and alkaline phosphatase activities, accelerate the speed of planting body early stage Integrated implant, so as to improve the stability and success rate of planting body.
Description
Technical field
The present invention relates to dentistry implant Material Field, more particularly to a kind of system of alkalescent Nanosurface dentistry implant
Preparation Method.
Background technology
Medical titanium and its alloy are during Clinical practice, due to being widely used for referring to quilt with good biocompatibility
Dentistry implant.But the biologically inert surface of titanium is difficult to be combined with the chemical key of bone tissue generation, in planting body and biological tissue
Interface easily forms fibr tissue interlayer, loosens implant, causes titanium dentistry implant material graft failure.
The biocompatibility and Integrated implant of dentistry implant material are how improved, is to improve dentistry plantation to repair success rate
The problem of firstly the need of solving.Suitable dentistry implant should not only have the mechanical property close to bone tissue, as relatively low
Modulus of elasticity, corrosion resistance, high specific strength etc., while should be needed to improve surface bioactive according to clinical practice.Cause
This, in order to obtain good bioactivity to reach excellent Integrated implant effect, shortens the Integrated implant cycle, raising is planted successfully
Rate, is very important by dentistry implant surface modification treatment with obtaining good osteogenic ability.
The Research on Surface Modification to planting body concentrates on two aspects at present, and one is to change surface topography, and two be excellent
Change surface chemical composition.Wherein remained in for the research that surface chemical composition is modified has simply by introducing to skeletonization
The element of benefit（Such as Ca, P, Sr, Zn）, or the organic biological active components such as protein, polypeptide are introduced, complex disposal process,
And for promoting the specific aim of cell Osteoblast Differentiation poor.Bio-medical material is to be functioned in biotic environment and can be with life
Thing system interaction, this requires the surface of titanium implant material to be modified, and not only to pay close attention to the chemical composition of superficial layer, power
Performance is learned, the cross reaction between its superficial layer and fluid environment and cell is also increasingly focused on, from structure implant material
Material surface promotes the microcell environment of skeletonization to set out, and shortens the combination cycle of planting body and surrounding tissue.
The content of the invention
In order to solve above-mentioned deficiency, the ability that dentistry implant forms bioconjugation with mandibular organization is improved, promotes surface
Bone tissue mineralising, the present invention provides a kind of dentistry implant and its system with alkalescent nano-structure bioactive composite surface
Preparation Method, and preparation method can be applied to the implant surface of any shape, it is slow after implantation to degrade and obtain alkalescent
Local environment, strengthen Gegenbaur's cell implant surface propagation, sprawl and alkaline phosphatase activities, accelerate planting body early
The speed of phase Integrated implant, so as to improve the stability and success rate of planting body.
The application is realized by herein below：
A kind of dentistry implant, the dentistry implant has alkalescent Nanosurface, and the alkalescent Nanosurface is degradable,
It is slow after dentistry implant implantation to degrade and obtain weakly alkaline local environment, strengthen increasing of the Gegenbaur's cell in implant surface
Grow, sprawl and alkaline phosphatase activities, accelerate planting body early stage Integrated implant speed so that improve planting body stability and
Success rate.The alkalescent refers to that PH is 8 ~ 8.5.
Further, the dentistry implant includes the titania nanotube that titanium-based material and its surface in situ are sequentially formed
Film layer, and the uniform magnesia film layer for coating nanometer inside pipe wall.
Further, the titanium-based material is medical pure titanium or titanium alloy.
Further, the titania nanotube film layer is made up of the titanium dioxide of anatase crystal, and thickness is 1 ~ 2 μ
M, a diameter of 30 ~ 100 nm of nanotube.
Further, the magnesia film layer for being uniformly wrapped on nano tube structure, thicknesses of layers is 10 ~ 40 nm.
Nanostructured surface, such as nano-tube array, its nanotube caliber size and pipe range will be to its biocompatibility, corrosion resistants
Corrosion, biological friction performance produce important influence.In vitro test is confirmed, due to the pattern of nanotube rough porous, compared to
General surface layer can effectively increase crystal surface product, be adsorbed onto more Ca2+、PO4 3-, improve induction hydroxyapatite surface
The ability of deposition, strengthens the bond strength at interface, so as to promote Gegenbaur's cell in its surface adhesion, growth.
Dentistry implant material is inevitably degraded simultaneously can locally build one different from physiology in bone regeneration around implant
The microenvironment of condition, its neutral and alkali microenvironment is significant to skeletonization, and with the raising of alkalescence, osteoblast activity is gradually stepped up
While osteoclast activity be suppressed, and pH be 8 ~ 8.5 when with optimal osteogenic differentiation activity, contribute to bone group
Knit mineralising.
The present invention also provides a kind of technical scheme for preparing dentistry implant：
A kind of method for preparing above-mentioned dentistry implant, methods described comprises the following steps：
In-situ oxidation：Anodized is carried out to medical Titanium base, surface in situ oxidation is made surface and forms nano tube structure
Titanium deoxid film titanium-based material dentistry implant；
Coated magnesium oxide presoma：Titanium-based material dentistry implant after anodized is soaked in ethylenediamine tetra-acetic acid successively
Solution is with magnesium nitrate solution, obtaining the chelate containing magnesium of the nanotube-shaped oxide layer of cladding, i.e. magnesia presoma；
Sintering：Dentistry implant after coated magnesium oxide presoma is placed in sintering furnace and heated, obtaining surface has magnesia
The dentistry implant of the titania nanotube of cladding.
Further, the in-situ oxidation is specially：Using constant voltage DC mode, operating voltage is 10 ~ 40 V, during oxidation
Between be 2 ~ 5 h, reaction temperature is room temperature, and electrolyte is the glycerin solution containing 0.5 ~ 1 wt% ammonium fluorides and 2 ~ 50 vol% water.
Further, the coated magnesium oxide presoma step is specially：Dentistry implant after in-situ oxidation is complete
In the ammonia spirit for being immersed in 0.5 ~ 1.25 mol/L ethylenediamine tetra-acetic acids, convolution 10 ~ 30 min of concussion will be abundant in nanotube
Infiltrate edta solution, be then completely soaked in 5 ~ 8 mol/L magnesium nitrate solutions 60 ~ 80 DEG C of hot baths immersions 10 ~
30 min。
Further, the sintering step is specially：By the tooth implant after coated magnesium oxide, with 5 DEG C/min heating
Speed is placed in 450 ~ 500 DEG C of 3 ~ 4 h of calcining in Muffle furnace, and room temperature is then naturally cooled in stove.
Beneficial effects of the present invention：
1. dentistry implant surface in situ that the present invention is provided grows orderly tubular nanostructures, be significantly greatly increased surface roughness with
And surface area, and retain its special degradable alkaline uniform alumina magnesium layer of tubulose structural load, slow down the degraded of magnesium oxide layer
Release, so as to obtain local high magnesium density and micro- alkali environment after the implantation, stimulates ostosis, improves osteoblast adhesion
Rate, the osteoclast activity that suppresses, the combination of promotion bone-material interface not only contribute to bone fixation, can also promote knitting.
2. the invention provides a kind of simple process for treating surface scheme, have by anodic oxidation in surface in situ growth
Sequence nanotube oxide layer, and by controlling water content and oxidization time realization in oxidation voltage, electrolyte straight to nanotube
Footpath and the control of length, by simply soaking and heat treatment process, nanotube are uniformly coated the alkaline oxygenated magnesium of loading
Layer, is applicable to the implant surface of any shape.
Brief description of the drawings
Fig. 1 is the structure route schematic diagram of dentistry implant alkalescent Nanosurface in the present invention；
Fig. 2 is the nano tube structure pattern of dentistry implant surface after Anodic Oxidation of the present invention（a、b）, dentistry kind of the invention
Implant alkaline nano layer surface microscopic appearance（c）And its composition power spectrum（d）；
Fig. 3 is the medical titanium substrate surface that uses in the present invention（a）, the nanotube surface obtained by anodic oxidation（b）, and
The alkaline nano layer surface that the present invention finally gives（c）Hydrophilic angle photo；
Fig. 4 is that the surface mouse skeletonization respectively obtained successively after medical titanium base material and anodized, alkaline layer cladding is thin
Cell after born of the same parents MC3T3-E1 is cultivated 1 day, 3 days, 7 days is bred（a）With alkaline phosphatase activities（b）As a result；
Fig. 5 is mouse bone-forming cell MC3T3-E1 respectively in medical titanium base material（a）And anodized（b）, alkaline layer bag
Cover（c）The cellular morphology fluorescent staining picture of 3 days is cultivated on the surface obtained afterwards, and nucleus, flesh are observed respectively by fluorescent staining
The form of filamentous actin and vinculin.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.In addition, it is to be understood that after the content of the invention lectured has been read, people in the art
Member can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Scope.
Embodiment 1
A kind of dentistry implant, its surface is handled by the following method：
（1）From medical pure-titanium tooth implantation as matrix, and carry out surface clean：Sequentially pass through acetone, absolute ethyl alcohol, go from
Sub- water is respectively cleaned by ultrasonic 15 minutes, spontaneously dries；
（2）Configure anodic oxidation electrolyte：The electrolyte used is the aqueous glycerin solution of ammonium fluoride, wherein ammonium fluoride quality
Fraction is 0.5 wt%, and the volume fraction of water is 2 vol%；
（3）Anodizing prepares uniform titania nanotube film layer：Using constant voltage DC anodizing technology, step（1）
Pure-titanium tooth implantation after cleaning is anode, and graphite electrode or platinum plate electrode are negative electrode, are put into step（2）The electrolyte of configuration
It is interior；Operating voltage is 20 V, and oxidization time is 3 hours, and reaction temperature is room temperature, is then cleaned by ultrasonic 30s in alcohol, and
Rinse, spontaneously dry in deionized water；
（4）1mol/L edta solution is configured with ammoniacal liquor, by step（3）Tooth implant after processing is fully immersed in
In the ammonia spirit of ethylenediamine tetra-acetic acid, convolution 30 min of concussion then exist side by side planting body vertical immersion in deionized water
Take out, to remove the unnecessary edta solution of adsorption；
（5）8 mol/L magnesium nitrate solution is configured with deionized water, by step（4）Dentistry implant after processing is totally submerged
In magnesium nitrate solution, and hot bath is heated to 60 DEG C, 30 min is soaked, then by planting body vertical immersion in deionized water
And take out immediately；
（6）By step（5）Tooth implant after processing is placed in Muffle furnace 500 DEG C and calcined 3 hours, and naturally cold with stove in stove
But to room temperature, that is, the dentistry implant in the present invention with alkalescent Nanosurface is obtained.
The pH value test on dentistry implant surface is detected that test shows by pH test paper and thymol blue indicator
By step（6）After processing, the acid-base value of implant surface is changed into obvious alkalescent by neutrality, and its pH value is about 8.0；
Fig. 2（a）（b）For through step（3）Obtained dentistry implant surface topography map.Dentistry implant surface is advised as seen from the figure
Then solid matter nano tube structure；Fig. 2（c）For the dentistry implant surface topography map finally obtained.It is observed that dentistry implant
The nano tube structure of coated with uniform magnesium oxide layer；Fig. 2（d）For the dentistry implant surface EDS power spectrum compositions finally obtained
Analysis chart.It can be seen that surface composition with titanium from power spectrum result（Ti）, magnesium（Mg）, oxygen（O）Based on element；
Fig. 3 is that dentistry implant passes through step（1）（3）With（6）After processing, the water contact angle on the surface obtained successively（a~c）.Say
Bright nano surface tubular structure drastically increases implant surface hydrophily, is conducive to the phase interaction of planting body and fluid environment
With；
Fig. 4 is in medical titanium base material and passes through step（3）With（6）The surface mouse bone-forming cell MC3T3- respectively obtained successively afterwards
E1 cultivate 1 day, 3 days, 7 days after cell proliferative conditions（a）And alkaline phosphatase activities result（b）.Its alkaline phosphatase
It is the product of cell osteogenic differentiation process, is usually used in illustrating the osteogenic activity of cell.In figure after visible long-term superficial cell culture,
The cell proliferating number and alkaline phosphatase activities on the dentistry implant surface finally obtained are above pure titanium control group, show this
Implant surface is conducive to cell to stick and Osteoblast Differentiation in the propagation of implant surface in invention；
Fig. 5 is mouse bone-forming cell MC3T3-E1 respectively in medical titanium base material（a）And pass through step（3）With（6）Obtained tooth
Section's implant surface（b、c）The cellular morphology fluorescent staining picture of culture 3 days.Contrast can be observed compared with variant surface, most
The dentistry implant superficial cell obtained eventually, which has, significantly sprawls stretching form, i.e., by the spindle point of analogy osteoblast initial state
The Gegenbaur's cell form of maturation is turned to, while the more filopodia of the expression display of actin stretches, and in filopodia
Place is expressed with higher vinculin, and showing the alkalescent Nanosurface of planting body can stimulate mouse bone-forming cell MC3T3-E1's
Osteoblast Differentiation is grown up and contributes to the filopodia of cell adherence to grow.
Embodiment 2
A kind of dentistry implant, its surface is handled by the following method：
（1）From medical pure-titanium tooth implantation as matrix, and carry out surface clean：Sequentially pass through acetone, absolute ethyl alcohol, go from
Sub- water is respectively cleaned by ultrasonic 15 minutes, spontaneously dries；
（2）Configure anodic oxidation electrolyte：The electrolyte used is the aqueous glycerin solution of ammonium fluoride, wherein ammonium fluoride quality
Fraction is 1.0 wt%, and the volume fraction of water is 25 vol%；
（3）Anodizing prepares uniform titania nanotube film layer：Using constant voltage DC anodizing technology, step（1）
Pure-titanium tooth implantation after cleaning is anode, and graphite electrode or platinum plate electrode are negative electrode, are put into step（2）The electrolyte of configuration
It is interior；Operating voltage is 30 V, and oxidization time is 4 hours, and reaction temperature is room temperature, is then cleaned by ultrasonic 30s in alcohol, and
Rinse, spontaneously dry in deionized water；
（4）1mol/L edta solution is configured with ammoniacal liquor, by step（3）Tooth implant after processing is fully immersed in
In the ammonia spirit of ethylenediamine tetra-acetic acid, convolution 30 min of concussion then exist side by side planting body vertical immersion in deionized water
Take out, to remove the unnecessary edta solution of adsorption；
（5）6 mol/L magnesium nitrate solution is configured with deionized water, by step（4）Dentistry implant after processing is totally submerged
In magnesium nitrate solution, and hot bath is heated to 80 DEG C, 30 min is soaked, then by planting body vertical immersion in deionized water
And take out immediately；
（6）By step（5）Tooth implant after processing is placed in Muffle furnace 450 DEG C and calcined 3 hours, and naturally cold with stove in stove
But to room temperature, that is, the dentistry implant in the present invention with alkalescent Nanosurface is obtained.
Embodiment 3
A kind of dentistry implant, its surface is handled by the following method：
（1）From medical pure-titanium tooth implantation as matrix, and carry out surface clean：Sequentially pass through acetone, absolute ethyl alcohol, go from
Sub- water is respectively cleaned by ultrasonic 15 minutes, spontaneously dries；
（2）Configure anodic oxidation electrolyte：The electrolyte used is the aqueous glycerin solution of ammonium fluoride, wherein ammonium fluoride quality
Fraction is 0.5 wt%, and the volume fraction of water is 50 vol%；
（3）Anodizing prepares uniform titania nanotube film layer：Using constant voltage DC anodizing technology, step（1）
Pure-titanium tooth implantation after cleaning is anode, and graphite electrode or platinum plate electrode are negative electrode, are put into step（2）The electrolyte of configuration
It is interior；Operating voltage is 40 V, and oxidization time is 3 hours, and reaction temperature is room temperature, is then cleaned by ultrasonic 30s in alcohol, and
Rinse, spontaneously dry in deionized water；
（4）0.5 mol/L edta solution is configured with ammoniacal liquor, by step（3）Tooth implant after processing soaks completely
Bubble is in the ammonia spirit of ethylenediamine tetra-acetic acid, convolution 20 min of concussion, then by planting body vertical immersion in deionized water
And take out immediately, to remove the unnecessary edta solution of adsorption；
（5）4 mol/L magnesium nitrate solution is configured with deionized water, by step（4）Dentistry implant after processing is totally submerged
In magnesium nitrate solution, and hot bath is heated to 60 DEG C, 20 min is soaked, then by planting body vertical immersion in deionized water
And take out immediately；
（6）By step（5）Tooth implant after processing is placed in Muffle furnace 500 DEG C and calcined 4 hours, and naturally cold with stove in stove
But to room temperature, that is, the dentistry implant in the present invention with alkalescent Nanosurface is obtained.
Embodiment 4
A kind of dentistry implant, its surface is handled by the following method：
（1）From medical pure-titanium tooth implantation as matrix, and carry out surface clean：Sequentially pass through acetone, absolute ethyl alcohol, go from
Sub- water is respectively cleaned by ultrasonic 15 minutes, spontaneously dries；
（2）Configure anodic oxidation electrolyte：The electrolyte used is the aqueous glycerin solution of ammonium fluoride, wherein ammonium fluoride quality
Fraction is 1.0 wt%, and the volume fraction of water is 2 vol%；
（3）Anodizing prepares uniform titania nanotube film layer：Using constant voltage DC anodizing technology, step（1）
Pure-titanium tooth implantation after cleaning is anode, and graphite electrode or platinum plate electrode are negative electrode, are put into step（2）The electrolyte of configuration
It is interior；Operating voltage is 10 V, and oxidization time is 4 hours, and reaction temperature is room temperature, is then cleaned by ultrasonic 30s in alcohol, and
Rinse, spontaneously dry in deionized water；
（4）1.5 mol/L edta solution is configured with ammoniacal liquor, by step（3）Tooth implant after processing soaks completely
Bubble is in the ammonia spirit of ethylenediamine tetra-acetic acid, convolution 10 min of concussion, then by planting body vertical immersion in deionized water
And take out immediately, to remove the unnecessary edta solution of adsorption；
（5）8 mol/L magnesium nitrate solution is configured with deionized water, by step（4）Dentistry implant after processing is totally submerged
In magnesium nitrate solution, and hot bath is heated to 80 DEG C, 30 min is soaked, then by planting body vertical immersion in deionized water
And take out immediately；
（6）By step（5）Tooth implant after processing is placed in Muffle furnace 500 DEG C and calcined 3 hours, and naturally cold with stove in stove
But to room temperature, that is, the dentistry implant in the present invention with alkalescent Nanosurface is obtained.
Claims (9)
1. a kind of dentistry implant, it is characterised in that the dentistry implant has alkalescent Nanosurface, the alkalescent is received
Rice surface is degradable, slow after dentistry implant implantation to degrade and obtain weakly alkaline local environment, strengthens Gegenbaur's cell and is planting
The propagation on implant surface, sprawl and alkaline phosphatase activities, accelerate the speed of planting body early stage Integrated implant, so as to improve plantation
The stability and success rate of body.
2. a kind of dentistry implant as claimed in claim 1, it is characterised in that the dentistry implant includes titanium-based material, titanium-based
Titania nanotube film layer, the magnesia film layer of uniform cladding titanium dioxide nano tube wall of material surface in situ formation.
3. a kind of dentistry implant as claimed in claim 2, it is characterised in that the titanium-based material is medical pure titanium or titanium alloy.
4. a kind of dentistry implant as claimed in claim 2, it is characterised in that the titania nanotube film layer is by anatase
The titanium dioxide composition of crystal formation, thickness is 1 ~ 2 μm, a diameter of 30 ~ 100 nm of nanotube.
5. a kind of dentistry implant as claimed in claim 2, it is characterised in that the thickness of the magnesia film layer is 10 ~ 40
nm。
6. a kind of preparation method of dentistry implant, it is characterised in that methods described comprises the following steps：
In-situ oxidation：Anodized is carried out to medical Titanium base, surface in situ oxidation is made surface and forms nano tube structure
Titanium deoxid film titanium-based material dentistry implant；
Coated magnesium oxide presoma：Titanium-based material dentistry implant after anodized is soaked in ethylenediamine tetra-acetic acid successively
Solution is with magnesium nitrate solution, obtaining the chelate containing magnesium of the nanotube-shaped oxide layer of cladding, i.e. magnesia presoma；
Sintering：Dentistry implant after coated magnesium oxide presoma is placed in sintering furnace and heated, obtaining surface has magnesia
The dentistry implant of the titania nanotube of cladding.
7. a kind of preparation method of dentistry implant as claimed in claim 6, it is characterised in that the in-situ oxidation is specially：
Using constant voltage DC mode, reaction temperature is room temperature, and electrolyte is the third three containing 0.5 ~ 1 wt% ammonium fluorides and 2 ~ 50 vol% water
Alcoholic solution.
8. a kind of preparation method of dentistry implant as claimed in claim 6, it is characterised in that the coated magnesium oxide presoma
Step is specially：Dentistry implant after in-situ oxidation is fully immersed in the ammoniacal liquor of 0.5 ~ 1.25 mol/L ethylenediamine tetra-acetic acids
In solution, convolution 10 ~ 30 min of concussion will fully infiltrate edta solution in nanotube, then be completely soaked in 5 ~ 8
10 ~ 30 min are soaked in 60 ~ 80 DEG C of hot baths in mol/L magnesium nitrate solutions.
9. a kind of preparation method of dentistry implant as claimed in claim 6, it is characterised in that the sintering step is specially：
By the tooth implant after coated magnesium oxide presoma, with 5 DEG C/min heating rate be placed in Muffle furnace 450 ~ 500 DEG C of calcinings 3 ~
4 h, then naturally cool to room temperature in stove.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467573A (en) * | 2020-04-21 | 2020-07-31 | 上海交通大学医学院附属第九人民医院 | Oral implant for preventing peri-implantitis |
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