CN106964057B

CN106964057B - Device for oral mucosa absorption of medicament, medicament and use method of device

Info

Publication number: CN106964057B
Application number: CN201710296680.XA
Authority: CN
Inventors: 张兴萍
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-04-28
Filing date: 2017-04-28
Publication date: 2020-12-22
Anticipated expiration: 2037-04-28
Also published as: CN106964057A

Abstract

The invention relates to a device for absorbing oral mucosa of a drug, which comprises a heat preservation bottle body, a cover body in threaded connection with the bottle mouth of the heat preservation bottle body, a thermometer and a pressurizing device arranged on the cover body, wherein the pressurizing device is provided with a pressure gauge; a pipette arranged in the cover body and the lower end of the pipette extends to the bottom of the heat preservation bottle body; the liquid outlet pipe is arranged on the cover body and communicated with the upper end of the liquid suction pipe, the hose is connected with the liquid outlet end of the liquid outlet pipe through a connector, and the liquid conveying pipe is connected with the hose through a three-way connector and is arranged on the oral mucosa; the air inlet pipe is arranged on the other connecting port of the three-way connecting plug and is provided with an air filter; a drip cup arranged on the transfusion tube and a flow rate regulating valve sleeved on the transfusion tube. Also relates to methods of use of the medicament and the device. The invention can improve the oral absorption rate of the medicine, the effective rate reaches about 80 percent, and the damage of the medicine to liver and kidney is reduced.

Description

Device for oral mucosa absorption of medicament, medicament and use method of device

Technical Field

The invention relates to a device for absorbing oral mucosa of a medicament, in particular to a device for absorbing oral mucosa of upper respiratory tract infection, and also relates to a medicament for the device and a using method of the device, and relates to the technical field of medical instruments.

Background

With the rapid development of biotechnology, peptides for treating upper respiratory tract infection are more and more widely applied as medicines in clinic, and corresponding preparation research is increasingly paid attention to. Most preparations are injections which bring inconvenience to patients, so that peptide oral preparations are intensively researched at home and abroad in recent years. The oral preparation is popular due to simple administration method, but the peptide drug is easy to be damaged and degraded by gastric acid and enzyme in gastrointestinal tract after being taken orally, is easy to be influenced by liver first-pass effect, is difficult to permeate gastrointestinal tract mucous membrane by macromolecular drug, and has low bioavailability and short half-life period. The peptide drugs have small molecular weight and can be absorbed by the epidermal cells of the oral cavity and the throat in a penetrating way, however, the temperature and the flow rate of the peptide drugs are key factors for ensuring the absorption rate, and at present, no device special for the peptide drugs is provided, so that how to improve the oral absorption stability and the oral bioavailability of the peptide drugs is a technical problem to be solved urgently at present, and no therapeutic drugs capable of being effectively absorbed by a human body exist aiming at the device.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides a special device for orally taking peptide drugs, which is stable in flow rate control, controllable in inlet temperature and high in absorption rate, and drugs matched with the device for use.

In order to solve the technical problems, the invention is realized by the following technical scheme:

a device for absorbing oral mucosa of medicine comprises a heat preservation bottle body, a cover body in threaded connection with the mouth of the heat preservation bottle body, a thermometer and a pressurizing device arranged on the cover body, wherein the pressurizing device is provided with a pressure gauge; a pipette arranged in the cover body and the lower end of the pipette extends to the bottom of the heat preservation bottle body; the liquid outlet pipe is arranged on the cover body and communicated with the upper end of the liquid suction pipe, the hose is connected with the liquid outlet end of the liquid outlet pipe through a connector, and the liquid conveying pipe is connected with the hose through a three-way connector and is arranged on the oral mucosa; the air inlet pipe is arranged on the other connecting port of the three-way connecting plug and is provided with an air filter; a drip cup arranged on the transfusion tube and a flow rate regulating valve sleeved on the transfusion tube.

Furthermore, the device also comprises a hook fixedly connected to the cover body.

Further, the temperature of the device is controlled to be 60-85 ℃, the pressure of the device is controlled to be 0.5-0.8Mpa, and the dripping speed is adjusted to be 60-70 drops per minute by the adjusting valve.

The invention relates to a medicine absorbed by oral mucosa and used for treating upper respiratory tract infection, which comprises 12 g of pithecellobium clypearia particles, 5-10 mg of loratadine, 50-100 mg of nimesulide particles and 6 g of small molecular peptide collagen solid beverage, and the medicine is mixed and dissolved by the medicine oral administration device.

The use method of the device comprises the following steps:

(1) dissolving the medicines into a heat-preservation bottle body by using 200 ml of warm water with the temperature of 80 ℃, and screwing down a cover body;

(2) the bottle body is hung at a high position, and the infusion tube is arranged on the oral mucosa;

(3) and opening the pressurizing device, controlling the pressure in the bottle through the pressure, enabling the liquid to enter the liquid outlet pipe from the liquid suction pipe through the meter, and simultaneously adjusting the dripping speed to be 60-70 drops per minute through the adjusting valve.

Compared with the prior art, the invention has the following advantages:

can be effectual carry the peptide medicine to the user oral cavity in, through observing its temperature, pressure and control its velocity of flow, guarantee that the medicine has suitable temperature and velocity of flow when entering the oral cavity, make oral cavity and throat inner wall can absorb by the at utmost, improve the oral absorptivity of peptide medicine. According to the invention, the pithecellobium clypearia granules, the loratadine, the nimesulide granules and the small molecular peptide collagen solid beverage are mixed, so that the medicine can be absorbed from oral mucosa, the effective rate reaches about 80%, and meanwhile, the first absorption of liver and kidney is avoided, and the damage of the medicine to the liver and kidney is reduced. The damage to the body is reduced under the condition of using less intravenous transfusion and less antibiotics; is convenient and time-saving, and saves a lot of medical expenses for patients.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.

As shown in fig. 1, the device for absorbing oral mucosa of drug in this embodiment comprises a heat-insulating bottle 1, a cover 2 screwed to the mouth of the heat-insulating bottle 1, a pipette 3 installed in the cover 2 and having a lower end extending to the bottom of the heat-insulating bottle 1, a liquid outlet pipe 4 disposed on the cover 2 and communicated with the upper end of the pipette 3, a hose 6 connected to the liquid outlet end of the liquid outlet pipe 4 via a connector 5, a fluid delivery pipe 8 connected to the hose 6 via a three-way connector 7, an air inlet pipe 10 installed on another connector of the three-way connector 7 and having an air filter 9, a drip cup 11 installed on the fluid delivery pipe 8, and a flow rate adjusting valve 12 sleeved on the fluid delivery pipe 8.

The medicine taking device also comprises a thermometer (not shown in the figure) which is arranged on the cover body 2 and is used for detecting the temperature in the heat preservation bottle body 1, the temperature of the medicine in the heat preservation bottle body 1 can be visually observed, and the medicine is taken orally when the temperature is in the optimal taking temperature range, so that the optimal absorption rate is ensured; and when the temperature is reduced and does not accord with the oral absorption requirement, the oral administration can be continued after heating, and the pressurizing device 13 is arranged on the cover body 2, the pressurizing device 13 is provided with a pressure gauge for detecting the pressure in the heat preservation bottle body 1, the pressure in the heat preservation bottle body 1 is observed through the pressure gauge, the stable conveying pressure in the heat preservation bottle body 1 is ensured, the fluctuation of the flow velocity caused by the pressure fluctuation in the heat preservation bottle body 1 is avoided, and the pressurizing device can be the existing inflating equipment and the like and can ensure the pressure in the bottle.

The surface of the cover body 2 is provided with anti-skid lines which are convenient for opening and closing the cover body 2, and the hook 14 fixedly connected on the cover body 2 is convenient for hanging and holding the heat preservation bottle body 1. As the preferred technical scheme, the heat preservation bottle body 1 adopts a stainless steel bottle body, so that the cleaning and the disinfection are convenient, and the aim of repeated use is fulfilled.

The drug for treating upper respiratory tract infection absorbed through oral mucosa comprises 12 g of pithecellobium clypearia particles, 8 mg of loratadine, 80 mg of nimesulide particles and 6 g of small molecule peptide collagen solid beverage, and is mixed and dissolved by the drug oral administration device, and is delivered to the oral mucosa at a certain flow rate.

The use method of the device related to the embodiment comprises the following steps:

(2) the bottle body is hung at a high position, the infusion tube is placed on the oral mucosa, and the pressurizing equipment can be operated at the height to observe the pressure gauge and the thermometer;

(3) opening the pressurizing device, controlling the pressure in the bottle to be 0.6Mpa by pressure, enabling the liquid to enter the liquid outlet pipe from the liquid suction pipe, adjusting the dropping speed to be 65 drops per minute by the adjusting valve, dropping the liquid into the oral cavity in about 30-35 minutes, and performing long-time infiltration and absorption through the oral mucosa to achieve long-time local administration; 1-2 times a day. The medicine is continuously taken for 3 to 5 days, and the effective rate reaches about 80 percent.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. A device for absorbing medicine oral mucosa is characterized in that: the vacuum bottle comprises a vacuum bottle body, a cover body in threaded connection with the bottleneck of the vacuum bottle body, a thermometer and a pressurizing device arranged on the cover body, wherein the pressurizing device is provided with a pressure gauge; a pipette arranged in the cover body and the lower end of the pipette extends to the bottom of the heat preservation bottle body; the liquid outlet pipe is arranged on the cover body and communicated with the upper end of the liquid suction pipe, the hose is connected with the liquid outlet end of the liquid outlet pipe through a connector, and the liquid conveying pipe is connected with the hose through a three-way connector and is arranged on the oral mucosa; the air inlet pipe is arranged on the other connecting port of the three-way connecting plug and is provided with an air filter; a drip cup arranged on the infusion tube and a flow rate regulating valve sleeved on the infusion tube;

the device also comprises a hook fixedly connected to the cover body;

the temperature of the device is controlled to be 60-85 ℃, the pressure of the device is controlled to be 0.5-0.8Mpa, and the dropping speed is adjusted to be 60-70 drops per minute by the adjusting valve;

the medicine comprises 12 g of pithecellobium clypearia particles, 5-10 mg of loratadine, 50-100 mg of nimesulide particles and 6 g of small molecular peptide collagen solid beverage, and the medicine is mixed and dissolved through a medicine oral administration device.