CN106963784A - The Probiotic supplement and preparation method of quick release in oral cavity - Google Patents
The Probiotic supplement and preparation method of quick release in oral cavity Download PDFInfo
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- CN106963784A CN106963784A CN201610019855.8A CN201610019855A CN106963784A CN 106963784 A CN106963784 A CN 106963784A CN 201610019855 A CN201610019855 A CN 201610019855A CN 106963784 A CN106963784 A CN 106963784A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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Abstract
The invention provides a kind of Probiotic supplement of quick release in oral cavity, probiotics 5-80mg, supporting agent 6-12mg, Propiram 6-12mg are included in the Probiotic supplement unit dose, and the suspending agent less than 0.2mg is included in unit dose.The Probiotic supplement of quick release in described oral cavity, the probiotics of high dose can be loaded and be quickly disintegrated in the oral cavity, there is good mouthfeel simultaneously, probiotics survival volume is high in preparation, suitable for taking for children particularly infant, and probiotics survival rate is high in the Probiotic supplement prepared using preparation method of the present invention, probiotics stable content is homogeneous in preparation, and can in 10s quick release.
Description
Technical field
The present invention relates to a kind of Probiotic supplement and preparation method, the Probiotic supplement and preparation method of quick release more particularly in a kind of oral cavity suitable for children.
Background technology
Existing solid oral agent includes conventional tablet, capsule, chewable tablets, granula and pulvis etc., but above-mentioned formulation is not suitable for children especially infant.When tablet is larger or must take many pieces, children are difficult to swallow or tablet will be bonded in throat or in oesophagus.Although chewable tablets is not required to use water, can be swallowed after chewing, but they are not suitable for the child of masticatory force difference.Granula and pulvis need water just to swallow, and their shortcoming is easily to stay in oral cavity, choke plug children.
Probiotics is a kind of active bacteria formulation, and it can promote internal colony balance, by suppressing or killing pathogenic bacteria, to promote the existence of beneficial bacterium, and then adjusts stomach flora, strengthens enteron aisle resistance, reach the dyspeptic effects such as treatment abdominal distension, diarrhoea, constipation.Children particularly infant belongs to the weaker colony of immunity, and Probiotic supplement is taken by the colony can improve immunity, prevention of various diseases, and can promote digestion, be conducive to growing up healthy and sound.Existing Probiotic supplement is usually drink or dry powder doses, the dosage that wherein drink need to be taken is larger and needs to add the additives such as sweetener to improve mouthfeel, dry powder doses need to use mixing in water for oral taking, the temperature requirement of water is higher during to preparing, and for infant due to needing father and mother's auxiliary to take, is likely to occur the problem of dose is inaccurate.
Patent WO2007111375A disclose it is a kind of by the mixed-powder of compression molding probiotics, avicel cellulose or light anhydrous silicic acid and starch-containing carbohydrate in the dry state after, obtained tablet hardness about 30N-60N, tablet of the moisture below 3.2% weight, but the press mold material hardness is higher, is still had for children and take difficult and may damage cavity interior.
Patent CN1689649A discloses a kind of oral instant preparation and production method comprising Propiram, and its mesostroma is mainly made up of the raw material of following parts by weight：Skeleton supporting agent 1-10 parts by weight, Propiram 1-10 parts by weight, the oral instant preparations shaping is more preferable, but for probiotics because solubility property in aqueous is not good, need to add suspending agent, meanwhile, the species and content of each auxiliary material can also influence the activity of probiotics in preparation prescription, may cause the reduction of probiotic effect.
WO2013123623A1 discloses a kind of oral disnitegration tablet and preparation method, it is prepared using freeze-drying, its component includes active constituents of medicine, skeleton supporting agent, binding agent and the suspending agent of effective dose, wherein binding agent is made up of Propiram and additional adhesive, using the compounding use of Propiram and additional adhesive under specific amount ranges, solve freeze-dried type oral disnitegration tablet and be disintegrated slow, the incomplete problem of dissolution when loading heavy dose of medicine.But need to add additional adhesive and suspending agent to increase drugloading rate in preparation prescription, mouthfeel to tablet can produce large effect, especially children, the interest that it can be influenceed persistently to take replenishers, and Propiram and additional adhesive are equally possible influences the activity of probiotics.
Therefore, the present invention overcomes the defect of prior art there is provided a kind of Probiotic supplement of quick release for applying to children and preparation method.
The content of the invention
A purpose of the invention is to provide a kind of Probiotic supplement for loading high dose, quickly can in the oral cavity be disintegrated, while having good mouthfeel, and can keep the number of viable of probiotics, it is adaptable to which children particularly infant's takes.
Another object of the present invention is to provide a kind of preparation method of Probiotic supplement, overcomes probiotics survival rate in Probiotic supplement preparation process in the prior art low, and prebiotic bacterial content heterogeneity in preparation, rate of release is slow, it is impossible to the defect of industrialized production.
Thus, the first aspect of the present invention provides a kind of Probiotic supplement of quick release in oral cavity suitable for children, probiotics 5-80 mg, supporting agent 6-12mg, Propiram 6-12mg are included in unit dose, the suspending agent less than 0.2mg is included wherein in unit dose.
Heretofore described probiotics be selected from Bifidobacterium class (for example bifidobacterium longum (Bifidobacterium
longum), bifidobacterium infantis (Bifidobacterium infantis), bifidobacterium bifidum (Bifidobacterium bifidun), bifidobacterium breve (Bifidobacterium breve) etc.), lactic acid bacteria class (thousand Lactobacillus paracaseis (Lactobacilluscasei), Lactobacillus gasseri (Lactobacillus
gasseri), Lactobacillus rhamnosus(Lactobacillus rhamnosus), lactobacillus acidophilus (Lactobacillusacidophilus), streptococcus fecalis (Streptococcus faecal), streptococcus thermophilus (Streptococcus thermophilus) etc.) and one or both of more than.It is preferred that, described probiotics is selected from more than one or both of bifidobacterium longum, bifidobacterium infantis, Lactobacillus gasseri, Lactobacillus rhamnosus, lactobacillus acidophilus.For Probiotic supplement, the activity of probiotics competence exertion probiotics in vivo containing high content is needed in its preparation, it is thus possible to which the probiotics for being loaded with higher doses in tablets is the problem of Probiotic supplement is to be solved.Contain 5-80 in unit dose in Probiotic supplement of the present invention
Mg probiotics, it is preferred that containing 40-80mg probiotics, it is furthermore preferred that containing 50-70
Mg probiotics.
Heretofore described supporting agent is selected from mannitol or glycine, it is preferred that described supporting agent is mannitol.In unit dose comprising supporting agent it is preferably 8-10mg in described Probiotic supplement, more preferably 10mg.
In unit dose comprising Propiram it is preferably 8-10mg in heretofore described Probiotic supplement, more preferably 10mg.
Because suspending agent has the effect of thickening suspending, the suspending agent of high content is often added when needing to load heavy dose of active component in preparation, but suspending agent can produce sticky mouthfeel and bad taste after dissolving in the oral cavity, and excessive xanthans produces influence to the disintegration time of tablet, thus needs to control the consumption of xanthans.The suspending agent included in unit dose less than 0.2mg is included in heretofore described Probiotic supplement in unit dose, it is preferred that include the suspending agent less than 0.1mg.In the further preferred embodiment of the present invention, suspending agent is not contained in described Probiotic supplement.Suspending agent of the present invention is preferably xanthans.
In one embodiment of the invention, sweetener is also included in described Probiotic supplement, the sweetener less than 0.3mg is included in described Probiotic supplement in unit dose, it is preferred that, the sweetener less than 0.2mg is also included in described Probiotic supplement in unit dose, it is furthermore preferred that the sweetener less than 0.1mg is also included in described Probiotic supplement in unit dose.Described sweetener is selected from Sucralose or Aspartame, more preferably Sucralose.
In one embodiment of the invention, flavouring is also included in described Probiotic supplement, described flavoring agent content can be that those skilled in the art are adjusted according to required mouthfeel, and described flavouring can be strawberry essence, flavoring banana essence, milk flavour etc..
In an embodiment of the invention, it is made up of in described Probiotic supplement unit dose probiotics 5-80 mg, supporting agent 6-12 mg, Propiram 6-12 mg, the mg of sweetener≤0.3, flavouring.
The trace elements such as Mecobalamin, vitamin B1, vitamin B2, vitamin B12, vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, vitamine E nicotinate, vitamin K, amino acid, carotene, inositol, nicotinic acid, taurine and calcium, iron, zinc, magnesium can also be included in oral cavity of the present invention suitable for children the Probiotic supplement of quick release.
The further aspect of the present invention provides a kind of preparation method of the Probiotic supplement of quick release in oral cavity suitable for children, and its raw material includes 1-16% probiotics, 1.2-2.4% supporting agents, 1.2-2.4% Propirams by mass percentage, and surplus is water.
In heretofore described raw material, probiotics is preferably powdery, it is furthermore preferred that including probiotics 8-16% in described raw material by mass percentage, it is furthermore preferred that including probiotics 10-12% in described raw material by mass percentage.
In heretofore described raw material, supporting agent preferably is 1.5-2.4%, more preferably 2% by mass percentage.
In heretofore described raw material, Propiram preferably is 1.5-2.4%, more preferably 2% by mass percentage.
Include the suspending agent less than 0.04% in raw material described in an embodiment of the invention by mass percentage, it is furthermore preferred that including the suspending agent less than 0.02% in raw material by mass percentage, most preferably, suspending agent is not included in raw material.
In one embodiment of the invention, sweetener is also included in described raw material, described sweetener is less than 0.06% by mass percentage, it is preferred that less than 0.05%, most preferably, less than 0.02%.Described sweetener is selected from Sucralose or Aspartame, more preferably Sucralose.
In one embodiment of the invention, flavouring is also included in described raw material, described flavouring mass percent can be that those skilled in the art are adjusted according to required mouthfeel, and described flavouring can be strawberry essence, flavoring banana essence, milk flavour etc..
The preparation method of the Probiotic supplement of quick release comprises the following steps in oral cavity of the present invention suitable for children：（1）Probiotics, supporting agent, Propiram are taken, the dry-mixed rear water that adds stirs, emulsified；（2）After emulsifying in material injection mould, after pre-freeze, freeze-drying obtains described Probiotic supplement.There is emulsion process in the preparation method of Probiotic supplement of the present invention, probiotics is uniformly dispersed, it is ensured that the replenishers uniform content finally given, the use of suspending agent can also be reduced.
In an embodiment of the invention, described step（1）To take combination more than one or both of probiotics, supporting agent, Propiram, and suspending agent, sweetener, flavouring, the dry-mixed rear water that adds stirs, emulsified.
The preparation method step of Probiotic supplement of the present invention（1）In emulsification use emulsification pretreatment method, it is preferred that the emulsification pretreatment method shear rate be 1000-6000rpm, more preferably, 2000-5000rpm.The emulsification pretreatment method emulsification times are 1-30min, preferably 5-10min.
The preparation method step of Probiotic supplement of the present invention（1）In, the step of also including degassing after described emulsification, it is preferred that described degassing is vacuum outgas, and the time is 1-20
Min, preferably 2-10 min.
The preparation method step of Probiotic supplement of the present invention（2）Described in mould be aluminum-plastic bubble-cap palte.
The preparation method step of Probiotic supplement of the present invention（2）Described in pre-freeze be in -70--40 DEG C of pre-freeze 1-20min, be preferably in 2-10min.
The preparation method step of Probiotic supplement of the present invention（2）Described in freeze-drying include：1-5h is kept at -25--10 DEG C, 10-30 DEG C is risen in 1-5h afterwards, 1-5h is kept；It is preferred that, 2h is freeze-dried at -20 DEG C, 20 DEG C are risen in 3h afterwards, 2h is kept.
In the present invention more specifically embodiment, the preparation method of described Probiotic supplement includes：
（1）Probiotics, supporting agent, Propiram are weighed, it is dry-mixed, add water and stir, with 2000-5000rpm, first time emulsification pretreatment 5-10min, the material after emulsifying uniformly is subjected to vacuum outgas, the time is 2-10min；
（2）By step（1）In the bubble eye of obtained material injection aluminum-plastic bubble-cap palte, through -70--40 DEG C of pre-freeze 2-10min, freeze-drying obtains described Probiotic supplement, and described freeze-drying is：1-5h is kept at -25--10 DEG C, 10-30 DEG C is risen in 1-5h afterwards, 1-5h is kept.
The further aspect of the present invention provides application of the described Probiotic supplement in children dietary replenishers and/nutritious supplementary pharmaceutical are prepared.
The further aspect of the present invention provides application of the described Probiotic supplement in the replenishers for improving immunity are prepared.
The further aspect of the present invention provides application of the described Probiotic supplement in the replenishers for promoting pipe intestinal digesting are prepared.
The Probiotic supplement of quick release in oral cavity of the present invention, the probiotics of high dose can be loaded and be quickly disintegrated in the oral cavity, there is good mouthfeel simultaneously, probiotics survival volume is high in preparation, suitable for taking for children particularly infant, and probiotics survival rate is high in the Probiotic supplement prepared using preparation method of the present invention, probiotics stable content is homogeneous in preparation, and can in 10s quick release.
The present invention is not limited to ad hoc approach described herein, scheme, because they can be varied from.In addition, term used herein is served only for describing the purpose of particular implementation, rather than for limiting the scope of the present invention.
Unless defined differently, all technologies and scientific terminology and any abbreviation all have the implication identical implication being generally understood that with field those of ordinary skill of the present invention herein.Although can use in the practice of the invention to those in the similar or of equal value method of approach described herein and material and material, illustrative method, equipment and material there is described herein.
Unless stated otherwise, term of the invention has implication commonly used in the art.
Term " quick release " in the present invention refers to that replenishers are less than 20s, most preferably less than more preferably less than 10s, 5s in the time of intra-oral disintegration or dissolving.
Term " Probiotic supplement " in the present invention refers to dietary supplements or nutritious supplementary pharmaceutical containing profitable probliotics.
Term " children " in the present invention refers to the children of 0-10 Sui, the most preferably preferably children of 0-5 Sui, the children of 0-3 Sui.
Embodiment
Embodiment
1
Prescription：
Lactobacillus rhamnosus 50.00g
Propiram 10.00g
Mannitol 10.00g
Sucralose 0.25g
Strawberry essence 1000ul
Purified water 428.75g
Amount to 500.00g
It is made 1000
Preparation technology：
（1）Lactobacillus rhamnosus, Propiram, mannitol, Sucralose, strawberry essence are weighed according to recipe quantity, is placed in appropriate vessel, it is dry-mixed uniform, plus purified water stirs, it is standby；
（2）Add strawberry essence（Measured by volume）, recipe quantity is settled to, is stirred, emulsification pretreatment is carried out, shear rate is 1000rpm, and emulsification times are 2min；
（3）By step（2）Obtained material carries out vacuum outgas, and the time is 10min；
（4）Dispensed, be injected separately into the bubble of aluminum-plastic bubble-cap palte eye with the volume of 0.5ml/ pieces；
（5）Will（4）Obtained material is in -40 DEG C of refrigerator pre-freeze 10min；
（6）Will（5）Obtained material is freeze-dried, and actual conditions is：Lyophilized initial temperature is set as -20 DEG C, the good bubble eye of pre-freeze is put into freeze drying box, is freeze-dried 4 hours, rises to 20 DEG C in 3h by -20 DEG C, maintain 20 DEG C, 3h.
（7）Bubble cap tray is taken out from freeze dryer, aluminium plastic bag heat sealed package is used.
Embodiment
2
Prescription：
Lactobacillus rhamnosus 40.00g
Propiram 12.00g
Mannitol 12.00g
Sucralose 0.25g
Strawberry essence 1000ul
Purified water 425.75g
Amount to 500.00g
It is made 1000
Preparation technology：
（1）Lactobacillus rhamnosus, Propiram, mannitol, Sucralose, strawberry essence are weighed according to recipe quantity, is placed in appropriate vessel, it is dry-mixed uniform, plus purified water stirs, it is standby；
（2）Add strawberry essence（Measured by volume）, recipe quantity is settled to, is stirred, progress emulsification pretreatment, shear rate, 5000rpm, emulsification times are 1min；
（3）By step（2）Obtained material carries out vacuum outgas, and the time is 5min；
（4）Dispensed, be injected separately into the bubble of aluminum-plastic bubble-cap palte eye with the volume of 0.5ml/ pieces；
（5）Will（4）Obtained material is in -50 DEG C of refrigerator pre-freeze 5min；
（6）Will（5）Obtained material is freeze-dried, and actual conditions is：Lyophilized initial temperature is set as -25 DEG C, the good bubble eye of pre-freeze is put into freeze drying box, is freeze-dried 4 hours, rises to 25 DEG C in 3h by -25 DEG C, maintain 25 DEG C, 1h.
（7）Bubble cap tray is taken out from freeze dryer, aluminium plastic bag heat sealed package is used.
Embodiment
3
Prescription：
Lactobacillus rhamnosus 80.00g
Propiram 6.00g
Mannitol 6.00g
Sucralose 0.25g
Strawberry essence 1000ul
Purified water 407.75g
Amount to 500.00g
It is made 1000
Preparation technology：
（1）Lactobacillus rhamnosus, Propiram, mannitol, Sucralose, strawberry essence are weighed according to recipe quantity, is placed in appropriate vessel, it is dry-mixed uniform, plus purified water stirs, it is standby；
（2）Add strawberry essence（Measured by volume）, recipe quantity is settled to, is stirred, emulsification pretreatment is carried out, shear rate is 2000rpm, and emulsification times are 10min；
（3）By step（2）Obtained material carries out vacuum outgas, and the time is 10min；
（4）Dispensed, be injected separately into the bubble of aluminum-plastic bubble-cap palte eye with the volume of 0.5ml/ pieces；
（5）Will（4）Obtained material is in -50 DEG C of refrigerator pre-freeze 5min；
（6）Will（5）Obtained material is freeze-dried, and actual conditions is：Lyophilized initial temperature is set as -20 DEG C, the good bubble eye of pre-freeze is put into freeze drying box, is freeze-dried 5 hours, rises to 20 DEG C in 4h by -20 DEG C, maintain 25 DEG C, 1h.
（7）Bubble cap tray is taken out from freeze dryer, aluminium plastic bag heat sealed package is used.
Comparative example
1-3
Prescription and technique see the table below
Comparative example 1-3 preparation technology is same as Example 1.
Comparative example
4
Prescription：
Lactobacillus rhamnosus 50.00g
Propiram 10.00g
Mannitol 10.00g
Sucralose 0.25g
Strawberry essence 1000ul
Purified water 429.75g
Amount to 500.00g
It is made 1000
Preparation technology：
（1）Lactobacillus rhamnosus, Propiram, mannitol, Sucralose, strawberry essence are weighed according to recipe quantity, is placed in appropriate vessel, it is dry-mixed uniform, plus purified water stirs, it is standby；
（2）Add strawberry essence（Measured by volume）, recipe quantity is settled to, is stirred；
（3）By step（2）Obtained material carries out vacuum outgas, and the time is 10min；
（4）Dispensed, be injected separately into the bubble of aluminum-plastic bubble-cap palte eye with the volume of 0.5ml/ pieces；
（5）Will（4）Obtained material is in -40 DEG C of refrigerator pre-freeze 10min；
（6）Will（5）Obtained material is freeze-dried, and actual conditions is：Lyophilized initial temperature is set as -20 DEG C, the good bubble eye of pre-freeze is put into freeze drying box, is freeze-dried 4 hours, rises to 20 DEG C in 3h by -20 DEG C, maintain 20 DEG C, 3h.
（7）Bubble cap tray is taken out from freeze dryer, aluminium plastic bag heat sealed package is used.
Embodiment
4
Probiotic supplement mouthfeel is tested
The Probiotic supplement that Example 1-3 and comparative example 1-4 are prepared carries out mouthfeel experiment.
Experimental method：Packaging is opened, freeze-drying tablet is taken out, is placed on tongue, should not chew, without water delivery service, whole suspensions in oral cavity spue after tablet is disintegrated completely.3 experimenter's mouths are evaluated after tasting, and are taken average grade and are obtained.Opinion rating divides as follows：
1）“+++++”：Entrance is instant, disintegration time<10 seconds, no agglomerate, without grittiness, sugariness is moderate.
2）“++++”：Entrance is instant, 10 seconds<Disintegration time<20s, no agglomerate, without grittiness, sugariness is moderate.
3）“+++”：Wherein any 1 is occurred in disintegration time limited, agglomerate, grittiness and sugariness four and divides these level into.
4）“++”：Occurred in which in disintegration time limited, agglomerate, grittiness and sugariness four and any 2-3 divide these level into.
5）“+”：Entrance do not collapse, in agglomerate, grittiness be strong, excessive sweetness.
Experimental result：
| Sample | Opinion rating |
| Embodiment 1 | +++++ |
| Embodiment 2 | +++++ |
| Embodiment 3 | +++++ |
| Comparative example 1 | +++ |
| Comparative example 2 | ++ |
| Comparative example 3 | +++ |
| Comparative example 4 | ++ |
Embodiment
5
Probiotic supplement probiotics carries out Viable detection experiment
Example 1-3 and comparative example 1-4 carries out Viable detection experiment.
Experimental method：By the calculating that feeds intake, a piece of freeze-drying tablet 5,000,000,000/piece containing profitable probliotics, the viable count of probiotics, survival rate=1 piece freeze-drying tablet viable count/5,000,000,000 × 100% according to contained by detecting in 1 freeze-drying tablet the above method.
Experimental result：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | |
| Viable detection | 98% | 95% | 95% | 46% | 62% | 31% | 55% |
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, within the spirit and principles of the invention, any modification, equivalent substitution for being made etc., should be included in the scope of the protection.
Claims (10)
1. the Probiotic supplement of quick release in a kind of oral cavity, it is characterised in that probiotics 5-80 mg, supporting agent 6-12 mg, Propiram 6-12 mg are included in the Probiotic supplement unit dose, and the suspending agent less than 0.2mg is included in unit dose.
2. the Probiotic supplement of quick release in a kind of oral cavity described in claim 1, characterized in that, described probiotics is selected from more than one or both of Bifidobacterium class, bifidobacterium bifidum, bifidobacterium breve, lactic acid bacteria class, Lactobacillus gasseri, Lactobacillus rhamnosus, lactobacillus acidophilus, streptococcus fecalis, streptococcus thermophilus.
3. the Probiotic supplement of quick release in a kind of oral cavity described in claim 1, it is characterised in that contain 40-80 mg probiotics in described Probiotic supplement in unit dose.
4. the Probiotic supplement of quick release in a kind of oral cavity described in claim 1, it is characterised in that described supporting agent is selected from mannitol or glycine.
5. the Probiotic supplement of quick release in a kind of oral cavity described in claim 1, it is characterised in that include the suspending agent included in unit dose less than 0.1 mg in described Probiotic supplement in unit dose.
6. the Probiotic supplement of quick release in a kind of oral cavity described in claim 5, it is characterised in that do not contain suspending agent in described Probiotic supplement.
7. the Probiotic supplement of quick release in a kind of oral cavity described in claim 1-6 any one, it is characterised in that also include the sweetener less than 0.3 mg in described Probiotic supplement in unit dose.
8. the preparation method of the Probiotic supplement of quick release in a kind of oral cavity, it is characterised in that raw material includes 8-16% probiotics, 1.2-2.4% supporting agents, 1.2-2.4% Propirams by mass percentage, and surplus is water.
9. the preparation method of the Probiotic supplement of quick release in a kind of oral cavity described in claim 8, it is characterised in that described preparation method comprises the following steps：
（1）Probiotics, supporting agent, Propiram are taken, the dry-mixed rear water that adds stirs, emulsified；
（2）After emulsifying in material injection mould, after pre-freeze, freeze-drying obtains described Probiotic supplement.
10. the preparation method of the Probiotic supplement of quick release in a kind of oral cavity described in claim 9, it is characterised in that step（1）In emulsification use emulsification pretreatment method, it is preferred that the emulsification pretreatment method shear rate be 1000-6000rpm, emulsification times are 1-30min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211099580.5A CN115463160A (en) | 2016-01-13 | 2016-01-13 | Probiotic supplement capable of being rapidly released in oral cavity and preparation method thereof |
| CN201610019855.8A CN106963784A (en) | 2016-01-13 | 2016-01-13 | The Probiotic supplement and preparation method of quick release in oral cavity |
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| CN201610019855.8A CN106963784A (en) | 2016-01-13 | 2016-01-13 | The Probiotic supplement and preparation method of quick release in oral cavity |
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| CN202211099580.5A Division CN115463160A (en) | 2016-01-13 | 2016-01-13 | Probiotic supplement capable of being rapidly released in oral cavity and preparation method thereof |
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| CN201610019855.8A Pending CN106963784A (en) | 2016-01-13 | 2016-01-13 | The Probiotic supplement and preparation method of quick release in oral cavity |
| CN202211099580.5A Pending CN115463160A (en) | 2016-01-13 | 2016-01-13 | Probiotic supplement capable of being rapidly released in oral cavity and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113069424A (en) * | 2021-04-06 | 2021-07-06 | 北京菲瑞阳林医药技术研发有限公司 | Probiotic saccharified freeze-dried flash-release tablet and preparation method thereof |
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| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
| CN102132883A (en) * | 2011-03-02 | 2011-07-27 | 润盈生物工程（上海）有限公司 | Probiotic bacterium food supplement, and preparation method and use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202010008308U1 (en) * | 2010-08-18 | 2010-10-21 | Rittinghausen, Reiner, Dr. | Composition for nutritive supplementation or treatment for urinary tract infections and / or bacterial inflammation of the mucous membranes |
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2016
- 2016-01-13 CN CN201610019855.8A patent/CN106963784A/en active Pending
- 2016-01-13 CN CN202211099580.5A patent/CN115463160A/en active Pending
Patent Citations (2)
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| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113069424A (en) * | 2021-04-06 | 2021-07-06 | 北京菲瑞阳林医药技术研发有限公司 | Probiotic saccharified freeze-dried flash-release tablet and preparation method thereof |
| CN113069424B (en) * | 2021-04-06 | 2022-08-30 | 河北菲瑞生物技术有限公司 | Probiotic saccharified freeze-dried flash-release tablet and preparation method thereof |
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| CN115463160A (en) | 2022-12-13 |
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Application publication date: 20170721 |