CN1069614C - Chemical hole-enlarging technology for natural coral hydroxyl apatite material - Google Patents

Chemical hole-enlarging technology for natural coral hydroxyl apatite material Download PDF

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Publication number
CN1069614C
CN1069614C CN98108584A CN98108584A CN1069614C CN 1069614 C CN1069614 C CN 1069614C CN 98108584 A CN98108584 A CN 98108584A CN 98108584 A CN98108584 A CN 98108584A CN 1069614 C CN1069614 C CN 1069614C
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natural coral
hydroxyl apatite
natural
chemical
coral
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CN1199034A (en
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冯守华
韩岚
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    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C04B38/04—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by dissolving-out added substances

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

The present invention relates to a chemical hole-enlarging technology for porous biological materials of natural coral hydroxyl apatite, which belongs to the technical field of inorganic chemistry. In the technology, pre-processed natural coral, chemical hole-enlarging agents, ion exchanging agents, deionized water, etc. are used as raw materials, the raw materials are placed in a steel reactor with a teflon liner according to an appropriate proportion, the raw materials reacts at 100 to 240 DEG C for 10 to 100 hours, and the hole-enlarging hydroxyl apatite materials are obtained by filtration, washing, desiccation and disinfection. The hole diameter of original hydroxyl apatite can be enlarged to 300 mu m from 200 mu m. The present invention has the advantages of simple technology and device, safe production, uniform hole diameter of the products, and pure phase.

Description

The chemical enlargement method of natural coral porous biological hydroxyl apatite material
The invention belongs to domain of inorganic chemistry, particularly the chemical enlargement method of natural coral porous biological hydroxyl apatite material.
Hydroxyapatite porous material through this technology reaming is that a kind of aperture is the biological active materials of the three-dimensional open-framework of 300 μ m, is applied to biological eye platform, biological bone, particular filter, sorbent material, support of the catalyst etc.
Have not yet to see the chemical enlargement method of the natural porous biological hydroxyl apatite material close with the present invention.
The pore size of natural hydroxyapatite is subjected to the restriction in the aperture of its raw material natural coral.At present the aperture of the coastal coral of China is about 200 μ m, and therefore the aperture by the natural hydroxyapatite of this class coral production also is about 200 μ m.In view of practical application to different apertures, the particularly requirement of the natural hydroxyapatite in wide aperture, easily grow into etc. the reaming of natural coral hydroxyapatite and the solution of aperture control urgent need with the fusion of biological tissue and blood vessel as the natural hydroxyapatite of macropore.
The present invention adopts the chemical enlargement technology of natural coral porous biological hydroxyl apatite material in order to solve an above-mentioned difficult problem, reaches both to keep natural coral hydroxyapatite 3 D pore canal feature, enlarges the purpose in original aperture again.
The chemical enlargement method of natural coral porous biological hydroxyl apatite material, be being raw material through the natural coral of pre-treatment, ion-exchanger, chemical enlargement agent, deionized water etc., mix by proportioning that is fit to and program, place reactor again, temperature of reaction is 100 ℃ to 240 ℃, reaction times is 10 to 100 hours, and product can obtain the natural hydroxyapatite porous material that the aperture is 300 μ m through aftertreatment.
Used reactor can be that tetrafluoroethylene is the closed stainless steel reactor of lining.The pre-treatment of natural coral comprises machine-shaping, and the oxidation of organic tissue is filtered and washing.The aftertreatment of product comprises filtration, washing, dry and sterilization.Said ion-exchanger comprises phosphoric acid ammonia, ammonium di-hydrogen phosphate or DAP etc.; Said chemical enlargement agent comprises hydrochloric acid, phosphoric acid, acetic acid, ammonia chloride and/or aqua ammonia etc.
Said pre-treatment machine-shaping is meant is processed into a platform or aggregate with the raw material coral.
The present invention is the chemical enlargement method of natural porous biological hydroxyl apatite material.When characteristics of the present invention are the reaming of applied chemistry expanding agent, do not destroy the crystalline structure and the pore passage structure of hydroxyapatite; The processing unit that expanding method requires is simple, is convenient to produce.
Through structure, composition and the foreign matter content of the hydroxyapatite porous material product of reaming through X-ray diffraction (XRD), infrared (IR), atomic emission spectrum (AEP), plasma emission spectroscopy (ICP) characterizes with scanning electronic microscope (SEM).The D value of its X-ray powder diffraction spectrum is identical with the D value of the product of not reaming.Its infrared spectra is identical with the infrared spectra of the product of reaming not.The chemical constitution of product still is Ca 10(PO 4) 6(OH) 2, impurity Mg in the product, Zn, Fe, Cu, Al, the content of Si is less than weight 1%.SEM before and after the reaming shows that aperture ratio had enlarged 100 μ m originally.
For reaction conditions of the present invention is described better, the spy is listed below example:
Example 1:
Reaction raw materials: natural coral (CaCO 3), deionized water (H 2O), ion-exchanger (NH 4) 3PO 4, chemical enlargement agent (HCl).
Reaction raw materials mol ratio: CaCO 3: 40H 2O: 2 (NH 4) 3PO 4: 0.1HCl.
Experimental arrangement and condition: at first will add the phosphoric acid ammonia solution of metering again through the natural coral of pre-treatment and the mixed in hydrochloric acid of metering.Said mixture is placed reaction kettle for reaction, and temperature of reaction is 180 ℃, and the reaction times is 10 hours, and product can obtain the natural hydroxyapatite porous material Ca that the aperture is 300 μ m through aftertreatment 10(PO 4) 6(OH) 2
Example 2:
Reaction raw materials: natural coral (CaCO 3), deionized water (H 2O), ion-exchanger (NH 4) H 2PO 4, chemical enlargement agent (H 3PO 4).
Reaction raw materials mol ratio: CaCO 3: 60H 2O: 4 (NH 4) H 2PO 4: 0.1H 3PO 4
Experimental arrangement and condition: at first will mix with the ammonium di-hydrogen phosphate of metering, add the phosphoric acid ammonia solution of metering again through the natural coral of pre-treatment.Said mixture is placed reaction kettle for reaction, and temperature of reaction is 200 ℃, and the reaction times is 40 hours, and product can obtain the natural hydroxyapatite porous material Ca that the aperture is 300 μ m through aftertreatment 10(PO 4) 6(OH) 2
Example 3:
Reaction raw materials: natural coral (CaCO 3), deionized water (H 2O), ion-exchanger (NH 4) 2HPO 4, chemical enlargement agent (HAc).
Reaction raw materials mol ratio: CaCO 3: 40H 2O: 3 (NH 4) 2HPO 4: 0.1HAc.
Experimental arrangement and condition: at first will mix with the acetic acid of metering, add the DAP solution of metering again through the natural coral of pre-treatment.Said mixture is placed reaction kettle for reaction, and temperature of reaction is 160 ℃, and the reaction times is 80 hours, and product can obtain the natural hydroxyapatite porous material Ca that the aperture is 300 μ m through aftertreatment 10(PO 4) 6(OH) 2

Claims (2)

1, a kind of chemical enlargement method of natural coral porous biological hydroxyl apatite material, it is characterized in that, with natural coral, ion-exchanger, chemical enlargement agent, deionized water through pre-treatment is raw material, place reactor, under 100～240 ℃ of conditions, reacted 10～100 hours, obtain product through aftertreatment; Said ion-exchanger comprises phosphoric acid ammonia, ammonium di-hydrogen phosphate or DAP; Said chemical enlargement agent comprises hydrochloric acid, phosphoric acid, acetic acid, ammonia chloride and/or aqua ammonia.
According to the chemical enlargement method of the described natural coral porous biological hydroxyl apatite material of claim 1, it is characterized in that 2, said reactor is that tetrafluoroethylene is the closed stainless steel reactor of lining; The pre-treatment of said natural coral comprises machine-shaping, and the oxidation of organic tissue is filtered and washing; Said product aftertreatment comprises filtration, washing, dry and sterilization.
CN98108584A 1998-05-16 1998-05-16 Chemical hole-enlarging technology for natural coral hydroxyl apatite material Expired - Fee Related CN1069614C (en)

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CN1069614C true CN1069614C (en) 2001-08-15

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100384488C (en) * 2004-05-28 2008-04-30 梁辉 Preparation technique of absorbent hydroxyapatite artificial bone

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108328622B (en) * 2018-02-28 2021-07-13 辽宁石油化工大学 Hole enlarging method for laminated copper silicate
CN110201227A (en) * 2019-06-06 2019-09-06 杭州口腔医院集团有限公司 A kind of antibacterial pattern method of the implant surface of 3D printing substrate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1161305A (en) * 1997-04-02 1997-10-08 陈问京 Method for preparing hydroxy phosphatic rock
CN1163094A (en) * 1996-10-25 1997-10-29 中山医科大学中山眼科中心 Preparing technology for changing coral into hydroxy apatite

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1163094A (en) * 1996-10-25 1997-10-29 中山医科大学中山眼科中心 Preparing technology for changing coral into hydroxy apatite
CN1161305A (en) * 1997-04-02 1997-10-08 陈问京 Method for preparing hydroxy phosphatic rock

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100384488C (en) * 2004-05-28 2008-04-30 梁辉 Preparation technique of absorbent hydroxyapatite artificial bone

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