CN106946980A - A kind of preparation method of the phenylalanine dipeptide self assembly product of iron ion induction - Google Patents
A kind of preparation method of the phenylalanine dipeptide self assembly product of iron ion induction Download PDFInfo
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- CN106946980A CN106946980A CN201710134982.7A CN201710134982A CN106946980A CN 106946980 A CN106946980 A CN 106946980A CN 201710134982 A CN201710134982 A CN 201710134982A CN 106946980 A CN106946980 A CN 106946980A
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- self assembly
- phenylalanine dipeptide
- assembly product
- preparation
- iron ion
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to a kind of preparation method of the phenylalanine dipeptide self assembly product of iron ion induction.Comprise the following steps：Prepare ferric ion solutions, prepare the phenylalanine dipeptide self assembly product of iron ion induction.The beneficial effects of the invention are as follows：The preparation method of the phenylalanine dipeptide self assembly product of iron ion induction is simple and environmentally-friendly.
Description
Technical field
The present invention relates to a kind of preparation method of the phenylalanine dipeptide self assembly product of iron ion induction, belong to material conjunction
Into field.
Technical background
In recent years, the self assembly research of peptide sill receives extensive concern, it has also become supramolecular chemistry, biomaterial section
Learn one of Disciplinary Frontiers of research.Simplest among peptide sill is two peptide molecules, and change condition can change its self assembly
Structure, forms the patterns such as nanotube, nano wire, vesica, nanosphere.It is main body material that the present invention, which chooses phenylalanine dipeptide,
Material, two peptide molecules that the material is made up of two phenylalanines amido link are similar with other peptide molecules.Phenylalanine
Dipeptides belongs to ampholytes, and its isoelectric point is about 5.5.Therefore, it is intermolecular to there is electrostatic phase in its free or assembling process
Interaction.Phenylalanine dipeptide can be self-assembled into various patterns by different method and condition.
Metal ion be widely used as additive with by metal ligand coordination or electrostatic interaction come Auto-regulator
Structure.This work induces phenylalanine dipeptide to carry out self assembly with ion.Iron ion is formed after iron loses 3 electronics
Ion, relatively stablizes, there is very strong oxidisability, is also a kind of important industrial dose.Iron ion ligancy be 6, coordination ability compared with
By force.Positively charged iron ion can pass through coordinate bond and electrostatic interaction and electronegative phenylalanine dipeptide (pH=7 situations
Under) combine, so as to induce phenylalanine dipeptide to carry out self assembly, show different patterns.
The content of the invention
It is to provide a kind of preparation side of the phenylalanine dipeptide self assembly product of iron ion induction that the purpose of the present invention, which is,
Method.
A kind of preparation method of the phenylalanine dipeptide self assembly product of iron ion induction of the present invention, including following step
Suddenly：
A, preparation ferric ion solutions：7.455g potassium chloride is weighed in 1L volumetric flasks, it is molten to obtain potassium chloride with ultra-pure water constant volume
Liquid.Then 4mg iron chloride is weighed again in 50mL volumetric flasks, with above-mentioned Klorvess Liquid constant volume, obtains certain density iron ion
Solution.
B, the phenylalanine dipeptide self assembly product for preparing iron ion induction：20 μ L hexafluoroisopropanols are added into 1mg phenylpropyl alcohols
In propylhomoserin dipeptides, the hexafluoroisopropanol solution of 50mg/mL phenylalanine dipeptides is made into, ultra-pure water is added into above-mentioned solution, it is dilute
It is interpreted into 3mg/mL phenylalanine dipeptide solution.Then the iron ion that step a preparations are added into phenylalanine dipeptide solution is molten
Liquid, obtains the phenylalanine dipeptide self assembly product of iron ion induction.
Further, Klorvess Liquid concentration is 0.05~0.15M in step a.
Further, the concentration of ferric ion solutions is 0.001~0.01mM in step a.
Further, the volume of the ferric ion solutions added in step b is 10~30 μ L.
The beneficial effects of the invention are as follows：The simple ring of preparation method of the phenylalanine dipeptide self assembly product of iron ion induction
Protect.
Embodiment
Presently in connection with specific embodiment, the present invention will be further described, following examples be intended to illustrate invention rather than
Limitation of the invention further.
Embodiment one：
A kind of phenylalanine dipeptide self assembly product of iron ion induction is prepared to comprise the following steps：
(1) ferric ion solutions are prepared：7.455g potassium chloride is weighed in 1L volumetric flasks, 0.1M chlorinations are obtained with ultra-pure water constant volume
Potassium solution.Then 4mg iron chloride is weighed again in 50mL volumetric flasks, with above-mentioned Klorvess Liquid constant volume, obtains 0.005mM iron ions
Solution.
(2) the phenylalanine dipeptide self assembly product of iron ion induction is prepared：20 μ L hexafluoroisopropanols are added into 1mg phenylpropyl alcohols
In propylhomoserin dipeptides, the hexafluoroisopropanol solution of 50mg/mL phenylalanine dipeptides is made into, ultra-pure water is added into above-mentioned solution, it is dilute
It is interpreted into 3mg/mL phenylalanine dipeptide solution.Then the iron of 20 μ L steps (1) preparation is added into phenylalanine dipeptide solution
Solion, obtains the phenylalanine dipeptide self assembly product of iron ion induction.
Claims (3)
1. a kind of preparation method of the phenylalanine dipeptide self assembly product of iron ion induction, step is as follows：
A, preparation ferric ion solutions：7.455g potassium chloride is weighed in 1L volumetric flasks, Klorvess Liquid is obtained with ultra-pure water constant volume.So
4mg iron chloride is weighed again afterwards in 50mL volumetric flasks, with above-mentioned Klorvess Liquid constant volume, certain density ferric ion solutions are obtained.
B, the phenylalanine dipeptide self assembly product for preparing iron ion induction：20 μ L hexafluoroisopropanols are added into 1mg phenylalanines
In dipeptides, the hexafluoroisopropanol solution of 50mg/mL phenylalanine dipeptides is made into, ultra-pure water is added into above-mentioned solution, is diluted to
3mg/mL phenylalanine dipeptide solution.Then ferric ion solutions prepared by step a are added into phenylalanine dipeptide solution, are obtained
The phenylalanine dipeptide self assembly product of iron ion induction.
2. the preparation method of the phenylalanine dipeptide self assembly product of a kind of iron ion induction according to claim 1, it is special
Levying is：Klorvess Liquid concentration is 0.05~0.15M in the step a, and the concentration of ferric ion solutions is 0.001~0.01mM.
3. the preparation method of the phenylalanine dipeptide self assembly product of a kind of iron ion induction according to claim 1, it is special
Levying is：The volume of the ferric ion solutions added in the step b is 10~30 μ L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710134982.7A CN106946980B (en) | 2017-03-08 | 2017-03-08 | Preparation method of iron ion-induced phenylalanine dipeptide self-assembly product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710134982.7A CN106946980B (en) | 2017-03-08 | 2017-03-08 | Preparation method of iron ion-induced phenylalanine dipeptide self-assembly product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106946980A true CN106946980A (en) | 2017-07-14 |
| CN106946980B CN106946980B (en) | 2020-09-08 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993264A (en) * | 2012-12-31 | 2013-03-27 | 东华大学 | Method for self-assembly dipeptide to be self-assembled to be different structures in different solvents |
| CN103224925A (en) * | 2013-03-29 | 2013-07-31 | 中南大学 | Ferrocene polypeptide nanowire-glucose oxidizing enzyme composite and preparing and applying method thereof |
| CN103417976A (en) * | 2013-07-29 | 2013-12-04 | 东华大学 | Method for preparing hydrogel through self-assembly of dipeptide derivative in chitosan solution |
| CN104610309A (en) * | 2015-02-02 | 2015-05-13 | 江苏科技大学 | Coordination polymer with ferroelectric properties and preparation method and application thereof |
| CN106046116A (en) * | 2016-06-28 | 2016-10-26 | 苏州大学 | Fc-FF-RGD composite as well as preparation method and application thereof |
-
2017
- 2017-03-08 CN CN201710134982.7A patent/CN106946980B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993264A (en) * | 2012-12-31 | 2013-03-27 | 东华大学 | Method for self-assembly dipeptide to be self-assembled to be different structures in different solvents |
| CN103224925A (en) * | 2013-03-29 | 2013-07-31 | 中南大学 | Ferrocene polypeptide nanowire-glucose oxidizing enzyme composite and preparing and applying method thereof |
| CN103417976A (en) * | 2013-07-29 | 2013-12-04 | 东华大学 | Method for preparing hydrogel through self-assembly of dipeptide derivative in chitosan solution |
| CN104610309A (en) * | 2015-02-02 | 2015-05-13 | 江苏科技大学 | Coordination polymer with ferroelectric properties and preparation method and application thereof |
| CN106046116A (en) * | 2016-06-28 | 2016-10-26 | 苏州大学 | Fc-FF-RGD composite as well as preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 贾怡等: "《二苯丙氨酸二肽有序纳米结构的组装及应用》", 《科学通报》 * |
| 赵君等: "《苯丙氨酸二肽类分子自组装: 分子设计、结构调控与材料应用》", 《化学进展》 * |
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| CN106946980B (en) | 2020-09-08 |
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