CN106943387A - A kind of composition for being used to treat electric ophthalmia - Google Patents
A kind of composition for being used to treat electric ophthalmia Download PDFInfo
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- CN106943387A CN106943387A CN201710249649.0A CN201710249649A CN106943387A CN 106943387 A CN106943387 A CN 106943387A CN 201710249649 A CN201710249649 A CN 201710249649A CN 106943387 A CN106943387 A CN 106943387A
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- sodium chloride
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
The invention discloses a kind of composition for being used to treat electric ophthalmia, said composition includes following component：Adrenalin hydrochloride, sodium chloride physiological saline, levofloxacin Lactate sodium chloride injection, the volume ratio of three is 15:1‑3:1‑5.Application method：Electric light hinder eye it is rubescent after, a Tropfen is dripped at angle within the eye, in half an hour after drip again 1 time, injured lighter drop 3 times, severely injured drop 45 times, morning drips 1 time again, is no more than 6 times per consumption per day.The composition for the treatment electric ophthalmia that the present invention is provided is also used for caused inflamed eyes pain discomfort of excessive internal heat etc. of staying up late, and hindering eye, long visual fatigue to electric welding has special efficacy.The composition material of the treatment electric ophthalmia that the present invention is provided is with low cost, make that simple, easy to use, access times are few, treatment cycle is short, instant effect, cheap, cure rate are high, there is preferable prevention and treatment function, with preferable market prospects, easily received by many patients.
Description
Technical field
The invention belongs to field of pharmaceutical technology, more particularly to a kind of composition for being used to treat electric ophthalmia.
Background technology
Electric ophthalmia is caused by the corneal epithelial cell and conjunctiva of eyes absorb a large amount of and strong ultraviolets
Acute inflammation, is common in the people for being engaged in electric welding, gas welding.Substantial amounts of ultraviolet can be produced during electrical welding operation, electric welder is injured and auxiliary
The eyes for the person of helping others, and influence its labour capacity.The ill reason of electric ophthalmia：One is due to electric welding protective mask eyeglass color
Pool is too deep, it is impossible to be certain about solder joint before weldering is played, and when having lighted a fire weldering in order to see weldment clearly, many electric welders can only bore hole operation；
Two be many welding machine associated working in narrow environment, and electric welder can be influenceed when changing welding rod by side arclight；
Three be to be welded backman when assisting electric welder to carry out big part welding, does not strictly wear necessary protective face mask on request.It is ultraviolet
Line is a part for electromagnetic wave, may be from lamp such as arc welding.Substantial amounts of ultraviolet is absorbed by eye corneal epithelium cell, meeting
Photo electric damage is produced, the division of cell is suppressed, and occurs a series of oedema, necrosis, cell detachment etc..During electric welding, electricity
Arc temperature is up to 3000~4000 DEG C, and produces red-hot and dazzling arclight.This arclight is in addition to containing visible ray, also
Containing a large amount of invisible infrared rays and ultraviolet, wherein maximum to eye injury is ultraviolet.If in electric welding
Do not note protection, ultraviolet radiation can cause cornea eye, conjunctival epithelial cell impaired and necrosis, come off, and cause acute cornea
Conjunctivitis.If incorrect wear protective articles, foreign body sensation occurs and slight uncomfortable in 6~8h after electric welding, workman's eyes；Seriously
When eyes have burn feeling and have an intense pain, keep in dark place and shed tears, eyelid twitch, spasm, blurred vision.According to investigations, electric light in electric welder
Property ophthalmia illness rate be up to 70%~80%, repetition suffers from the number of times of electric ophthalmia from several times to tens of times.Except generation
Outside electric ophthalmia, it can also cause chronic blepharitis, conjunctivitis formation or corneal degeneration, affect one's power of vision.
The prevention and protection of electric ophthalmia mainly include：Strict implement safety regulation for operations, in intensive ultraviolet environment work
When making, blackish green filter glass safety goggles or mask are put on.Electric ophthalmia autotherapy and protection mainly include：Acute period of disease
With 0.5% totokaine eyedrops local analgesia, 3min once, stop by drop 3 times to pain, and drip guttae sulfacetamidi natrici and prevent infection, auxiliary
To promote the treatment method of corneal epithelium reparation.It should be noted that should not be analgesic abuse totokaine eyedrops, because this eyedrops has
Excitant, can hinder the growth of corneal epithelium.After healing, it is orally available that workman can be engaged in former work under conditions of protection is strengthened
Anodyne and sedative.Treatment time for having of eyedrops of existing treatment electric ophthalmia is long, what is had expensive, cost performance
It is not high, a kind of cost performance height is developed, the medicine of the treatment electric ophthalmia of instant effect is particularly important.
The content of the invention
It is used to treat the composition of electric ophthalmia it is an object of the invention to provide a kind of, the excessive internal heat that is also used for staying up late causes
Inflamed eyes pain discomfort etc., materials for improving vision is sterilized, and hindering eye, long visual fatigue to electric welding has special efficacy.
To achieve the above object, the present invention provides following technical scheme：
A kind of composition for being used to treat electric ophthalmia, formula includes following component：Adrenalin hydrochloride, sodium chloride life
Salt solution, levofloxacin Lactate sodium chloride injection are managed, the volume ratio of three is 1-5:1-3:1-5.
As the further scheme of the present invention, formula includes following component：Adrenalin hydrochloride, sodium chloride physiological saline,
Levofloxacin Lactate sodium chloride injection, the volume ratio of three is 1-3:1:1-3.
As the further scheme of the present invention, formula includes following component：Adrenalin hydrochloride, sodium chloride physiological saline,
Levofloxacin Lactate sodium chloride injection, the volume ratio of three is 2:1:2.
As the further scheme of the present invention, preparation method is as follows：Adrenalin hydrochloride is added to sodium chloride physiology salt
In water, levofloxacin Lactate sodium chloride injection is added, three mixes and kept in dark place.
Adrenalin hydrochloride is a kind of vasoactive drug of Hemorrhagic shock, rescue and anaphylactic shock for heart arrest
Rescue, it can also be used to the treatment of other anaphylactias (such as bronchial astehma, nettle rash).Favourable part is shared with local anaesthetics to stop
Blood and extension drug effect.
Levofloxacin Lactate sodium chloride injection, indication be this product suitable for following caused by sensitive bacterial,
Severe infection：Infection in respiratory system：Acute bronchitis, AECB, diffusivity capillary bronchitis, branch gas
Enlargement of pipe concurrent infection, pneumonia, tonsillitis (quinsy)；Urinary system infection contamination：Pyelonephritis, complexity urinary tract sense
Dye etc.；Genital system infection：Acute prostatitis, acute epididymitis, uterine cavity infection, adnexitis, pelvic infecton (are suspected to have anaerobism
Bacterium can share metronidazole when infecting)；Skin soft-tissue infection：Infective pustule, cellulitis, lymphatic vessel (knot) are scorching, skin
Lower abscess, perianal abscess etc.；Enteric infection：Bacillary dysentery, infective enteritis, Salmonella enteritis, typhoid fever and paratyphoid；Lose
Mass formed by blood stasis, granulocyte reduction and the various infection of immuuoeorapromised host；Other infection：Mastitis, wound, burn and Post operation
Wound infection, abdominal cavity infection (sharing metronidazole if necessary), cholecystitis, cholangitis, Arthropyosis infection and ENT dept.'s infection
Deng.
Physiological saline, refers to Physiology Experiment or clinically conventional osmotic pressure and animal or the osmotic pressure phase of human plasma
Deng sodium chloride solution.Concentration：It is 0.67~0.70% during for amphibian animal, is during for mammal and human body
0.85~0.9%.The sodium chloride injection concentration of the usual drop of people is 0.9%, can be used as physiological saline.Its
Osmotic pressure is approximate with blood of human body, and the content of sodium is also close with blood plasma, but chlorine content apparently higher than chlorine in blood plasma content,
Therefore physiological saline is that, comparatively in accordance with physiology, its purposes is supply electrolyte and the tension force of maintenance body fluid.Also can external application, such as
Applied when clean wound or dressing.0.9% physiological saline can maintain the normal morphology of cell.
Compared with prior art, the beneficial effects of the invention are as follows：
The composition material of the treatment electric ophthalmia that the present invention is provided is with low cost, it is simple, easy to use to make, use
Number of times is few, treatment cycle is short, instant effect, cheap, cure rate are high, has preferable prevention and treatment function, with preferable
Market prospects, are easily received by many patients.
Embodiment
Embodiment 1
A kind of composition for being used to treat electric ophthalmia, formula and preparation method are：1ml adrenalin hydrochlorides are added
Into 0.5ml sodium chloride physiological saline, 1ml levofloxacin Lactate sodium chloride injections are added, three mixes and can and kept away
Light is preserved.
Application method：Electric light hinder eye it is rubescent after, a Tropfen is dripped at angle within the eye, in half an hour after drip again 1 time, it is injured compared with
Light drop 3 times, severely injured drop 4-5 times, morning drips 1 time again, is no more than 6 times per consumption per day.
Embodiment 2
A kind of composition for being used to treat electric ophthalmia, formula and preparation method are：1ml adrenalin hydrochlorides are added
Into 1ml sodium chloride physiological saline, add 1ml levofloxacin Lactate sodium chloride injections, three mix can and lucifuge
Preserve.
Embodiment 3
A kind of composition for being used to treat electric ophthalmia, formula and preparation method are：1.5ml adrenalin hydrochlorides are added
Enter into 0.5ml sodium chloride physiological saline, add 1.5ml levofloxacin Lactate sodium chloride injections, three mixes
And keep in dark place.
Embodiment 4
A kind of composition for being used to treat electric ophthalmia, formula and preparation method are：0.5ml adrenalin hydrochlorides are added
Enter into 0.5ml sodium chloride physiological saline, add 0.5ml levofloxacin Lactate sodium chloride injections, three mixes
And keep in dark place.
Embodiment 5
Present composition clinical test：
Clinical data
2 months 2015 to 2 months 2017 city's ophthalmologic hospitals are seen and treated patients electric ophthalmia patient 158, man 109, female 49,
It is age 20-53 Sui, average 39 years old, it is eyes morbidity.Wherein, working radiation 138, ultraviolet lamp irradiation 20 by mistake are welded.
Clinical manifestation
Patient has ultraviolet lamp or electric welding strong illumination history, rises and occurs severe pain, photophobia after being ill, looks into visible bulbar conjunctiva hyperemia
Oedema, corneal epithelium point-like, tufted or sheet are stripped off, and fluorescent staining is positive.Parting：According to coincident with severity degree of condition point it is light, in,
Weight three types；It is light-duty：Mild pain or only foreign body sensation, corneal fluorescein stained area is below 1/3；It is medium-sized：Eye aches
Bitterly, there is foreign body sensation, photophobia is shed tears, conjunctival congestion, eyelid flush, corneal fluorescein stained area is in 1/3-2/3；It is heavy：Eyes
Have an intense pain, substantially, blepharospasm, red swelling of the skin, foreign body sensation is obvious, and corneal fluorescein stained area is 2/ for conjunctival congestion oedema
More than 3.It is medium-sized 54 light-duty 50 in above-mentioned case, it is heavy 54.
Two groups are randomly divided into per type.
Control group：It is light-duty 25, medium-sized 27, it is heavy 27.Treatment method：1. 0.5% dicaine eye drip surface is given
Anesthesia；2. localized sustained cold compress；3. 4 times/d of Compound Neomycin Sulfate Eye Drops eye drip preventions infection.
Experimental group：It is light-duty 25, medium-sized 27, it is heavy 27.Treatment method：On control group treatment method basis
Composition upper plus with the embodiment of the present invention 1, per half an hour eye drip once.
Treatment results
All patients are cured, and do not occur ocular infection and complication.Two groups of patient's curative days are shown in Table 1.
The different curative days of 1 two groups of patients of table
| Group | It is light-duty | It is medium-sized | It is heavy |
| Control group | 2.1 | 3.8 | 4.5 |
| Experimental group | 0.8 | 1.1 | 1.5 |
There were significant differences between two groups are various, p<0.05.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It may be appreciated other embodiment.
Claims (4)
1. a kind of composition for being used to treat electric ophthalmia, it is characterised in that including following component：Adrenalin hydrochloride, chlorine
Change sodium physiological saline, levofloxacin Lactate sodium chloride injection, the volume ratio of three is 1-5:1-3:1-5.
2. the composition according to claim 1 for being used to treat electric ophthalmia, it is characterised in that including following component：
Adrenalin hydrochloride, sodium chloride physiological saline, levofloxacin Lactate sodium chloride injection, the volume ratio of three is 1-3:1:1-
3。
3. the composition according to claim 1 for being used to treat electric ophthalmia, it is characterised in that including following component：
Adrenalin hydrochloride, sodium chloride physiological saline, levofloxacin Lactate sodium chloride injection, the volume ratio of three is 2:1:2.
4. a kind of being used for as described in claim 1-3 is any treats the composition of electric ophthalmia, it is characterised in that preparation side
Method is as follows：Adrenalin hydrochloride is added in sodium chloride physiological saline, levofloxacin Lactate sodium chloride injection is added,
Three mixes and kept in dark place.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710249649.0A CN106943387A (en) | 2017-04-17 | 2017-04-17 | A kind of composition for being used to treat electric ophthalmia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710249649.0A CN106943387A (en) | 2017-04-17 | 2017-04-17 | A kind of composition for being used to treat electric ophthalmia |
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| Publication Number | Publication Date |
|---|---|
| CN106943387A true CN106943387A (en) | 2017-07-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710249649.0A Pending CN106943387A (en) | 2017-04-17 | 2017-04-17 | A kind of composition for being used to treat electric ophthalmia |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528342A (en) * | 2003-10-13 | 2004-09-15 | 赵 凯 | Electrooptical eye drops for preventing and treating electric ophthalmia |
| CN104436079A (en) * | 2014-12-29 | 2015-03-25 | 国家电网公司 | Preparing method for composition used for treating electric ophthalmia |
| CN104436076A (en) * | 2014-12-29 | 2015-03-25 | 国家电网公司 | Composition for treating electric ophthalmia and application of composition |
| CN104491729A (en) * | 2014-12-26 | 2015-04-08 | 国家电网公司 | Pharmaceutical preparation for treating electric ophthalmia |
| CN104491730A (en) * | 2014-12-26 | 2015-04-08 | 国家电网公司 | Process for preparing pharmaceutical preparation for treating electric ophthalmitis |
-
2017
- 2017-04-17 CN CN201710249649.0A patent/CN106943387A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528342A (en) * | 2003-10-13 | 2004-09-15 | 赵 凯 | Electrooptical eye drops for preventing and treating electric ophthalmia |
| CN104491729A (en) * | 2014-12-26 | 2015-04-08 | 国家电网公司 | Pharmaceutical preparation for treating electric ophthalmia |
| CN104491730A (en) * | 2014-12-26 | 2015-04-08 | 国家电网公司 | Process for preparing pharmaceutical preparation for treating electric ophthalmitis |
| CN104436079A (en) * | 2014-12-29 | 2015-03-25 | 国家电网公司 | Preparing method for composition used for treating electric ophthalmia |
| CN104436076A (en) * | 2014-12-29 | 2015-03-25 | 国家电网公司 | Composition for treating electric ophthalmia and application of composition |
Non-Patent Citations (2)
| Title |
|---|
| 丁力等主编: "《318种中西药注射剂配伍变化快捷检索及应用手册》", 31 January 2006, 天津科学技术出版社 * |
| 吴秋云等: "电光性眼炎的调查分析与治疗", 《包头医学院学报》 * |
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Application publication date: 20170714 |
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