CN106923850A - The generation method and equipment of a kind of digital subtraction image - Google Patents

The generation method and equipment of a kind of digital subtraction image Download PDF

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Publication number
CN106923850A
CN106923850A CN201710097313.7A CN201710097313A CN106923850A CN 106923850 A CN106923850 A CN 106923850A CN 201710097313 A CN201710097313 A CN 201710097313A CN 106923850 A CN106923850 A CN 106923850A
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image
filter
digital
digital subtraction
wave
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俞龙江
解菁
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Beijing Medical Equipment Co Ltd
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Beijing Medical Equipment Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48Diagnostic techniques
    • A61B6/481Diagnostic techniques involving the use of contrast agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Image Processing (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

The present invention discloses the generation method and equipment of a kind of digital subtraction image.The method comprising the steps of:To contrast agent is injected in human body, survey meter is exposed to human body, collects original image;By original image importing digital low pass filter, it is smoothed, obtains frisket image;The original image is input into subtracter together with frisket image, carries out subtracting each other treatment, obtain digital subtraction image.The equipment is the equipment for realizing the above method.The present invention utilizes digital processing technology, obtains frisket image, need to only carry out single exposure, and device structure is simple, easy to operate.

Description

The generation method and equipment of a kind of digital subtraction image
Technical field
The invention belongs to medical treatment detection device technical field, more particularly to a kind of digital subtraction image for intervening operation Generation method and equipment.
Background technology
In clinical intervention surgical application, doctor generally needs to double expose patient body to determine to intervene Surgery The particular location of position.Its flow shoots for exposure for the first time, obtains the frisket image of body part, injects contrast agent, carries out the Re-expose shoots, and obtains injecting the image of contrast agent.By the image of angioplerosis contrast agent and frisket image subtraction, blood is obtained The digital subtraction image (Digital Subtraction Angiography, be abbreviated as DSA) of pipe.This application model is present Problem have:
1. excessive contrast agent is used.DSA is carried out every time, it is necessary to inject contrast agent to patient, contrast agent is in itself to human body Health has certain harm, but if contrast agent underfilling in intravascular, just cannot be presented right in DSA result images Than degree clearly blood vessel.Due to patient tissue and its diversity of pathology, in order to ensure DSA imaging results, during DSA very The suitable dose of hardly possible control contrast agent.
2. excessive radiant exposure.Carry out DSA every time and respectively obtain frisket picture and the full figure of contrast agent, it is necessary to double expose Picture, the radiation exposure dose needs that operation is related to reduce to reduce the injury to human body as far as possible, often increase a radiant exposure, all It is a radiation injury to patient, doctor needs the necessity for considering X-ray exposure, to reduce excessive radiant exposure, reduce The radiation injury of patient.
3. the motion artifacts for introducing.Carry out DSA every time and respectively obtain frisket picture and the full figure of contrast agent, it is necessary to double expose Picture, but the breathing of patient, shake can cause the image misalignment that double exposes during double exposure, cause occur motion when shadow is subtracted Artifact, this motion artifacts reduce picture contrast, cause to reduce the positioning precision of intervention operation.
The content of the invention
It is topic to solve above-mentioned, the invention is intended to proposing a kind of real-time frisket generation method of digital subtraction image and setting It is standby, using digital processing method, original image is processed using wave digital lowpass filter, frisket image is obtained, it is not required to two Secondary exposure, device structure is simple, easy to operate.
The present invention provides a kind of generation method for intervening the digital subtraction image of operation, comprises the following steps:
A, to contrast agent is injected in human body, survey meter is exposed to human body, collects original image;
B, by the original image importing digital low pass filter, be smoothed, obtain frisket image;
C, the original image is input into subtracter together with frisket image, carries out subtracting each other treatment, obtain Digital Subtraction figure Picture.
Using wave digital lowpass filter traditionally, DSA can be caused image blurring unclear.Currently preferred digital lowpass Wave filter is edge preserving filter.Above-mentioned steps B is:The original image is imported into the edge preserving filter, smooth place is carried out Reason, obtains frisket image.
Edge preserving filter also has multiple species, and currently preferred edge preserving filter is wave filter.Above-mentioned steps B is For:The original image is imported into the wave filter, is smoothed, obtain frisket image.
The cut-off frequency of wave filter is controlled by the window size of wave filter.Using above-mentioned wave filter During treatment original image, the window size of the wave filter is 4~6.
As preferred scheme of the invention, the wave digital lowpass filter and subtracter are embedded in image processor;Profit With image processor, the step B and step C is realized.
Preferably, when digital subtraction image (DSA images) is obtained using image processor, the wave digital lowpass filter is During wave filter, wave filter is comprised the following steps to the smoothing processing of original image:
F, the pixel to the original image carry out the accumulative summation of point-by-point integration, generate integrogram, obtain integrogram number Value, by integrogram numerical value storage to list;
G, the calculating that average and variance are carried out to the integrogram numerical value in the list, obtain value before filtering;
H, to value before the filtering guide filtering calculate, obtain frisket image.
In addition, the present invention provide it is a kind of generate digital subtraction image equipment, including survey meter, subtracter, display and Operating desk and image processor;
Described image processor includes signal input port and signal outlet, and described image processor is embedded with digital low-pass filtering Device;
The subtracter is embedded in described image processor, and the signal input port connects the wave digital lowpass filter respectively And subtracter, the wave digital lowpass filter connection subtracter, the subtracter connection signal outlet;
The survey meter connects the operating desk, and the operating desk connects the signal input port, the signal outlet connection The display.
Further, the wave digital lowpass filter is edge preserving filter.Further, the edge preserving filter is to draw Waveguide filter.
Used as preferred embodiments of the present invention, the equipment further includes holder, and the holder connects the operation Platform.After operating desk reads the digital subtraction image of image processor generation, holder is stored to, in case subsequently using.
Digital subtraction image generation method and equipment that the present invention is provided, Digital Subtraction figure is generated by being not required to re-expose Picture;Reduce the dose of radiation suffered by patient;Operating time is shortened, so as to reduce the implantation dosage of contrast agent;Use Device structure it is simple, it is easy to operate;Average and variance are calculated using integrogram method is converted into the process of tabling look-up, so as to shorten Operation time, guiding filtering is accelerated to calculate.
Brief description of the drawings
Fig. 1 is the flow chart that the method for the present invention generates DSA images;
Fig. 2 is the flow chart that the method for the present invention generates DSA images using wave filter;
Fig. 3 is the schematic diagram of equipment of the invention;
Fig. 4 is the flow chart of the embodiment of the present invention 1;
Fig. 5 is the flow chart of the embodiment of the present invention 2.
Specific embodiment
Below in conjunction with drawings and Examples, specific embodiment of the invention is described in more details, so as to energy Enough more fully understand the advantage of the solution of the present invention and its various aspects.However, specific embodiments described below and implementation Example is only descriptive purpose, rather than limitation of the present invention.
As shown in figure 1, the first purpose of the embodiment of the present invention is to provide a kind of digital subtraction image for intervening operation Generation method, comprise the following steps:
1st, to contrast agent is injected in human body, survey meter is exposed to human body, collects original image;
2nd, by original image importing digital low pass filter, it is smoothed, obtains frisket image;
3rd, original image is input into subtracter together with frisket image, carries out subtracting each other treatment, obtain digital subtraction image (DSA images).
Wherein, wave digital lowpass filter can be traditional linear filter such as average filter, Gaussian filter.But It is that linear filter can cause image border excess smoothness while image background is smooth, image border when causing to subtract shadow Misalignment, it is smudgy so as to cause DSA images contrast at vessel boundary to decline, and then cause to reduce intervention operation Positioning precision.(this problem of Edge-preserving filter) Ke Xie Decision conventional filters is improved edge preserving filter The vessel boundary contrast of DSA images, therefore, the preferred edge preserving filter of method of the embodiment of the present invention carries out digital lowpass filter Ripple, i.e. smoothing processing.
Edge preserving filter is divided into multiple species, such as two-sided filter (Bi-lateral filter), wave filter (Guided filter), L0 smoothing filters (L0 smoothing) etc., because the requirement of real-time of intervention operation is very high, The edge preserving filter that amount of calculation must be selected relatively low, therefore, the preferred wave filter of this method carries out digital low-pass filtering.
The cut-off frequency of wave filter is controlled by the window size of wave filter, and window set conference causes meter Calculation amount increases, it is preferred, therefore, that the window size of wave filter is 4~6.Window size refers to participating in what filtering was calculated Pixel dimension.
As the preferred scheme of the embodiment of the present invention, wave digital lowpass filter and subtracter are embedded in image processor (GPU).The treatment of above-mentioned steps 2 and step 3 to original image and frisket image, is carried out on GPU, final to obtain DSA images.
As shown in Fig. 2 digital subtraction image (DSA images) is obtained using image processor, when wave digital lowpass filter is During wave filter, wave filter is comprised the following steps to the smoothing processing of original image:
4th, the pixel to original image carries out the accumulative summation of point-by-point integration, generates integrogram, obtains integrogram numerical value, will Integrogram numerical value is stored in list;
5th, the calculating of average and variance is carried out to the integrogram numerical value in list, value before filtering is obtained;
6th, guide filtering to value before filtering to calculate, obtain frisket image.
Integrogram is that original image carried out into the accumulative summation of point-by-point integration according to pixel, and such as image is from the upper left corner Pixel starts, in image the 1st row the 1st row pixel integration and be the pixel pixel value, by that analogy, in image The integration and the pixel exactly before it of the pixel of the row of m rows n-th are the integration of the pixel of the row of m rows (n-1)th Pixel with the pixel arranged plus m rows n-th is worth to.
The integrogram numerical value that will be calculated is stored in a list, and the integrogram numerical value of such a specific region is just Can be obtained by searching corresponding position in the list.
Average in image in a region is equal to integrogram numerical value in the region divided by the area size, and variance is just Equal to the integrogram numerical value of each pixel of region subtract average square divided by the area size.
As shown in figure 3, the another object of the embodiment of the present invention is to provide a kind of equipment for generating digital subtraction image, including Survey meter 1, operating desk 2, image processor 3, display 4 and holder 5.Using digital processing technology, image processor 3 can be real Shi Shengcheng digital subtraction images.
Survey meter 1 includes x-ray bulb 11, flat panel detector (FPD) 12 and video frequency collection card 13.X-ray bulb 11 projects x-ray Through patient body, original image is formed on flat panel detector 12, original image output is arrived video acquisition by flat panel detector Card 13.
Operating desk 2 is used to read the raw image data of the caching of video frequency collection card 13, and sends it to image processor 3。
Image processor 3 includes signal input port and signal outlet, and wave digital lowpass filter 31 and subtracter 32 are embedded in figure As processor 3.
Raw image data passes through signal input port input picture processor 3;Signal input port passes raw image data respectively It is defeated by wave digital lowpass filter 31 and subtracter 32;Wave digital lowpass filter 31 obtains frisket by the treatment to original image Image, and by frisket image transmitting to subtracter 32;Subtracter 32 combines original image and frisket image, obtains DSA images. The preferred wave digital lowpass filter 31 of the embodiment of the present invention is wave filter.
DSA images are transferred to display by signal outlet, are checked for healthcare givers.
The connection operation platform 2 of holder 5, to operating desk 2, operating desk 2 will for the DSA image transmittings that image processor 3 will be generated Holder 5 is arrived in its storage, in case subsequently using.
Embodiment 1
As shown in figure 4, when needing the digital subtraction image of patient, during auxiliary treatment, doctor start contrast medium injector to Push-in contrast agent, treats that contrast agent flows in intravascular and reaches expanded state in patient vessel, restarts X-ray exposure and opens the light.By x-ray Bulb projects x-ray and passes through patient body, and original image is formed on flat panel detector (FPD), and flat panel detector is through video acquisition Original image is sent to image processing system by card.
Image processing system includes operating desk, GPU and display.Operating desk reads figure from the caching of video frequency collection card As data, and send it to graphic process unit GPU and carry out the calculating of real-time frisket generation, the DSA images being calculated are by scheming Shape processor GPU is sent to video card device, and DSA images are shown by video card device.
Above-mentioned x-ray bulb, flat panel detector and video frequency collection card are all the doctor towards medical interventional imaging application scenario Treat apparatus.Image processing system, typically towards the system of medical interventional imaging application, wherein, operating desk is typically desktop platform Formula machine, it is also possible to which there is the smart machine of calculation processing power similar with desktop desktop computer using other according to actual needs.Doctor Belong to the display device towards clinical medicine image field with the video card of display and its outfit.Graphic process unit is typically to support The graphic process unit plug-in card of CUDA computing architectures, while also including supporting that the graphic process unit of OpenCL and OpenGL frameworks is inserted Card.
Embodiment 2
As shown in figure 5, as different from Example 1, after graphic process unit (GPU) generation DSA images, being returned to behaviour Make platform, DSA images are sent to CD drive, DSA result images are burnt into CD by CD drive by operating desk again In.CD drive can be integrated on operating desk, it is also possible to used as separate devices, and CD is the conventional electricity such as VCD, DVD Brain consumptive material.
It should be noted that each embodiment above by reference to described by accompanying drawing is only used to illustrate rather than limitation originally The scope of invention, it will be understood by those within the art that, it is right under the premise without departing from the spirit and scope of the present invention Modification or equivalent that the present invention is carried out, all should cover within the scope of the present invention.Additionally, signified unless the context Outward, the word for occurring in the singular includes plural form, and vice versa.In addition, unless stated otherwise, then any embodiment All or part of can combine any other embodiment all or part of use.

Claims (10)

1. a kind of generation method of digital subtraction image, it is characterised in that including step:
A, to contrast agent is injected in human body, survey meter is exposed to human body, collects original image;
B, by the original image importing digital low pass filter, be smoothed, obtain frisket image;
C, the original image is input into subtracter together with frisket image, carries out subtracting each other treatment, obtain digital subtraction image.
2. the generation method of digital subtraction image according to claim 1, it is characterised in that the wave digital lowpass filter It is edge preserving filter.
3. the generation method of digital subtraction image according to claim 2, it is characterised in that the edge preserving filter is to draw Waveguide filter.
4. the generation method of digital subtraction image according to claim 3, it is characterised in that the window of the wave filter Mouth size is 4~6.
5. the generation method of digital subtraction image according to claim 1, it is characterised in that by the digital low-pass filtering Device and subtracter are embedded in image processor;Using image processor, the step B and step C is realized.
6. the generation method of digital subtraction image according to claim 5, it is characterised in that the wave digital lowpass filter It is wave filter, the smoothing processing includes step:
F, the pixel to the original image carry out the accumulative summation of point-by-point integration, generate integrogram, obtain integrogram numerical value, will The integrogram numerical value is stored in list;
G, the calculating that average and variance are carried out to the integrogram numerical value in the list, obtain value before filtering;
H, to value before the filtering guide filtering calculate, obtain frisket image.
7. a kind of equipment for generating digital subtraction image, including survey meter, subtracter, display and operating desk, it is characterised in that Further include image processor;
Described image processor includes signal input port and signal outlet, and described image processor is embedded with wave digital lowpass filter;
The subtracter is embedded in described image processor, and the signal input port connects the wave digital lowpass filter and subtracts respectively Musical instruments used in a Buddhist or Taoist mass, the wave digital lowpass filter connects the subtracter, and the subtracter connects the signal outlet;
The survey meter connects the operating desk, and the operating desk connects the signal input port, and the signal outlet connection is described Display.
8. it is according to claim 7 generation digital subtraction image equipment, it is characterised in that the wave digital lowpass filter It is edge preserving filter.
9. the equipment of generation digital subtraction image according to claim 8, it is characterised in that the edge preserving filter is to draw Waveguide filter.
10. it is according to claim 7 generation digital subtraction image equipment, it is characterised in that further include holder, The holder connects the operating desk.
CN201710097313.7A 2017-02-22 2017-02-22 The generation method and equipment of a kind of digital subtraction image Pending CN106923850A (en)

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