CN106913397B - A kind of Simple hip joint - Google Patents

A kind of Simple hip joint Download PDF

Info

Publication number
CN106913397B
CN106913397B CN201510990923.0A CN201510990923A CN106913397B CN 106913397 B CN106913397 B CN 106913397B CN 201510990923 A CN201510990923 A CN 201510990923A CN 106913397 B CN106913397 B CN 106913397B
Authority
CN
China
Prior art keywords
vestibule
grade
hip joint
refers
average value
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201510990923.0A
Other languages
Chinese (zh)
Other versions
CN106913397A (en
Inventor
叶雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chongqing Runze Pharmaceutical Co Ltd
Original Assignee
Chongqing Runze Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chongqing Runze Pharmaceutical Co Ltd filed Critical Chongqing Runze Pharmaceutical Co Ltd
Priority to CN201510990923.0A priority Critical patent/CN106913397B/en
Publication of CN106913397A publication Critical patent/CN106913397A/en
Application granted granted Critical
Publication of CN106913397B publication Critical patent/CN106913397B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • A61F2/36Femoral heads ; Femoral endoprostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • A61F2/36Femoral heads ; Femoral endoprostheses
    • A61F2/3609Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30011Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • A61F2/36Femoral heads ; Femoral endoprostheses
    • A61F2/3609Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
    • A61F2002/3611Heads or epiphyseal parts of femur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • A61F2/36Femoral heads ; Femoral endoprostheses
    • A61F2/3609Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
    • A61F2002/3625Necks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001Designing or manufacturing processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00023Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00035Other metals or alloys
    • A61F2310/00131Tantalum or Ta-based alloys

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

The present invention relates to a kind of Simple hip joints.It includes femoral stem (1) and neck of femur (2), it is characterised in that: the head upper end face of the femoral stem (1) is equipped with mounting hole (4);The lower end of the neck of femur (2) is fitted directly in the mounting hole (4);The lower part of the femoral stem (1) is by shank body (8) and is attached to the cyclic annular jacket layer (9) of shank body (8) appearance and forms, which is made of multilevel hole material;The cyclic annular jacket layer (9) is stretched out in the shank body end of femoral stem (1) lower part, and shank body end is set as the intermittent cyclic annular product (10) coaxial with femoral stem (1).Structure of the invention design simplifies, biocompatibility with higher, stable connection after implantation, and postoperation recovery effect is faster and better.

Description

A kind of Simple hip joint
Technical field
The present invention relates to human synovial displacement more particularly to a kind of Simple hip joints.
Background technique
Currently, existing artificial hip prosthesis' structure design multiplicity, for the connective stability for increasing structure itself, individually Design is especially complicated, and building block is more, is unfavorable for the efficient progress of replacement operation.It and is convenient for implant procedure, the prior art In there is also unitary design, although structure have many advantages, such as it is easily processed into type, if there are individual portions in application Fracture such as neck in position is broken situation, then will will lead to the failure of its structure allomeric function, this undoubtedly causes huge waste.This Outside, existing artificial hip prosthesis easily loosen, revolve generally there is also connective stability is not high between tissue after implantation Turn and falls off;Easily occur stress concentration in replacement prosthesis, easily causes replacement prosthesis fracture failure;Biocompatibility is poor, plants Repulsion easily is generated with tissue after entering, service life is shorter etc., and general character problem, these problems rely on simple optimizing structure design It is difficult to whole realizations.
Porous material has the characteristics such as relative density is low, specific strength is high, specific surface area is high, light-weight, good penetrability, is changing The numerous areas such as work, medicine have a wide range of applications.In the porous material, multilevel hole material is due to its unique performance --- and it is same When the advantage with holes at different levels, and there is advantage not available for the material in single hole simultaneously, thus obtained more and more Concern.For example, mesoporous (aperture 2nm < < 50nm)-micropore (the aperture < of macropore (aperture > 50nm)-with three-dimensional order 2nm) the molecular sieve of structure combines the advantage of multi-stage artery structure and the nanocrystalline the two of molecular sieve, imparts molecular sieve and more open The three-dimensional open-framework put, while nano molecular sieve crystal substantially reduces mass transfer path, effectively improves institute's score The materialization activity of son sieve.However, the porous structure used in current prosthetic replacement's prosthese is mostly single Porous materials, and Report about selection multilevel hole material is even more extremely limited.This may be mainly due to existing porous material itself there is also Along with porosity raising, structural mechanics intensity can be remarkably decreased, therefore porosity is generally relatively low, and connectivity is lower, no Conducive to the efficient exchange of substance in tissue, biocompatibility is bad, is self-possessed heavier, postoperative human feeling is bad, Yi Jikong The defects of gap, which is unevenly distributed, leads to the uneven distributions such as mechanical strength, elasticity modulus, causes hidden danger of quality.Such as CN201210185031 discloses a kind of preparation method of the biomimetic artificial bone of multistage (micrometer/nanometer) pore structure, preparation Three-dimensional multistage pore structure, due to the randomness of its pore structure, scrambling, the function of not still being able to satisfy biomimetic artificial bone is wanted It asks.In addition, needing material itself uniform, i.e. the distribution of pore size, hole as the multilevel hole material for being applied to biomimetic artificial bone Uniformly, so that performance uniformity, but in fact, there are many multilevel hole materials that the requirement, lack of uniformity is not achieved;To the greatest extent The material that pipe has, which is called oneself, has reached higher uniformity, but its uniformity is still the uniformity under large volume scale, if using corpusculum Product scale carries out measurement comparison, for example takes up an official post in material and take said three-dimensional body of the muti-piece volume no more than one cubic centimetre, surveys it respectively Quality, degree of irregularity difference is still very big, therefore causes various the performances such as mechanical strength, springform of multilevel hole material Amount etc. is uneven, to seriously affect its function.
Summary of the invention
The purpose of the present invention is to provide a kind of Simple hip joint, structure design simplifies, bio-compatible with higher Property, stable connection after implantation, postoperation recovery effect are faster and better.
The purpose of the present invention is achieved through the following technical solutions:
A kind of Simple hip joint, it includes femoral stem and neck of femur, it is characterised in that: the head upper end of the femoral stem Face is equipped with mounting hole;The lower end of the neck of femur is fitted directly in the mounting hole;The lower part of the femoral stem is by handle Body and the cyclic annular jacket layer composition for being attached to shank body appearance, the ring-type jacket layer are made of multilevel hole material;The femoral stem lower part Shank body end stretch out the cyclic annular jacket layer, and shank body end is set as the intermittent ring-type product coaxial with femoral stem.
To meet different patient personalized demands, to reach best installation effect requirement, the lower part of above-mentioned neck of femur is whole Body is in positive bar shape, and top is set as biasing tilt column;The lower end of above-mentioned neck of femur is set as threaded rod;The threaded rod and institute State mounting hole mating connection.The case where according to different patients, by the length and the neck of femur top and the bottom that control neck of femur top Between tilt angle, can make neck of femur have many kinds of variable specifications, to adapt to the demand of different patients.
While stress concentration phenomenon occurs after preventing shank body to be implanted into, for the knot for further enhancing femoral stem lower end Structure intensity, above-mentioned intermittent cyclic annular product are preferably set to 2~6 interruption component parts.
It for the position of resected femur handle after the implantation, and prevents it from sinking and rotation, is added on the middle part of above-mentioned femoral stem There is hole, is added in the hole and be combined with fastening inserted link.
To further prevent the relative motion between femoral stem and femur, and the sinking of femoral stem after implantation is prevented, and made It combines stronger, and the upper side close to above-mentioned neck of femur is provided with tapered protrusion in the middle part of above-mentioned femoral stem.
Excellent as further selecting, above-mentioned multilevel hole material used by above-mentioned ring-type jacket layer specifically can be by multistage porous Material is constituted, including material body, ontology are the vestibules being classified with material pore size, and around the cavity wall for forming vestibule It constitutes, vestibule is in uniform distribution, and junior's vestibule is arranged in the cavity wall for constituting higher level's vestibule in three-dimensional space;Holes at different levels Chamber is respectively mutually communicated and vestibule at different levels also penetrates through each other each other, and vestibule refers to each vestibule in multi-stage porous in uniform distribution It is in uniform distribution under arbitrary unit grade volume on material.
More specifically, above-mentioned multilevel hole material, intrinsic every grade of porous material are certainly a continuous structure body.And The maximum outer boundary of its every level-one porous material is suitable with the space boundary of entire material body.I.e. every grade of porous material is ok It is present in ontology as the independent porous material of level-one, and the physical and chemical performance with it alone.Such structure can make The physical and chemical performance of porous materials at different levels difference has different physical and chemical performances in the entire space of relatively-stationary material, Preferably meet various functional requirements.
More specifically, the cavity wall of above-mentioned multilevel hole material, higher level's vestibule can be made of next stage porous material, so that Vestibule is layered step by step, and the structure and pore size of reasonable Arrangement vestibule;The cavity wall of higher level's vestibule can also be by the more of its junior The grade compound composition of porous material, or constituted by the porous materials at different levels of its junior are compound, so that material meets specific function It can demand.
More specifically, above-mentioned unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
More specifically, above-mentioned vestibule refers in uniform distribution takes up an official post the volume taken no more than 1 in the multilevel hole material The said three-dimensional body of the same size of cubic centimetre, their quality are substantially suitable.
More specifically, above-mentioned quality quite refers to vertical no more than 1 in take up an official post multiple volumes for taking of multilevel hole material substantially The said three-dimensional body of square centimetre of same size claims its quality respectively, obtains the average value of their quality, and any three-dimensional weight phase The 4% of said three-dimensional body mass average value is not more than for the absolute value of the bias of mass average value.
Conventional medical metal, alloy and the materials such as nonmetallic specifically can be used in above-mentioned multilevel hole material in the present invention It is made.
The present invention has the following beneficial effects:
(1) the present invention provides a kind of Simple hip joint, neck of femur has a variety of variable specifications, has adapted to different trouble The individual demand of person;It is connected through a screw thread, and is combined together between neck of femur and femoral stem in structure, it is therefore prevented that neck of femur It is detached from from femoral stem, in turn simplifies structure design;And when such as there are being broken at the situations in neck, and can be by neck of femur and femoral stem It separates, avoid causes integrally-built failure to waste because of component failure.In addition, by by the handle of its femoral stem lower part Body end is arranged to by the intermittent cyclic annular product coaxial with femoral stem, it is therefore prevented that the hair of stress concentration phenomenon after shank body implantation It is raw.
(2) it is provided with the shank body appearance attachment in femoral stem lower part using ring-type jacket layer made of multilevel hole material, Since the ring-type jacket layer is made of multilevel hole material, and the multilevel hole material be three-dimensional perforation (including every grade of hole three-dimensional perforation, Holes at different levels three-dimensional perforation mutually), connectivity is greatly improved, and sufficiently meets material as the more of biomimetic artificial bone Kind functional requirement greatly alleviates structure certainly for example, having both good structural mechanical property and higher porosity simultaneously Weight, enhances the efficient exchange of substance between tissue, greatly accelerates the convalescence after Miles operation;And pass through the handle in femoral stem lower part The attachment of external this specific region of table, so that the ring-type jacket layer made of the multilevel hole material, the phase increases it before implantation Contact area between structure and femur, increases adhesive force, it is therefore prevented that the rotation of femoral stem, and phase after the implantation, due to its knot The distribution mode approximation trabecular bone structure in the multistage gap that vestibule is constituted in structure, thus provided for the fast-growth of tissue It is good to grow into space, so that tissue enters gaps at different levels, and then form multistage and grow into robust structure, is greatly promoted The connective stability of structure, also greatly reduces the rejection of human body, and the thus bad impression of bring, heals Effect is faster and better.
(3) it is also evenly distributed to the vestibule of multilevel hole material in the present invention and proposes the metric form of specific, concrete, it is clear It is the pore size distribution uniformity that multilevel hole material is measured under the scale compared with the subsection grade volume, such multilevel hole material is High uniformity, to ensure that the uniformity consistency of the various performances of multilevel hole material, avoid the internal flaw of selection.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of Simple hip joint described in the embodiment of the present invention 1.
Fig. 2 is the A-A cross-sectional view of femoral stem substructure in Simple hip joint described in Fig. 1.
Fig. 3 is the B-B cross-sectional view of femoral stem lower part shank body end structure in Simple hip joint described in Fig. 1.
Fig. 4 is the structural schematic diagram of Simple hip joint described in the embodiment of the present invention 2.
Fig. 5 is the C-C cross-sectional view of femoral stem lower part shank body end structure in Simple hip joint described in Fig. 4.
Fig. 6 is the structural schematic diagram of Simple hip joint described in the embodiment of the present invention 3.
Fig. 7 is the D-D cross-sectional view of femoral stem lower part shank body end structure in Simple hip joint described in Fig. 6.
Specific embodiment
Based on the technical solution of the present invention, following present its detailed embodiment, but protection scope of the present invention It is not limited only to embodiment disclosed below.When not departing from and changing above-mentioned technical idea of the invention, according to the general of this field Logical technological know-how and/or customary means, it is clear that the replacement or change of diversified forms can also be made, and the present invention should all be included in Within the scope of.
Embodiment 1
As shown in Figure of description 1-3, a kind of Simple hip joint, it includes femoral stem 1, neck of femur 2 and fastening inserted link 3;The head upper end face of its femoral stem 1 is equipped with threaded hole 4;The lower part of its neck of femur 2 is integrally in positive bar shape, and top is set as biasing Tilt column, and the lower end of neck of femur 2 is set as threaded rod 5;Threaded rod 5 and threaded hole 4 are directly cooperatively connected;Its femoral stem 1 Middle part on have additional hole 6, interference fit has fastening inserted link 3 in the hole 6, and the upper side close to neck of femur 2 in the middle part of femoral stem 1 It is provided with tapered protrusion 7;The lower part of its femoral stem 1 is made of shank body 8 with the cyclic annular jacket layer 9 for being attached to 8 appearance of shank body, the ring-type Jacket layer 9 is made of multilevel hole material;Cyclic annular jacket layer 9 is stretched out in the shank body end of its 1 lower part of femoral stem, and shank body end be set as with Four coaxial intermittent cyclic annular products 10 of femoral stem 1;Multilevel hole material used by cyclic annular jacket layer 9 is porous in the present embodiment Tantalum has three-level hole, wherein is uniformly distributed, has in the cavity wall of first order vestibule that is mutually communicated and to be uniformly distributed, be mutually communicated Second level vestibule has the third level vestibule for being uniformly distributed, being mutually communicated in the cavity wall of second level vestibule;And vestibule at different levels is mutual Also it penetrates through each other, the perforation is three-dimensional perforation;Every grade of porous material is certainly a continuous structure body, every level-one porous material Maximum outer boundary is suitable with entire material body space boundary, and every grade of porous material has physical and chemical performance alone.Total effective hole Gap rate is 80%, and first order hole average pore size is 510 μm, there is the of 25 μm of average pore size of perforation in the cavity wall in first order hole Second hole, the third level hole for thering is average pore size 780nm to penetrate through in the cavity wall in second level hole.
Taken up an official post with conventional machining method in the multilevel hole material and takes the identical size of 9 10mm × 10mm × 10mm Said three-dimensional body tests its quality with plum Teller-support benefit XP26Microbalance balance, and the results are shown in Table 1, wherein opposite It is expressed as a percentage in the absolute value of the bias of average value, value is average divided by quality for the absolute value of the bias relative to average value Value, as shown in Table 1, mass deviation are not more than 4%.
Table 1
Piece number Quality (mg) Absolute value of the bias (%) relative to average value
1 3282.624 1.6%
2 3292.63 1.3%
3 3242.592 2.8%
4 3265.944 2.1%
5 3285.960 1.5%
6 3469.440 4%
7 3409.392 2.2%
8 3396.048 1.8%
9 3379.368 1.3%
Mass average value 3336
The preparation method of this kind of material is:
(1) material prepares
The polystyrene sphere that partial size is 900 ± 30nm is chosen, the colloid template to form three-dimensional order arrangement is assembled, Tantalum nanocrystal solution is prepared, tantalum nanocrystal solution is introduced into three-dimensional colloid template made of polystyrene sphere, by three-dimensional glue Body template/tantalum nanocrystal solution mixture is dry, is then broken for the particle that partial size is 5 μm;
(2) taking partial size is the starch of 900 ± 30nm, mixes according to weight ratio 1:40 with distilled water, starch solution is made, Slurry is made according to weight ratio 12:1:8 in above-mentioned particle, the ethyl cellulose that partial size is 35 μm and starch solution, equably It is impregnated on the polyester form that aperture is 600 ± 20 μm;
(3) polyester form after dipping is sintered in vacuum or protective atmosphere, is carried out according still further to tantalum technique conventional subsequent The porous tantalum with three-level hole is made in processing.
This kind of porous tantalum is grown into as bone-regeneration material, first order pore size particularly suitable for meeting the vital tissues such as blood vessel Demand;Second level hole is lived away from home particularly suitable for various kinds of cell;Third level hole is particularly conducive to meet thin because of its a large amount of nano-pore The sticking of born of the same parents, differentiation demand, and specific surface area is very big, many growth factors can be loaded, the adhesive force between femur is also more By force, moreover, the connectivity in hole is good, holes at different levels are respectively mutually communicated and hole at different levels also penetrates through each other each other, can sufficiently be met Blood, the infiltration of tissue fluid, transmission realize the discharge of protein degradation products and metabolism product, therefore it is a kind of true Positive bone-regeneration material.In addition, according to the actual conditions of different patients, the length of selection control 2 top of neck of femur biasing tilt column The tilt angle A between L and 2 top and the bottom of neck of femur is spent, i.e., so that neck of femur 2 is provided with a variety of variable specifications, is adapted to The individual demand of different patients.
Embodiment 2
As shown in Figure of description 4-5, a kind of Simple hip joint, it includes femoral stem 1 and neck of femur 2;Its femoral stem 1 Head upper end face be equipped with threaded hole 4;The lower part of its neck of femur 2 is integrally in positive bar shape, and top is set as biasing tilt column, and stock The lower end of bone neck 2 is set as threaded rod 5;Threaded rod 5 and threaded hole 4 are directly cooperatively connected;It is upper close to stock in the middle part of its femoral stem 1 The side of bone neck 2 is provided with tapered protrusion 7;The lower part of its femoral stem 1 is by shank body 8 and the cyclic annular jacket layer 9 for being attached to 8 appearance of shank body Composition, the ring-type jacket layer 9 are made of multilevel hole material;Cyclic annular jacket layer 9, and handle are stretched out in the shank body end of its 1 lower part of femoral stem Body end is set as the two intermittent cyclic annular products 10 coaxial with femoral stem 1;Multistage used by cyclic annular jacket layer 9 in the present embodiment Porous materials are POROUS TITANIUM, have three-level hole, wherein are uniformly distributed, have in the cavity wall of first order vestibule that is mutually communicated uniformly point Cloth, the second level vestibule being mutually communicated have the third level vestibule for being uniformly distributed, being mutually communicated in the cavity wall of second level vestibule;And Vestibules at different levels also penetrate through each other each other, and the perforation is three-dimensional perforation.Every grade of porous material is from being a continuous structure body, often The maximum outer boundary of level-one porous material is suitable with entire material body space boundary, and every grade of porous material has materialization alone Performance.Total effective drainage porosity is 75%, and first order hole average pore size is 450 μm, has average pore size in the cavity wall in first order hole There is the third level hole of the perforation of average pore size 670nm in the second level hole of 30 μm of perforation in the cavity wall in second level hole.
Taken up an official post with conventional machining method in the POROUS TITANIUM and takes the three-dimensional of the identical size of 9 10mm × 10mm × 10mm Body tests its quality with plum Teller-support benefit XP26Microbalance balance, and the results are shown in Table 2, wherein relative to flat The absolute value of the bias of mean value is expressed as a percentage, and value is the absolute value of the bias relative to average value divided by mass average value, by Table 2 is it is found that its mass deviation is not more than 4%.
Table 2
Piece number Quality (mg) Absolute value of the bias (%) relative to average value
1 1156.184 1.4%
2 1135.077 3.2%
3 1151.493 1.8%
4 1157.356 1.3%
5 1145.630 2.3%
6 1217.159 3.8%
7 1197.225 2.1%
8 1191.362 1.6%
9 1201.915 2.5%
Mass average value 1172.600
The preparation method of this kind of POROUS TITANIUM is:
(1) material prepares
Using partial size for 2 μm of titanium valve is raw material, minimum one of the starch as multilevel hole material to be made that partial size is 770nm The pore creating material of grade vestibule, uses the stearic acid that partial size is 770nm as adhesive, according to titanium valve: starch: stearic acid: distilled water is pressed Volume ratio 3:1:1:11 is configured to slurry.
It uses rib diameter for 30 μm of polyester form, the slurry is uniformly filled wherein with foam impregnation method, forms base Then body and drying are crushed and obtain the hybrid particles containing raw material, pore creating material and polyester form that particle is 30 μm.
It (2) is that 3:1 equably pours into rib after evenly mixing by volume for 30 μm of methylcellulose by hybrid particles, partial size In the polyester form of three-dimensional perforation that diameter is 560 ± 20 μm, aperture is 400 ± 15 μm, then polyester form is put into closed Mold is pressed into dense green.
(3) by dense green vacuum-sintering;Sintered green body carries out conventional subsequent heat treatment according to titanium technique and obtains POROUS TITANIUM with three-level hole.
Similar to embodiment 1, this kind of material is particularly suitable for doing bone-regeneration material;In when occur neck fracture etc. feelings When shape, can be directly realized by and separate neck of femur 2 and femoral stem 1, avoid because neck fracture etc. component failures due to cause it is whole The failure of body structure wastes.
Embodiment 3
As shown in Figure of description 6-7, a kind of Simple hip joint, it includes femoral stem 1, neck of femur 2 and fastening inserted link 3;The head upper end face of its femoral stem 1 is equipped with mounting hole 4;The lower part of its neck of femur 2 is in positive bar shape, and top is set as biasing inclination Column;The lower part of its neck of femur 2 is directly mounted in mounting hole 4 via interference fit;Hole 6 is had additional on the middle part of its femoral stem 1, Interference fit has fastening inserted link 3 in the hole 6;The lower part of its femoral stem 1 is by shank body 8 and the cyclic annular jacket layer 9 for being attached to 8 appearance of shank body Composition, the ring-type jacket layer 9 are made of multilevel hole material;Cyclic annular jacket layer 9, and handle are stretched out in the shank body end of its 1 lower part of femoral stem Body end is set as an intermittent cyclic annular product 10 coaxial with femoral stem 1;Multi-stage porous used by cyclic annular jacket layer 9 in the present embodiment Material is same as Example 1.

Claims (29)

1. a kind of Simple hip joint, it includes femoral stem (1) and neck of femur (2), it is characterised in that: the femoral stem (1) Head upper end face is equipped with mounting hole (4);The lower end of the neck of femur (2) is fitted directly in the mounting hole (4);It is described The lower part of femoral stem (1) is by shank body (8) and is attached to the cyclic annular jacket layer (9) of shank body (8) appearance and forms, which adopts It is made of multilevel hole material;The cyclic annular jacket layer (9) is stretched out in the shank body end of femoral stem (1) lower part, and shank body end is set For the intermittent cyclic annular product (10) coaxial with femoral stem (1).
2. Simple hip joint as described in claim 1, it is characterised in that: the lower part of the neck of femur (2) is integrally in positive bar shape, Top is set as biasing tilt column;The lower end of the neck of femur (2) is set as threaded rod (5);The threaded rod (5) and the peace Hole (4) are filled to be cooperatively connected.
3. Simple hip joint as claimed in claim 1 or 2, it is characterised in that: the intermittent cyclic annular product (10) is set as 2~6 A interruption component part;Hole (6) are had additional on the middle part of the femoral stem (1), is added in the hole (6) and is combined with fastening inserted link (3).
4. Simple hip joint as claimed in claim 1 or 2, it is characterised in that: close to the femur on femoral stem (1) middle part The side of neck (2) is provided with tapered protrusion (7).
5. Simple hip joint as claimed in claim 3, it is characterised in that: close to the neck of femur on femoral stem (1) middle part (2) side is provided with tapered protrusion (7).
6. Simple hip joint as claimed in claim 1 or 2, it is characterised in that: the multilevel hole material, by multistage porous material structure At, including material body, ontology are the vestibules being classified with material pore size, and are constituted around the cavity wall for forming vestibule, Its vestibule is in uniform distribution, and junior's vestibule is arranged in the cavity wall for constituting higher level's vestibule in three-dimensional space;Vestibules at different levels are equal It is respectively mutually communicated and vestibule at different levels also penetrates through each other each other, vestibule refers to each vestibule in multilevel hole material in uniform distribution It is in uniform distribution under upper arbitrary unit grade volume.
7. Simple hip joint as claimed in claim 3, it is characterised in that: the multilevel hole material is made of multistage porous material, Including material body, ontology is the vestibule being classified with material pore size, and is constituted around the cavity wall for forming vestibule, hole Chamber is in uniform distribution, and junior's vestibule is arranged in the cavity wall for constituting higher level's vestibule in three-dimensional space;Vestibules at different levels are respective It is mutually communicated and vestibule at different levels also penetrates through each other each other, vestibule refers to that each vestibule is taken up an official post in multilevel hole material in uniform distribution It is in uniform distribution under unit grade volume of anticipating.
8. Simple hip joint as claimed in claim 4, it is characterised in that: the multilevel hole material is made of multistage porous material, Including material body, ontology is the vestibule being classified with material pore size, and is constituted around the cavity wall for forming vestibule, hole Chamber is in uniform distribution, and junior's vestibule is arranged in the cavity wall for constituting higher level's vestibule in three-dimensional space;Vestibules at different levels are respective It is mutually communicated and vestibule at different levels also penetrates through each other each other, vestibule refers to that each vestibule is taken up an official post in multilevel hole material in uniform distribution It is in uniform distribution under unit grade volume of anticipating.
9. Simple hip joint as claimed in claim 5, it is characterised in that: the multilevel hole material is made of multistage porous material, Including material body, ontology is the vestibule being classified with material pore size, and is constituted around the cavity wall for forming vestibule, hole Chamber is in uniform distribution, and junior's vestibule is arranged in the cavity wall for constituting higher level's vestibule in three-dimensional space;Vestibules at different levels are respective It is mutually communicated and vestibule at different levels also penetrates through each other each other, vestibule refers to that each vestibule is taken up an official post in multilevel hole material in uniform distribution It is in uniform distribution under unit grade volume of anticipating.
10. Simple hip joint as claimed in claim 6, it is characterised in that: the multilevel hole material, intrinsic every grade more Porous materials are from being a continuous structure body, and the space boundary of the maximum outer boundary of its every level-one porous material and entire material body Quite;Every grade of porous material has physical and chemical performance alone in material body.
11. Simple hip joint as claimed in claim 7, it is characterised in that: the multilevel hole material, intrinsic every grade more Porous materials are from being a continuous structure body, and the space boundary of the maximum outer boundary of its every level-one porous material and entire material body Quite;Every grade of porous material has physical and chemical performance alone in material body.
12. Simple hip joint as claimed in claim 8, it is characterised in that: the multilevel hole material, intrinsic every grade more Porous materials are from being a continuous structure body, and the space boundary of the maximum outer boundary of its every level-one porous material and entire material body Quite;Every grade of porous material has physical and chemical performance alone in material body.
13. Simple hip joint as claimed in claim 9, it is characterised in that: the multilevel hole material, intrinsic every grade more Porous materials are from being a continuous structure body, and the space boundary of the maximum outer boundary of its every level-one porous material and entire material body Quite;Every grade of porous material has physical and chemical performance alone in material body.
14. Simple hip joint as claimed in claim 6, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, or It is made of, or is constituted by the multistage porous material of its junior is compound, or by the at different levels porous of its junior next stage porous material Material cladding is constituted;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
15. Simple hip joint as claimed in claim 7, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, or It is made of, or is constituted by the multistage porous material of its junior is compound, or by the at different levels porous of its junior next stage porous material Material cladding is constituted;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
16. Simple hip joint as claimed in claim 8, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, or It is made of, or is constituted by the multistage porous material of its junior is compound, or by the at different levels porous of its junior next stage porous material Material cladding is constituted;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
17. Simple hip joint as claimed in claim 9, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, or It is made of, or is constituted by the multistage porous material of its junior is compound, or by the at different levels porous of its junior next stage porous material Material cladding is constituted;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
18. Simple hip joint as claimed in claim 10, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, Or it is made of next stage porous material, or constituted by the multistage porous material of its junior is compound, or by the at different levels more of its junior The compound composition of Porous materials;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
19. Simple hip joint as claimed in claim 11, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, Or it is made of next stage porous material, or constituted by the multistage porous material of its junior is compound, or by the at different levels more of its junior The compound composition of Porous materials;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
20. Simple hip joint as claimed in claim 12, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, Or it is made of next stage porous material, or constituted by the multistage porous material of its junior is compound, or by the at different levels more of its junior The compound composition of Porous materials;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
21. Simple hip joint as claimed in claim 13, it is characterised in that: the cavity wall of higher level's vestibule in the multilevel hole material, Or it is made of next stage porous material, or constituted by the multistage porous material of its junior is compound, or by the at different levels more of its junior The compound composition of Porous materials;The unit grade volume refers to cubic centimetre grade or cubic millimeter grade or more subsection grade volume.
22. Simple hip joint as claimed in claim 14, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
23. Simple hip joint as claimed in claim 15, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
24. Simple hip joint as claimed in claim 16, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
25. Simple hip joint as claimed in claim 17, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
26. Simple hip joint as claimed in claim 18, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
27. Simple hip joint as claimed in claim 19, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
28. Simple hip joint as claimed in claim 20, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
29. Simple hip joint as claimed in claim 21, it is characterised in that: the vestibule refers in uniform distribution in the multistage Porous materials take up an official post the volume taken no more than 1 cubic centimetre and each said three-dimensional body of same size, their quality are substantially suitable;The matter Amount quite refers to substantially takes up an official post the said three-dimensional body of the same size of multiple volumes for taking no more than 1 cubic centimetre in multilevel hole material, Claim its quality respectively, obtains the average value of their quality, and any three-dimensional weight is absolute relative to the deviation of mass average value Value is not more than the 4% of said three-dimensional body mass average value.
CN201510990923.0A 2015-12-25 2015-12-25 A kind of Simple hip joint Active CN106913397B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510990923.0A CN106913397B (en) 2015-12-25 2015-12-25 A kind of Simple hip joint

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510990923.0A CN106913397B (en) 2015-12-25 2015-12-25 A kind of Simple hip joint

Publications (2)

Publication Number Publication Date
CN106913397A CN106913397A (en) 2017-07-04
CN106913397B true CN106913397B (en) 2019-02-19

Family

ID=59460159

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510990923.0A Active CN106913397B (en) 2015-12-25 2015-12-25 A kind of Simple hip joint

Country Status (1)

Country Link
CN (1) CN106913397B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109316267B (en) * 2018-12-12 2024-02-02 陕西四正医疗器械有限责任公司 Femoral head membrane testing tool for hip joint replacement operation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0543099A3 (en) * 1991-11-19 1994-05-25 Bristol Myers Squibb Co Implant fixation stem
KR100932949B1 (en) * 2008-07-14 2009-12-21 한국기계연구원 Porous ceramic ball including hierarchically porous structure and the preparation method thereof
WO2011091466A1 (en) * 2010-02-01 2011-08-04 Maxx Health Inc Artificial joint component having hollow interior and means for load dissipation
CN203244473U (en) * 2013-05-16 2013-10-23 重庆润泽医药有限公司 Hip joint combined stem for bone replacement transplantation
CN203388966U (en) * 2013-06-13 2014-01-15 重庆润泽医药有限公司 Femoral component prosthesis for hip joint of human body
CN203328868U (en) * 2013-06-24 2013-12-11 重庆润泽医药有限公司 Implantable femoral head
CN203341864U (en) * 2013-07-18 2013-12-18 重庆润泽医药有限公司 Implanted femoral handle

Also Published As

Publication number Publication date
CN106913397A (en) 2017-07-04

Similar Documents

Publication Publication Date Title
CN106943213A (en) A kind of bionical Invasive lumbar fusion device
CN106109032A (en) A kind of gradient porous structure tooth implant
CN106913398B (en) A kind of hip-joint replacement prosthesis
CN106913397B (en) A kind of Simple hip joint
CN106913402B (en) A kind of modular hip prosthesis
US9889011B2 (en) Hard scaffold
CN106913395B (en) A kind of bion hip joint
CN106880422B (en) A kind of shoulder joint prosthesis
CN106880419B (en) A kind of hip prosthesis
CN106913399B (en) A kind of buffer-type hip joint
CN106913396B (en) A kind of implantation hip joint
CN106880421B (en) A kind of artificial hip joint
CN106913401B (en) A kind of multisection type hip joint
CN106913403B (en) A kind of artificial hip joint
CN106913404B (en) A kind of compound hip joint
CN106880420B (en) A kind of bionic hip-joint
CN106880424A (en) A kind of artificial shoulder joint prosthesis
CN107198598A (en) A kind of artificial knee joint
CN108201635B (en) Support for repairing articular subchondral bone
CN106923938A (en) A kind of bionical acetabular component
CN107198596B (en) Acetabular cup
CN106923939A (en) A kind of combined type acetabular component
CN107349031B (en) Porous metal rod
CN106955174A (en) A kind of elastic Invasive lumbar fusion device
US11278646B2 (en) Porous material

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant