CN106902726A - For the reactor of medical drugs low temperature preparation - Google Patents
For the reactor of medical drugs low temperature preparation Download PDFInfo
- Publication number
- CN106902726A CN106902726A CN201710242777.2A CN201710242777A CN106902726A CN 106902726 A CN106902726 A CN 106902726A CN 201710242777 A CN201710242777 A CN 201710242777A CN 106902726 A CN106902726 A CN 106902726A
- Authority
- CN
- China
- Prior art keywords
- reactor
- reactor body
- housing
- low temperature
- feed tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/005—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the outlet side being of particular interest
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00054—Controlling or regulating the heat exchange system
- B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
- B01J2219/00058—Temperature measurement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
- B01J2219/00081—Tubes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention discloses the reactor for medical drugs low temperature preparation, including reactor body, motor and agitating shaft, the condenser pipe of multiple levels is sequentially provided with reactor body from top to bottom, reactor body is stretched out at the two ends of the condenser pipe, one end of condenser pipe is connected with feed tube, the other end is connected with drain pipe, and feed tube is provided with valve；Housing is arranged with outside reactor body and feed tube, drain pipe, feed tube and drain pipe are stretched out outside housing, and reactor body is connected with the top of housing by feed pipe, and reactor body is connected with the lower section of housing by discharge nozzle.Low-temp reaction kettle of the invention, can quickly be reduced to temperature required in reactor, and can real-time regulation cooling liquid flow, improve refrigerating efficiency and effect, and save energy consumption.
Description
Technical field
The present invention relates to chemical industry and medical synthesis field, and in particular to for the reactor of medical drugs low temperature preparation.
Background technology
Low-temp reaction is commonly used, it is necessary to reaction temperature is controlled at -50 DEG C in the preparation production in medication chemistry synthesis field
To -80 DEG C of even lower scopes.Contain the reaction of metallo-organic compound participation, metallo-organic compound activity such as some
By force, in normal temperature condition stability inferior extreme difference, this kind of reaction need to be carried out at low temperature.
Common chuck cooling, typically by refrigeration unit cooling refrigeration agent, after by refrigerant send into reacting kettle jacketing with
Reactive material carries out heat exchange in kettle, and this mode equipment volume is big, and operation energy consumption is high, and reaction temperature control is no to be ensured, and
Poor refrigerating efficiency, it is impossible to control temperature in real time.
The content of the invention
The technical problems to be solved by the invention are existing low-temp reaction kettle inefficiencies, complex structure inconvenient operation,
A kind of high energy consumption, it is therefore intended that provide the reactor for medical drugs low temperature preparation, there is provided reactor of simple structure, can
Quickly be reduced to temperature required in reactor, and can real-time regulation cooling liquid flow, improve refrigerating efficiency with effect
Really, and save energy consumption.
The present invention is achieved through the following technical solutions：
For the reactor of medical drugs low temperature preparation, it is characterised in that including reactor body, motor and agitating shaft,
The condenser pipe of multiple levels is sequentially provided with reactor body from top to bottom, reactor body is stretched out at the two ends of the condenser pipe,
One end of condenser pipe is connected with feed tube, and the other end is connected with drain pipe, and feed tube is provided with valve；Reactor body and feed liquor
Pipe, be arranged with housing outside drain pipe, feed tube and drain pipe are stretched out outside housing, the top of reactor body and housing pass through into
Expects pipe is connected, and reactor body is connected with the lower section of housing by discharge nozzle.
Low-temp reaction kettle of the invention, can quickly be reduced to temperature required in reactor, and can real-time regulation
The flow of cooling liquid, improves refrigerating efficiency and effect, and save energy consumption.When reactor is reacted, cooling liquid
Such as liquid nitrogen is entered into each condenser pipe by feed tube, is distributed in from top to bottom in reactor body due to condenser pipe, because
This can sufficiently be freezed to reaction mass in reactor, the low temperature for making it quickly reach needs reaction, then be passed through
Condenser pipe carries out the liquid after heat exchange and is flowed out from drain pipe；The flow of cooling liquid can be controlled by control valve,
Just when starting, flow can be tuned up so as to be rapidly achieved low temperature, in the insulating process after reaching low temperature, flow can be fitted
When turn down, meanwhile, under the stirring action of agitating shaft, accelerate the heat exchange between cooling liquid and material；Housing sets
Put is, in order to protect feed tube and drain pipe, to prevent to collide the damage of generation equipment, and also to prevent and reactor
Body contacts frost bitten.
Filter is provided with discharge nozzle, when reaction completion carries out blowing, by filter, material can be slowed down
Dispensing speed, can lengthen discharging time, it is to avoid quickly discharging temperature contrast is excessive.
Temperature measuring equipment is provided with reactor body, temperature that can be in real-time monitoring reactor, so that control valve is adjusted
The flow of cooling liquid.
The condenser pipe is S-shaped, increases the contact area of condenser pipe and material in reactor, increases the face of heat exchange
Product, improves refrigerating efficiency.
Discharge nozzle upper end diameter is less than lower end diameter, has further slowed down the discharge velocity of material.
Heat-insulation layer is provided between reactor body and housing, effective insulation is carried out to reactor body, prevent reactor
In body heat exchange is carried out with outside housing.
The present invention compared with prior art, has the following advantages and advantages：
1st, the present invention is provided with temperature measuring equipment, Neng Goushi for the reactor of medical drugs low temperature preparation in reactor body
When monitoring reactor in temperature so that control valve adjust cooling liquid flow, quickly can be reduced in reactor
Required temperature, and can real-time regulation cooling liquid flow, improve refrigerating efficiency and effect, and save energy consumption；
2nd, the present invention for medical drugs low temperature preparation reactor, filter is provided with discharge nozzle, reaction complete into
When row blowing, by filter, the dispensing speed of material can be slowed down, discharging time can be lengthened, it is to avoid be quick
Drop temperature contrast is excessive, and discharge nozzle upper end diameter is less than lower end diameter, has further slowed down the discharge velocity of material；
3rd, the present invention for medical drugs low temperature preparation reactor, the condenser pipe be S-shaped, increase condenser pipe with it is anti-
The contact area of material in kettle is answered, the area of heat exchange is increased, refrigerating efficiency is improved, guarantor is provided between reactor body and housing
Warm layer, effective insulation is carried out to reactor body, prevents from carrying out heat exchange with outside housing in reactor body.
Brief description of the drawings
Accompanying drawing described herein is used for providing further understanding the embodiment of the present invention, constitutes of the application
Point, do not constitute the restriction to the embodiment of the present invention.In the accompanying drawings：
Fig. 1 is schematic structural view of the invention.
Mark and corresponding parts title in accompanying drawing：
1- reactor bodies, 2- motors, 3- agitating shafts, 4- condenser pipes, 5- feed tubes, 6- drain pipes, 7- valves, 8- shells
Body, 9- feed pipes, 10- discharge nozzles.
Specific embodiment
To make the object, technical solutions and advantages of the present invention become more apparent, with reference to embodiment and accompanying drawing, to this
Invention is described in further detail, and exemplary embodiment of the invention and its explanation are only used for explaining the present invention, do not make
It is limitation of the invention.
Embodiment
As shown in figure 1, the present invention for medical drugs low temperature preparation reactor, including reactor body 1, motor 2 with
The condenser pipe 4 of multiple levels is sequentially provided with agitating shaft 3, reactor body 1 from top to bottom, the two ends of the condenser pipe 4 are stretched out
Reactor body 1, one end of condenser pipe 4 is connected with feed tube 5, and the other end is connected with drain pipe 6, and feed tube 5 is provided with valve
7；Housing 8 is arranged with outside reactor body 1 and feed tube 5, drain pipe 6, feed tube 5 and drain pipe 6 are stretched out outside housing, reaction
Kettle body 1 is connected with the top of housing 8 by feed pipe 9, and reactor body 1 is connected with the lower section of housing 8 by discharge nozzle 10.
Low-temp reaction kettle of the invention, can quickly be reduced to temperature required in reactor, and can real-time regulation
The flow of cooling liquid, improves refrigerating efficiency and effect, and save energy consumption.When reactor is reacted, cooling liquid
Such as liquid nitrogen is entered into each condenser pipe by feed tube, is distributed in from top to bottom in reactor body due to condenser pipe, because
This can sufficiently be freezed to reaction mass in reactor, the low temperature for making it quickly reach needs reaction, then be passed through
Condenser pipe carries out the liquid after heat exchange and is flowed out from drain pipe；The flow of cooling liquid can be controlled by control valve,
Just when starting, flow can be tuned up so as to be rapidly achieved low temperature, in the insulating process after reaching low temperature, flow can be fitted
When turn down, meanwhile, under the stirring action of agitating shaft, accelerate the heat exchange between cooling liquid and material；Housing sets
Put is, in order to protect feed tube and drain pipe, to prevent to collide the damage of generation equipment, and also to prevent and reactor
Body contacts frost bitten.
Preferably, filter is provided with discharge nozzle, when reaction completion carries out blowing, by filter, can be subtracted
The dispensing speed of slow material, can lengthen discharging time, it is to avoid quickly discharging temperature contrast is excessive.
Preferably, temperature measuring equipment is provided with reactor body, temperature that can be in real-time monitoring reactor, so as to control valve
The flow of door regulation cooling liquid.
Preferably, the condenser pipe is S-shaped, increases the contact area of condenser pipe and material in reactor, increases heat and hands over
The area for changing, improves refrigerating efficiency.
Preferably, discharge nozzle upper end diameter is less than lower end diameter, has further slowed down the discharge velocity of material.
Preferably, heat-insulation layer is provided between reactor body and housing, effective insulation is carried out to reactor body, prevented
In reactor body heat exchange is carried out with outside housing.
Above-described specific embodiment, has been carried out further to the purpose of the present invention, technical scheme and beneficial effect
Describe in detail, should be understood that and the foregoing is only specific embodiment of the invention, be not intended to limit the present invention
Protection domain, all any modification, equivalent substitution and improvements within the spirit and principles in the present invention, done etc. all should include
Within protection scope of the present invention.
Claims (6)
1. the reactor of medical drugs low temperature preparation is used for, it is characterised in that including reactor body (1), motor (2) and stirring
The condenser pipe (4) of multiple levels, the two ends of the condenser pipe (4) are sequentially provided with axle (3), reactor body (1) from top to bottom
Reactor body (1) is stretched out, one end of condenser pipe (4) is connected with feed tube (5), and the other end is connected with drain pipe (6), feed tube
(5) it is provided with valve (7)；Housing (8), feed tube (5) are arranged with outside reactor body (1) and feed tube (5), drain pipe (6)
Stretched out outside housing with drain pipe (6), reactor body (1) is connected with the top of housing (8) by feed pipe (9), reactor
Body (1) is connected with the lower section of housing (8) by discharge nozzle (10).
2. the reactor for medical drugs low temperature preparation according to claim 1, it is characterised in that in discharge nozzle (10)
It is provided with filter.
3. the reactor for medical drugs low temperature preparation according to claim 1, it is characterised in that reactor body
(1) temperature measuring equipment is provided with.
4. the reactor for medical drugs low temperature preparation according to claim 1, it is characterised in that the condenser pipe
(4) it is S-shaped.
5. the reactor for medical drugs low temperature preparation according to claim 1, it is characterised in that on discharge nozzle (10)
End diameter is less than lower end diameter.
6. the reactor for medical drugs low temperature preparation according to claim 1, it is characterised in that reactor body
(1) it is provided with heat-insulation layer and housing (8) between.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710242777.2A CN106902726A (en) | 2017-04-14 | 2017-04-14 | For the reactor of medical drugs low temperature preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710242777.2A CN106902726A (en) | 2017-04-14 | 2017-04-14 | For the reactor of medical drugs low temperature preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106902726A true CN106902726A (en) | 2017-06-30 |
Family
ID=59209552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710242777.2A Pending CN106902726A (en) | 2017-04-14 | 2017-04-14 | For the reactor of medical drugs low temperature preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106902726A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107175058A (en) * | 2017-05-31 | 2017-09-19 | 张家港市科华化工装备制造有限公司 | The energy-conservation reactor of accurate temperature control |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202590786U (en) * | 2012-04-28 | 2012-12-12 | 苏州市金翔钛设备有限公司 | Reaction kettle with double coiled pipes |
| CN204933479U (en) * | 2015-09-15 | 2016-01-06 | 南京信息工程大学 | A kind of strong exothermal reaction device carried out at low temperatures |
| CN206082529U (en) * | 2016-10-12 | 2017-04-12 | 杭州百事特实业股份有限公司 | Surface sizing agent reation kettle |
-
2017
- 2017-04-14 CN CN201710242777.2A patent/CN106902726A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202590786U (en) * | 2012-04-28 | 2012-12-12 | 苏州市金翔钛设备有限公司 | Reaction kettle with double coiled pipes |
| CN204933479U (en) * | 2015-09-15 | 2016-01-06 | 南京信息工程大学 | A kind of strong exothermal reaction device carried out at low temperatures |
| CN206082529U (en) * | 2016-10-12 | 2017-04-12 | 杭州百事特实业股份有限公司 | Surface sizing agent reation kettle |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107175058A (en) * | 2017-05-31 | 2017-09-19 | 张家港市科华化工装备制造有限公司 | The energy-conservation reactor of accurate temperature control |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170630 |