CN106885764B - A kind of biomembrane anti-permeability detection device and application - Google Patents
A kind of biomembrane anti-permeability detection device and application Download PDFInfo
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- CN106885764B CN106885764B CN201510929702.2A CN201510929702A CN106885764B CN 106885764 B CN106885764 B CN 106885764B CN 201510929702 A CN201510929702 A CN 201510929702A CN 106885764 B CN106885764 B CN 106885764B
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- 230000003487 anti-permeability effect Effects 0.000 title claims abstract description 31
- 238000001514 detection method Methods 0.000 title claims abstract description 27
- 239000000463 material Substances 0.000 claims abstract description 21
- 230000002706 hydrostatic effect Effects 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000002474 experimental method Methods 0.000 claims description 4
- 230000004888 barrier function Effects 0.000 claims description 2
- RKTYLMNFRDHKIL-UHFFFAOYSA-N copper;5,10,15,20-tetraphenylporphyrin-22,24-diide Chemical compound [Cu+2].C1=CC(C(=C2C=CC([N-]2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3[N-]2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 RKTYLMNFRDHKIL-UHFFFAOYSA-N 0.000 claims 1
- 238000007789 sealing Methods 0.000 abstract description 4
- 238000005259 measurement Methods 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 230000035945 sensitivity Effects 0.000 abstract description 2
- 210000004379 membrane Anatomy 0.000 description 13
- 239000012528 membrane Substances 0.000 description 12
- 210000004556 brain Anatomy 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 239000012620 biological material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 239000002657 fibrous material Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 206010008164 Cerebrospinal fluid leakage Diseases 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 241001269524 Dura Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/082—Investigating permeability by forcing a fluid through a sample
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention provides a kind of designs rationally, the low pressure biomembrane anti-permeability detection device that is simple and convenient to operate of structure, the anti-permeability for the material that it is suitable for detection densities is low, resistance to hydrostatic pressure value is low.High with measurement sensitivity, the not damaged fixed material of sealing, provides the pressure value of wider range.Simultaneously have the characteristics that the speed of pressure applied can be regulated and controled according to dissimilar material properties.
Description
Technical field
The present invention relates to mechanics of biomaterials, the hydrodynamics conduction technical fields such as pressure, more particularly to low-density,
The detection of the low biomaterial anti-permeability of resistance to hydrostatic pressure value.
Background technique
Hard brain (ridge) membrane tissue is the natural barrier for protecting brain and myeloid tissue.Dura defect easily causes to cause brain ridge
Liquid leakage, therefore, it is necessary to repair the dura mater of defect with the excellent alternative materials of anti-permeability, to meet clinical needs.
In recent years, with the continuous research and development of organizational project and biomaterial subject, the research of biomembrane material is taken
Considerable degree of progress was obtained, researchers it is expected that it can replace hard brain (ridge) membrane, protect brain (spinal cord) tissue, reduce postoperative cerebral
The incidence of cerebrospinal fluid leakage.Therefore, the excellent of anti-permeability is an important indicator for evaluating biomembrane material performance.
Type i collagen film is to use the collagen extracted from animal tissue with low concentration, freeze-dried technique and friendship
The class spongy material with three dimensional pore structures for joining technique and obtaining.What its collagenous fibres was formed exempts to suture film material power
Performance is low, and tensile strength (tensile strength) only has 60-150KPa, and the stretching of material, sewing properties are very weak.But
It is that there is good anthemorrhagic performance due to collagen itself, material has good anti-permeability simultaneously thus.Principle is that collagen is fine
The contact with blood is tieed up, blood platelet and collagenous fibres are quickly combined, are filled in the three-dimensional pore space of material and in factor
Under assistance, the higher firm bonding of toughness is formed.Even so, when detecting material anti-permeability, three-dimensional collagen
Fiber is still very sensitive to the power being added in thereon --- excessive, material easy fracture；Too small, inspection does not measure the impervious of material bonding
Effect is leaked, needs a kind of special detection device the loose collagenous fiber material of detection low-density, low hydrostatic pressure resistant for this
Complete the test of mechanical property.
The clamper for the fixation test sample that existing anti-permeability detection device (domestic 812 type of YG (B)) uses is mostly gold
Belong to material.It is suitable for the tests that high molecular synthetic material etc. has the anti-permeability of the fabric of ultra high density, give birth to fixed
Easily occur damage sample or poorly sealed phenomenon when object membrane sample.In addition, existing anti-permeability detection device apply it is stressed
Instantaneous velocity is very fast, and measurement sensitivity is lower, when the resistance to hydrostatic pressure value of biomembrane is very low, is difficult to do its anti-permeability level
It evaluates out.
Biomembrane anti-permeability detection device working principle: using the principle of hydrodynamics liquid conductive pressure, in device
The not damaged sealing fixed biofilm in one end, the device other end contain the liquid of certain volume according to material property, and pass through piston
Control applies hydraulic speed.It is hydrostatic and when keeping non-leakage at this pressure by testing maximum that biomembrane can be born
Between judge its anti-permeability.
Summary of the invention
The present invention provides a kind of structures to be simple and convenient to operate, the biomembrane low suitable for low-density, resistance to hydrostatic pressure value is anti-
Permeability detection device.Its not damaged sealing fixed biofilm material of energy, can provide the pressure value of wider range, and apply pressure
Speed can be regulated and controled according to dissimilar material properties.
The present invention is achieved by the following technical solutions:
A kind of structure of biomembrane anti-permeability detection device includes kerve, four part of U-tube, fixture and straight tube.
Preferably, one a length of 20~60cm of configuration, width is 20~40cm, the kerve of a height of 5~10cm, and in kerve
" convex " type opening is equipped at 5~20cm of central location, size is 1~1.5 times of U-tube, and both ends are equipped with solid
Fixed column, pillar height are 5~50cm, convenient for fixed U-tube, and keep its holding horizontal；
Preferably, kerve is surrounded by baffle, height of baffle plate is 2~10cm, is completed to prevent from containing liquid or experiment
Discharge unrestrained table top when liquid in straight tube and U-tube.
Preferably, kerve both ends are equipped with 2 water outlets, respectively apart from bottom edge 0.5~1cm and 1~3cm；The latter one
Discharge outlet connection in the rubber hose and U-tube for being 0.6~1cm by diameter, and its level height is low compared with U-tube discharge outlet
0.5~2cm, it is easy to clean convenient for liquid discharges in slot and in U-tube.
The not damaged sealing fixed biofilm of frosted platform energy of U-tube and straight tube, and berm width is 0.5~5cm.
U-tube frosted platform and plunger distance 2~10cm of kerve, facilitate operation.
The piston of U-tube controls flow rate of liquid, realizes that hydrodynamics liquid conductive pressure and control apply hydraulic speed.
The internal diameter and height of U-tube can be designed adjustment according to material property, provide the pressure value of wider range, make it
The biomembrane material different with resistance to hydrostatic ability suitable for various specifications model.
Detailed description of the invention:
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is the top view of Fig. 1；
Specific embodiment
It is biomembrane anti-permeability detection device, including kerve 1,4 four part of U-tube 2, fixture 3 and straight tube such as Fig. 1.
" convex " type of kerve 1 opening matches with U-tube 2, and both ends are equipped with fixed column 1-2, convenient for fixed U-tube 2, and makes
It keeps horizontal；The baffle 1-1 of 1 surrounding of kerve completes liquid in discharge straight tube 3 and U-tube 2 to prevent from containing liquid or experiment
When unrestrained table top.The not damaged fixed biofilm of frosted platform 2-1 and 4-1 of U-tube 2 and straight tube 4, the piston 2-2 control of U-tube 2
Controlling flow speed, realizes hydrodynamics liquid conductive pressure.The horizontal bottom of the tube of U-tube 2 is equipped with discharge outlet 2-2, passes through hose
It is directly connect with one of discharge outlet 1-3 of kerve, the liquid being convenient to clean in U-tube.Another discharge outlet on kerve
1-2 can directly be connect with waste liquid barrel, convenient for the liquid in cleaning kerve.
Embodiment 1: individually exempt to suture the anti-permeability detection of collagem membrane
Apparatus of the present invention detection specification is used to exempt from suture collagem membrane anti-permeability for 5 × 60 × 60mm.
It takes one piece of 5 × 60 × 60mm's to exempt from suture collagem membrane, is placed on the frosted platform of U-tube, straight tube is placed on glue
On former film, it is completely coincident U-tube and straight tube, with the not damaged fixation of fixture.Liquid is contained in U-tube, reaches its hydrostatic
3cm water column (0.294KPa).When experiment starts, piston is opened, observation is exempted to suture collagem membrane non-leakage in 3s at this pressure.
Embodiment 2: exempt to suture the anti-permeability detection after collagem membrane infiltration blood
Apparatus of the present invention detection specification is used to exempt from suture collagem membrane anti-permeability for 5 × 60 × 60mm.
It takes one piece of 5 × 60 × 60mm's to exempt from suture collagem membrane, is infiltrated 15 seconds in the blood of fresh (no anti-coagulants).It will leaching
The collagem membrane of profit new blood is placed on the frosted platform of U-tube, and straight tube is placed on collagem membrane, keeps U-tube and straight tube complete
Full weight is closed, with the not damaged fixation of fixture.Liquid is contained in U-tube, its is made hydrostatic to reach 30cm water column (2.94KPa).It is real
When testing beginning, piston is opened, observation is exempted to suture collagem membrane non-leakage in 5min at this pressure.
Conclusion:
This equipment can detecte low-density, low hydrostatic pressure resistant loose collagenous fiber material and can control hydrostatic 0~
5.88Kpa range.
Claims (9)
1. a kind of biomembrane anti-permeability detection device, it is characterised in that it is suitable for the low materials of low-density, resistance to hydrostatic pressure value
The detection of anti-permeability, structure include kerve, four part of U-tube, fixture and straight tube, and kerve is to be open with " convex " type
Tetragonal body is closed, openings of sizes matches with U-tube；It is equipped with fixed column at opening both ends, convenient for fixed U-tube, and makes its guarantor
Water holding is flat；The baffle of kerve surrounding, unrestrained platform when to prevent from containing liquid in liquid or experiment completion discharge straight tube and U-tube
Face；The piston of the not damaged fixed biofilm of the frosted platform of U-tube and straight tube, U-tube controls flow rate of liquid, realizes hydrodynamics
Liquid conductive pressure；The horizontal bottom of the tube of U-tube be equipped with discharge outlet, by rubber hose directly with one of draining of kerve
Mouth connection；U-tube is equipped with 1 piston, 2~10cm of plunger distance kerve；The frosted platform and piston of U-tube are in same level height
Degree.
2. a kind of biomembrane anti-permeability detection device shown according to claim 1, it is characterised in that: a length of 20~60cm,
Width is 20~40cm, and the kerve surface of a height of 5~10cm is equipped with " convex " type opening at 5~20cm of central location,
Its size is 1~1.5 times of U-tube.
3. a kind of biomembrane anti-permeability detection device shown according to claim 1, it is characterised in that: kerve " convex " type opening
Both ends are equipped with fixed column, and pillar height is 5~50cm.
4. a kind of biomembrane anti-permeability detection device shown according to claim 1, it is characterised in that: kerve surrounding baffle is high
Degree is 2~10cm.
5. a kind of biomembrane barrier type detection device shown according to claim 1, it is characterised in that: kerve both ends are equipped with 2
Water outlet, respectively apart from bottom edge 0.5~1cm and 1~3cm；The latter one by diameter be 0.6~1cm rubber hose with it is U-shaped
Discharge outlet connection on pipe, and its level height 0.5~2cm low compared with U-tube discharge outlet.
6. a kind of biomembrane anti-permeability detection device shown according to claim 1, it is characterised in that: U-tube internal diameter is 1-
20cm。
7. a kind of biomembrane anti-permeability detection device shown according to claim 1, it is characterised in that: U-tube height is 10-
100cm。
8. a kind of biomembrane anti-permeability detection device shown according to claim 1, it is characterised in that: U-tube and straight tube
Frosted berm width is 0.5~5cm.
9. a kind of biomembrane anti-permeability detection device shown according to claim 1, it is characterised in that: U-tube frosted platform
Apart from 2~10cm of kerve.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510929702.2A CN106885764B (en) | 2015-12-16 | 2015-12-16 | A kind of biomembrane anti-permeability detection device and application |
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| CN201510929702.2A CN106885764B (en) | 2015-12-16 | 2015-12-16 | A kind of biomembrane anti-permeability detection device and application |
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| CN106885764B true CN106885764B (en) | 2019-08-27 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110243691B (en) * | 2019-06-25 | 2024-04-19 | 山东省水利科学研究院 | System and method for testing seepage-proof composite geomembrane |
| CN112649293B (en) * | 2020-11-05 | 2024-03-26 | 华北水利水电大学 | Testing device for hydraulic characteristic decay of geomembrane under large deformation state |
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