CN106880502A - A kind of Janus nano particles are used for the application of dental prosthetic packing material as bonding agent - Google Patents
A kind of Janus nano particles are used for the application of dental prosthetic packing material as bonding agent Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/871—Quartz; SiO2
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Abstract
The present invention relates to the application that a kind of Janus nano particles are used for dental prosthetic packing material as bonding agent, belong to dental restorative area.The important factor in order such as Division area, chemical composition, particle size distribution, the double bond group numbers that the present invention passes through accuracy controlling Janus nano composite materials difference chemical composition subregion, preparing hydrophobic side has the nanoscale Janus materials of polymerizable unsaturated double bond.HEMA (material of hydrophilic component and hydrophobic ingredient in now widely used stable adhesion agent) is substituted with the Janus nano particles for synthesizing, it is applied to potting resin Nian Jie with tooth body interface, solve the problems, such as that (hydrophily is too strong for current HEMA, bonding interface facile hydrolysis is destroyed, cytotoxicity is obvious), the adhesive linkage of long-acting stabilization is constructed, adhesives durability is improved.
Description
Technical field
The present invention relates to the application that a kind of Janus nano particles are used for dental prosthetic packing material as bonding agent, belong to
Dental restorative area.
Background technology
From France de Gennes in 1991 in Nobel's prize-giving speech, same particle two is stated with the vocabularys of Janus mono- first
Face has different chemical composition properties, and predicts that the similar amphiphilic of Janus particles can be in liquid/liquid interface self assembly.de
Gennes has triggered the research boom of Janus particles full of enlightening speech.Surface has double properties (hydrophilic/to dredge simultaneously
Water) Janus microns or nano particle assign two kinds of differences of micron or nano particle even opposite (polar/non-polar, positive electricity
Lotus/negative electrical charge etc.) property.At present, Janus material categorys are become increasingly abundant, and its special nature and tempting application prospect are constantly opened up
It is existing.Surface has the Janus materials of different chemical subregions because its special structure and performance have turned into material science study hotspot.
This kind of Janus materials with parents' feature are the ideal materials for solving interface problem.Janus nano materials have greatly due to it
Specific surface area, and hydrophilic component and hydrophobic ingredient are realized into stabilization subregion on its surface on surface, can effectively improve and fill out
Fill material and repair tooth body interface stability, improve adhesive strength.
At present, becoming increasingly abundant with Janus preparation method of granules, the application study of Janus particles is also increasingly subject to
Concern, the study hotspot as recent modified field.But, because nano particle is easily assembled, and in oil-water interfaces due to it
Small size causes to be difficult to stablize not rotate, and the Janus materials of nanoscale are difficult to be realized efficiently by Pickering emulsion process
Synthesis.
Further, amphipathic Interfacial compatibilization is based on using it to act on, should using Janus nano particles as interface bonding agent
For the dental prosthetic packing material of biomedical materials field.At present, hydrophilic component in oromaxillo-facial region vertex-gluing graph system
The stability of rear system miscible with hydrophobic components is study hotspot.Conventional stabilizer is HEMA at present, and this molecule was both included
Hydrophilic radical includes hydrophobic grouping again, but it has cytotoxicity and diffluent, leverages the stabilization of system
Property.Janus nano particles have extremely strong Interfacial compatibilization ability, can solve the problem that hydrophilic component and the miscible rear system of hydrophobic components not
The problem of stabilization, and by using nano biological particle as Janus material of main parts, can solve the problem that the cytotoxicity of HEMA is asked
Topic.
Since nineteen fifty-five first Application enamel acid etching adhesive technology, teeth restoration enters adhesive technology field.At present,
Field is bonded in oromaxillo-facial region, the dental adhesive for using at present is the mixture of hydrophilic component and hydrophobic components.In order that
Hydrophilic component and hydrophobic components are stable in bonding system and bonding interface, and the addition of bulking agent is essential.Conventional at present
Bulking agent is 2-hydroxyethyl methacry-late (2-hydroxyethyl methacrylate, HEMA), and its content is from 35%-
55%.But it is too strong that HEMA has a hydrophily, cause adhesive strength not enough, cytotoxicity problem；
There is Janus nano particles extremely strong Interfacial compatibilization to act on, frequently as particle emulsifying agents.By early-stage Study we
It was found that it can hydrophilic component and hydrophobic components effectively in stable adhesion agent, it is believed that Janus materials being capable of stable adhesion system and viscous
Border face, strengthens bonding agent adhesive property.
The content of the invention
Added to oral and maxillofacial surgery the invention aims to the Janus nano composite materials by the way that accuracy controlling is synthesized
In portion's caking agent series, to solve current HEMA, to there is hydrophily too strong, causes adhesive strength not enough, the problem of cytotoxicity,
There is provided a kind of Janus nano particles is used for the application of dental prosthetic packing material as bonding agent.The present invention will make Janus nanometers
The effect of composite material interface increase-volume expands to bio-medical research field.
The purpose of the present invention is achieved through the following technical solutions.
Janus nano particles, main body is nano SiO 2 particle, and side hemisphere carries amino group, the spherical zone of side half
There is carbon-carbon double bond group；White powder；It is nontoxic；It is spherical in size uniformity, size 5-200nm or so；
The preparation method of Janus nano particles, comprises the following steps that：
1) nano SiO 2 particle of biologically inert is prepared；
2) the modified nano SiO 2 particle of surface amino groups is prepared；
3) Pickering emulsion methods are used, constituency is carried out to its surface and is modified and selective chemical modification, prepare Janus
Nano particle；The amino modified nano SiO 2 particle that step 2 is obtained is dispersed in the mixed system of water and paraffin；
Stirring causes nano biological particle in paraffin/water termination monolayer distribution；Cooling obtains nano particle/paraffin composite balls；To nanometer
The exposed surface of particle/paraffin composite balls is performed etching and exposes unsalted surface, then with double bond containing silane coupler modified；Then
Washing removes deparaffnize, that is, obtain Janus nano particles；
Step 3) described in mixing time be 10-60 minutes；
Step 3) described in washing remove deparaffnize when solvent for use include tetrahydrofuran, n-hexane, dichloromethane and ethanol；
Preferred alcohol；Stirring is needed when washing is except deparaffnize, mixing time is 1-24 hours；
The double bond containing silane coupler includes A-171 (vinyltrimethoxy silane), γ-methacryloxy
Propyl trimethoxy silicane MTPMS, A-151 (VTES), KH-560 (3- glycydoxies three
Methoxy silane).
Using：Into without HEMA bonding agents, can be stablized viscous with HEMA or addition in Janus nano particles replacement bonding agent
Connect agent and improve adhesion durability；
Beneficial effect
1st, the present invention assigns nano particle provisional Janus amphiphilic natures in emulsion interface using dynamic key, helps it
Emulsion interface is arranged in form of single sheet, the Pickering emulsions of stabilization are obtained.Further can be repaiied subregion after partition protecting
Decorations, prepare Janus nano particles.Energy of adsorption of the nano particle at interface is higher, it is not easy to rotate, can be in breast
Liquid interfacial mono layer is distributed.
2nd, the present invention introduces group good with oil, water two-phase compatibility respectively by nano grain surface, in profit circle
Face forms " dynamic " Janus structures, obtains the nano particle of monolayer alignment.Further chemically reacted by favored area modified, obtained
To the Janus nano particles of " stabilization " structure.By dividing for accuracy controlling Janus nano composite materials difference chemical composition subregion
The important factor in order such as area's area, chemical composition, particle size distribution, double bond group numbers, prepare hydrophobic side have it is polymerizable
The nanoscale Janus materials of unsaturated double-bond.HEMA is substituted with the Janus nano particles for synthesizing (now widely used steady
Determine the material of hydrophilic component and hydrophobic ingredient in bonding agent), it is Nian Jie with tooth body interface to be applied to potting resin, solves current HEMA
Problem (hydrophily is too strong, the destruction of bonding interface facile hydrolysis, and cytotoxicity is obvious), construct the adhesive linkage of long-acting stabilization, improve
Adhesives durability.
3rd, preparation method of the present invention is simple and easy to apply, is adapted to extensive preparation and produces, and preparation process is simple is easy to implement exploitation
The preparation of the domestic bonding agent with independent intellectual property right, optimizes adhesive performance.
4th, Janus nanospheres mode of appearance prepared by preparation method of the present invention is completely uniform, in typical sphere, with typical case
Core shell structure, size tunable is 5-200nm or so, and size is controllable.
5. adhesive property can be significantly improved after Janus nano particles prepared by the present invention are added into without HEMA bonding agents
(P<0.05), significant difference.Janus nano particles prepared by the present invention contain as main component preparation Janus bonding agents are same
The bonding agent of HEMA is compared, and can significantly improve adhesive strength, significant difference (P<0.05).
Brief description of the drawings
Fig. 1 is TEM figures after the gold absorption of Janus nano particles；
Fig. 2 is that Janus nano particles and HEMA act on cell growth state figure after 3T3 cells, compared with HEMA,
Janus nano particles substantially reduce the cytotoxicity of HEMA；
Fig. 3 is hydrophilic component and hydrophobic components design sketch in Janus nanoparticles stable bonding agents；Left figure is to use
The system of stabilization is formed after Janus nano particles, right figure is free of Janus nano particles；
Fig. 4 is bonding test experiments schematic flow sheet
Specific embodiment
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
Embodiment 1
Janus nano particles, main body is silica, and side hemisphere carries amino group, and side hemisphere is double with carbon carbon
Key；Size is about 100nm or so, in homogeneous spherical, as shown in Figure 1；White is powdered；Nontoxicity, as shown in Figure 2；Energy
Enough stable adhesion agent reclaimed water/oil two-phases, occur without phase separation, as shown in Figure 3.
Prepared by Janus nano particles, comprise the following steps that：
1) nano SiO 2 particle of a diameter of 100nm of biologically inert or so is prepared；
2) the modified nano SiO 2 particle of surface amino groups, modification temperature 76 DEG C modified using APTMS are prepared；
3) Pickering emulsion methods are used, constituency is carried out to its surface and is modified and selective chemical modification, prepare Janus
Nano particle；
The nano SiO 2 particle that the surface amino groups that step 2 is obtained are modified is dispersed in the mixed system of water and paraffin
In；Amino modified nano SiO 2 particle, water, Quality of Paraffin Waxes ratio are 1:100:20；Stirring causes nanometer in 15 minutes
Grain is in paraffin/water termination monolayer distribution, 70 DEG C of reaction temperature；Subsequent room temperature cooling obtains nano particle/paraffin composite balls；Using
Amine fluoride is performed etching to the exposed surface of nano particle/paraffin composite balls and exposes unsalted surface, then uses 3- glycidyl ether oxygens
Base propyl trimethoxy silicane is modified；Then n-hexane washing removes deparaffnize, that is, obtain Janus nano particles；
Using：Added into bonding agent in substituting HEMA with Janus nano particles, bonding agent bonding can be significantly improved strong
Degree, as shown in table 1.
Table 1 adds G-bond bonding agent adhesive strengths after embodiment 1Janus nano particles
Specific adhesive strength method of testing is as shown in Figure 4：Janus nano particles are added into bonding agent, vibration is mixed,
People's mandibular third molar that surgery is pulled out recently is taken, corona is completely bad without dental caries.1% chlorine is stored in after surface cleaning under normal temperature
In amine T solution, used in 3 months.Removed around corona and be engaged perpendicular to tooth major axis under water cooling with diamond dust car pin
Cover-coat enamel matter, exposes shallow-layer dentine, is checked under stereomicroscope and confirms that enamel has been removed.Tooth is formed with the wet polishing of 220 mesh sand paper
Essential plane, is cleaned by ultrasonic 1 minute, then forms smear layer within 1 minute with the moist polishing dentin surface of 600 mesh sand paper.Coating
Bonding agent, photocuring, design carries out micro-stretching adhesive strength tester and uses Clearfil AP-X resin shapes after bonding agent solidification
Into 4mm high resins hat, it is stored in 37 DEG C of distilled water, water bath with thermostatic control embeds tooth after 24 hours with self-curing resin, perpendicular to
Bonding interface cuts into the bar-shaped sample of section about 1.0mm × 1.0mm.With the length in each bar-shaped sample section of miking
And width, calculate bond area S (mm2), then sample two ends are fixed on alpha-cyanoacrylate bonding agent (Bisco, USA) micro-
On the sample bench of tester for elongation, major axis is parallel with sample bench, bonding plane is located at sample bench and hits exactly and viscous without alpha-cyanoacrylate
Connect agent pollution.Start tester, speed (Crosshead speed) is set to 1mm/min, when sample fracture, record fracture
Pulling force peak F (N), calculates micro-stretching adhesive strength μ TBS (MPa) computing formula：MTBS=F/S.Experimental result counts credit
Analysis：Counted using SPSS13.0 softwares, adhesive strength difference between comparing two groups.Addition Janus nano particles can be obvious
Improve dentine adhesive strength (P<0.05).
Embodiment 2
Janus nano particles, main body is silica, and side hemisphere carries amino group, and side hemisphere is double with carbon carbon
Key；White is powdered；It is nontoxic；Size is about 50nm or so, in homogeneous spherical；
Prepared by Janus nano particles, comprise the following steps that：
1) nano SiO 2 particle of a diameter of 50nm of biologically inert or so is prepared；
2) the modified nano SiO 2 particle of surface amino groups, modification temperature 76 DEG C modified using APTMS are prepared；
3) Pickering emulsion methods are used, constituency is carried out to its surface and is modified and selective chemical modification, prepare Janus
Nano particle；The amino modified nano SiO 2 particle that step 2 is obtained is dispersed in the mixed system of water and paraffin；
Amino modified nano SiO 2 particle, water, the mass ratio of paraffin are 1:600:10), 70 DEG C of reaction temperature；Stirring 15 minutes
So that nano biological particle is in paraffin/water termination monolayer distribution；It is cooled to room temperature and obtains nano biological particle/paraffin composite balls；
The exposed surface of nano biological particle/paraffin composite balls is performed etching using amine fluoride exposes unsalted surface, then shunk with 3-
Glycerin ether epoxide propyl trimethoxy silicane is modified；Then n-hexane washing removes deparaffnize, that is, obtain Janus nano particles；
Using：HEMA is substituted with Janus nano particles to add into bonding agent, can be remarkably reinforced bonding agent adhesive strength
(P<0.05), as shown in table 2.
Table 2 adds G-bond bonding agent adhesive strengths after embodiment 2Janus nano particles
Janus nano particles are added into bonding agent, vibration is mixed, and takes people's lower jaw the 3rd that surgery is pulled out recently
Grind one's teeth in sleep, corona is completely bad without dental caries.It is stored under normal temperature in 1% toluene-sodium-sulfonchloramide solution after surface cleaning, is used in 3 months.Use diamond dust
Car pin is removed around corona and occlusal surface enamel under water cooling perpendicular to tooth major axis, exposes shallow-layer dentine, stereoscopic micro-
Checked under mirror and confirm that enamel has been removed.Dentine plane is formed with the wet polishing of 220 mesh sand paper, is cleaned by ultrasonic 1 minute, Ran Houyong
The moist polishing dentin surface of 600 mesh sand paper forms smear layer in 1 minute.Coating adhesive, photocuring is designed after bonding agent solidification
Carrying out micro-stretching adhesive strength tester uses Clearfil AP-X resins to form 4mm high resins hat, is stored in 37 DEG C of distillation
In water, tooth is embedded with self-curing resin after water bath with thermostatic control 24 hours, perpendicular to bonding interface cut into section about 1.0mm ×
The bar-shaped sample of 1.0mm.With the length and width in each bar-shaped sample section of miking, bond area S (mm are calculated2),
Then sample two ends are fixed on the sample bench of micro-stretching test instrument with alpha-cyanoacrylate bonding agent (Bisco, USA), major axis
It is parallel with sample bench, bonding plane is located at sample bench and hit exactly and polluted without alpha-cyanoacrylate bonding agent.Start tester, speed
(Crosshead speed) is set to 1mm/min, and pulling force peak F (N), calculates micro-stretching and glue when sample fracture, record fracture
Connect intensity μ TBS (MPa) computing formula：MTBS=F/S.Experimental result statistical analysis：United using SPSS13.0 softwares
Meter, adhesive strength difference between comparing two groups.Result shows that addition Janus nano particles can significantly improve dentine adhesive strength
(P<0.05)。
Embodiment 3
Janus nano particles, main body is silica, and side hemisphere carries amino group, and side hemisphere is double with carbon carbon
Key；White is powdered；It is nontoxic；Size is about 10nm or so, in homogeneous spherical；
Prepared by Janus nano particles, comprise the following steps that：
1) nano SiO 2 particle of a diameter of 10nm of biologically inert or so is prepared；
2) the modified nano SiO 2 particle of surface amino groups, modification temperature 76 DEG C modified using APTMS are prepared；
3) Pickering emulsion methods are used, constituency is carried out to its surface and is modified and selective chemical modification, prepare Janus
Nano particle；The amino modified nano SiO 2 particle that step 2 is obtained is dispersed in the mixed system of water and paraffin；
Amino modified nano SiO 2 particle, water, the mass ratio of paraffin are 1:300:20；Stirring causes nano biological in 15 minutes
Grain is in paraffin/water termination monolayer distribution, 70 DEG C of reaction temperature；It is cooled to room temperature and obtains nano biological particle/paraffin composite balls；Adopt
The exposed surface of nano biological particle/paraffin composite balls is performed etching with amine fluoride exposes unsalted surface, then shrink sweet with 3-
Oily ether epoxide propyl trimethoxy silicane is modified；Then n-hexane washing removes deparaffnize, that is, obtain Janus nano particles；
Using：HEMA is substituted with Janus nano particles to add into bonding agent, can strengthen bonding agent adhesive strength (P<
0.05), as shown in table 3.
Table 3 adds G-bond bonding agent adhesive strengths after embodiment 3Janus nano particles
Janus nano particles are added into bonding agent, vibration is mixed, and takes people's lower jaw the 3rd that surgery is pulled out recently
Grind one's teeth in sleep, corona is completely bad without dental caries.It is stored under normal temperature in 1% toluene-sodium-sulfonchloramide solution after surface cleaning, is used in 3 months.Use diamond dust
Car pin is removed around corona and occlusal surface enamel under water cooling perpendicular to tooth major axis, exposes shallow-layer dentine, stereoscopic micro-
Checked under mirror and confirm that enamel has been removed.Dentine plane is formed with the wet polishing of 220 mesh sand paper, is cleaned by ultrasonic 1 minute, Ran Houyong
The moist polishing dentin surface of 600 mesh sand paper forms smear layer in 1 minute.Coating adhesive, photocuring is designed after bonding agent solidification
Carrying out micro-stretching adhesive strength tester uses Clearfil AP-X resins to form 4mm high resins hat, is stored in 37 DEG C of distillation
In water, tooth is embedded with self-curing resin after water bath with thermostatic control 24 hours, perpendicular to bonding interface cut into section about 1.0mm ×
The bar-shaped sample of 1.0mm.With the length and width in each bar-shaped sample section of miking, bond area S (mm are calculated2),
Then sample two ends are fixed on the sample bench of micro-stretching test instrument with alpha-cyanoacrylate bonding agent (Bisco, USA), major axis
It is parallel with sample bench, bonding plane is located at sample bench and hit exactly and polluted without alpha-cyanoacrylate bonding agent.Start tester, speed
(Crosshead speed) is set to 1mm/min, and pulling force peak F (N), calculates micro-stretching and glue when sample fracture, record fracture
Connect intensity μ TBS (MPa) computing formula：MTBS=F/S.Experimental result statistical analysis：United using SPSS13.0 softwares
Meter, adhesive strength difference between comparing two groups.Result shows that addition Janus nano particles can significantly improve dentine adhesive strength
(P<0.05)。
Embodiment 4
Janus nano particles, main body is silica, and side hemisphere carries amino group, and side hemisphere is double with carbon carbon
Key；White is powdered；It is nontoxic；Size is about 5nm or so, in homogeneous spherical；
Prepared by Janus nano particles, comprise the following steps that：
1) nano SiO 2 particle of a diameter of 5nm of biologically inert or so is prepared；
2) the modified nano SiO 2 particle of surface amino groups, modification temperature 76 DEG C modified using APTMS are prepared；
3) Pickering emulsion methods are used, constituency is carried out to its surface and is modified and selective chemical modification, prepare Janus
Nano particle；The amino modified nano SiO 2 particle that step 2 is obtained is dispersed in the mixed system of water and paraffin；
Amino modified nano SiO 2 particle, water, the mass ratio of paraffin are 1:300:20；Stirring causes nano biological in 15 minutes
Grain is in paraffin/water termination monolayer distribution, 70 DEG C of reaction temperature；It is cooled to room temperature and obtains nano biological particle/paraffin composite balls；Adopt
The exposed surface of nano biological particle/paraffin composite balls is performed etching with amine fluoride exposes unsalted surface, then shrink sweet with 3-
Oily ether epoxide propyl trimethoxy silicane is modified；Then n-hexane washing removes deparaffnize, that is, obtain Janus nano particles；
Using：HEMA is substituted with Janus nano particles and prepare experiment bonding agent, can strengthen bonding agent adhesive strength (P
<0.05), as shown in table 4.
Table 4 adds embodiment 4Janus bonding agents and HEMA bonding agent adhesive strengths
Janus nano particles and HEMA are mixed in proportion with TEGDMA, CQ, inorganic filler, acetone, water etc. respectively, point
Two kinds of experiment bonding agents are not prepared, and vibration is mixed, and takes people's mandibular third molar that surgery is pulled out recently, the complete nothing of corona
Dental caries are bad.It is stored under normal temperature in 1% toluene-sodium-sulfonchloramide solution after surface cleaning, is used in 3 months.With diamond dust car pin under water cooling
Removed around corona perpendicular to tooth major axis and occlusal surface enamel, expose shallow-layer dentine, checked under stereomicroscope and confirm glaze
Matter has been removed.Dentine plane is formed with the wet polishing of 220 mesh sand paper, is cleaned by ultrasonic 1 minute, then beaten with 600 mesh sand paper are moist
Mill dentin surface forms smear layer in 1 minute.It is respectively coated Janus bonding agents and HEMA bonding agents, photocuring, bonding agent solidification
Design afterwards carries out micro-stretching adhesive strength tester and uses Clearfil AP-X resins formation 4mm high resin hats, is stored in 37 DEG C
Distilled water in, embed tooth with self-curing resin after water bath with thermostatic control 24 hours, cut into section about 1.0mm perpendicular to bonding interface
The bar-shaped sample of × 1.0mm.With the length and width in each bar-shaped sample section of miking, bond area S is calculated
(mm2), then sample two ends are fixed on the sample bench of micro-stretching test instrument with alpha-cyanoacrylate bonding agent (Bisco, USA)
On, major axis is parallel with sample bench, bonding plane is located at sample bench and hits exactly and polluted without alpha-cyanoacrylate bonding agent.Start test
Instrument, speed (Crosshead speed) is set to 1mm/min, and pulling force peak F (N), calculates when sample fracture, record fracture
Micro-stretching adhesive strength μ TBS (MPa) computing formula：MTBS=F/S.Experimental result statistical analysis：Use SPSS13.0 softwares
Counted, adhesive strength difference between comparing two groups.Result shows to be compared with HEMA bonding agents, and addition Janus bonding agents can
Significantly improve dentine adhesive strength (P<0.05).
Principle of the invention is, using nano biological particle as main body, subregion to be carried out to particle bilateral and is modified, and distinguishes it
Containing hydrophilic radical and hydrophobic grouping, as shown in figure 1, from the figure, it can be seen that only gold grain has been adsorbed in side, then nanosphere is double
Side has different performances.It is easy to it being capable of hydrophilic component and hydrophobic components in stable adhesion system.
By adjusting raw material rate of charge, the particle diameter for preparing nano biological particle can be adjusted.
The principle of the invention is, using the effect of Janus nano-particle stable interfaces, to be introduced into bonding agent, forms stabilization
Caking agent series and stable adhesion interface.
Claims (8)
1. a kind of Janus nano particles are used for the application of dental prosthetic packing material as bonding agent, it is characterised in that：With
Janus nano particles substitute HEMA in bonding agent.
2. a kind of Janus nano particles are used for the application of dental prosthetic packing material as bonding agent, it is characterised in that：Will
Janus nano particles substitute the HEMA in bonding agent or add into the bonding agent without HEMA.
3. a kind of Janus nano particles as claimed in claim 1 or 2 are used for answering for dental prosthetic packing material as bonding agent
With, it is characterised in that：The Janus nano particles, main body is nano SiO 2 particle, and side hemisphere carries amino group,
Side hemisphere carries carbon-carbon double bond；White powder；It is nontoxic；It is spherical in size uniformity, size 5-200nm or so.
4. a kind of Janus nano particles as claimed in claim 3 are used for the application of dental prosthetic packing material as bonding agent,
It is characterized in that：The preparation method of the Janus nano particles, comprises the following steps that：
1) nano SiO 2 particle of biologically inert is prepared；
2) the modified nano SiO 2 particle of surface amino groups is prepared；
3) Pickering emulsion methods are used, constituency is carried out to its surface and is modified and selective chemical modification, prepare Janus nanometers
Particle；The amino modified nano SiO 2 particle that step 2 is obtained is dispersed in the mixed system of water and paraffin；Stirring
So that nano particle is in paraffin/water termination monolayer distribution；Cooling obtains nano particle/paraffin composite balls；To nano particle/paraffin
The exposed surface of composite balls is performed etching and exposes unsalted surface, then with double bond containing silane coupler modified；It is washed out removing
Paraffin, that is, obtain Janus nano particles.
5. a kind of Janus nano particles as claimed in claim 4 are used for the application of dental prosthetic packing material as bonding agent,
It is characterized in that：Step 3) described in mixing time be 10-60 minutes.
6. a kind of Janus nano particles as claimed in claim 4 are used for the application of dental prosthetic packing material as bonding agent,
It is characterized in that：Step 3) described in washing remove deparaffnize when solvent for use include tetrahydrofuran, n-hexane, dichloromethane and second
Alcohol；Stirring is needed when washing is except deparaffnize, mixing time is 1-24 hours.
7. a kind of Janus nano particles as claimed in claim 6 are used for the application of dental prosthetic packing material as bonding agent,
It is characterized in that：Step 3) described in washing remove deparaffnize when solvent for use be ethanol.
8. a kind of Janus nano particles as claimed in claim 4 are used for the application of dental prosthetic packing material as bonding agent,
It is characterized in that：Step 3) the double bond containing silane coupler includes：Vinyltrimethoxy silane, γ-methacryl
Epoxide propyl trimethoxy silicane, VTES or 3- glycydoxy trimethoxy silanes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114983832A (en) * | 2022-06-29 | 2022-09-02 | 中山大学附属口腔医院 | Janus nanoparticle-based dental chemical curing adhesive resin and preparation method thereof |
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