CN106875409A - A kind of light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method - Google Patents

A kind of light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method Download PDF

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CN106875409A
CN106875409A CN201710181583.6A CN201710181583A CN106875409A CN 106875409 A CN106875409 A CN 106875409A CN 201710181583 A CN201710181583 A CN 201710181583A CN 106875409 A CN106875409 A CN 106875409A
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region
sorted
feature
sticking patch
coronal
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CN106875409B (en
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吴俊�
赵柳
徐丹
张学杰
李海燕
张榆锋
高莲
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Yunnan University YNU
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    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • G06T5/70
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/40Extraction of image or video features
    • G06V10/44Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10132Ultrasound image
    • G06T2207/101363D ultrasound image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20036Morphological image processing
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20092Interactive image processing based on input by user
    • G06T2207/20104Interactive definition of region of interest [ROI]

Abstract

The invention belongs to technical field of image processing, specially a kind of light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method.The present invention quantifies to extract from dynamicization three-dimensional breast ultrasound automatically first by textural characteristics extraction algorithm(ABUS)The three-dimensional volume of interest of image(VOI)In region to be sorted associated texture characteristic parameter, for use in the differentiation to sticking patch and manadesma;Then the spatial alternation more sensitive issue such as the postoperative curling of incisional hernia sticking patch, contraction is introduced three-D grain parameter and three-dimensional position parameter to improve the robustness of light-type sticking patch classification and identification algorithm for 2 d texture parameter;Finally feature selecting is carried out using class spacing algorithm and sequential advancement search method.The inventive method feature selecting effect is good, efficiency high, can effectively improve the nicety of grading of light-type incisional hernia sticking patch three-dimensional ultrasound pattern, is easy to automatic Classification and Identification.

Description

A kind of light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method
Technical field
The invention belongs to technical field of image processing, and in particular to a kind of light-type incisional hernia sticking patch three-dimensional ultrasound pattern is special Levy extracting method.
Background technology
Generally less than 0.5mm, in more than 3mm, foreign matter residual quantity very little causes its time to light-type sticking patch thickness in braiding aperture Acoustical signal is weaker, and the echo picture high of the linear in imaging results is not obvious enough.Meanwhile, in ventral hernia repair art, light-type Sticking patch can be placed on before stomach wall manadesma (Inlay), the space (Sublay) between manadesma and peritonaeum and abdomen between (Onlay), flesh Peritonaeum inwall (IPOM) four in the chamber position (as shown in Figure 2) related to stomach wall anatomical structure level, and all implantation positions Put and be all closer to fascia tissue.However, in the cross section view of HHUS (hand-held ultrasound, two-dimentional hand-held ultrasound) In (cross section and/or sagittal plane), because light-type sticking patch and fascia tissue are generally all shown as a high echogenic area for wire Domain [9].Therefore, what the linear marking feature of HHUS cross section views was reflected is that light-type sticking patch and fascia tissue are overlapped Hybrid texture attribute.Manadesma can be regarded as anatomy noise when light-type sticking patch differentiates, not only be harmful to manual detection, more The linear marking is greatly reduced in computer picture recognition to manadesma and the differential diagnosis value of light-type sticking patch.
Because light-type sticking patch and fascia tissue are overlapped in HHUS images, therefore it is difficult light-type sticking patch from its week Distinguished in the fascia tissue for enclosing.However, ABUS (automated 3-D breast ultrasound, automatized three-dimensional breast Gland ultrasound) pass through its coronal-plane (surgical plane) for the discriminating of light-type sticking patch provides extra diagnostic message, new is coronal Face view can isolate light-type sticking patch from fascia tissue, can so as to present significant light-type sticking patch mesh texture Depending on change.Therefore, ABUS provides the possibility for selectively analyzing light-type sticking patch coronal-plane textural characteristics, with offer more Plus accurately characteristic parameter describes the potential of mesh texture, can inherently for the identification of light-type sticking patch provides more accurate Characteristic parameter.
The content of the invention
It is an object of the invention to propose a kind of light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method, so as to Light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature can be exactly extracted, automatic classification is known in being easy to subsequent processes Not.
Light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method proposed by the present invention, first by textural characteristics Extraction algorithm quantifies region to be sorted in the VOI (volume of interest, volume of interest) for extract ABUS images automatically Associated texture characteristic parameter, for use in the differentiation to sticking patch and manadesma;Then incisional hernia is mended for 2 d texture parameter The spatial alternation more sensitive issue such as the postoperative curling of piece, contraction, introduces three-D grain parameter and three-dimensional position parameter to carry The robustness of light-type sticking patch classification and identification algorithm high;Finally spy is carried out using class spacing algorithm and sequential advancement search method Levy selection.
It is of the invention to comprise the following steps that:
S1:Build a 2-D for ABUS coronal-planes (two-dimensional, two dimension) foreground mask;
S2:Extract VOI;
S3:Pretreatment operation is carried out to VOI images;
S4:After by pretreatment, one group of region to be sorted of VOI is given, spy is carried out to each region to be sorted one by one Extraction is levied, 40 features are extracted altogether to each region to be sorted;
S5:40 features to extracting carry out feature selecting, and final selection 11 makes the classification of light-type sticking patch and manadesma Error reaches the feature of minimum as combinations of features.
The relevant technical details being related to regard to step in the inventive method below are further described specifically:
1. described to build a 2-D foreground mask for coronal-plane in step S1, its step is:
S1.1:0.5 to 0.9 times of ABUS coronal-planes section C of scanning total depth is located at by all1-CnTake out, to all C1- CnThe pixel of same position does average value processing in image, obtains a coronal-plane average image Cmean
S1.2:Using Otsu algorithms to image CmeanThreshold process is carried out, bianry image C is obtainedbinary
S1.3:Using morphology opening operation to CbinaryConnected region in image carries out edge smoothing treatment, and to it most The black cavity caused by focus or shade in big white connected region is filled, and obtains coronal-plane 2-D foreground mask images Cmask
2. in step S2, the extraction VOI, its step is:
S2.1:From ABUS coronal-plane mask images CmaskThe upper left corner starts, and image is divided into the image of 50 × 50 pixels Block;Run at boundary on the right and lower boundary pixel deficiency cannot piecemeal when, then add appropriate black region;
S2.2:By the coronal-plane position feature of all black picture blocks (the binaryzation value sum of all pixels point is 0) 0 is set to, by all image blocks intersected with foreground mask border (the binaryzation value sum of all pixels point is between 1 to 49) Coronal-plane position feature be set to 1, by the coronal of all full white image blocks (the binaryzation value sum of all pixels point be 50) Face position feature is set to 2;
S2.3:One by one by all coronal-plane position features not for 0 image block is chosen for current ROI (region of Interest, current interest region);Using all ABUS cross sections related to ROI and sagittal plane image-region, by 2-D ROI expand to the VOI of 3-D;One by one by current VOI send into subsequent characteristics extraction module, until complete to all VOI time Go through.
3. described to carry out pretreatment operation to VOI images in step S3, its step is:
S3.1:Use 3-D ISRAD (intelligent speckle reducing anisotropic Diffusion, intelligent spot noise reduction anisotropy parameter) algorithm [1] carries out three-dimensional filtering treatment to the VOI for automatically extracting out, It is thin without destruction such as light-type sticking patch reticular texture etc. to filter contained speckle noise in ABUS image homogeneous regions as far as possible Section feature;
S3.2:The single frames cross-sectional image for being pointed to VOI centers using Otsu algorithms [8] does binary conversion treatment, obtains standby The white connected region of choosing;
S3.3:White connected region using all areas in opening operation deletion bianry image less than 15 pixels;
S3.4:Extract the minimum circumscribed bounding box of each white connected region, calculate the width of bounding box, height and Apex coordinate;
S3.5:Delete the width of bounding box<The white connected region of 15 pixels;
S3.6:Mark is numbered to all remaining white connected regions, as region to be sorted.
4. in step S4, described to carry out feature extraction to each region to be sorted one by one, its step is:
S4.1:Extract the 2-D textural characteristics in region to be sorted;
S4.2:Extract the 3-D textural characteristics in region to be sorted;
S4.3:The local feature of scan depths residing for region to be sorted is extracted, is based on being swept residing for region to be sorted with one Retouch the local feature f in the Y- directions of the i.e. ABUS of depthdepthTo characterize the occurrence probability of sticking patch;
S4.4:The environmental characteristic in region to be sorted and hernical sac position relationship is extracted, region to be sorted and hernia are based on one The location parameter f of capsule position relationshipadjacencyTo characterize the occurrence probability of sticking patch.
Here it is main to use GLCM (gray level co- that are effective by theoretical proof and being used widely Occurrence matrix, gray level co-occurrence matrixes) gray value in area image to be sorted is converted into texture information by [2]. Meanwhile, for light-type sticking patch the characteristics of coronal-plane can show significant reticular texture, it is also added into being more suited to netted FD (fractal dimension, fractal dimension) [3] feature of texture analysis.May go out after surgery for light-type sticking patch The clinical picture of the existing contraction with spatial alternation feature, curling etc., has also been further introduced into 3-D GLCM [4] and 3-D FD [5] extracting the three-D grain feature in region to be sorted.For ABUS scan attributes and incisional hernia sticking patch implantation position characteristic, also Propose two position features in region to be sorted (i.e. local feature is corresponding with environmental characteristic).To sum up, 40 ginsengs are used altogether Count to carry out feature statement to each region to be sorted.Wherein, including 25 2-D textural characteristics, 13 3-D textural characteristics, 1 Based on the local feature of scan depths residing for region to be sorted, 1 special with the environment of hernical sac position relationship based on region to be sorted Levy.
5. in step S4.1, the 2-D textural characteristics for extracting region to be sorted are carried out in two steps:
The first step, calculates 12 2-D GLCM textural characteristics of region cross section to be sorted single frames section.First, extract The single frames cross section noise-reduced image at VOI centers;Secondly, upper and lower 5 pixel is done in scan depths direction to each region to be sorted Region extends;Then, it is partitioned into the cross section single frames section in each region to be sorted;Finally, 12 are calculated to single frames section Descriptor, as the 2-D GLCM textural characteristics that the region cross section to be sorted single frames is cut into slices;
Second step, calculates 12 2-D GLCM textural characteristics and 1 2-D FD of coronal-plane Slice Sequence in region to be sorted Feature.First, all coronal-plane Slice Sequences corresponding with each scan depths residing for region to be sorted are extracted;Secondly, it is right In each descriptor fi(i=1...n, n are the numbers of plies of coronal-plane Slice Sequence), uses descriptor fiSuccessively to every coronal-plane Section is calculated, and draws one group of characteristic value [f1...fn];Finally, [f is taken1...fn] average FmeanAs this descriptor pair In the characteristic value of coronal-plane Slice Sequence in region to be sorted.
For 2-D GLCM, such as definition initially by scholar Haralick in document [2] to GLCM, in two dimensional image Two differences in spatial location of pixel can use motion vectorTo describe.D is the distance between two pixels, It is two pixels and the angle of reference axis.Set a distance d is given for one, on 4 independent directionsThere may be 8 adjacent pixels altogether to occurring, as shown in Figure 4.So, in two dimensional image Direction is separated by a pair of pixels pair of d, the probability for occurring with gray scale i and j respectively, i.e.,It is designated as pij.Will be by pijGroup Into matrix normalization be the gray level co-occurrence matrixes that can obtain image.
Haralick proposes 14 textural characteristics calculated from GLCM in document [2], altogether.The present invention have selected it In 12 features, comprising energy (f1- Energy), contrast (f2- Contrast), correlation (f3- Correlation), variance (f4- Variance), homogeney (f5- Homogeneity), average (f6- Sum Average), entropy (f7- Entropy), from phase Close (f8- Autocorrelation), otherness (f9- Dissimilarity), cluster shade (f10- Cluster Shade), collection Group's protrusion (f11- Cluster Prominence) and maximum probability (f12-Maximum Probability)。
Wherein, NgBe grey level, p (i, j) is the probability that gray scale occurs to (i, j), i.e. gray level co-occurrence matrixes normalization Result.The average value and standard deviation of matrix row and column isWith
For 2-D FD, two-dimensional fractal dimension is estimated by the power spectrum of image Fourier transformation.Use following FFT (fast fourier transform, Fast Fourier Transform (FFT)) carries out DFT (discrete fourier to two dimensional image Transform, discrete Fourier transform):
Wherein, I is the two dimensional image region that size is (M, N), and u and v is respectively the spatial frequency (u=in x and y directions 0,1 ... M-1, v=0,1 ... N-1).Power spectral density P is estimated as follows by F (u, v):
P (u, v)=| F (u, v) |2 (14)
To calculate 2-D FD, P is carried out averagely along the radial section direction across FFT frequency domains.Frequency space is by equably It is divided into 24 directions, and 30 points of equably being sampled to the radial component in each direction.Calculate log (Pf) to log's (f) Least square fitting, whereinRadial frequency [10] is represented, then FD is relevant to this double-log in following form Slope of a curve β:
Wherein, DTIt is topological dimension, for two dimensional image, DT=2.
6. in step S4.2, the 3-D textural characteristics for extracting region to be sorted, to the volume number in each region to be sorted According to calculating 12 3-D GLCM textural characteristics and 1 3-D FD feature.
For 3-D GLCM, 2-D GLCM are extended to 3-D GLCM by the method for document [4].Two in 3-D view The differences in spatial location of tissue points can use motion vectorTo describe.D is the distance between two tissue points,It is two bodies Azimuth between vegetarian refreshments, θ is the zenith angle between two tissue points.Set a distance d is given for one, on 13 independent directions, altogether There may be 26 adjacent voxels to occurring, as shown in Figure 5.Here, still selective extraction and identical 12 in 2-D GLCM 3-D GLCM textural characteristics.
For 3-D FD, three-dimensional fractal dimension is estimated by the power spectrum of the 3-D Fourier transformations of volume images.Use Following 3-D FFT to whole 3-D view carry out 3-D DFT:
Wherein, I be size be (M, N, K) 3-D view region, u, v and w be respectively in the space of x, y and z directionss frequently Rate.Power spectral density P estimates as follows:
P (u, v, w)=| F (u, v, w) |2 (17)
To calculate 3-D FD, P is carried out averagely along the radial sector direction across 3-D FFT frequency domains.Frequency space is equal Decile is carried out in 24 azimuth directions and 12 zenith angular direction evenly, and the radial component in each direction is equably sampled 30 points.Calculate log (Pf) to the least square fitting of log (f), whereinRepresent radial frequency [10], then 3-D FD are relevant to the slope β of this double logarithmic curve in following form:
Wherein, DTIt is topological dimension, for 3-D view, DT=3.
7. in step S4.3, the local feature for extracting scan depths residing for region to be sorted, based on stomach wall along ABUS The anatomical features and four kinds of sticking patch implantation position features of strain less repair formula of Y-direction are scanned, light-type sticking patch is in belly Occurrence probability in 1-3cm depth areas below skin is maximum.It is therefore proposed that one is based on scan depths residing for region to be sorted The local feature f in (the Y- directions of ABUS)depthTo characterize the occurrence probability of sticking patch, and along ABUS scan depths direction to the part Feature situation as shown in Figure 6 is divided, i.e., carry out interval division to skin depth below from probe interface, respectively interval 0~1cm, 1~3cm of interval and 3~6cm of interval.According to the depth parameter in region to be sorted, to local feature fdepthSet such as Under:1) 0~1cm of interval, light-type sticking patch occurrence probability is medium on the upper side, i.e. fdepthBe set to 3., reason be this regional location compared with Shallow, only Onlay and Inlay arts formula is possible to place sticking patch in this region.But both are higher because of recurrence rate, at present should in clinic With not too much many.2) 1~3cm of interval, light-type sticking patch occurrence probability highest, i.e. fdepthBe set to 4., reason be this region just It is well the position for placing sticking patch in clinic using most Sublay and IPOM arts formulas at present;3) it is interval in 3~6cm, with depth The increase of degree, the possibility for placing sticking patch is gradually reduced, therefore from top to bottom, i.e. the f in this regiondepth2. and 1. it is set to.
8. in step S4.4, the environmental characteristic for extracting region to be sorted and hernical sac position relationship is divided to following two stepping OK.
The first step, to determine hernical sac position, proposes a kind of quick hernical sac detection location algorithm based on ABUS data.It is first First, all black objects in detection ABUS coronal images;Secondly, after pseudo- black objects are filtered, maximum black is calculated The size of target i.e. hernical sac in X-, Y- and Z- direction;3rd, to ensure that whole hernical sac is all contained among VOI volumes, Hernical sac size is all expanded into 40 pixels in three directions;4th, the VOI appearances cut out containing hernical sac are concentrated from ABUS volume datas Product;5th, spot noise reduction process is carried out to VOI using 3-D ISRAD algorithms;Finally, divide from every frame cross-sectional image of VOI Hernical sac profile is cut out, detection and localization process of the algorithm to hernical sac in ABUS data is completed.
Second step, after the completion of hernical sac detection, is adjusted to coronal-plane position feature.Pair with hernical sac coronal-plane projected area The coronal-plane position feature in the region to be sorted that domain overlaps or intersects adds 2;Pair with hernical sac coronal-plane projected area within 3cm The coronal-plane position feature in region to be sorted adds 1.There is the probability of sticking patch in the to be sorted region nearer apart from hernical sac position It is bigger, it is therefore proposed that a location parameter f based on region to be sorted with hernical sac position relationshipadjacencyTo characterize sticking patch Occurrence probability.So, using the coronal-plane position feature value in region to be sorted as environmental characteristic fadjacencyValue.Treat point The f in class regionadjacencyValue is bigger, and corresponding sticking patch occurrence probability is bigger.
9. in step S5,40 features of described pair of extraction carry out feature selecting, and its step is:
(1) between using DBC (distance between class, class spacing) method [6] to calculate the class of each feature respectively Away from.First, all 18 cases (case group) and incision tract 55 without sticking patch containing light-type sticking patch in incision tract In case (control group), with reference to this experiment case load, 278 and the present invention for representing all different cases are artificially chosen by doctor The area size's identical typical sample region to be sorted for automatically obtaining.Only contain the typical case of light-type sticking patch including 125 Region and 153 representative regions for only containing manadesma;Secondly, 40 features extracted before use are to all 278 sample areas Do calculation of characteristic parameters and normalization in domain;3rd, the class spacing of each feature is calculated respectively;
(2) being sorted from big to small by class spacing to 40 features, chooses larger preceding 25 features of class spacing, as spy Levy the primary dcreening operation result of selection;
(3) feature to tentatively select 25 uses SFS (sequential forward selection, before order Enter search) method [7] selected, to obtain making classification accuracy rate highest combinations of features.First, it is true by doctor from 278 In fixed sample, training set 139 and test set 139 are randomly selected.Secondly, grader selects SVM (support vector Machine, SVMs), grader is trained with training set, with test set testing classification effect.In order to reduce experiment sample Limited caused error, carries out 100 random experiments altogether, is evenly dividing training set and test set at random again every time.Root According to final result, when 4 2-D textural characteristics (energy, homogeney, entropy, the fractal dimension of two-dimensional coronal face image) of selection, 6 3-D textural characteristics (energy, correlation, homogeney, entropy, auto-correlation, the fractal dimension of three-dimensional volume to be sorted) and 1 area to be sorted Three dimensionality location parameter (the f in domainadjacency) this 11 features when, can reach light-type sticking patch and the error in classification of manadesma Minimum, so finally choosing 11 features as combinations of features.
As it was previously stated, being extracted 40 features altogether to each region to be sorted.Due to having one between these features Fixed redundancy, and the classification capacity of each feature is also not quite similar.Meanwhile, in order to reduce intrinsic dimensionality, improve classification accurate Property, reduce classification the working time.The present invention carries out feature selecting by from DBC and SFS to above-mentioned 40 features.Finally, select Taking 11 makes the error in classification of light-type sticking patch and manadesma reach the feature of minimum as combinations of features.They are 4 2-D textures Feature (energy, homogeney, entropy, the fractal dimension of two-dimensional coronal face image), 6 3-D textural characteristics be (three-dimensional volume to be sorted Energy, correlation, homogeney, entropy, auto-correlation, fractal dimension) and 1 three dimensionality location parameter (f in region to be sortedadjacency)。
Compared with prior art, it is of the invention not only to the light-type sticking patch having a extensive future, using ABUS technologies to it Effectively reliable feature extraction is carried out, and realizes the optimization choosing to light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature Select, effectively improve the accuracy of Classification and Identification, reduce the classification working time.The inventive method feature selecting effect is good, efficiency high, The nicety of grading of light-type incisional hernia sticking patch three-dimensional ultrasound pattern can be effectively improved.
Brief description of the drawings
Fig. 1 is light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method flow chart of the invention.
Fig. 2 is abdominal wall structure and four kinds of sticking patch implantation position schematic diagrames.Light-type sticking patch (black dotted lines) can be positioned over Before stomach wall manadesma (Onlay), between being positioned over flesh (Inlay), the space (Sublay) between manadesma and peritonaeum is positioned over, or be positioned over Intraperitoneal peritonaeum inwall (IPOM).
Fig. 3 is the typical ABUS images of light-type sticking patch and manadesma.Wherein, (a) and (b) is respectively light-type sticking patch and muscle Image of the film in ABUS coronal-planes;C () and (d) is the two image in ABUS cross sections.
Fig. 4 is pixel to the spatial relation figure in two dimensional image.The central pixel point given for one is (white Color), it is independent at 4On direction, there may be 8 pixels at a distance of normalized cumulant d altogether to (grey).
Fig. 5 is pixel to the spatial relation figure in 3-D view.The center tissue points given for one are (white Color), it is independent at 13On direction, there may be 26 voxels at a distance of normalized cumulant d altogether to (grey).
Local feature value setting schematic diagrames of the Fig. 6 for the ABUS imaging schematic diagrams in stomach wall region and based on scan depths.
Fig. 7 is automatically extracted for ROI's.Wherein, (a) foreground mask image Cmask;B () is by CmaskAdded at lower boundary black Color region, and it is divided into the image block of 50 × 50 pixels;C () ROI extracts result, coronal-plane position feature be 1 ROI with thin white Color frame represents, coronal-plane position feature is that 2 ROI is represented with thick white box.
Fig. 8 is VOI expansion process.Wherein, three orthogonal plane (A of (a) ABUS original volume data:Cross section, S:Arrow Shape face, C:Coronal-plane);The three orthogonal plane views of (b) VOI;The 3-D view of (c) VOI.
Fig. 9 .VOI image preprocessing process schematics.Wherein, (a) is located at the single frames cross section original image at VOI centers; (b) 3-D ISRAD noise-reduced images;(c) bianry image;D the small objects of () image (c) delete result;E () image (d) most Small circumscribed bounding box extraction results;F () narrow goal is deleted and alternative target numbering annotation results.
Figure 10 is that the cross section single frames in 5 regions to be sorted in Fig. 9 (f) is cut into slices and coronal-plane Slice Sequence.Wherein, (a) 5 single frames section in cross section;5 groups of Slice Sequences of (b) coronal-plane.
Figure 11 is that the quick hernical sac based on ABUS data detects location algorithm to automatically extracting result containing hernical sac VOI.(a) Three orthogonal plane (A of ABUS original volume data:Cross section, S:Sagittal plane, C:Coronal-plane);Three orthogonal planes of (b) VOI View;The 3-D view of (c) VOI.
Figure 12 is the adjustment result of coronal-plane position feature in region to be sorted.A the three-dimensional reconstruction of () hernical sac testing result is regarded Figure;B () hernical sac coronal-plane is projected and all regions to be sorted;C () needs to be adjusted coronal-plane position feature to be sorted Region.The region to be sorted that coronal-plane position feature adds 2 represents with thick white box, the area to be sorted that coronal-plane position feature adds 1 Domain is represented with thin white box.
Figure 13 is whole 40 DBC result of calculations of feature.Wherein feature f39It is scan depths feature fdepth, feature f40 It is region coronal-plane position feature f to be sortedadjacency
Specific embodiment
The present invention is illustrated with reference to the accompanying drawings and detailed description, it is clear that described embodiment is only It is a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill people The every other embodiment that member is obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
Referring to the drawings 1, the light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method of the technical program include with Under step:
S1:A 2-D foreground mask for ABUS coronal-planes is built, shown in experimental result such as Fig. 7 (a);
(1) it is located at 0.5 to 0.9 times of ABUS coronal-planes section C of scanning total depth by all1-CnTake out, to all C1-Cn The pixel of same position does average value processing in image, obtains a coronal-plane average image Cmean
(2) using Otsu algorithms to image CmeanThreshold process is carried out, bianry image C is obtainedbinary
(3) using morphology opening operation to CbinaryConnected region in image carries out edge smoothing treatment, and maximum to it The black cavity caused by focus or shade in white connected region is filled, and obtains coronal-plane 2-D foreground mask images Cmask
S2:Extract VOI;
(1) from ABUS coronal-plane mask images CmaskThe upper left corner starts, and image is divided into the image block of 50 × 50 pixels. Run at boundary on the right and lower boundary pixel deficiency cannot piecemeal when, then add appropriate black region, experimental result such as Fig. 7 Shown in (b);
(2) the coronal-plane position feature of all black picture blocks (the binaryzation value sum of all pixels point is 0) is put It is 0, by all image blocks intersected with foreground mask border (the binaryzation value sum of all pixels point is between 1 to 49) Coronal-plane position feature is set to 1, by the coronal-plane of all full white image blocks (the binaryzation value sum of all pixels point is 50) Position feature is set to 2, shown in experimental result such as Fig. 7 (c);
(3) one by one by all coronal-plane position features not for 0 image block is chosen for current ROI.Using all with ROI phases The ABUS cross sections of pass and sagittal plane image-region, the ROI of 2-D is expanded to the VOI of 3-D.After current VOI is sent into one by one Continuous characteristic extracting module, until completing the traversal to all VOI, experimental result is as shown in Figure 8.
S3:Pretreatment operation is carried out to VOI images, experimental result is as shown in Figure 9;
(1) three-dimensional filtering treatment is carried out to the VOI for automatically extracting out using 3-D ISRAD algorithms;
(2) the single frames cross-sectional image for being pointed to VOI centers using Otsu algorithms does binary conversion treatment, obtains alternative white Connected region;
(3) the white connected region using all areas in opening operation deletion bianry image less than 15 pixels;
(4) the minimum circumscribed bounding box of each white connected region is extracted, width, height and the top of bounding box is calculated Point coordinates;
(5) width of bounding box is deleted<The white connected region of 15 pixels;
(6) mark is numbered to all remaining white connected regions, as region to be sorted.
S4:After by pretreatment, one group of region to be sorted of VOI is given, each region to be sorted can be carried out one by one Feature extraction, 40 features are extracted to each region to be sorted altogether;
(1) the 2-D textural characteristics in region to be sorted are extracted;
A () calculates 12 2-D GLCM textural characteristics of region cross section to be sorted single frames section.First, VOI is extracted The single frames cross section noise-reduced image at center;Secondly, the region of upper and lower 5 pixel is done in scan depths direction to each region to be sorted Extension;Then, it is partitioned into the cross section single frames section in each region to be sorted;Finally, 12 descriptions are calculated to single frames section Symbol, as the 2-D GLCM textural characteristics that the region cross section to be sorted single frames is cut into slices.Figure 10 (a) is given as shown in Fig. 9 5 region cross section to be sorted single frames sections;
B () calculates 12 2-D GLCM textural characteristics and 1 2-D FD feature of coronal-plane Slice Sequence in region to be sorted. First, all coronal-plane Slice Sequences corresponding with each scan depths residing for region to be sorted are extracted;Secondly, for each Descriptor fi(i=1...n, n are the numbers of plies of coronal-plane Slice Sequence), uses descriptor fiEvery coronal-plane is cut into slices successively into Row is calculated, and draws one group of characteristic value [f1...fn];Finally, [f is taken1...fn] average FmeanAs this descriptor for treating point The characteristic value of class region coronal-plane Slice Sequence.As shown in Fig. 95 region coronal-planes to be sorted are given such as Figure 10 (b) to cut Piece sequence;
12 2-D GLCM textural characteristics include energy (f1- Energy), contrast (f2- Contrast), correlation (f3- Correlation), variance (f4- Variance), homogeney (f5- Homogeneity), average (f6- Sum Average), entropy (f7- Entropy), auto-correlation (f8- Autocorrelation), otherness (f9- Dissimilarity), cluster shade (f10- Cluster Shade), cluster protrude (f11- Cluster Prominence) and maximum probability (f12-Maximum Probability), calculated by formula 1-12 respectively;
For 2-D FD, two-dimensional fractal dimension is estimated by the power spectrum of image Fourier transformation.Use formula 13 FFT carries out DFT to two dimensional image, and spectrum density P estimated by F (u, v) by formula 14;
To calculate 2-D FD, P is carried out averagely along the radial section direction across FFT frequency domains.Frequency space is by equably It is divided into 24 directions, and 30 points of equably being sampled to the radial component in each direction.Calculate log (Pf) to log's (f) Least square fitting, whereinRadial frequency is represented, then FD is relevant to this double logarithmic curve by formula 15 Slope β;
(2) the 3-D textural characteristics in region to be sorted are extracted, 12 3-D GLCM textural characteristics is calculated and 1 3-D FD is special Levy.2-D GLCM are extended to 3-D GLCM by the method for document [4].For 3-D FD, three-dimensional fractal dimension is by volume images The power spectrum of 3-D Fourier transformations estimated.3-D is carried out to whole 3-D view using the 3-D FFT of formula 16 DFT, power spectral density P is estimated by formula 17;
To calculate 3-D FD, P is carried out averagely along the radial sector direction across 3-D FFT frequency domains.Frequency space is equal Decile is carried out in 24 azimuth directions and 12 zenith angular direction evenly, and the radial component in each direction is equably sampled 30 points.Calculate log (Pf) to the least square fitting of log (f), whereinRepresent radial frequency, Then 3-D FD are relevant to the slope β of this double logarithmic curve by formula 18;
(3) local feature of scan depths residing for region to be sorted is extracted, proposes that one is based on being swept residing for region to be sorted Retouch the local feature f in depth (the Y- directions of ABUS)depthTo characterize the occurrence probability of sticking patch, and along ABUS scan depths direction pair Local feature situation as shown in Figure 6 is divided.According to the depth parameter in region to be sorted, to local feature fdepthSet It is as follows:1) interval 0~1cm, fdepth=3., and 2) interval 1~3cm, fdepth=4., and 3) it is interval in 3~6cm, by this region fdepth2. and 1. feature is set to;
(4) environmental characteristic in region to be sorted and hernical sac position relationship is extracted, proposes that one is based on region to be sorted and hernia The location parameter f of capsule position relationshipadjacencyTo characterize the occurrence probability of sticking patch.
To determine hernical sac position, a kind of quick hernical sac detection location algorithm based on ABUS data is proposed.First, detect All black objects in ABUS coronal images;Secondly, after pseudo- black objects are filtered, maximum black target is calculated also just It is size of the hernical sac in X-, Y- and Z- direction;3rd, to ensure that whole hernical sac is all contained among VOI volumes, by hernical sac size All expand 40 pixels in three directions;4th, concentrated from ABUS volume datas and cut out the VOI volumes containing hernical sac;5th, make Spot noise reduction process is carried out to VOI with 3-D ISRAD algorithms;Finally, it is partitioned into hernical sac wheel from every frame cross-sectional image of VOI Exterior feature, completes detection and localization process of the algorithm to hernical sac in ABUS data.Algorithm containing hernical sac VOI to automatically extracting result as schemed Shown in 11.
After the completion of hernical sac detection, coronal-plane position feature is adjusted.It is pair Chong Die with hernical sac coronal-plane view field Or the coronal-plane position feature in intersecting region to be sorted adds 2;It is pair to be sorted within 3cm with hernical sac coronal-plane projected area The coronal-plane position feature in region adds 1.It is final using the coronal-plane position feature value in region to be sorted as environmental characteristic fadjacencyValue.The adjustment result of coronal-plane position feature in region to be sorted is as shown in figure 12.
S5:40 features to extracting carry out feature selecting, and final selection 11 makes the classification of light-type sticking patch and manadesma Error reaches the feature of minimum as combinations of features;
(1) the class spacing of each feature is calculated respectively using DBC.First, in whole of the incision tract containing light-type sticking patch In 55 cases (control group) of 18 cases (case group) and incision tract without sticking patch, 278 are selected manually by doctor The area size's identical typical sample region to be sorted automatically obtained with this paper.Only mended containing light-type including 125 The representative region of piece and 153 representative regions for only containing manadesma.Secondly, 40 features extracted before use are to all 278 Individual sample areas do calculation of characteristic parameters and normalization.3rd, the class spacing of each feature is calculated respectively and 40 features are pressed Class spacing is ranked up from big to small.Finally, primary dcreening operation result of larger preceding 25 features of class spacing as feature selecting is chosen. Experimental result is as shown in figure 13;
(2) being sorted from big to small by class spacing to 40 features, chooses larger preceding 25 features of class spacing;
(3) feature to tentatively select 25 is selected using SFS.First, from 278 samples for having been determined by doctor In this, training set 139 and test set 139 are randomly selected.Secondly, grader selects SVM, and grader is trained with training set, With test set testing classification effect.In order to reduce the limited caused error of experiment sample, 100 random experiments are carried out altogether, often It is secondary to be evenly dividing training set and test set at random again.Finally, choosing 11 makes the error in classification of light-type sticking patch and manadesma The feature of minimum is reached as combinations of features.They be 4 2-D textural characteristics (energy of two-dimensional coronal face image, homogeney, Entropy, fractal dimension), 6 3-D textural characteristics (energy, correlation, homogeney, entropy, auto-correlation, FRACTAL DIMENSIONs of three-dimensional volume to be sorted Number) and 1 three dimensionality location parameter (f in region to be sortedadjacency)。
The present invention chooses makes the error in classification of light-type sticking patch and manadesma reach the feature of minimum as combinations of features, realizes To the optimum choice of light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature, effectively improve the accuracy of Classification and Identification, reduce The classification working time.The present invention is for 2 d texture parameter to the spatial alternations such as the postoperative curling of incisional hernia sticking patch, contraction sensitivity Problem, it is proposed that using three-D grain parameter and be aided with ABUS three dimensionalities location parameter and extract light-type incisional hernia sticking patch feature Method, the nicety of grading of light-type incisional hernia sticking patch three-dimensional ultrasound pattern can be effectively improved.
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Claims (9)

1. a kind of light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method, it is characterised in that comprise the following steps:
S1:Build a two dimension for ABUS coronal-planes(2-D)Foreground mask;
S2:Extract VOI;
S3:Pretreatment operation is carried out to VOI images;
S4:To giving one group of region to be sorted of VOI, can be to 40 features of each extracted region to be sorted;
S5:40 features to extracting are selected, and final selection makes light-type sticking patch and the error in classification of manadesma reach minimum Feature as combinations of features;
It is described to build concretely comprising the following steps for 2-D foreground mask for coronal-plane in step S1:
S1.1:0.5 to 0.9 times of ABUS coronal-planes section of scanning total depth is located at by allC 1-C nTake out, to allC 1-C nFigure The pixel of same position does average value processing as in, obtains a coronal-plane average imageC mean
S1.2:Using Otsu algorithms to imageC meanThreshold process is carried out, bianry image is obtainedC binary
S1.3:Using morphology opening operation pairC binaryImage is processed, and obtains coronal-plane 2-D foreground mask imagesC mask
2. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 1, it is characterised in that In step S2, the extraction VOI's concretely comprises the following steps:
S2.1:From ABUS coronal-plane mask imagesC maskThe upper left corner starts, and image is divided into the image block of 50 × 50 pixels;
S2.2:The coronal-plane position feature of all black picture blocks is set to 0, by all images intersected with foreground mask border The coronal-plane position feature of block is set to 1, and the coronal-plane position feature of all full white image blocks is set into 2;
S2.3:One by one by all coronal-plane position features not for 0 image block is chosen for current interest region(ROI);Use All ABUS cross sections related to ROI and sagittal plane image-region, the ROI of 2-D is expanded to the VOI of 3-D;One by one will be current VOI sends into subsequent characteristics extraction module, until completing the traversal to all VOI.
3. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 2, it is characterised in that It is described pretreatment operation is carried out to VOI images to concretely comprise the following steps in step S3:
S3.1:Use 3-D intelligence spot noise reduction anisotropy parameters(ISRAD)Algorithm carries out three-dimensional to the VOI for automatically extracting out Filtering process;
S3.2:The single frames cross-sectional image for being pointed to VOI centers using Otsu algorithms does binary conversion treatment;
S3.3:White connected region using all areas in opening operation deletion bianry image less than 15 pixels;
S3.4:The minimum circumscribed bounding box of each white connected region is extracted, width, height and the summit for calculating bounding box are sat Mark;
S3.5:Delete the width of bounding box<The white connected region of 15 pixels;
S3.6:Mark is numbered to all remaining white connected regions, as region to be sorted.
4. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 3, it is characterised in that It is described feature extraction is carried out to each region to be sorted one by one to concretely comprise the following steps in step S4:
S4.1:The 2-D textural characteristics in region to be sorted are extracted, is carried out in two steps;The first step, calculates region cross section to be sorted list 12 2-D gray level co-occurrence matrixes of frame section(GLCM)Textural characteristics;Second step, calculates coronal-plane Slice Sequence in region to be sorted 12 2-D GLCM textural characteristics and 1 2-D fractal dimension(FD)Feature, is total up to 25;
S4.2:Extract the 3-D textural characteristics in region to be sorted;To the volume data in each region to be sorted, 12 3-D are calculated GLCM textural characteristics and 1 3-D FD feature, are total up to 13;
S4.3:The local feature of scan depths residing for region to be sorted is extracted, it is deep based on being scanned residing for region to be sorted with one Degree is the local feature f in the Y- directions of ABUSdepthTo characterize the occurrence probability of sticking patch;
S4.4:The environmental characteristic in region to be sorted and hernical sac position relationship is extracted, with one based on region to be sorted and hernical sac position Put the location parameter f of relationadjacencyTo characterize the occurrence probability of sticking patch;
12 textural characteristics, including 2-D GLCM and 3-D GLCM, specially:Energy(f1), contrast(f2), it is related (f3), variance(f4), homogeney(f5), average(f6), entropy(f7), auto-correlation(f8), otherness(f9), cluster shade(f10), collection Group's protrusion(f11)And maximum probability(f12).
5. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 4, it is characterised in that In step S5,40 features of described pair of extraction carry out concretely comprising the following steps for feature selecting:First, class spacing method is used(DBC) The class spacing of each feature is calculated respectively;Secondly, being sorted from big to small by class spacing to 40 features, chooses class spacing larger Preceding 25 features;Finally, the feature to tentatively select 25 uses sequential advancement search method(SFS)Selected, with To making classification accuracy rate highest combinations of features.
6. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 4, it is characterised in that In step S4.1,12 2-D gray level co-occurrence matrixes for calculating the section of region cross section to be sorted single frames(GLCM)Texture Feature, concretely comprises the following steps:First, the single frames cross section noise-reduced image at VOI centers is extracted;Secondly, to each region to be sorted The region extension of upper and lower 5 pixel is done in scan depths direction;Then, the cross section single frames for being partitioned into each region to be sorted is cut Piece;Finally, 12 descriptors are calculated to single frames section, as the 2-D GLCM lines that the region cross section to be sorted single frames is cut into slices Reason feature;
12 2-D GLCM textural characteristics for calculating coronal-plane Slice Sequence in region to be sorted, concretely comprise the following steps:For 2-D GLCM, the differences in spatial location motion vector D of two pixels in two dimensional image(φ,d)To describe, d is two pixels Between distance, φ is the angle of two pixels and reference axis;Set a distance d is given for one, on 4 independent directions:φ = 0th, 45,90,135, there may be 8 adjacent pixels altogether to occurring, then, the φ directions in two dimensional image are separated by d's A pair of pixels pair, the probability for occurring with gray scale i and j respectively, i.e. p(i,j/φ,d), it is designated as pij;Will be by pijThe matrix of composition Normalization obtains the gray level co-occurrence matrixes of image;Then, the calculating formula of 12 2-D GLCM textural characteristics is as follows:
(1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12)
Wherein, NgIt is grey level, p(i,j)It is gray scale pair(i,j)The normalized knot of the probability of appearance, i.e. gray level co-occurrence matrixes Really;The average value and standard deviation of matrix row and column is,, and,
1 2-D fractal dimension for calculating coronal-plane Slice Sequence in region to be sorted(FD)Feature, concretely comprises the following steps:For 2-D FD, two-dimensional fractal dimension is estimated by the power spectrum of image Fourier transformation;Use following Fast Fourier Transform (FFT) (FFT)To carry out discrete Fourier transform to two dimensional image(DFT):
(13)
Wherein, I is that size is(M,N)Two dimensional image region, u and v is respectively the spatial frequency in x and y directions, u=0, 1 ... M-1, v=0,1 ... N-1;Power spectral density P passes through F(u,v)Estimate as follows:
(14)
To calculate 2-D FD, P is carried out averagely along the radial section direction across FFT frequency domains, frequency space is by equably decile It is 24 directions, and 30 points of equably being sampled to the radial component in each direction;Calculate log(Pf)To log(f)Minimum Two multiply fitting, whereinRadial frequency is represented, then FD is relevant to this double logarithmic curve in following form Slope β:
(15)
Wherein, DTIt is topological dimension, for two dimensional image, DT = 2。
7. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 4, it is characterised in that In step S4.2,12 3-D GLCM textural characteristics of the calculating are concretely comprised the following steps:For 3-D GLCM, in 3-D view Two tissue points differences in spatial location motion vector D(φ,θ,d)To describe, d is the distance between two tissue points, and φ is Azimuth between two tissue points, θ is the zenith angle between two tissue points;Set a distance d is given for one, in 13 independent directions On, there may be 26 adjacent voxels altogether to occurring;Here, still selective extraction and 12 3-D of identical in 2-D GLCM GLCM textural characteristics;
1 3-D FD feature of the calculating, concretely comprises the following steps:For 3-D FD, three-dimensional fractal dimension by volume images Fu 3-D In the power spectrum of leaf transformation estimated;3-D DFT are carried out to whole 3-D view using following 3-D FFT:
(16)
Wherein,IIt is that size is(M,N,K)3-D view region,u, vWithwBe respectivelyx, yWithzThe spatial frequency in direction, Power spectral densityPEstimate as follows:
(17)
To calculate 3-D FD, P is carried out averagely along the radial sector direction across 3-D FFT frequency domains;Frequency space is by equably Decile is carried out in 24 azimuth directions and 12 zenith angular direction, and the radial component in each direction is equably sampled 30 Point, calculates log(Pf)To log(f)Least square fitting, whereinRepresent radial frequency, Then 3-D FD are relevant to the slope β of this double logarithmic curve in following form:
(18)
Wherein, DTIt is topological dimension, for 3-D view, DT = 3。
8. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 4, it is characterised in that In step S4.3, scan depths residing for region to be sorted are the local feature f in the Y- directions of ABUSdepthSet as follows:Edge ABUS scan depths direction carries out interval division by probe interface to local feature to skin depth below:Respectively interval 0 ~ 1 Cm, 1 ~ 3 cm of interval and 3 ~ 6 cm of interval;According to the depth parameter in region to be sorted, to local feature fdepthSet:1)Interval 0 ~ 1 cm, light-type sticking patch occurrence probability is medium on the upper side, i.e. fdepthIt is set to 3.; 2)1 ~ 3 cm of interval, light-type sticking patch goes out Existing probability highest, i.e. fdepthIt is set to 4.;3)It is interval in 3 ~ 6 cm, with the increase of depth, place the possibility of sticking patch by It is decrescence small, therefore from top to bottom, i.e. the f in this regiondepth2. and 1. it is set to.
9. light-type incisional hernia sticking patch three-dimensional ultrasound pattern feature extracting method according to claim 4, it is characterised in that In step S4.4, the environmental characteristic for extracting region to be sorted and hernical sac position relationship is divided to following two step to carry out:
The first step, detects location algorithm, to determine hernical sac position using the quick hernical sac based on ABUS data:First, detect All black objects in ABUS coronal images;Secondly, after pseudo- black objects are filtered, maximum black target is calculated also just It is size of the hernical sac in X-, Y- and Z- direction;3rd, to ensure that whole hernical sac is all contained among VOI volumes, by hernical sac size All expand 40 pixels in three directions;4th, concentrated from ABUS volume datas and cut out the VOI volumes containing hernical sac;5th, Spot noise reduction process is carried out to VOI using 3-D ISRAD algorithms;Finally, it is partitioned into hernical sac from every frame cross-sectional image of VOI Profile, completes the detection to hernical sac in ABUS data and localization process;
Second step, after the completion of hernical sac detection, is adjusted to coronal-plane position feature:Pair with hernical sac coronal-plane view field weight The coronal-plane position feature in folded or intersecting region to be sorted adds 2;Pair with the cm of hernical sac coronal-plane projected area distance 3 within treat The coronal-plane position feature of specification area adds 1;The probability for sticking patch occur in the to be sorted region nearer apart from hernical sac position is just It is bigger, therefore, with a location parameter f based on region to be sorted with hernical sac position relationshipadjacencyTo characterize the appearance of sticking patch Probability;So, using the coronal-plane position feature value in region to be sorted as environmental characteristic fadjacencyValue;Area to be sorted The f in domainadjacencyValue is bigger, and corresponding sticking patch occurrence probability is bigger.
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