CN106859806A - A kind of mouse fixing - Google Patents
A kind of mouse fixing Download PDFInfo
- Publication number
- CN106859806A CN106859806A CN201710120994.4A CN201710120994A CN106859806A CN 106859806 A CN106859806 A CN 106859806A CN 201710120994 A CN201710120994 A CN 201710120994A CN 106859806 A CN106859806 A CN 106859806A
- Authority
- CN
- China
- Prior art keywords
- fixed
- mouse
- panel
- fixing
- fixed panel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 claims description 7
- 239000004033 plastic Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 5
- 238000005424 photoluminescence Methods 0.000 abstract description 12
- 230000002618 waking effect Effects 0.000 abstract description 8
- 210000004556 brain Anatomy 0.000 abstract description 6
- 238000010171 animal model Methods 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 45
- 238000002474 experimental method Methods 0.000 description 12
- 230000000638 stimulation Effects 0.000 description 5
- 239000007769 metal material Substances 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000027089 Parkinsonian disease Diseases 0.000 description 1
- 206010034010 Parkinsonism Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Catching Or Destruction (AREA)
Abstract
The present invention relates to a kind of experimental animal fixing device, mouse brain electro photoluminescence fixing device under specifically related to a kind of waking state, covered including fixed, fixing band, also include fixed mechanism, the fixed mechanism includes fixed panel, fixture, rotatable bar, fixed hook nail, the fixture is arranged on fixed panel, the rotatable bar is fixed on fixed panel by fixture, hook nail is arranged on fixed panel two sides, the rotatable bar middle part is provided with circular arc fixing port, the fixed cover is arranged on fixed panel, the fixing band is tied up to be nailed in stay hook and fixes fixed panel and fixed cover.Mouse fixing simple structure of the invention, easy to assembly, easy to operate, low cost is easy to make, and mouse can be allowed to keep effectively fixing mouse under waking state；Fixation cover of the invention, fixed mechanism, fixing band and base are detachably readily cleaned sterilization.
Description
Technical field
The present invention relates to a kind of experimental animal fixing device, and in particular to mouse brain electro photoluminescence under a kind of waking state
Use fixing device.
Background technology
Mouse is the experimental animal commonly used in a kind of medical research, and mouse brain electro photoluminescence is studied to many neurological disorders such as
Apoplexy, action obstacle, parkinsonism, A Cihaimo diseases, depression, schizophrenia etc. have certain researching value.To mouse
Carry out brain electro photoluminescence experiment needs mouse to be operated in the case where waking state is kept often, is entered with direct current, exchange, random polarity inversions electric current
Assassinate and swash, change cerebral cortex excitability.But because experiment mice is small, flexible movements, it is clear-headed when it is difficult fixed etc., electrode holds
Easily loosen or slide, cause electrode position, stimulate the multiple parameters such as area to change, finally influence effect of stimulation.So,
Needing to fix mouse before experiment be smoothed out to test.
It is made of metal material more than existing mouse fixing, although can firmly determine mouse, but because of metal material
Matter temperature in itself is low compared with room temperature, and stimulation can be produced to mouse when fixing mouse with it, is unfavorable for the carrying out of experiment, and metal material
Material is relatively costly, is difficult to make.Existing mouse fixing there is also the fixator of plastic material, but need mouse in anesthesia
Be fixed under state, exist mouse waking state fix it is insecure, and cleaning not easy to remove shortcoming.In addition existing fixation
Device does not have special head fixed structure, is unfavorable for carrying out mouse brain electro photoluminescence experiment.
The content of the invention
It is easy to assembly the invention provides a kind of simple structure to solve the problems, such as background technology, easy to operate, low cost, system
Make convenient waking state mouse fixing.
Its technical scheme is：
A kind of mouse fixing, including fixed cover, fixing band, also including fixed mechanism, the fixed mechanism includes stationary plane
Plate, fixture, rotatable bar, fixed hook nail, the fixture are arranged on fixed panel, and the rotatable bar passes through fixture
It is fixed on fixed panel, hook nail is arranged on fixed panel two sides, the rotatable bar middle part is provided with circular arc fixing port, institute
State fixed cover to be arranged on fixed panel, the fixing band is tied up to be nailed in stay hook and fixes fixed panel and fixed cover.
Further, the mouse fixing also includes base, and base is the cuboid of bottom hollow out, and base is arranged on solid
Determine panel bottom, base is provided with screwed hole, and fixed panel is provided with screw, position and screwed hole of the screw on fixed panel
Position correspondence on base, base and fixed panel are fixed by screw.
Further, through hole is offered on the fixed panel, through hole is offered on the base, through holeIn fixed panel
Position and through holeIn the position correspondence of base.
Further, the fixture is drawing pin or fixed nail.
Further, the fixing band is elastic buckles band or rubber band.
Further, the fixed panel is covered by plastic material is made with fixed.
Further, the hook nail is two or more, and the fixing band is more than one.
Beneficial effects of the present invention：
1st, mouse fixing simple structure of the invention, easy to assembly, easy to operate, can have mouse under mouse waking state
Effect is fixed；
2nd, it is special head fixed structure that fixing device of the invention is provided with circular arc fixing port, then the fixation for coordinating body part
Cover, it is more firm that mouse is fixed, and is difficult to shake off；And fixed cover size, fixture position can need to be adjusted according to specific experiment；
3rd, mouse fixing of the invention both can be used for brain electro photoluminescence experiment use, it is also possible to for the mouse that other are tested
It is fixed；
4th, fixed panel of the invention, fixed cover are plastic material, and its temperature is close with room temperature, are conducive to small in experimentation
The holding of mouse body temperature, the fixator of injury and stimulation much smaller than existing metal material to experimental mouse, receives beneficial to experimental data
Collect, and material is easily obtained, low cost is easy to make, can be according to the multiple various sizes of fixed covers of the big little makings of experimental mouse
It is standby；
5th, the front and back position that the present invention can adjust fixture and rotatable bar according to experimental mouse build ensures that its thorax abdomen electrode connects
The accurate of site is touched, the size of through hole I and through hole II determines that the position and size that can effectively ensure that electro photoluminescence contact surface avoid reality
Test mouse belly bump contact electric current and indifferent stimulus and injury are produced to it, it is ensured that the validity of experimental result and data；
6th, fixation cover of the invention, fixed mechanism, fixing band and base are detachably readily cleaned sterilization.
Brief description of the drawings
Fig. 1 is the structural representation when present invention is used；
Fig. 2 is the structural representation of the fixed cover of present invention removal；
Fig. 3 is the structural representation of base of the present invention；
Fig. 4 is the structural representation of fixed mechanism of the present invention；
Fig. 5 is the structural scheme of mechanism of the fixed cover of the present invention；
Wherein, 1- bases, 2- fixed panels, 3- screws, 4- fixtures, the rotatable bars of 5-, 6- fix hook nail, 7- and fix cover, 8-
Fixing band, 9- through holes, 10- through holes, 31- screwed holes, 51- circular arc fixing ports.
Specific embodiment
As shown in Fig. 1 ~ 5, a kind of mouse fixing, including fixed cover 7, fixing band 8, it is described also including fixed mechanism
Fixed mechanism includes fixed panel 2, fixture 4, rotatable bar 5, fixed hook nail 6, and the fixture 4 is arranged on fixed panel 2
On, the rotatable bar 5 is fixed on fixed panel 2 by fixture 4, and hook nail 6 is arranged on the two sides of fixed panel 2, institute
State the middle part of rotatable bar 5 and be provided with circular arc fixing port 51, the fixed cover 7 is arranged on fixed panel 2, and the fixing band 8 is tied up
Fixed panel 2 and fixed cover 7 are fixed on fixed hook nail 6.The mouse fixing also includes base 1, and base 1 is to engrave bottom
Empty cuboid, base 1 is arranged on the bottom of fixed panel 2, and base 1 is provided with screwed hole 31, and fixed panel 2 is provided with screw 3,
Position of position of the screw 3 on fixed panel 2 with screwed hole 31 on base 1 is corresponding, and base 1 and fixed panel 2 pass through spiral shell
Nail 3 is fixed.Through hole is offered on the fixed panel 29, offer through hole on the base 110, through hole9 in fixed panel 2
Position and through hole10 is corresponding in the position of base 1.The fixture 4 is drawing pin or fixed nail.The fixing band 8 is elasticity
Cingulum or rubber band.The fixed panel 2 is with fixed cover 7 by plastic material is made.The hook nail 6 is two or more, described solid
Fixed band 8 is more than one.
When being fixed formula to the mouse of waking state using this fixing device, fixed mechanism as shown in Figure 4 is placed
On base 1 as shown in Figure 3, rotary screw 3 makes it screw in the screwed hole 31 on base 1, so as to by fixed panel 2 and bottom
Seat 1 is fixed；Experimental mouse head is placed on fixed panel 2 towards the direction of rotary screw 3, the body part of mouse is fixed
Cover 7 to fix, then tied up with elastic buckles band or rubber band and 7 outer surfaces of fixed cover are bypassed on the hook nail 6 of the both sides of fixed panel 2 by admittedly
Surely cover 7 and fixed panel 2 are fixed, and the head front end card of mouse and the circular arc in the middle part of rotatable bar 5 are consolidated in adjustment mouse position
Determine under mouth 51, the through hole on the predetermined electrode site alignment fixed panel 2 of mouse chest9, as shown in figure 1, now mouse has been consolidated
Set, circuit connectable carries out follow-up electro photoluminescence experiment.Carry out electro photoluminescence and cross Cheng Qian to be connected to plastic syringe in mouse head, it is small
The absorbent cotton fully soaked with physiological saline is put into pipe, one plastic syringe end of electrode connection mouse head during experiment,
The through hole of connection10 and through holeThe absorbent cotton that physiological saline fully soaks is put into 9, hollow part of another electrode from base 1
Insertion connection through holeCotton in 10, two electrodes are positive and negative conversely, constituting a loop, control stimulation instrument switch can be carried out
Mouse electro photoluminescence is tested, and the parameters such as the sense of current can be set on stimulation instrument, carries out various types of direct currents, exchange electro photoluminescence
Or both cross-reference, carry out two kinds of thorns of cathode current and anode current also dependent on needing flexibly to exchange two positions of electrode
Swash.
When mouse electro photoluminescence experiment need not be carried out, base 1 can be separated with fixed panel 2, directly in fixed machine
Mouse is fixed on structure, carries out other experiments.When in experiment mouse head need not be fixed, rotatable bar 5 can be rotated
Make circular arc fixing port 51 parallel with fixed panel 2, directly fixed mouse with fixed cover 7.
Claims (7)
1. a kind of mouse fixing, including fixed cover（7）, fixing band（8）, it is characterised in that it is described also including fixed mechanism
Fixed mechanism includes fixed panel（2）, fixture（4）, rotatable bar（5）, fixed hook nail（6）, the fixture（4）It is arranged on
Fixed panel（2）On, the rotatable bar（5）By fixture（4）It is fixed on fixed panel（2）On, hook nail（6）It is arranged on solid
Determine panel（2）On two sides, the rotatable bar（5）Middle part is provided with circular arc fixing port（51）, the fixed cover（7）It is arranged on solid
Determine panel（2）On, the fixing band（8）Tie up in fixed hook nail（6）On by fixed panel（2）Covered with fixed（7）It is fixed.
2. mouse fixing according to claim 1, it is characterised in that the mouse fixing also includes base
（1）, base（1）It is the cuboid of bottom hollow out, base（1）It is arranged on fixed panel（2）Bottom, base（1）It is provided with screw thread
Hole（31）, fixed panel（2）It is provided with screw（3）, screw（3）In fixed panel（2）On position and screwed hole（31）The bottom of at
Seat（1）On position correspondence, base（1）And fixed panel（2）By screw（3）It is fixed.
3. mouse fixing according to claim 2, it is characterised in that the fixed panel（2）On offer through hole
（9）, the base（1）On offer through hole（10）, through hole（9）In fixed panel（2）Position and through hole（10）In base
（1）Position correspondence.
4. mouse fixing according to claim 1, it is characterised in that the fixture（4）It is drawing pin or fixed nail.
5. mouse fixing according to claim 1, it is characterised in that the fixing band（8）It is elastic buckles band or rubber
Rubber band.
6. mouse fixing according to claim 1, it is characterised in that the fixed panel（2）Covered with fixed（7）For
Plastic material is made.
7. mouse fixing according to claim 1, it is characterised in that the hook nail（6）It is two or more, it is described solid
Determine band（8）It is more than one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120994.4A CN106859806A (en) | 2017-03-02 | 2017-03-02 | A kind of mouse fixing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120994.4A CN106859806A (en) | 2017-03-02 | 2017-03-02 | A kind of mouse fixing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106859806A true CN106859806A (en) | 2017-06-20 |
Family
ID=59169257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710120994.4A Pending CN106859806A (en) | 2017-03-02 | 2017-03-02 | A kind of mouse fixing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106859806A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107898526A (en) * | 2017-11-20 | 2018-04-13 | 仇子涵 | Toy heavy burden fatigue experiment system |
| CN110584823A (en) * | 2018-06-12 | 2019-12-20 | 南通大学 | Fixing device for animal experiment |
| CN110916841A (en) * | 2018-09-20 | 2020-03-27 | 中国科学院深圳先进技术研究院 | Preparation method of mouse thrombotic stroke model |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261295A (en) * | 1977-09-06 | 1981-04-14 | Humie Kanetake | Restraining device for small animals |
| EP0584357A1 (en) * | 1992-02-13 | 1994-03-02 | Senju Seiyaku Kabushiki Kaisha | Apparatus for supporting animal fixing tool |
| CN201409993Y (en) * | 2009-06-16 | 2010-02-24 | 南京中医药大学 | Animal-fixing device |
| CN202397642U (en) * | 2011-12-22 | 2012-08-29 | 燕铁斌 | Animal positioning device |
| CN202605051U (en) * | 2012-06-28 | 2012-12-19 | 滨州医学院 | Animal fixing device for medical experiment |
| CN203341845U (en) * | 2013-07-02 | 2013-12-18 | 王琛 | Small animal sobering and fixing device used for experiment |
| CN203354687U (en) * | 2013-03-26 | 2013-12-25 | 燕铁斌 | 3D-adjusted animal restriction and fixation device |
| CN204600778U (en) * | 2015-05-06 | 2015-09-02 | 邵勇 | A kind of locating rack of veterinary procedures |
| CN105287040A (en) * | 2015-12-01 | 2016-02-03 | 上海市第一人民医院 | Medical experiment animal treating and fixing equipment |
| CN205626168U (en) * | 2016-03-10 | 2016-10-12 | 首都医科大学附属北京中医医院 | Rat fixing device |
-
2017
- 2017-03-02 CN CN201710120994.4A patent/CN106859806A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261295A (en) * | 1977-09-06 | 1981-04-14 | Humie Kanetake | Restraining device for small animals |
| EP0584357A1 (en) * | 1992-02-13 | 1994-03-02 | Senju Seiyaku Kabushiki Kaisha | Apparatus for supporting animal fixing tool |
| CN201409993Y (en) * | 2009-06-16 | 2010-02-24 | 南京中医药大学 | Animal-fixing device |
| CN202397642U (en) * | 2011-12-22 | 2012-08-29 | 燕铁斌 | Animal positioning device |
| CN202605051U (en) * | 2012-06-28 | 2012-12-19 | 滨州医学院 | Animal fixing device for medical experiment |
| CN203354687U (en) * | 2013-03-26 | 2013-12-25 | 燕铁斌 | 3D-adjusted animal restriction and fixation device |
| CN203341845U (en) * | 2013-07-02 | 2013-12-18 | 王琛 | Small animal sobering and fixing device used for experiment |
| CN204600778U (en) * | 2015-05-06 | 2015-09-02 | 邵勇 | A kind of locating rack of veterinary procedures |
| CN105287040A (en) * | 2015-12-01 | 2016-02-03 | 上海市第一人民医院 | Medical experiment animal treating and fixing equipment |
| CN205626168U (en) * | 2016-03-10 | 2016-10-12 | 首都医科大学附属北京中医医院 | Rat fixing device |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107898526A (en) * | 2017-11-20 | 2018-04-13 | 仇子涵 | Toy heavy burden fatigue experiment system |
| CN107898526B (en) * | 2017-11-20 | 2019-08-20 | 贺晓燕 | Toy weight bearing fatigue experiment system |
| CN110584823A (en) * | 2018-06-12 | 2019-12-20 | 南通大学 | Fixing device for animal experiment |
| CN110916841A (en) * | 2018-09-20 | 2020-03-27 | 中国科学院深圳先进技术研究院 | Preparation method of mouse thrombotic stroke model |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170620 |
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| RJ01 | Rejection of invention patent application after publication |