CN106841183A - 1,8 naphthoyl imide compounds and its for determining iodide ion concentration - Google Patents
1,8 naphthoyl imide compounds and its for determining iodide ion concentration Download PDFInfo
- Publication number
- CN106841183A CN106841183A CN201710041555.4A CN201710041555A CN106841183A CN 106841183 A CN106841183 A CN 106841183A CN 201710041555 A CN201710041555 A CN 201710041555A CN 106841183 A CN106841183 A CN 106841183A
- Authority
- CN
- China
- Prior art keywords
- iodide ion
- imide compounds
- concentration
- naphthoyl imide
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCCCN(C(c(cc1)c2c3cccc2c1NN(C(C=C1)=O)C1=O)=*)C3=O Chemical compound CCCCN(C(c(cc1)c2c3cccc2c1NN(C(C=C1)=O)C1=O)=*)C3=O 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
The invention discloses a kind of 1,8 naphthoyl imide compounds and its measure for the iodide ion concentration that dissociates in water.The present invention has following beneficial effect, 1, after 8 naphthoyl imide compounds are dissolved in tetrahydrofuran, obvious color change can occur with the free-iodine ionization in water, generally by yellow virescence and with the increase of iodide ion concentration in sample, green is deepened, according to optical colorimetry can the easily qualitative concentration range for measuring the iodide ion that dissociates in sample, or change using spectrophotometry solution absorbance and the iodide ion that obtains dissociating in sample using standard working curve method actual concentrations.The method have sensitivity it is high, it is simple to operate the characteristics of, and 1,8 naphthoyl imide compounds do not interact with other ions in water, only produce color and absorbance change with free iodide ion.
Description
Technical field
The present invention relates to a kind of method for determining free iodide ion concentration in water.
Background technology
Iodine is the essential trace elements of the human body, is often existed in the form of iodide in vivo, and the change of content of iodine is to human body
The aspect such as physiological function have very important influence, such as：
1st, there is important influence for thyroid function, be the important source material of synthetic thyroid element, suitable iodine intake level is
Ensure the essential condition of normal thyroid function；
2nd, iodine plays an important roll for regulating cell metabolism, neuro-muscular organizational development and growth；
3rd, for maintaining human body energy to be metabolized, such as carbohydrate, the metabolism of fat plays the role of important iodine；Body iodine insufficiency of intake, makes
Into being main pathogenetic Iodine nutrition deficiency disease with thyroid hormone synthesis deficiency, cause the various damages of body.Such as first shape
Adenoncus, hyperthyroidism, hypothyroidism etc..But the excessive body injury for also resulting in of iodine intake, disposably
Take in suitable high dose iodine or long-term Iodine intake it is too high can also cause iodine excessively sick the damage of body, even result in certain
The generation of a little tumours.At present it is known that iodine participates in many physiology courses, and play an important role, on iodine to thyroid cell
The research of Apoptosis, different study conditions, researcher, result of study is often not quite similar.Excessive iodine is to thyroid work(
The influence of energy, structure, immune state and Apoptosis still lacks to be goed deep into and systematic research.Therefore, being badly in need of development can detect in vivo
The analysis method of iodide ion concentration, accurately and reliably analyzes for further investigation iodine is provided in the effect that physiology and pathologic process are played
Detection means.
Current traditional iodide ion detection method mainly has titration, capillary electrophoresis, supramolecular chemistry, nanometer material
The method and fluorescent method of material.But these methods have such-and-such weak point, such as high cost, take or sample
Pretreatment is more complicated.Therefore, it is badly in need of a kind of simple, fast and easy iodide ion detection method.
The content of the invention
It is an object of the invention to provide a kind of 1,8- naphthoyl imide compounds and its for the iodide ion concentration that dissociates in water
Measure.
The technical scheme is that, one kind 1,8- naphthoyl imide compounds, its formula is：
R represents the unsubstituted alkyl of C1-C18 in formula.
The method that 1,8- of one kind naphthoyl imide compounds determine free iodide ion concentration in water, it is characterised in that：
(1), the preparation of standard liquid：KI or NaI are configured to concentration range 1 × 10 in being dissolved in pure water-6Mol/L~1 × 10- 4The different solution of the series concentration of mol/L, it is 2 × 10 to take 100 μ L and be added to 10mL concentration-5Mol/L1,8- naphthalimides
In the tetrahydrofuran solution of compound, series of standards solution is configured to；
(2) the μ L of the testing sample aqueous solution 100 containing free iodide ion, are added to the four of 10mL1,8- naphthoyl imide compounds
In hydrogen tetrahydrofuran solution, colorimetric method or measurement of ultraviolet-visible spectrophotometer go out in sample the concentration of the iodide ion that dissociates by visual observation.
The present invention have following beneficial effect, after 1,8- naphthoyl imide compounds are dissolved in tetrahydrofuran, can with water in
Free-iodine ionization and there is obvious color change, generally by yellow virescence and with the increasing of iodide ion concentration in sample
Plus, green is deepened, according to optical colorimetry can the easily qualitative concentration for measuring free-iodine radical ion in sample, or utilize
Spectrophotometry solution in the change of absorbance obtains sample using standard working curve method dissociate iodide ion it is accurate
Concentration.The method have sensitivity it is high, it is simple to operate the characteristics of, and 1,8- naphthoyl imide compounds not with water in its
His anion interacts, and only produces color and absorbance change with free iodide ion.
Brief description of the drawings
Fig. 1 is that a series of KI aqueous solution of various concentrations is dissolved in N- octyl groups -1,8- naphthalimides -4- [maleic anhydride]
In the tetrahydrofuran solution of hydrazone, it is 2 × 10 to be allowed to concentration-5Mol/L, obtains standard liquid, using spectrophotometer measurement they
The standard curve that absorbance (ordinate) at 623nm is drawn with iodide ion concentration (abscissa).
Specific embodiment
Examples below is described further for the present invention.
Embodiment 1：
0.67mmol N- octyl group -1,8- naphthalimide -4- hydrazines are added to the second dissolved with 0.67mmol maleic anhydrides at room temperature
In sour (5ml) solution, then agitating solution 6 hours filters, and dries, and obtains yellow solid, and product is put into round bottom again after drying burns
In bottle, 7ml acetic anhydrides are added, 24h is stirred under normal temperature, filtered, vacuum drying at room temperature removes solvent, obtains a kind of N- pungent
Base -1,8- naphthalimides -4- [maleic anhydride] hydrazone, its structural formula is:
KI is dissolved in pure water and is configured to 1 × 10-6Mol/L~1 × 10-4The standard liquid of mol/L concentration, by N- octyl group -1,8-
Naphthalimide -4- [maleic anhydride] hydrazone is dissolved in tetrahydrofuran, and it is 2 × 10 to be allowed to concentration-5mol/L；By various concentrations
Iodine standard solution is added to N- octyl group -1, in the tetrahydrofuran solution of 8- naphthalimides -4- [maleic anhydride] hydrazone, separately takes and contains
The testing sample aqueous solution of free iodide ion adds the tetrahydrochysene furan of N- octyl group -1,8- naphthalimides -4- [maleic anhydride] hydrazone
Mutter in solution, it is 2 × 10 to be allowed to concentration-5Mol/L, take solution be placed in colorimetric cylinder by visual observation colorimetric method can it is qualitative determine it is to be measured
The concentration substantially 5 × 10 of free iodide ion in sample aqueous solution-6mol/L。
Embodiment 2：
0.67mmol N- butyl -1,8- naphthalimide -4- hydrazines are added to the second dissolved with 0.67mmol maleic anhydrides at room temperature
In sour (5ml) solution, then agitating solution 6 hours filters, and dries, and obtains yellow solid, and product is put into round bottom again after drying burns
In bottle, 7ml acetic anhydrides are added, 24h is stirred under normal temperature, filtered, vacuum drying at room temperature removes solvent, obtains a kind of N- fourths
Base -1,8- naphthalimides -4- [maleic anhydride] hydrazone, its structural formula is:
NaI is dissolved in pure water and is configured to 1 × 10-6Mol/L~1 × 10-4The standard liquid of mol/L concentration, by N- butyl -1,
8- naphthalimides -4- [maleic anhydride] hydrazone is dissolved in tetrahydrofuran solution, and it is 2 × 10 to be allowed to concentration-5Mol/L, by difference
The iodine standard solution of concentration is added to N- butyl -1, in the tetrahydrofuran solution of 8- naphthalimides -4- [maleic anhydride] hydrazone,
Using uv-vis spectra, the absorbance at 623nm is determined, make standard curve, as shown in Figure 1；It is another to take containing free iodide ion
The testing sample aqueous solution add N- butyl -1, in the tetrahydrofuran of 8- naphthalimides -4- [maleic anhydride] hydrazone, be allowed to dense
Spend is 2 × 10-5Mol/L, is dissociated by determining absorbance at 623nm and being determined using standard curve in the testing sample aqueous solution
The concentration of iodide is 3.75 × 10-6mol/L。
Claims (2)
1. one kind 1,8- naphthoyl imide compounds, its formula is：
R represents the unsubstituted alkyl of C1-C18 in formula.
2. the method that 1, the 8- naphthoyl imide compounds in a kind of utilization claim 1 determine free iodide ion concentration in water,
It is characterized in that：
(1), the preparation of standard liquid：KI or NaI are configured to concentration range 1 × 10 in being dissolved in pure water-6Mol/L~1 × 10-4
The different solution of the series concentration of mol/L, it is 2 × 10 to take 100 μ L and be added to 10 mL concentration-5 Mol/L1,8- naphthalimides
In the tetrahydrofuran solution of compound, series of standards solution is configured to；
(2) the μ L of the testing sample aqueous solution 100 containing free iodide ion, are added to 10 mL1,8- naphthoyl imide compounds
In tetrahydrofuran solution, colorimetric method or measurement of ultraviolet-visible spectrophotometer go out the dense of iodide ion that dissociate in sample by visual observation
Degree.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710041555.4A CN106841183A (en) | 2017-01-20 | 2017-01-20 | 1,8 naphthoyl imide compounds and its for determining iodide ion concentration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710041555.4A CN106841183A (en) | 2017-01-20 | 2017-01-20 | 1,8 naphthoyl imide compounds and its for determining iodide ion concentration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106841183A true CN106841183A (en) | 2017-06-13 |
Family
ID=59120029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710041555.4A Pending CN106841183A (en) | 2017-01-20 | 2017-01-20 | 1,8 naphthoyl imide compounds and its for determining iodide ion concentration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106841183A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104531138A (en) * | 2014-12-29 | 2015-04-22 | 大连理工常熟研究院有限公司 | Fluorescent probe used for identifying specificity of hydrazine and application thereof |
| CN105985291A (en) * | 2015-11-10 | 2016-10-05 | 济南大学 | High-selectivity quick fluorine ion analyzing colorimetric fluorescent probe |
| CN106008463A (en) * | 2016-04-22 | 2016-10-12 | 山西大学 | Maleimide derivative and preparation method and application thereof |
-
2017
- 2017-01-20 CN CN201710041555.4A patent/CN106841183A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104531138A (en) * | 2014-12-29 | 2015-04-22 | 大连理工常熟研究院有限公司 | Fluorescent probe used for identifying specificity of hydrazine and application thereof |
| CN105985291A (en) * | 2015-11-10 | 2016-10-05 | 济南大学 | High-selectivity quick fluorine ion analyzing colorimetric fluorescent probe |
| CN106008463A (en) * | 2016-04-22 | 2016-10-12 | 山西大学 | Maleimide derivative and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| JIAYI CHEN ET AL.: "1,8-Naphthalimide-based turn-on fluorescent chemosensor for Cu2+ and its application in bioimaging", 《JOURNAL OF LUMINESCENCE》 * |
| 姜思泉等: "一种1,8-萘酰亚胺类铁离子荧光探针的合成和性能研究", 《山东理工大学学报（自然科学版）》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | An FRET-ICT-based ratiometric fluorescent and colorimetric probe for pH monitoring in lysosomes and water | |
| Sun et al. | Kaempferol as an AIE-active natural product probe for selective Al3+ detection in Arabidopsis thaliana | |
| CN103344588B (en) | Method for detecting trace concentration of copper ions | |
| CN112939957B (en) | Benzoindole derivative In-XY1, and synthesis method and application thereof | |
| Yan et al. | Synthesis and spectral analysis of fluorescent probes for Ce4+ and OCl− ions based on fluorescein Schiff base with amino or hydrazine structure: application in actual water samples and biological imaging | |
| CN102879381B (en) | Method for detecting antibacterial drugs of furazolidone and furacilin through surface-enhanced raman spectroscopy | |
| CN108956840A (en) | A kind of method that ultra performance liquid chromatography-tandem mass spectrum detects 5 kinds of sweeteners in electronic cigarette liquid | |
| CN104297359B (en) | A kind of method of seven kinds of composition Simultaneously test in flavoring essence spices | |
| Cai et al. | A multicolor fluorescent sensor array based on curcumin and its analogs as a shrimp freshness indicator | |
| CN110746420B (en) | Perylene bisimide derivative, preparation method and application of perylene bisimide derivative in preparation of ATP fluorescent probe | |
| Li et al. | Development of a responsive probe for colorimetric and fluorescent detection of bisulfite in food and animal serum samples in 100% aqueous solution | |
| Luo et al. | Visual screening and colorimetric determination of clenbuterol and ractopamine using unmodified gold nanoparticles as probe | |
| CN102141531B (en) | Method for measuring water content in ethanol supernatant of salvia miltiorrhiza bunge injection | |
| Sochorova et al. | Electrochemical and others techniques for the determination of malic acid and tartaric acid in must and wine | |
| CN105044065B (en) | A kind of preparation method of algae solution for fluorescence spectrometry chlorophyll content | |
| CN106841183A (en) | 1,8 naphthoyl imide compounds and its for determining iodide ion concentration | |
| CN103091305A (en) | Method for detecting quinolone antibiotic by means of electrochemical luminescence | |
| MacLean et al. | Analytical method for thujaplicins | |
| CN111562227B (en) | Nanogold colorimetric method for detecting lysine | |
| CN108195830A (en) | A kind of visible detection method for trace copper ion | |
| CN114324647A (en) | Method for simultaneously measuring vitamin K in milk powder1And K2Method and application of | |
| CN103323417A (en) | Method for rapidly detecting dicyandiamide in milk based on nanogold visualization | |
| CN108752272B (en) | 8-aminoquinoline amide derivative, preparation method, application and fluorescence analysis method thereof | |
| CN113354618A (en) | Hypochlorous acid fluorescent probe capable of targeting cell lysosome, preparation method and application | |
| CN111007027A (en) | Method for measuring iron content in thiourea dioxide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170613 |
|
| RJ01 | Rejection of invention patent application after publication |