CN106831566B - A kind of preparation method of the chloro- 3- formyl quinoline analog derivative of 2- - Google Patents
A kind of preparation method of the chloro- 3- formyl quinoline analog derivative of 2- Download PDFInfo
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- CN106831566B CN106831566B CN201710029012.0A CN201710029012A CN106831566B CN 106831566 B CN106831566 B CN 106831566B CN 201710029012 A CN201710029012 A CN 201710029012A CN 106831566 B CN106831566 B CN 106831566B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Abstract
The present invention relates to a kind of preparation methods of the chloro- 3- formyl quinoline analog derivative of 2-.The method is to react to obtain target compound in organic solvent with double trichloromethyl carbonate BTC and n,N-Dimethylformamide DMF using antifebrin or substituted antifebrin as raw material.The method of the present invention substitutes phosphorous or sulfur-bearing chlorination reagent with double trichloromethyl carbonates, to solve the problems such as phosphorous or sulfur byproduct species processing and discharge of wastewater in production process, have the characteristics that raw material is easy to get, is at low cost, operating procedure is simple, reaction condition is mild, less energy consumption, reaction process safety, environmental pollution is small, is able to achieve clean manufacturing, has industrial applications prospect.
Description
Technical field
The present invention relates to a kind of preparation methods of quinoline, in particular to double trichloromethyl carbonate BTC, N, N-
The method that dimethylformamide DMF, antifebrin or substituted acetanilide prepare the chloro- 3- formyl quinoline analog derivative of 2-.
Background technique
Heterocyclic compound containing chinoline backbone is widely present in natural production as important nitrogenous heteroaromatic compound
In object, significant bioactivity is shown, such as antibacterial, antiviral and antitumor, antiallergy, anti-asthma, anti-hypertension, enhancing note
Recall, antidepression etc..It is also used as a kind of important industrial chemicals simultaneously, in fields such as organic synthesis, pharmaceutical synthesis, materials chemistries
It has been widely used.The chloro- 3- formyl quinoline derivative of 2- is easy to be converted to it there are chlorine and formoxyl labile functional groups
His quinoline heterocyclic compound, in organic synthesis, chemical analysis, Coordinative Chemistry, auxiliary chemicals, drug, pesticide, dyestuff, shine material
Material, photosensitive material, magnetic material etc. all have potential application and significance.
Currently, the chloro- 3- formyl quinoline of the 2- reported both at home and abroad mainly by antifebrin or substituted acetanilide with
Vilsmeier reagent is prepared by cyclisation, aromatisation and hydrolysis one kettle way.This method raw material is easy to get, high income.
Common halide reagent has phosphorus trichloride, thionyl chloride, phosgene, oxalyl chloride etc. in Vilsmeier reagent.These halide reagents tool
Toxic and corrosivity, being exposed to air can the moisture absorption.Phosphorus trichloride, thionyl chloride can also generate phosphoric acid and two in use
A series of waste liquids such as sulfur oxide, exhaust gas, corrosion equipment, pollution environment.Phosgene is a kind of good halide reagent, is prepared with phosgene
Product content is high, high income, but phosgene is hypertoxic gas, has very big risk during use, transport and storage.Cause
This seeks new synthetic method or green halide reagent is the inexorable trend of technology development.
Double trichloromethyl carbonate abbreviation solid phosgenes, triphosgene or BTC, molten boiling point is high, volatility is low, toxicity is low,
It is industrially only treated as the processing of general toxicity substance, has the advantages that transport and using safe compared with gas phosgene.Its
Participating in chemical reaction has safety economy, easy to use, pollution-free, reaction accurate measurement, synthesis technology simple, caused secondary anti-
Should less, high income, post-processing it is simple the advantages that.Currently, the large-scale production of the oxide spinel dimethyl ester of domestic existing solid phosgene,
So that solid phosgene preparation cost is greatly lowered.
Summary of the invention
To solve the above problems, being adopted the purpose of the present invention is to provide a kind of preparation method of the chloro- 3- formyl quinoline of 2-
It is halogenating agent with double trichloromethyl carbonates, with n,N-Dimethylformamide and antifebrin or substituted acetanilide mild
The chloro- 3- formyl quinoline analog derivative of 2- is synthesized under synthesis condition, has the characteristics that environmentally protective, the reaction time is short, yield is high.
In order to achieve the above objectives, the present invention provides a kind of chloro- 3- formyl quinoline analog derivative preparation methods of 2-, special
Sign is that related chloro- 3- formyl quinoline analog derivative (I) structural formula of 2- is as follows:
R indicates halogen atom, cyano, alkyl, alkenyl, alkynyl, hydroxyl, oxyl, acyloxy, sulfydryl, hydrocarbon sulphur in Formulas I
Base, acyl sulfenyl, amino, substituted amido, aryl, heteroaryl, nitro, acyl group, carboxyl, hydrocarbon carbonyl oxygen, hydrocarbon nitrone, sulfonic group or
One of semi-annular jade pendant acyl ester group；R is in the ortho position of amino, meta position and/or contraposition, but it is unsubstituted at least to retain an ortho position；N is benzene
The number of ring substituents, n=0,1,2 or 3.
The preparation method of the chloro- 3- formyl quinoline analog derivative of 2- of the present invention, includes the following steps:
1) in organic solvent, at -10~40 DEG C, antifebrin or substituted acetanilide and solid phosgene BTC and N, N-
Dimethylformamide mixes in 20~80min；
2) 5~20min is kept after mixing at -10~40 DEG C, temperature programming, will after reaction 3~10 hours to 30~80 DEG C
Reaction mass directly pours into ice water, and alkali adjusts pH to 8~9, filters, and it is derivative to be recrystallized to give the chloro- 3- formyl quinoline class of 2-
Object.
Organic solvent of the present invention include methylene chloride, chloroform, dichloroethanes, dimethoxy-ethane, n-hexane,
The combination of one or more of tetrahydrofuran, ethyl acetate, acetonitrile, benzene, toluene, preferably chloroform, dichloroethanes.
The molar ratio of antifebrin or substituted acetanilide of the present invention and BTC and DMF are 1: 0.2~4: 1~10.
The mixing of antifebrin or substituted acetanilide of the present invention and BTC and DMF include four kinds of methods, the first is by second
Anilide or substituted acetanilide, DMF are dissolved in organic solvent, and the organic solution of BTC is added dropwise；Second is to dissolve BTC
In organic solvent, the organic solution of antifebrin or substituted acetanilide, DMF is added dropwise；The third is by antifebrin or to take
It is dissolved in organic solvent for antifebrin, BTC, DMF is added dropwise；4th kind be by antifebrin or substituted acetanilide, DMF,
BTC is added in reaction kettle, and organic solvent, stirring and dissolving is added；It is preferred that the third method, is by antifebrin or to replace acetyl
Aniline, BTC are dissolved in organic solvent, and DMF is added dropwise.
Antifebrin or substituted acetanilide of the present invention and solid phosgene BTC and N,N-dimethylformamide DMF
In organic solvent, it at -10~40 DEG C, is mixed in 20~80min, low temperature keeps 5~20min after mixing, and temperature programming is extremely
It 30~80 DEG C, reacts 3~10 hours, post-processing.
Post-processing of the present invention are as follows: it is cooling in reaction mass, it directly pours into ice water, filters；Or adjusting pH to 8~
9, it filters or is centrifuged, be recrystallized to give the chloro- 3- formyl quinoline analog derivative of 2-.
Alkali of the present invention is sodium hydroxide, potassium hydroxide or the potassium carbonate of mass fraction 10~50%.
Advantages of the present invention compared with prior art: this method solid phosgene substitutes phosphorous or sulfur-bearing or phosgene halogenation tries
Agent realizes to thoroughly solve the problems, such as a large amount of phosphorous or sulfur byproduct species processing and discharge of wastewater in production process
3- formyl quinoline analog derivative traditional handicraft chloro- to 2- carries out green chemistry process transformation, there is raw material to be easy to get, is at low cost,
Operating procedure is simple, reaction condition is mild, less energy consumption, reaction process safety, and environmental pollution is small, is able to achieve the spies such as clean manufacturing
Point has industrial applications prospect.
Technical hydrochloric acid can be made in this method Main By product hydrogen chloride generated, to improve the economy of chlorine, subtract
Resource consumption is lacked.
Solvent dichloroethanes, ethyl acetate etc. used in this method can be recycled through distillation, be reused.
Specific embodiment
The present invention is further illustrated below with reference to embodiment, but the scope of protection of present invention is not limited to implement
The range of example statement.
Embodiment 1
The synthetic method of the chloro- 3- formyl quinoline of 2- is present embodiments provided, key step is as follows:
Under ice salt bath, by 2.73g (20.22mmol) antifebrin, 8.19g (27.58mmol) BTC and 10mL chloroform
It is stirred, after temperature is maintained at -5 DEG C or less, 4.2mL (54.66mmol) DMF is added dropwise in 30min, is filled by tail gas absorption
It sets bubble and overflows rate control rate of addition；DMF, which is all added dropwise under rear ice salt bath, to be continued to stir 10min, is used water-bath instead, is added
Heat is reacted 4 hours to 40 DEG C, steams partial solvent, and ice water is added, and 10%NaOH adjusts pH to 8~9, is filtered, ethyl acetate weight
Crystallization, yield 91.62%.Fusing point: 157~159 DEG C, m/Z:192.04 [M+H]+。
Comparative example 1
The synthetic method of the chloro- 3- formyl quinoline of 2- is present embodiments provided, key step is as follows:
Under ice salt bath, by 2.73g (20.22mmol) antifebrin, 8.12g (27.34mmol) BTC and 10mL 1,2- bis-
Chloroethanes is stirred, and after temperature is maintained at -5 DEG C or less, 4.2mL (54.66mmol) DMF is slowly added dropwise, is inhaled by tail gas
Receiving apparatus bubble overflows rate control rate of addition.DMF, which is all added dropwise under rear ice salt bath, to be continued to stir 10min, uses water instead
Bath, is heated to 40 DEG C, monitors reaction process by TLC, reacts 4 hours, steams partial solvent, ice water quenching, 10%NaOH tune
PH to 8~9 is saved, is filtered, re-crystallizing in ethyl acetate, yield 84.55%.
Embodiment 2
The synthetic method of the chloro- 3- formyl quinoline of 2- is present embodiments provided, key step is as follows:
Under ice salt bath, by 2.73g (20.22mmol) antifebrin, 4.17g (14.04mmol) BTC and 10mL chloroform
It is stirred, after temperature is maintained at -5 DEG C or less, 4.2mL (54.66mmol) DMF is added dropwise in 30min, is filled by tail gas absorption
It sets bubble and overflows rate control rate of addition.DMF, which is all added dropwise under rear ice salt bath, to be continued to stir 10min, is used water-bath instead, is added
Heat monitors reaction process to 41 DEG C, by TLC, reacts 4 hours, steams partial solvent, ice water quenching, 10%NaOH adjust pH to
8~9, it filters, re-crystallizing in ethyl acetate, yield 75.92%.
Embodiment 3
The synthetic method of the chloro- 3- formyl quinoline of 2- is present embodiments provided, key step is as follows:
Under ice salt bath, 2.73g (20.22mmol) antifebrin and 4.2mL (54.66mmol) DMF are stirred, temperature is worked as
The 10mL chloroform soln dissolved with 8.03g (27.04mmol) BTC is added dropwise after degree is maintained at -5 DEG C or less, in 50min, passes through
Device for absorbing tail gas bubble overflows rate control rate of addition.It is all added dropwise under rear ice salt bath and continues to stir 10min, use instead
Water-bath is heated to 45 DEG C, monitors reaction process by TLC, reacts 4 hours, steams partial solvent, ice water quenching, 10%NaOH
PH to 8~9 is adjusted, is filtered, re-crystallizing in ethyl acetate, yield 76.18%.
Embodiment 4
The synthetic method of the chloro- 3- formoxyl -6- methylquinoline of 2- is present embodiments provided, key step is as follows:
Under ice salt bath, 3.00g (20.13mmol) stirs exalgine and 4.2mL (54.66mmol) DMF mixed
It closes, after temperature is maintained at -5 DEG C or less, dropwise addition is molten dissolved with the 10mL chloroform of 8.03g (27.04mmol) BTC in 80min
Liquid overflows rate control rate of addition by device for absorbing tail gas bubble.It is all added dropwise under rear ice salt bath and continues to stir
10min uses water-bath instead, is heated to 51 DEG C, monitors reaction process by TLC, reacts 5 hours, steam partial solvent, ice water is sudden
It goes out, 10%NaOH adjusts pH to 8~9, filters, recrystallization, yield 84.83%.Fusing point: 124~125 DEG C.
Embodiment 5
The synthetic method of the chloro- 3- formoxyl -6- nitroquinoline of 2- is present embodiments provided, key step is as follows:
Under ice salt bath, 3.61g (20.22mmol) paranitroacetanilide and 4.2mL (54.66mmol) DMF are stirred mixed
It closes, the 10mL chloroform dissolved with 8.03g (27.04mmol) BTC is added dropwise after temperature is maintained at -5 DEG C or less, in 60min, leads to
It crosses device for absorbing tail gas bubble and overflows rate control rate of addition.It is all added dropwise under rear ice salt bath and continues to stir 10min, change
With water-bath, 60 DEG C are heated to, reaction process is monitored by TLC, is reacted 7 hours, steams partial solvent, ice water quenching, alkali is adjusted
PH to 8~9 is filtered, recrystallization, yield 88.76%.Fusing point: 233~235 DEG C.
Particular embodiments described above has carried out the purpose of the present invention, technical scheme and beneficial effects further detailed
Describe in detail bright, but the scope of protection of present invention is not limited to the scope of the embodiments.
Claims (1)
1. a kind of preparation method of the chloro- 3- formyl quinoline analog derivative of 2-, which comprises the steps of:
Under ice salt bath, by 2.73 g (20.22 mmol) antifebrin, 8.19 g (27.58 mmol) BTC and 10 mL, tri- chloromethane
Alkane is stirred, and after temperature is maintained at -5 DEG C or less, 4.2 mL (54.66 mmol) DMF is added dropwise in 30 min, passes through tail gas
Absorption plant bubble overflows rate control rate of addition；DMF, which is all added dropwise under rear ice salt bath, to be continued to stir 10 min, is used instead
Water-bath is heated to 40 DEG C, reacts 4 hours, steams partial solvent, and ice water is added, and 10%NaOH adjusts pH to 8~9, filters, acetic acid
Ethyl ester recrystallization, yield 91.62%, fusing point: 157~159 DEG C,m/Z: 192.04[M+H] +。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101367760A (en) * | 2008-10-08 | 2009-02-18 | 南开大学 | Synthesis of 2-chlorine apellagrin |
| CN101863782A (en) * | 2010-06-25 | 2010-10-20 | 北京英力精化技术发展有限公司 | Method for synthesizing ultraviolet photoinitiator of p-dimethylamin benzoic ether compounds |
| CN102532009A (en) * | 2012-01-12 | 2012-07-04 | 浙江大学 | Compounds for inhibiting dipeptidyl peptidase, preparation method for compounds and application of compounds |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101367760A (en) * | 2008-10-08 | 2009-02-18 | 南开大学 | Synthesis of 2-chlorine apellagrin |
| CN101863782A (en) * | 2010-06-25 | 2010-10-20 | 北京英力精化技术发展有限公司 | Method for synthesizing ultraviolet photoinitiator of p-dimethylamin benzoic ether compounds |
| CN102532009A (en) * | 2012-01-12 | 2012-07-04 | 浙江大学 | Compounds for inhibiting dipeptidyl peptidase, preparation method for compounds and application of compounds |
Non-Patent Citations (2)
| Title |
|---|
| Facile and selective synthesis of chloronicotinaldehydes by the Vilsmeier reaction;B. Gangadasu，等;《Tetrahedron》;20060707;第62卷;第8398-8403页 * |
| 喹啉醛衍生物的合成;齐家娟;《中国矿业大学硕士学位论文》;20150215;第6页，第15-16页 * |
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