CN106823120B - Preparation method of degradable radioactive particle chain with shape memory function - Google Patents
Preparation method of degradable radioactive particle chain with shape memory function Download PDFInfo
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- CN106823120B CN106823120B CN201710060177.4A CN201710060177A CN106823120B CN 106823120 B CN106823120 B CN 106823120B CN 201710060177 A CN201710060177 A CN 201710060177A CN 106823120 B CN106823120 B CN 106823120B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
Abstract
The invention relates to a preparation method of a radioactive brachytherapy device, in particular to a preparation method of a degradable radioactive particle chain with a shape memory function. The method comprises the following steps: (1) manufacturing a pipe: the pipe material is manufactured into a pipe by an extrusion mode, or is directly manufactured into the pipe by a pipe die; (2) loading of radioactive particles: sequentially filling radioactive particles into the pipe; (3) molding: placing the pipe filled with the radioactive particles into a mould with a preset shape for heating, melting the pipe, cooling, and demoulding to obtain the finished product; the tubing material comprises polycaprolactone PCL. The method has the advantages that the manufacturing process is simple and convenient, the manufacturing flow is convenient, the manufactured product can be repeatedly heated/cooled and molded, and a plurality of particle chains manufactured by taking PCL as a main molding material can be spliced, woven, fused and cut into a plurality of particle chains with different shapes and different functions to be combined so as to adapt to complex clinical situations.
Description
Technical Field
The invention relates to a preparation method of a radioactive brachytherapy device, in particular to a preparation method of a degradable radioactive particle chain with a shape memory function.
Background
Malignant tumors have been a major disease threatening human health, and the use of radioactive particles for inter-tissue brachytherapy is a new technology developed in recent decades. The radioactive particles are small radioactive sources which contain a radioisotope in a titanium tube and are welded at both ends using laser or electron beam techniques to form a sealed source, typically having a size of 0.8mm outside diameter and 4.5mm length. The nuclides commonly used for radioactive particles are 192 Ir、 198 Au、 169 Y、 131 Cs、 103 Pd and Pd 125 I, etc., especially 103 Pd and Pd 125 I. The near-distance treatment is to implant radioactive particles directly into focus, continuously irradiate at near distance, destroy DNA double bond of tumor cell nucleus, kill or subkill tumor cells, and make them lose replicative capacity, so as to achieve the purpose of treatment, and simultaneously the isotope radiation energy is low, so that it can effectively prevent the radiation from damaging normal tissue during irradiation.
The implantation of radioactive particles between tissues for treating tumors is an effective treatment means, has the advantages of high tumor inhibition efficiency, reasonable dose distribution, convenience for complementation with surgery, and the like, and also has the defects of displacement in tissues after the implantation of radioactive particles, complicated particle implantation surgery, and the like. The radioactive particle chain is a new technology which appears in the application of the radioactive particle brachytherapy, namely, various components such as radioactive particles, image markers and the like are assembled into the particle chain through a biocompatible material (especially biodegradable) by a physical or chemical method.
The application of the radioactive particle chain has the following advantages: (1) After the radioactive particle chain is implanted, migration conditions are not generated due to body position change, tumor shape change and the like, so that the particle dose distribution meets the requirement of a Treatment Planning System (TPS) distribution source dose. (2) The indication of radioactive particle implantation is increased, especially when loose tissue exists at the tumor site, such as when a large number of glands exist at the tumor site, and the implantation site is not suitable for single particle implantation. (3) The radioactive particle chains generally have better elastic and mechanical properties, which can be deformed conformally as the tumor tissue shrinks. (4) The radioactive particle chain forming material is generally made of a biocompatible material (particularly a biodegradable material), and the biodegradation time of the material is several weeks, which is equivalent to the atrophy period of the tumor after being irradiated by radioactive particles, and normal tissues are not affected after the treatment is finished. (5) The radioactive particles are not in direct contact with tumor tissue by using the molding material of the radioactive particle chain, so that the necrosis phenomenon of local tissue caused by overdose is avoided. (6) The particle chains are implanted through the implantation system, so that the layout of a plurality of radioactive particles can be realized at one time, and the implantation operation time and the irradiation dose of medical staff are reduced. (7) The radioactive particle chain assembly is completed by manufacturers, so that convenience is brought to users, and the added value of products is improved.
The inventor of the present invention has previously invented a Chinese patent name of a radioactive particle chain, application publication No. CN103736201A, proposes a particle chain formed by wrapping hydrophilic alginate as a molding material, after implantation, the particle chain can be rapidly softened in a wet environment in vivo, and finally deformed and finally degraded along with shrinkage of tumor tissues, but the particle chain lacks sufficient supporting force after in vivo softening, is only suitable for implantation at tumors with large tissue density, and for tumors with large burette cavities and gland parts, the particle chain is easy to displace, so that dosage deviation is caused.
The inventor of the present invention has previously proposed a method for preparing a molded particle chain by using a mold in chinese patent application publication No. CN 103736200a, but the method requires a curing operation, cannot be molded in one step, and is easy to corrode the mold due to the use of a salt-containing solution during the molding operation.
In view of the above drawbacks, the present inventors have finally achieved the present creation through long-time studies and practices.
Disclosure of Invention
Aiming at the problems in the background art, the invention provides a preparation method of a degradable radioactive particle chain with a shape memory function, which is used for overcoming the technical defects.
In order to achieve the above purpose, the present invention proposes the following technical scheme:
a preparation method of a degradable radioactive particle chain with a shape memory function is characterized by comprising the following steps of: the method comprises the following steps:
(1) And (3) manufacturing a pipe: the pipe material is manufactured into a pipe by an extrusion mode, or is directly manufactured into the pipe by a pipe die;
(2) Loading of radioactive particles: sequentially filling radioactive particles into the pipe manufactured in the step (1);
(3) And (3) forming: placing the pipe filled with the radioactive particles into a mould with a preset shape for heating, melting the pipe, cooling, and demoulding to obtain the finished product;
the tubing material comprises polycaprolactone PCL.
Further, the tubing material also includes a filler and/or plasticizer;
the filler comprises an inorganic filler and a polymer filler, wherein the filler accounts for not more than 20% of the specific gravity of the coating layer;
the plasticizer comprises natural or synthetic liquid ester materials, and the plasticizer accounts for not more than 10% of the specific gravity of the wrapping layer.
Further, the inorganic filler is one or more of calcium carbonate, calcium sulfate, hydroxyapatite, carbon black, silicon nitride and aluminum hydroxide;
the polymer filler is one or more of polylactic acid, polyglycolic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, starch and cellulose;
the plasticizer is one or more of tributyl citrate, acetyl tributyl citrate, glyceryl triacetate, castor oil and coconut oil.
Further, the step (2) further comprises loading other components into the tubing;
the other components include a spacer component, an anchor and a marker component;
the individual components may be sequentially loaded in a non-spaced manner or individual components may be reloaded into the tubing at predetermined locations with spaces between the components.
Further, the inner diameter of the tube is greater than the largest outer diameter of the radioactive particles and the other components, and the difference between the inner diameter of the tube and the largest outer diameter is less than or equal to 0.4mm.
Further, the wall thickness of the pipe is 0.05mm-2mm.
Further, in the step (3), the pipe is heated to not lower than 60 ℃;
the heating time of the pipe is 1 second to 10 minutes.
Further, in the step (3), the pipe is heated to 60-100 ℃;
the heating time of the tube is preferably 10 seconds to 1 minute.
The invention has the beneficial effects that:
the invention adopts the degradable material PCL with shape memory function as the molding material, and the particle chain manufactured by taking PCL as the main molding material has the following advantages:
1. the PCL has a shape memory function, so that the implantation operation of particle chains with different shapes can be completed at one time through a puncture needle, and particularly when a tumor with a complex position needs to be used, the implantation operation of the particle chains is simplified.
2. The shape memory function of the PCL can provide enough supporting force in different directions, especially for tumors near the lumen and gland parts of a human body, and the particle chain made of the PCL as a main molding material can simultaneously maintain a certain supporting force for the lumen and gland, especially for the spiral or other complex-shaped particle chains, has stronger supporting force for the axial direction of the chain, and ensures that the normal physiological functions of the lumen and gland are not affected after the particle chain is implanted.
3. PCL has biodegradability, and by adjusting components such as fillers with different molecular weight ratios and accelerating degradation, the PCL is synchronously degraded when the radioactive dose in a particle chain is basically released.
4. The melting point of PCL is low, only about 60 ℃, and the PCL is suitable for medical staff to adjust the shape and layout of the particle chain at any time before and even during operation so as to cope with various conditions during operation.
5. The particle chain in which PCL is the main molding material can form a composite structure of a plurality of particle chains as needed.
The particle chain preparation method using PCL as main molding material has the following advantages:
1. the manufacturing process is simple and convenient, and the product can be formed by heating once.
2. The manufacturing process is convenient, complex equipment is not needed, the manufacturing time is short, and the operation can be performed on the operation site.
3. The product can be repeatedly heated/cooled for molding.
4. The particle chains made of the PCL as the main molding materials can be spliced, woven, fused and cut into a plurality of particle chains with different shapes and different functions to be combined so as to adapt to complex clinical situations.
Drawings
FIG. 1 is a flow chart of a method for preparing a degradable radioactive particle chain with a shape memory function.
FIG. 2 is a block diagram of a product obtained by a method for preparing a degradable radioactive particle chain with a shape memory function according to the present invention.
In the figure, 1-radioactive particles, 2-coating, 3-spacer assembly.
Detailed Description
The invention provides a preparation method of a degradable radioactive particle chain with a shape memory function, which is shown in figure 1 and comprises the following steps:
1. and (3) manufacturing a pipe:
after mixing PCL with filler and plasticizer, preparing PCL tube by extrusion mode, or directly preparing tube by tube mould, wherein the inner diameter of tube is matched with the outer diameter of radioactive particles, the outer diameter of radioactive particles is 0.8mm, the inner diameter of tube is 0.8mm-1.2mm, the radioactive particles cannot be loaded if the inner diameter of tube is too small, the inner diameter of tube is too large, and the loading position of radioactive particles is easy to deviate; the wall thickness of the pipe is 0.05mm-2mm, the mechanical supporting force of the particle chain is insufficient due to the fact that the pipe wall is too thin, the cost is increased due to the fact that the pipe wall is too thick, and the particle chain is not suitable for being implanted in a puncture needle mode. After the tubing is formed, it can be cut to an appropriate length as desired.
2. Loading of radioactive particles:
according to the requirements designed in advance, the components such as radioactive particles, markers, spacers and the like are sequentially loaded into the PCL tube, the components can be sequentially loaded in a non-interval mode, or a single component can be transferred into a preset position in the PCL tube, gaps can exist between the components, the components can be sequentially pushed into the preset position in the tube by using a push rod in the loading mode, the diameter of the push rod is smaller than the inner diameter of the tube, or the corresponding components are sequentially inserted into the tube without gaps, and the components sequentially slide into the preset position in the inserting process.
3. And (3) forming:
and (3) putting the PCL pipe into a mould with a preset shape, heating to not lower than 60 ℃, preferably 60-100 ℃ and most preferably 70 ℃, melting the PCL pipe, cooling, and demoulding to obtain the PCL pipe. The PCL tube is rapidly molded and heated for 1 second to 10 minutes, preferably 10 seconds to 1 minute, and most preferably 20 seconds, to complete the molding process. The forming process can be repeated for a plurality of times, and a plurality of particle chains can be assembled to form a complex particle chain structure.
The degradable radioactive particle chain prepared by the method comprises at least one radioactive particle 1 and a coating layer 2, as shown in fig. 2.
The radioactive particles are radioactive sources and at least a portion of the radioactive particles are surrounded by the coating.
The wrapper material comprises PCL.
Polycaprolactone, PCL for short, is generally a thermoplastic semi-crystalline polyester obtained from epsilon-caprolactone monomers by ring-opening polymerization. The PCL has a melting point of 59-64 ℃ and a glass transition temperature of-60 ℃, and 5 nonpolar methylene and one polar ester group are arranged on the structural repeating unit, so that the PCL has good flexibility and processability, and the prepared particle chain has shape memory and biodegradability.
The material of the wrapping layer also comprises a filler and/or a plasticizer.
The filler comprises an inorganic filler and a polymer filler, and can reduce cost, improve the mechanical property of the coating material and adjust the degradation time of the coating in vivo. The inorganic filler is any one or a mixture of any several of calcium carbonate, calcium sulfate, hydroxyapatite, carbon black, silicon nitride and aluminum hydroxide in any proportion, the polymer filler is any one or a mixture of any several of polylactic acid, polyglycolic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, starch and cellulose in any proportion, and the filler accounts for not more than 20% of the specific gravity of the coating layer.
The plasticizer comprises natural or synthetic liquid ester materials, has better compatibility with PCL, and can adjust the toughness of the wrapping layer. The plasticizer is any one or a mixture of any more of tributyl citrate, acetyl tributyl citrate, glyceryl triacetate, castor oil and coconut oil according to any proportion, and the specific gravity of the plasticizer is not more than 10 percent.
The degradable radioactive particle chain further comprises at least one spacer component 3, at least one part of the spacer component is wrapped in the wrapping layer, the spacer component is used for optimizing the radioactive particle radiation dose and improving the mechanical property of the radioactive particle chain, and the spacer component material is a biocompatible material.
The degradable radioactive particle chains are in any one structure of straight lines, circular arcs, rings, spiral shapes, forked shapes, cross shapes and net shapes or in any combination structure of a plurality of particle chains.
The degradable radioactive particle chain also includes components having functions of anchoring the radioactive particle chain position and/or labeling and/or isolating.
The anchor assembly is used to fix the position of the particle chain, and is typically a protrusion that can be located on any surface of the particle chain, ensuring that the particle chain does not shift within the tissue after implantation. The marker is made of an impermeable material such as X-ray or CT and is used for calibrating the position of the particle chain in an operation by means of X-ray, ultrasound, CT and the like, and the marker can be marked at two ends of the particle chain or in the gap between every two adjacent radioactive particles.
The quality control of the particle chain made of PCL as the main molding material is mainly as follows:
1. appearance detection: the radioactive particle chains manufactured by taking PCL as a main molding material are uniform in appearance, and the radioactive particles are uniformly arranged and uniformly spaced.
2. Puncture needle test: the linear, circular arc-shaped or other curve-shaped particle chains pass through the 18-size puncture needle head without obvious resistance, and the radioactive particle chains remain intact after passing through.
3. Mechanical stability test: the two ends of the radioactive particle chain (whatever shape) are placed on the two wood boards, the middle of the radioactive particle chain is suspended, the radioactive particle chain is not deformed due to dead weight, and the radioactive particle chain still has no macroscopic deformation after the middle of the chain bears 0.1 gram, so that the mechanical property of the radioactive particle chain is stable.
4. Shape memory performance test: the radioactive particle chain is deformed by applying a certain external force, the radioactive particle chain returns to the original shape after the external force is removed, and the radioactive particle chain is characterized in that the arc-shaped or other curve-shaped particle chain can return to the original shape after passing through an 18-gauge puncture needle, two ends of the radioactive particle chain (whatever shape) are placed on two wood boards, the middle of the radioactive particle chain is suspended, the load in the middle of the radioactive particle chain is deformed after being loaded by 2 g, the particle chain returns to the original shape after being removed, the particle chain is suspended for the spiral particle chain, the load is applied to the bottom, the elastic stretching occurs when the load is applied to 2 g, the spiral diameter is reduced, and the spiral particle chain returns to the original shape when the load is removed.
5. Storage stability performance test: the prepared radioactive particle chain is stored for one month in a sealing way at the temperature of 4 ℃ and the room temperature, and then the appearance test, the puncture needle test, the mechanical property test and the shape memory property test are carried out on the radioactive particle chain, so that the result shows that the radioactive particle chain has no obvious change on various properties during the storage period.
6. Biodegradation performance test: the radioactive particle chain is put into physiological saline at 37 ℃, the particles in the particle chain are scattered and are not chain, the forming material is broken into fragments to be used as a standard of complete degradation, and the test result shows that the degradation time of the radioactive particle chain manufactured by taking PCL as a main forming material is 10 months, so that the radioactive particle chain meets the clinical application requirements.
The examples provided below are presented in more detail to facilitate a further understanding of the present invention. These examples are provided only for the purpose of illustration and are not intended to limit the scope or practice of the invention, which is defined by the claims as interpreted according to the obvious variations or modifications made thereto.
Example 1:
and (3) manufacturing a pipe: PCL (molecular weight: 50000) was added separately to an extruder to prepare a tube having an inner diameter of 0.8mm and a wall thickness of 0.2 mm.
Loading of radioactive particles: 10 pieces of the material with the outer diameter of 0.8mm and the length of 4.5mm are prepared 125 The I radioactive particles are sequentially filled into the PCL tube, and gaps among the particles are avoided.
And (3) forming: will be filled with 125 The PCL tube of the I radioactive particles is heated to 70 ℃ on a heating plate, the heating is stopped after the tube wall becomes transparent, and a linear particle chain is formed after cooling.
The prepared radioactive particle chain is detected, the appearance is linear, the surface is uniform, two ends of the radioactive particle chain can be smoothly placed on two wood boards through an 18-gauge puncture needle, the middle of the radioactive particle chain is suspended, the radioactive particle chain is not deformed due to self weight, and the radioactive particle chain still has no macroscopic deformation after the chain is loaded by 0.1 gram in the middle, so that the radioactive particle chain is stable in mechanical performance, obvious bending deformation occurs after the chain is loaded by 2 grams in the middle, and the radioactive particle chain is restored to be linear after the load is removed, so that the radioactive particle chain has a shape memory function.
Example 2:
and (3) manufacturing a pipe: PCL (molecular weight 50000), PLA (polylactic acid, molecular weight 5000) and acetyl tributyl citrate are added into an extruder according to the weight ratio of 80:19:1, and the pipe with the inner diameter of 0.8mm and the wall thickness of 0.2mm is manufactured.
Loading of radioactive particles: 10 pieces of the material with the outer diameter of 0.8mm and the length of 4.5mm are prepared 125 The I radioactive particles are sequentially filled into the PCL tube, and gaps among the particles are avoided.
And (3) forming: will be filled with 125 And (3) placing the PCL tube of the radioactive particles I in a circular arc tubular mold, heating the mold at 70 ℃, stopping heating after 20 seconds, cooling, and demolding to form a circular arc particle chain.
The prepared radioactive particle chain is detected, the appearance is arc-shaped, the surface is uniform, the radioactive particle chain can smoothly pass through an 18-number puncture needle head, and the arc shape is still maintained after the radioactive particle chain passes through the puncture needle. The radioactive particle chain is suspended, the radioactive particle chain is not deformed due to dead weight, the arc shape is still maintained, no macroscopic deformation is caused after the bottom of the chain bears 0.1 g of load, the mechanical property of the radioactive particle chain is stable, obvious bending deformation occurs after the weight bears 2 g, the arc shape is straightened, and the radioactive particle chain is restored to the arc shape after the weight is removed, so that the radioactive particle chain has a shape memory function.
Example 3:
and (3) manufacturing a pipe: PCL (molecular weight 50000), nano calcium carbonate and acetyl tributyl citrate are added into an extruder according to the weight ratio of 90:5:5, and a pipe with the inner diameter of 0.8mm and the wall thickness of 1mm is manufactured.
Loading of radioactive particles: 20 pieces of the material with the outer diameter of 0.8mm and the length of 4.5mm are prepared 125 I radioactive particles are sequentially filled into PCL tubes, eachThe particles were spaced 2mm apart.
And (3) forming: will be filled with 125 The PCL tube of the radioactive particles I was wound in a spiral shape on a heating rod having a diameter of 10mm and heated to 70℃and, after the winding, the heating was stopped, and after the demolding, a spiral particle chain was formed.
The prepared radioactive particle chain is detected, the appearance is spiral, the surface is uniform, the radioactive particle chain is suspended, the radioactive particle chain is not deformed due to dead weight, still maintains the spiral shape, no macroscopic deformation exists after the bottom of the chain is loaded by 0.1 g, the mechanical property of the radioactive particle chain is stable, obvious tensile deformation occurs after the weight is loaded by 2 g, the spiral is straightened, the spiral diameter is reduced, the spiral is restored after the load is removed, the radioactive particle chain has a shape memory function, and the radioactive particle chain has radial supporting and rebound performance similar to that of a spring, and is suitable for implantation of radioactive particles in a lumen.
Example 4:
and (3) manufacturing a pipe: PCL (molecular weight 50000), thermoplastic starch and acetyl tributyl citrate are added into an extruder according to the weight ratio of 80:15:5 to prepare the pipe with the inner diameter of 0.8mm and the wall thickness of 1 mm.
Loading of radioactive particles: 20 pieces of the material with the outer diameter of 0.8mm and the length of 4.5mm are prepared 125 The radioactive particles are sequentially filled into PCL tubes, and the interval between each two particles is 2mm.
And (3) forming: will be filled with 125 The PCL tube of the I radioactive particles is heated to 70 ℃ on a heating plate, the heating is stopped after the tube wall becomes transparent, and a linear particle chain is formed after cooling. And placing the two formed particle chains on a heating plate, overlapping the two formed particle chains in a crossing way to form a cross shape, heating to 70 ℃ to perform secondary forming, and cooling to form the cross-shaped particle chains.
The obtained radioactive particle chains were examined, and the method and results for detecting a single particle chain among the cross-shaped particle chains were the same as in example 1.
Claims (7)
1. A preparation method of a degradable radioactive particle chain with a shape memory function is characterized by comprising the following steps of: the method comprises the following steps:
(1) And (3) manufacturing a pipe: the pipe material is manufactured into a pipe by an extrusion mode, or is directly manufactured into the pipe by a pipe die;
(2) Loading of radioactive particles and other components: sequentially filling radioactive particles into the pipe manufactured in the step (1); the other components include a spacer component, an anchor and a marker component;
the components can be sequentially loaded in a non-interval manner or single components are loaded at preset positions in the pipe, and intervals exist between the components;
(3) And (3) forming: placing the pipe with the radioactive particles and other components into a mould with a preset shape for heating, melting the pipe, cooling, and demoulding to form a degradable radioactive particle chain with a shape memory function;
the degradable radioactive particle chain comprises at least one radioactive particle and a coating layer;
the radioactive particles are radioactive sources and at least a portion of the radioactive particles are surrounded by the coating;
the wrapping layer is the pipe material, and the pipe material comprises polycaprolactone PCL; the tubing material further comprises a filler and/or a plasticizer;
the degradable radioactive particle chain further comprises at least one spacer component, at least a portion of which is wrapped in the wrapping layer;
the degradable radioactive particle chain further includes an anchor and tag assembly having an anchor and tag radioactive particle chain position;
the degradable radioactive particle chains are in any one structure of straight lines, circular arcs, rings, spiral shapes, forked shapes, cross shapes and net shapes or in any combination structure of a plurality of particle chains.
2. The method for preparing the degradable radioactive particle chain with the shape memory function according to claim 1, wherein the method comprises the following steps of:
the filler comprises an inorganic filler and a polymer filler, wherein the filler accounts for not more than 20% of the specific gravity of the coating layer;
the plasticizer comprises natural or synthetic liquid ester materials, and the plasticizer accounts for not more than 10% of the specific gravity of the wrapping layer.
3. The method for preparing the degradable radioactive particle chain with the shape memory function according to claim 2, wherein the method comprises the following steps of:
the inorganic filler is one or more of calcium carbonate, calcium sulfate, hydroxyapatite, carbon black, silicon nitride and aluminum hydroxide;
the polymer filler is one or more of polylactic acid, polyglycolic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, starch and cellulose;
the plasticizer is one or more of tributyl citrate, acetyl tributyl citrate, glyceryl triacetate, castor oil and coconut oil.
4. The method for preparing the degradable radioactive particle chain with the shape memory function according to claim 1, wherein the method comprises the following steps of:
the inner diameter of the tube is larger than the maximum outer diameter of the radioactive particles and other components, and the difference between the inner diameter of the tube and the maximum outer diameter is less than or equal to 0.4mm.
5. The method for preparing the degradable radioactive particle chain with the shape memory function according to any one of claims 1 to 4, wherein the method comprises the following steps:
the wall thickness of the pipe is 0.05mm-2mm.
6. The method for preparing the degradable radioactive particle chain with the shape memory function according to claim 1, wherein the method comprises the following steps of:
in the step (3), the pipe is heated to not lower than 60 ℃;
the heating time of the pipe is 1 second to 10 minutes.
7. The method for preparing the degradable radioactive particle chain with the shape memory function according to claim 6, wherein the method comprises the following steps:
in the step (3), the pipe is heated to 60-100 ℃;
the heating time of the tube is preferably 10 seconds to 1 minute.
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| CN1887364A (en) * | 2006-07-20 | 2007-01-03 | 中国科学院长春应用化学研究所 | Biodegradable medical extracorporeal fixing material possessing shape memory function |
| CN103736200A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Preparation method of radioactive particle chain |
| CN103736201A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Radioactive particle chain |
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| CN1887364A (en) * | 2006-07-20 | 2007-01-03 | 中国科学院长春应用化学研究所 | Biodegradable medical extracorporeal fixing material possessing shape memory function |
| CN103736200A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Preparation method of radioactive particle chain |
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