CN106822234A - It is a kind of to treat Chinese and western medicinal composition of hypertension and preparation method thereof - Google Patents
It is a kind of to treat Chinese and western medicinal composition of hypertension and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
Abstract
The invention discloses a kind of Chinese and western medicinal composition for treating hypertension, the Chinese and western medicinal composition of the treatment hypertension is according to the primary raw material of weight portion：5 12 parts of Ligusticum wallichii, 89 parts of selfheal, 20 35 parts of Folium Apocyni Veneti, 47 parts of cyclopamine, 15 20 parts of orange oil lactone, 24 parts of Isosakuranetin, 79 parts of menthol, 48 parts of 7 O glucuronides of cyanidenon, 46 parts of 3 Bdph.Chinese and western medicinal composition of the present invention is strictly selected material composition according to the understanding mechanism of hypertension, the comprehensive adjustment treatment of centering senile hypertension patient physiology, pathology, its blood pressure level is recovered normal.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Chinese and western medicinal composition for treating hypertension.
Background technology
Hypertension is a kind of common disease and frequently-occurring disease, and the general onset of this disease is slow, and patient's early stage is often asymptomatic, or only head
The symptoms such as dizzy, headache, palpitaition, tinnitus, seemingly a kind of independent disease, actually triggers the heart, the cerebrovascular and ephrosis
Become an important hazards, if malpractice will lesion turn into more serious headstroke, myocardial infarction and kidney work(
These common hypertension complications such as energy exhaustion.In recent years, as people's living standard is improved constantly, dietary structure occurs larger
Change, the generation of China's Cardial or cerebral vascular diseases and death toll are also constantly rising, and wherein death toll accounts for China's general mortality rate
Ratio even reached 40% or so, hypertension has become a problem for allowing people to worry.In the market Chinese medicine Western medicine has
Treatment hypertension, but some medicine long term usages lose blood pressure reduction, some medicines it is desirable that long-term taking, patient medicine is generated according to
Lai Xing, and common hypertension Western medicine has side effect to body, and especially reduction of blood pressure in high-speed medicine side effect is bigger, and medication blood pressure is then
Drop, disobedience then rises, and the Western medicine of side effect necessarily certain to body other parts generation, and this step-down in the course of time is in city
The share accounted on field is very big.The chemicals of these treatment hypertension, although effect is fast, but cures the symptoms, not the disease, and side effect is more,
Dependence can be also produced to medicine, it is undesirable for patient.The old complaint main cause of hypertension is：Blood, blood vessel, human body base
Because impaired, for the organ being damaged, it is desirable that, promoting blood circulation and removing blood stasis, regulation blood fat, softening blood vessel recovers regulation and control blood pressure
Mechanism, improves human body gene defect.Although have in Chinese medicinal material many taste medical instruments have it is promoting blood circulation and removing blood stasis, regulation blood fat, softening blood vessel,
Recover the function of the mechanism of regulation and control blood pressure, reached by Chinese traditional treatment high blood pressure and treated both principal and secondary aspect of disease, in also there are many kinds on the market
Medicine composition treats hypertension, but effect is less desirable.
Therefore, it is badly in need of a kind of suitable good effect of research and development, speed is fast, price is low, the Chinese and western medicinal composition that has no toxic side effect.
The content of the invention
It is an object of the invention to provide a kind of Chinese and western medicinal composition for treating hypertension, with solving above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese and western medicinal composition for treating hypertension, be according to the primary raw material of weight portion：Ligusticum wallichii 5-12 parts, selfheal
8-9 parts, Folium Apocyni Veneti 20-35 parts, cyclopamine 4-7 parts, 15-20 parts of orange oil lactone, Isosakuranetin 2-4 parts, menthol 7-9
Part, 4-8 parts of cyanidenon -7-O- glucuronides, 4-6 parts of 3- Bdphs.
As further scheme of the invention：The Chinese and western medicinal composition of the treatment hypertension, according to the main of weight portion
Raw material is：Ligusticum wallichii 7-10 parts, selfheal 8-9 parts, Folium Apocyni Veneti 24-30 parts, cyclopamine 4-7 parts, 18-20 parts of orange oil lactone,
Isosakuranetin 2-4 parts, menthol 7-9 parts, 4-8 parts of cyanidenon -7-O- glucuronides, 4-6 parts of 3- Bdphs.
As further scheme of the invention：The Chinese and western medicinal composition of the treatment hypertension, according to the main of weight portion
Raw material is：It is 8 parts of Ligusticum wallichii, 9 parts of selfheal, 27 parts of Folium Apocyni Veneti, 6 parts of cyclopamine, 19 parts of orange oil lactone, 3 parts of Isosakuranetin, thin
8 parts of lotus alcohol, 6 parts of cyanidenon -7-O- glucuronides, 5 parts of 3- Bdphs.
A kind of preparation method of the Chinese and western medicinal composition for treating hypertension, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Ligusticum wallichii, selfheal, Folium Apocyni Veneti, cyclopamine, orange are weighed by above-mentioned metering ratio
Skin oil lactone, Isosakuranetin, menthol, cyanidenon -7-O- glucuronides, 3- Bdphs, sieving, machinery are mixed
Addition ultra-pure water after even, places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing,
At 4-8 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hypertension to temperature control.
As further scheme of the invention：Mix 6min in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Chinese and western medicinal composition of the present invention is strictly selected material composition according to the understanding mechanism of hypertension, to person in middle and old age
The comprehensive adjustment treatment of people hyperpietic physiology, pathology, makes its blood pressure level recover normal.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Chinese and western medicinal composition for treating hypertension, be according to the primary raw material of weight portion：5 parts of Ligusticum wallichii, selfheal 8
Part, 20 parts of Folium Apocyni Veneti, 4 parts of cyclopamine, 15 parts of orange oil lactone, 2 parts of Isosakuranetin, 7 parts of menthol, cyanidenon -7-O-
4 parts of glucuronide, 4 parts of 3- Bdphs.
A kind of preparation method of the Chinese and western medicinal composition for treating hypertension, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Ligusticum wallichii, selfheal, Folium Apocyni Veneti, cyclopamine, orange are weighed by above-mentioned metering ratio
Skin oil lactone, Isosakuranetin, menthol, cyanidenon -7-O- glucuronides, 3- Bdphs, sieving, machinery are mixed
Addition ultra-pure water after even, places in pharmacy mixer, mixes 4min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature
At 4 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hypertension for degree control.
Embodiment 2
A kind of Chinese and western medicinal composition for treating hypertension, be according to the primary raw material of weight portion:7 parts of Ligusticum wallichii, selfheal 8
Part, 24 parts of Folium Apocyni Veneti, 4 parts of cyclopamine, 18 parts of orange oil lactone, 2 parts of Isosakuranetin, 7 parts of menthol, cyanidenon -7-O-
4 parts of glucuronide, 4 parts of 3- Bdphs.
A kind of preparation method of the Chinese and western medicinal composition for treating hypertension, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Ligusticum wallichii, selfheal, Folium Apocyni Veneti, cyclopamine, orange are weighed by above-mentioned metering ratio
Skin oil lactone, Isosakuranetin, menthol, cyanidenon -7-O- glucuronides, 3- Bdphs, sieving, machinery are mixed
Addition ultra-pure water after even, places in pharmacy mixer, mixes 4min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature
At 4 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hypertension for degree control.
Embodiment 3
A kind of Chinese and western medicinal composition for treating hypertension, be according to the primary raw material of weight portion：8 parts of Ligusticum wallichii, selfheal 9
Part, 27 parts of Folium Apocyni Veneti, 6 parts of cyclopamine, 19 parts of orange oil lactone, 3 parts of Isosakuranetin, 8 parts of menthol, cyanidenon -7-O-
6 parts of glucuronide, 5 parts of 3- Bdphs.
A kind of preparation method of the Chinese and western medicinal composition for treating hypertension, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Ligusticum wallichii, selfheal, Folium Apocyni Veneti, cyclopamine, orange are weighed by above-mentioned metering ratio
Skin oil lactone, Isosakuranetin, menthol, cyanidenon -7-O- glucuronides, 3- Bdphs, sieving, machinery are mixed
Addition ultra-pure water after even, places in pharmacy mixer, mixes 6min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature
At 6 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hypertension for degree control.
Embodiment 4
A kind of Chinese and western medicinal composition for treating hypertension, be according to the primary raw material of weight portion：10 parts of Ligusticum wallichii, selfheal 9
Part, 30 parts of Folium Apocyni Veneti, 7 parts of cyclopamine, 20 parts of orange oil lactone, 4 parts of Isosakuranetin, 9 parts of menthol, cyanidenon -7-O-
8 parts of glucuronide, 6 parts of 3- Bdphs.
A kind of preparation method of the Chinese and western medicinal composition for treating hypertension, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Ligusticum wallichii, selfheal, Folium Apocyni Veneti, cyclopamine, orange are weighed by above-mentioned metering ratio
Skin oil lactone, Isosakuranetin, menthol, cyanidenon -7-O- glucuronides, 3- Bdphs, sieving, machinery are mixed
Addition ultra-pure water after even, places in pharmacy mixer, mixes 8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature
At 8 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hypertension for degree control.
Embodiment 5
A kind of Chinese and western medicinal composition for treating hypertension, be according to the primary raw material of weight portion：12 parts of Ligusticum wallichii, selfheal 9
Part, 35 parts of Folium Apocyni Veneti, 7 parts of cyclopamine, 20 parts of orange oil lactone, 4 parts of Isosakuranetin, 9 parts of menthol, cyanidenon -7-O-
8 parts of glucuronide, 6 parts of 3- Bdphs.
A kind of preparation method of the Chinese and western medicinal composition for treating hypertension, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Ligusticum wallichii, selfheal, Folium Apocyni Veneti, cyclopamine, orange are weighed by above-mentioned metering ratio
Skin oil lactone, Isosakuranetin, menthol, cyanidenon -7-O- glucuronides, 3- Bdphs, sieving, machinery are mixed
Addition ultra-pure water after even, places in pharmacy mixer, mixes 8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature
At 8 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hypertension for degree control.
Pharmacology test
1st, acute toxicity test
It is experiment with Chinese and western medicinal composition obtained in the embodiment of the present invention 3, it is continuous in 24h using gastric infusion mode
Administration 4 times, per minor tick 6h, is administered 375mg/kg doses every time, and daily accumulation medicine total amount reaches 1500mg medicines/kg, quite
In 100 times of people's quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, its
Average weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung,
Kidney, brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This
Invention Chinese and western medicinal composition is without acute toxic reaction.
2nd, long term toxicity test
It is experiment with Chinese and western medicinal composition obtained in the embodiment of the present invention 3, using gastric infusion mode, by Chinese and Western of the present invention
Drug composition is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 150,300,450mg medicines/
Kg/d, 10,20,30 times equivalent to clinical dosage.After gastric infusion 24 weeks, general status, blood of the medicine of the present invention to animal
, without obvious influence, Systematic anatomy, organ coefficient and histopathological examination do not find yet for liquid index, blood parameters
Abnormal pathologic changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Chinese and western medicinal composition of the present invention is in long term toxicity test
In, do not find overt toxicity reaction and delayed toxicity reaction.It can be seen that, Chinese and western medicinal composition non-toxic reaction of the present invention is long-term to use
Medicine is safe and reliable.
3rd, clinical test
Case-data：Hebei medical institutions hyperpietic 200, wherein male 100, women 100.
Medicament selection：The Chinese and western medicinal composition that treatment group is prepared using the embodiment of the present invention 3, using 3 courses for the treatment of, (each is treated
Journey 3 days).One time a day, each 15mg/kg.
Diagnostic criteria：Check for 3 times after examining, it is high to be divided into normal arterial pressure, BH and diagnosis by the height of pressure value
Blood pressure.(1) normal arterial pressure：Systolic pressure in 18.7kPa (140mmHg) or following, diastolic pressure 12.0kPa (90mmHg) or following,
And non-hypotensive, should be regarded as normal arterial pressure.(2) BH：Systolic pressure 18.8-21.2kPa (141~
159mmHg) and diastolic pressure person between 12.1-12.5kPa (91-95mmHg) is yes.(3) Definite Hypertension：Systolic pressure reaches
Or more than 21.3kPa (160mmHg) and diastolic pressure to meet or exceed 12.7kPa (95mmHg) person be yes.
Criterion of therapeutical effect：It is effective：1. more than diastole drops 1.3KPa (10mmHg), and reach normal range (NR)；2. diastolic pressure
Though do not drop to normally, decline more than 2.6KPa (20mmHg).Effectively：1. diastole drops are not as good as 1.3KPa (10mmHg),
But reach normal range (NR)；2. decline 1.3~2.34KPa (10~19mmHg) before diastolic pressure is relatively treated, but do not reach normal range (NR)；
3. 4.0KP (30mmHg) is declined before systolic pressure is relatively treated.It is invalid：Not up to effective standard.
Therapeutic effect：In 200 patients, effective 162, effective 25, invalid 13, total effective rate 93.5%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (5)
1. a kind of Chinese and western medicinal composition for treating hypertension, it is characterised in that the primary raw material according to weight portion is：Ligusticum wallichii 5-12
Part, selfheal 8-9 parts, Folium Apocyni Veneti 20-35 parts, cyclopamine 4-7 parts, 15-20 parts of orange oil lactone, Isosakuranetin 2-4 parts, it is thin
7-9 parts of lotus alcohol, 4-8 parts of cyanidenon -7-O- glucuronides, 4-6 parts of 3- Bdphs.
2. it is according to claim 1 treatment hypertension Chinese and western medicinal composition, it is characterised in that the treatment hypertension
Chinese and western medicinal composition, be according to the primary raw material of weight portion：Ligusticum wallichii 7-10 parts, selfheal 8-9 parts, Folium Apocyni Veneti 24-30 parts, ring
4-7 parts of bar amine, 18-20 parts of orange oil lactone, Isosakuranetin 2-4 parts, menthol 7-9 parts, cyanidenon -7-O- glucuronic acids
Glycosides 4-8 parts, 4-6 parts of 3- Bdphs.
3. it is according to claim 1 and 2 treatment hypertension Chinese and western medicinal composition, it is characterised in that the treatment blood high
The Chinese and western medicinal composition of pressure, be according to the primary raw material of weight portion：8 parts of Ligusticum wallichii, 9 parts of selfheal, 27 parts of Folium Apocyni Veneti, cyclopamine
6 parts, 19 parts of orange oil lactone, 3 parts of Isosakuranetin, 8 parts of menthol, 6 parts of cyanidenon -7-O- glucuronides, the positive fourths of 3-
5 parts of alkenyl phthalide.
4. a kind of preparation method of the Chinese and western medicinal composition for the treatment of hypertension as described in claim 1-3 is any, its feature exists
In concretely comprising the following steps：
First, in pharmaceutical grade clean area, Ligusticum wallichii, selfheal, Folium Apocyni Veneti, cyclopamine, orange oil are weighed by above-mentioned metering ratio
Lactone, Isosakuranetin, menthol, cyanidenon -7-O- glucuronides, 3- Bdphs, sieving, after machinery is mixed
Addition ultra-pure water, places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, compressing tablet and low temperature drying, temperature after mixing
At 4-8 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hypertension for control.
5. the preparation method of the Chinese and western medicinal composition for the treatment of hypertension according to claim 4, it is characterised in that specific step
Mixing 6min in rapid.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800307A (en) * | 2013-12-20 | 2014-05-21 | 中国人民解放军第三军医大学第三附属医院 | Medicinal composition for reducing blood pressure and preparation method thereof |
| CN105833043A (en) * | 2015-08-25 | 2016-08-10 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating primary hypertension |
-
2016
- 2016-12-17 CN CN201611171918.8A patent/CN106822234A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800307A (en) * | 2013-12-20 | 2014-05-21 | 中国人民解放军第三军医大学第三附属医院 | Medicinal composition for reducing blood pressure and preparation method thereof |
| CN105833043A (en) * | 2015-08-25 | 2016-08-10 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating primary hypertension |
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| 吴映蓉等: "《吃对五色蔬果：营养学博士教你认识植物营养素》", 31 August 2011, 生活读书新知三联书店出版 * |
| 王俊儒编: "《天然产物提取分离与鉴定技术》", 30 May 2006, 西北农林科技大学出版社 * |
| 王清等: ""藜芦胺降压作用的实验研究"", 《中国老年学杂志》 * |
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Application publication date: 20170613 |