CN106806886B - Breath freshener for quickly eliminating halitosis and medical application thereof - Google Patents
Breath freshener for quickly eliminating halitosis and medical application thereof Download PDFInfo
- Publication number
- CN106806886B CN106806886B CN201510870376.2A CN201510870376A CN106806886B CN 106806886 B CN106806886 B CN 106806886B CN 201510870376 A CN201510870376 A CN 201510870376A CN 106806886 B CN106806886 B CN 106806886B
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- halitosis
- breath freshener
- hydrogen peroxide
- breath
- dimethyl sulfide
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- 206010006326 Breath odour Diseases 0.000 title claims abstract description 24
- 208000032139 Halitosis Diseases 0.000 title claims abstract description 22
- 239000008376 breath freshener Substances 0.000 title claims abstract description 16
- 239000002324 mouth wash Substances 0.000 claims abstract description 8
- 229940051866 mouthwash Drugs 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 229940112822 chewing gum Drugs 0.000 claims abstract description 4
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 35
- 108010041559 Methionine Sulfoxide Reductases Proteins 0.000 claims description 9
- 102000000532 Methionine Sulfoxide Reductases Human genes 0.000 claims description 9
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 8
- 235000018417 cysteine Nutrition 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 6
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 abstract description 48
- 239000000126 substance Substances 0.000 abstract description 5
- 238000006911 enzymatic reaction Methods 0.000 abstract description 2
- 239000012567 medical material Substances 0.000 abstract description 2
- 230000000474 nursing effect Effects 0.000 abstract description 2
- 229940034610 toothpaste Drugs 0.000 abstract description 2
- 239000000606 toothpaste Substances 0.000 abstract description 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 6
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000005842 biochemical reaction Methods 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 108010020410 methionine sulfoxide reductase Proteins 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- 241000234282 Allium Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101000581498 Methylosinus trichosporium Methanobactin mb-OB3b Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 229920006295 polythiol Polymers 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a biotechnology breath freshener which eliminates main odor-causing substances in halitosis, namely dimethyl sulfide and the like through enzymatic reaction, thereby quickly eliminating halitosis. The additive has mild and quick action, can be added into products such as mouthwash, toothpaste or chewing gum and the like, can also be added into medicinal preparations or oral medical materials, and has important significance for treating and nursing halitosis.
Description
Technical Field
The invention relates to a biotechnology breath freshener, which eliminates main odor-causing substances in halitosis, namely dimethyl sulfide and the like through an enzymatic reaction, can be added into products such as mouthwash, toothpaste or chewing gum and the like, can also be added into medicinal preparations or oral medical materials, and has important significance for treating and nursing halitosis.
Background
Halitosis is an unpleasant gas emitted from the oral cavity or other physiological cavities such as the nose, sinuses, pharynx, etc., and seriously affects social interaction and mental health of people, and WHO has reported halitosis as a disease. The survey shows that the prevalence rate of the Chinese halitosis is about 27.5%. While chronic halitosis is found in 25% of the people worldwide, most adults occasionally have halitosis when the mouth is dry. 80-90% of the bad breath originates from the oral cavity. Gingivitis, periodontitis and oral mucosa diseases in the oral cavity, a large amount of saliva is reduced, and halitosis can be caused by eating certain medicines or irritant foods such as onion, garlic and the like. Scientific data indicate that odorous gas sulfides such as hydrogen sulfide, dimethyl sulfide and the like are the direct causes of halitosis.
Currently, there are two main types of products on the market for breath: firstly, the breath freshener mostly shields the taste of the breath through various odor masking agents with aromatic odor, and the odor masking agents cannot effectively eliminate odor causing halitosis, so that the action time is short; and oral cleaning products, such as mouthwash products, can be used for removing oral bacteria and maintaining oral hygiene. The invention obtains a brand-new high-efficiency breath freshener through a biological enzyme technology and a scientific formula, can quickly remove odor-causing components (dimethyl sulfide and hydrogen sulfide) in breath, eliminate peculiar smell of oral cavity, and can also inhibit oral bacteria for a long time.
Disclosure of Invention
The task of the invention is to provide a biotechnology breath freshener for quickly eliminating halitosis and a medical application thereof.
The technical scheme for realizing the invention is as follows: the biotechnology breath freshener for quickly eliminating the ozostomia provided by the invention comprises 0.1-0.5% of hydrogen peroxide in the proportion; recombinant humanized methionine sulfoxide reductase A0.0001-0.0005%; 0.0001 percent of cysteine; the rest part is mixed with sterile distilled water. The biotechnology breath freshener for preventing and treating halitosis can be directly used, and also can be used for preparing mouthwash, chewing gum, medical products or medical appliances and the like. The biotechnology breath freshener for quickly eliminating the ozostomia can quickly eliminate sulfur-containing organic matters contained in the oral cavity, thereby effectively relieving the ozostomia.
The invention is mainly based on two biochemical reactions discovered in the inventor laboratory, and two main substances causing bad breath odor are respectively eliminated: hydrogen sulfide and dimethyl sulfide.
The biochemical reaction for removing hydrogen sulfide is as follows: under certain physiological conditions and pH environment, hydrogen sulfide generates polythioether under the catalysis of hydrogen peroxide, and then reacts with cysteine to generate cysteine in a sulfhydrylation state.
nH2S+n H2O2→H2(S)n+2n H2O
H2(S)n+Cystein-SH→H2(S)n-1+Cystein-SSH
The biochemical reaction for removing dimethyl sulfide is as follows: under certain physiological conditions and pH environment, dimethyl sulfide can react with hydrogen peroxide with lower concentration rapidly under the catalysis of methionine sulfoxide reductase A to generate odorless dimethyl sulfoxide.
Many mouthwash products have been used to disinfect ulcer surfaces and maintain oral hygiene by adding high concentrations of hydrogen peroxide (1% -5%). However, the high concentration of hydrogen peroxide has great irritation and oxidative damage to oral mucosa, and the single use of hydrogen peroxide has no effect of removing odor-causing components (dimethyl sulfide and hydrogen sulfide) in the oral cavity. The concentration of the hydrogen peroxide used in the invention is less than one tenth of the concentration of the hydrogen peroxide, so that the side effects of the hydrogen peroxide on the oral mucosa, such as irritation, oxidation and the like are effectively avoided. The hydrogen peroxide used by the invention realizes the removal effect of DMS in the breath mainly through the catalytic oxidation effect of methionine sulfoxide reductase A.
Drawings
FIG. 1: the elimination effect of the breath freshener on dimethyl sulfide, a main odor causing substance in halitosis, is detected by using a gas chromatography-mass spectrometry combined technology. As can be seen from fig. 1, the content of dimethyl sulfide (with a peak time of about 1.9 minutes) was significantly reduced after 1 hour of the reaction at 37 c with the addition of the breath freshener.
Detailed Description
The features of the present invention may be further described with reference to the following examples, which should not be construed as in any way limiting the scope of the invention.
Example 1:
a biotech breath freshener comprising: hydrogen peroxide (0.1%); recombinant human methionine sulfoxide reductase A (0.0005%); cysteine (0.0001%); sterile distilled water. The preparation method comprises the following steps: 1 part of medical hydrogen peroxide solution (30%) and 300 parts of sterile distilled water were mixed to prepare a solution, and 0.0005g of recombinant human-derived methionine sulfoxide reductase A and 0.0001g of cysteine were added per 100ml of the solution volume. Filtering under aseptic condition, and packaging into spray bottles. And (5) pressurizing and packaging.
Example 2:
an enzymatic halitosis removing mouthwash. The method comprises the following steps: 1% of peppermint oil, 2% of xylitol, 10% of ethanol, 0.5% of hydrogen peroxide, 1% of calcium hydrophosphate, 86% of distilled water and 0.0005% of methionine sulfoxide reductase A; cysteine (0.0001%). The preparation method comprises the following steps: 5 parts of medical hydrogen peroxide solution (30 percent), 30 parts of ethanol and 300 parts of sterile distilled water are mixed to prepare solution, and 1g of peppermint oil, 2g of xylitol, 1g of calcium hydrophosphate, 0.0005g of recombinant humanized methionine sulfoxide reductase A and 0.0001g of cysteine are added into each 100ml of the solution according to the volume. Filtering under aseptic condition, and bottling.
Example 3:
the scavenging effect of hydrogen peroxide and methionine sulfoxide reductase A on dimethyl sulfide was observed in the proportions written in the patent of the present invention. Dimethyl sulfide in breath is the main odorous substance in healthy people. 50 ml of dimethyl sulfide solution (0.5%) was prepared, and the same volume of hydrogen peroxide (0.1%) and the same volume of methionine sulfoxide reductase A solution (0.0005%) were added and reacted at 37 ℃ for 1 hour. Similarly, 50 ml of dimethyl sulfide solution (0.5%) was prepared, and the same volume of hydrogen peroxide (0.1%) was added as a control, and reacted at 37 ℃ for 1 hour. After the reaction is finished, detecting the content of dimethyl sulfide by gas chromatography-mass spectrometry. It was found that the content of dimethyl sulfide was significantly reduced in the system in which methionine sulfoxide reductase A was added. See fig. 1.
Claims (3)
1. The breath freshener for preventing and treating halitosis is characterized by comprising 0.1 mass percent of hydrogen peroxide, 0.0005 mass percent of recombinant humanized methionine sulfoxide reductase A, 0.0001 mass percent of cysteine and the balance of sterile distilled water.
2. Use of the breath freshener for preventing and treating halitosis according to claim 1 in the preparation of mouth wash and chewing gum.
3. A mouthwash comprising the breath freshener for preventing halitosis according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510870376.2A CN106806886B (en) | 2015-12-01 | 2015-12-01 | Breath freshener for quickly eliminating halitosis and medical application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510870376.2A CN106806886B (en) | 2015-12-01 | 2015-12-01 | Breath freshener for quickly eliminating halitosis and medical application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106806886A CN106806886A (en) | 2017-06-09 |
| CN106806886B true CN106806886B (en) | 2021-07-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510870376.2A Active CN106806886B (en) | 2015-12-01 | 2015-12-01 | Breath freshener for quickly eliminating halitosis and medical application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106806886B (en) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2231685T3 (en) * | 2001-04-05 | 2005-05-16 | Torrent Pharmaceuticals Ltd | HETEROCICLICAL COMPOUNDS FOR DIABETIC VASCULAR COMPLICATIONS AND RELATED TO AGE. |
| EP1492486A2 (en) * | 2002-04-10 | 2005-01-05 | Ruey J. Dr. Yu | Urea compositions |
| SG186129A1 (en) * | 2010-06-01 | 2013-01-30 | Belle Aire Fragrances Inc | Oral odor control method and product |
| PL2736520T3 (en) * | 2011-07-26 | 2020-11-30 | Wm. Wrigley Jr. Company | Compositions containing zinc salts and isothiocyanates for reduction of oral volatile sulfur compounds (vscs) |
| CN103622991A (en) * | 2012-08-29 | 2014-03-12 | 武汉伢典生物科技有限公司 | Synergistic diluent for root canal washing fluids and preparation method therefor |
| CN104414886A (en) * | 2013-08-21 | 2015-03-18 | 左华炜 | Mouthwash |
| BR112016013531A8 (en) * | 2013-12-20 | 2020-05-19 | Colgate Palmolive Co | oral care composition |
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2015
- 2015-12-01 CN CN201510870376.2A patent/CN106806886B/en active Active
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| Publication number | Publication date |
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| CN106806886A (en) | 2017-06-09 |
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