CN106798953A - A kind of coating stent of medicine drying means - Google Patents
A kind of coating stent of medicine drying means Download PDFInfo
- Publication number
- CN106798953A CN106798953A CN201710178209.0A CN201710178209A CN106798953A CN 106798953 A CN106798953 A CN 106798953A CN 201710178209 A CN201710178209 A CN 201710178209A CN 106798953 A CN106798953 A CN 106798953A
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- China
- Prior art keywords
- medicine
- drying means
- coating stent
- coating
- stent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
- B05D3/0493—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases using vacuum
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of coating stent of medicine drying means, and it includes coating stent of medicine is slowly warmed up to 46 DEG C~52 DEG C, then vacuumizes, and vacuum valve is closed when reaching setting vacuum values, keeps air pressure T1 for a period of time, is then turned on the air valve air inlet T2 times;Finally repeat the above steps 0~20 circulation.Drying means of the invention reduces solvent boiling point by vacuumizing the method for decompression, promotes the volatilization of various solvents, increased dry efficiency.
Description
Technical field
The present invention relates to medical biotechnology field, and in particular to a kind of coating stent of medicine drying means.
Background technology
Bracket for eluting medicament needs to be loaded medicine using drug-carried coat, and the method for generally using at present is for using molten
Medicine and macromolecule carrier co-dissolve are formed solution by agent, are formed the solution spraying to metal support surface using flush coater
One layer of macromolecule drug-loaded layer containing medicine, in order that macromolecule forms polymeric membrane, it is necessary to by solvent evaporation drying on surface,
Macromolecule and medicine are left, and tetrahydrofuran is not only included in solvent, the low boiling point solvent, also N, N- dimethyl second such as MEK
The high boiling solvents such as acid amides, normal temperature is difficult volatile dry.Generally drying uses high temperature drying techniques, and shortcoming is too high temperature, meeting
The effect of medicine is damaged, meanwhile, need air blast to increase air circulation in baking oven, increase the contaminated probability of support.
In order to solve the above-mentioned technical problem, the present invention comes therefrom.
The content of the invention
The technical problems to be solved by the invention are the defects for overcoming coating stent of medicine dry technology in the prior art, are carried
For a kind of coating stent of medicine drying means.
The technical scheme is that, coating stent of medicine drying means, it comprises the following steps:
(1) coating stent of medicine is slowly warmed up to 46 DEG C~52 DEG C,
(2) and then vacuumize, vacuum valve is closed when reaching setting vacuum values, keep air pressure T1 for a period of time, be then turned on
The air valve air inlet T2 times;
(3) repeat the above steps (2) 0~20 circulations.
In currently preferred technical scheme, in the step (1), coating stent of medicine is warmed up to 50 DEG C in 2h~3h.
In currently preferred technical scheme, in the step (2), the vacuum values for setting are 0.093~0.094MPa.
In currently preferred technical scheme, in step (2), air pressure 25min~80min, Ran Houkai for a period of time are kept
Open air valve air inlet 10min~30min.
In currently preferred technical scheme, in step (2), the air inlet of air valve adds filter tip, with removing air
Dust granules.
In currently preferred technical scheme, when the medicine that coating stent of medicine is loaded uses low boiling point solvent, it is done
Drying method, comprises the following steps:
L1., coating stent of medicine is slowly warmed up to 46 DEG C~52 DEG C,
L2. 5~10min then is vacuumized, vacuum valve is closed when reaching 0.093~0.094MPa of vacuum values, wait 5s, protected
Air pressure 25min~35min is held, air valve air inlet 15min~25min is then turned on;
L3. 1s is waited, repeat the above steps (2) 0-5 circulation.
In currently preferred technical scheme, when the medicine that coating stent of medicine is loaded uses high boiling solvent, it is done
Drying method, comprises the following steps:
H1., coating stent of medicine is slowly warmed up to 46 DEG C~52 DEG C,
H2. 5~10min then is vacuumized, vacuum valve is closed when reaching 0.093~0.094MPa of vacuum values, wait 5s, protected
Air pressure 60min~80min is held, air valve air inlet 15min~25min is then turned on;
H3. 1s is waited, repeat the above steps (2) 10-20 circulation.
In currently preferred technical scheme, coating stent of medicine drying means, it comprises the following steps:Support is sprayed
The low boiling point solvent of medicine is loaded, is then dried using above-mentioned low boiling point solvent drying means;Then support is sprayed again
The high boiling solvent for loading medicine is applied, is then dried using above-mentioned high boiling solvent drying means.
In currently preferred technical scheme, the low boiling point solvent includes but is not limited to tetrahydrofuran, isopropanol, 2- fourths
Ketone etc..
In currently preferred technical scheme, the high boiling solvent includes but is not limited to DMA, second
Glycol etc..
More than 160 DEG C, normal temperature is difficult to volatilize completely the boiling point of DMA in coating, if high temperature is dried,
Harmful effect can be produced to medicine contained in coating, medicine is denatured failure.Carried this invention takes the mode for taking out negative pressure
The rate of volatilization of high boiling solvent high, 50 DEG C are set as by vacuum drying temperature, using " smoking negative pressure-pressure release " iterative cycles
Drying mode, pressure release after taking out negative pressure for a period of time, admits air into vacuum drying oven, then takes out negative pressure, and iterative cycles vacuumize utilization
Air takes away solvent, promotes solvent volatilization.To prevent the dust in air from can pollute product, filtering is mounted with pressure relief opening
Head, air enters before vacuum drying oven through filtering head, removes the pollutant such as dust that may be present in air, maintains bracket coating
The cleannes on surface.
The advantage of the invention is that:
1. solvent boiling point is reduced by vacuumizing the method for decompression, promote the volatilization of various solvents, increased dry
Efficiency.
2. under conditions of low pressure, drying temperature can be reduced suitably, protect the activity of drug ingedient.
3., in air inlet plus the dust granules in filter tip removal air, holding needs the cleannes of dry products.
Specific embodiment
Such scheme is described further below in conjunction with specific embodiment.It should be understood that these embodiments are for illustrating
The present invention and be not limited to limit the scope of the present invention.The implementation condition used in embodiment can be done according to the condition of specific producer
Further adjustment, unreceipted implementation condition is usually the condition in normal experiment.
Introduce and summarize
The present invention by way of example rather than provides the mode of limitation and illustrates.It should be noted that in present disclosure
Described " one " or " one kind " implementation method is not necessarily referring to same specific embodiment, and refers at least a kind of.
Various aspects of the invention are described below.However, as will be readily apparent to one of skill in the art, can
Only some or all of aspects of the invention implement the present invention.For purposes of illustration, be given herein specific numbering, material and
Configuration, enables one to thoroughly understand the present invention.However, be evident that for those of skill in the art,
The present invention can be implemented without concrete details.In other examples, not make, the present invention is obscure to be omitted or simplified many institutes
Known feature.
Embodiment 1
In currently preferred technical scheme, the tetrahydrofuran that medicine is first loaded to support spraying is solvent, is then dried,
Drying means comprises the following steps:
L1. coating stent of medicine is placed in vacuum drying chamber, 50 DEG C is slowly warmed up in 2h,
L2. air valve is then shut off, 5~10min is vacuumized, vacuum valve is closed when reaching 0.093~0.094MPa of vacuum values,
5s is waited, air pressure 25min~35min is kept, air valve air inlet 20min is then turned on;
L3. 1s is waited, circulation terminates.
Then, the DMA solvent of medicine is loaded to support spraying, is then dried, drying means is included such as
Lower step:
H1. coating stent of medicine is placed in vacuum drying chamber, 50 DEG C is slowly warmed up in 3h,
H2. air valve is then shut off, 5~10min is vacuumized, vacuum valve is closed when reaching 0.093~0.094MPa of vacuum values,
5s is waited, air pressure 60min~80min is kept, air valve air inlet 15min~25min is then turned on;
H3. 1s is waited, repeat the above steps (2) 10-20 circulation.
General principle of the invention, principal character and advantages of the present invention has been shown and described above.The technology of the industry
Personnel simply illustrate the present invention it should be appreciated that the present invention is not limited by examples detailed above described in examples detailed above and specification
Principle, various changes and modifications of the present invention are possible without departing from the spirit and scope of the present invention, these change and
Improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appending claims and its is equal to
Thing is defined.
Claims (8)
1. coating stent of medicine drying means, it comprises the following steps:
(1) coating stent of medicine is slowly warmed up to 46 DEG C~52 DEG C,
(2) and then vacuumize, vacuum valve is closed when reaching setting vacuum values, keep air pressure T1 for a period of time, be then turned on air valve
The air inlet T2 times;
(3) repeat the above steps (2) 0~20 circulations.
2. coating stent of medicine drying means according to claim 1, it is characterised in that in step (1), medication coat branch
Frame is warmed up to 50 DEG C in 2h~3h.
3. coating stent of medicine drying means according to claim 1, it is characterised in that in step (2), the vacuum of setting
It is 0.093~0.094MPa to be worth.
4. coating stent of medicine drying means according to claim 1, it is characterised in that in step (2), keeps air pressure one
Section time 25min~80min, is then turned on air valve air inlet 10min~30min.
5. coating stent of medicine drying means according to claim 1, it is characterised in that in step (2), the air inlet of air valve
Mouth adds filter tip.
6. coating stent of medicine drying means according to claim 1, it is characterised in that when coating stent of medicine is loaded
When medicine uses low boiling point solvent, its drying means comprises the following steps:
L1., coating stent of medicine is slowly warmed up to 46 DEG C~52 DEG C,
L2. 5~10min then is vacuumized, vacuum valve is closed when reaching 0.093~0.094MPa of vacuum values, wait 5s, keep gas
Pressure 25min~35min, is then turned on air valve air inlet 15min~25min;
L3. 1s is waited, repeat the above steps (2) 0-5 circulation.
7. coating stent of medicine drying means according to claim 1, it is characterised in that when coating stent of medicine is loaded
When medicine uses high boiling solvent, its drying means comprises the following steps:
H1., coating stent of medicine is slowly warmed up to 46 DEG C~52 DEG C,
H2. 5~10min then is vacuumized, vacuum valve is closed when reaching 0.093~0.094MPa of vacuum values, wait 5s, keep gas
Pressure 60min~80min, is then turned on air valve air inlet 15min~25min;
H3. 1s is waited, repeat the above steps (2) 10-20 circulation.
8. coating stent of medicine drying means according to claim 1, it is characterised in that it comprises the following steps:It is first right
Support sprays the coating of low boiling point solvent, is then dried using low boiling point solvent drying means as claimed in claim 6;
Then high boiling solvent coating is sprayed to support again, is then entered using high boiling solvent drying means as claimed in claim 7
Row drying.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710178209.0A CN106798953A (en) | 2017-03-23 | 2017-03-23 | A kind of coating stent of medicine drying means |
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CN201710178209.0A CN106798953A (en) | 2017-03-23 | 2017-03-23 | A kind of coating stent of medicine drying means |
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Publication Number | Publication Date |
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CN106798953A true CN106798953A (en) | 2017-06-06 |
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ID=58988416
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CN201710178209.0A Pending CN106798953A (en) | 2017-03-23 | 2017-03-23 | A kind of coating stent of medicine drying means |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1465410A (en) * | 2002-06-27 | 2004-01-07 | 微创医疗器械(上海)有限公司 | Drug-eluting stent (DES) with multicoating |
CN1806857A (en) * | 2005-01-17 | 2006-07-26 | 李庆范 | Multilayer-coated stent for controlled drug release and manufacturing method thereof |
CN201449126U (en) * | 2009-07-31 | 2010-05-05 | 潍坊沃尔特化学有限公司 | A vacuum drying cabinet filtering equipment |
CN103307857A (en) * | 2012-03-16 | 2013-09-18 | 东莞新科技术研究开发有限公司 | Vacuum drying method |
CN106288665A (en) * | 2016-08-19 | 2017-01-04 | 东莞市超业精密设备有限公司 | A kind of vacuum drying process |
-
2017
- 2017-03-23 CN CN201710178209.0A patent/CN106798953A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1465410A (en) * | 2002-06-27 | 2004-01-07 | 微创医疗器械(上海)有限公司 | Drug-eluting stent (DES) with multicoating |
CN1806857A (en) * | 2005-01-17 | 2006-07-26 | 李庆范 | Multilayer-coated stent for controlled drug release and manufacturing method thereof |
CN201449126U (en) * | 2009-07-31 | 2010-05-05 | 潍坊沃尔特化学有限公司 | A vacuum drying cabinet filtering equipment |
CN103307857A (en) * | 2012-03-16 | 2013-09-18 | 东莞新科技术研究开发有限公司 | Vacuum drying method |
CN106288665A (en) * | 2016-08-19 | 2017-01-04 | 东莞市超业精密设备有限公司 | A kind of vacuum drying process |
Non-Patent Citations (1)
Title |
---|
王小燕等: "《化学实验室工作手册》", 31 January 2016 * |
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Application publication date: 20170606 |
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