CN106795211B - 芋螺毒素衍生物、其制备方法和抗氧化应用 - Google Patents
芋螺毒素衍生物、其制备方法和抗氧化应用 Download PDFInfo
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- CN106795211B CN106795211B CN201480082612.8A CN201480082612A CN106795211B CN 106795211 B CN106795211 B CN 106795211B CN 201480082612 A CN201480082612 A CN 201480082612A CN 106795211 B CN106795211 B CN 106795211B
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- conus
- antioxidant
- peptide
- polypeptide
- free radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
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- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
Description
名称 | 序列 | 分子量 | Seq ID No. |
CP-btl01 | RCCVHPACHDCICCIT | 1775.69道尔顿 | 1 |
CP-btl02 | RCCSVSICQPPPVCECCA | 1896.76道尔顿 | 2 |
CP-btl03 | RCCSQDCRVCIPCCPY | 1847.71道尔顿 | 3 |
CP-btl04 | RPCCPRDTWCCGFP | 1639.66道尔顿 | 4 |
CPTx-btl01 | KCCTMSVCQPPPVCTCCA | 1872.72道尔顿 | 5 |
CPTx-btl02 | RCRCEQTCGTCVPCC | 1660.61道尔顿 | 6 |
CPTx-btl04 | SLCCPEDRWCC | 1313.47道尔顿 | 7 |
CP-btl01 | CP-btl02 | CP-btl03 | CP-btl04 | CPTx-btl01 | CPTx-btl02 | CPTx-btl04 | GSH | |
IC50(mM) | 0.030 | 0.037 | 0.027 | 0.043 | 0.032 | 0.028 | 0.035 | 0.169 |
Claims (7)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2014/093417 WO2016090563A1 (zh) | 2014-12-10 | 2014-12-10 | 芋螺毒素衍生物、其制备方法和抗氧化应用 |
Publications (2)
Publication Number | Publication Date |
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CN106795211A CN106795211A (zh) | 2017-05-31 |
CN106795211B true CN106795211B (zh) | 2021-05-14 |
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ID=56106432
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Application Number | Title | Priority Date | Filing Date |
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CN201480082612.8A Active CN106795211B (zh) | 2014-12-10 | 2014-12-10 | 芋螺毒素衍生物、其制备方法和抗氧化应用 |
Country Status (2)
Country | Link |
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CN (1) | CN106795211B (zh) |
WO (1) | WO2016090563A1 (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101205251A (zh) * | 2007-11-29 | 2008-06-25 | 中山大学 | 中国南海信号芋螺神经毒素基因Lt3.2及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10633416B2 (en) * | 2014-09-30 | 2020-04-28 | Bgi Shenzhen Co., Ltd | Conotoxin polypeptide κ-CPTx-bt104, and method for preparation thereof and application thereof |
-
2014
- 2014-12-10 WO PCT/CN2014/093417 patent/WO2016090563A1/zh active Application Filing
- 2014-12-10 CN CN201480082612.8A patent/CN106795211B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101205251A (zh) * | 2007-11-29 | 2008-06-25 | 中山大学 | 中国南海信号芋螺神经毒素基因Lt3.2及其应用 |
Non-Patent Citations (1)
Title |
---|
Characterizing the evolution and functions of the M-superfamily conotoxins;Maojun Zhou et.al.,;《Toxicon》;20130927;第76卷;第3.1节,图1 * |
Also Published As
Publication number | Publication date |
---|---|
CN106795211A (zh) | 2017-05-31 |
WO2016090563A1 (zh) | 2016-06-16 |
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Address after: Beishan Industrial Zone Building in Yantian District of Shenzhen city of Guangdong Province in 518083 Applicant after: BGI SHENZHEN Address before: Beishan Industrial Zone Building in Yantian District of Shenzhen city of Guangdong Province in 518083 Applicant before: BGI SHENZHEN |
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Effective date of registration: 20211227 Address after: 518083 8th floor, building 11, Beishan Industrial Zone, 146 Beishan Road, Yangang community, Yantian street, Yantian District, Shenzhen, Guangdong Patentee after: BGI SHENZHEN Co.,Ltd. Address before: 518083 comprehensive building, Beishan Industrial Zone, Yantian District, Guangdong, Shenzhen Patentee before: BGI SHENZHEN |
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Effective date of registration: 20230525 Address after: No.7 Pengfei Road, Dapeng Office, Dapeng New Area, Shenzhen City, Guangdong Province, 518000 Patentee after: Shenzhen Huada Sansheng Garden Technology Co.,Ltd. Address before: 518083 8th floor, building 11, Beishan Industrial Zone, 146 Beishan Road, Yangang community, Yantian street, Yantian District, Shenzhen, Guangdong Patentee before: BGI SHENZHEN Co.,Ltd. |
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