CN106794228B - 用于治疗麸质不耐受和由其引起的病症的组合物和方法 - Google Patents

用于治疗麸质不耐受和由其引起的病症的组合物和方法 Download PDF

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CN106794228B
CN106794228B CN201580043762.2A CN201580043762A CN106794228B CN 106794228 B CN106794228 B CN 106794228B CN 201580043762 A CN201580043762 A CN 201580043762A CN 106794228 B CN106794228 B CN 106794228B
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nepenthesin
pharmaceutical composition
protein
seq
gluten
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CN106794228A (zh
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戴维·施里默
马尔什·雷伊
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Kodak Heath
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NEPETX LLC
Codexis Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23012—Nepenthesin (3.4.23.12)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
CN201580043762.2A 2014-06-16 2015-06-16 用于治疗麸质不耐受和由其引起的病症的组合物和方法 Active CN106794228B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110951692.8A CN113827708A (zh) 2014-06-16 2015-06-16 用于治疗麸质不耐受和由其引起的病症的组合物和方法

Applications Claiming Priority (5)

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US201462012865P 2014-06-16 2014-06-16
US62/012,865 2014-06-16
US201562118396P 2015-02-19 2015-02-19
US62/118,396 2015-02-19
PCT/CA2015/000389 WO2015192211A1 (en) 2014-06-16 2015-06-16 Compositions and methods for treating gluten intolerance and disorders arising therefrom

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CN106794228B true CN106794228B (zh) 2021-09-03

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CN202110951692.8A Pending CN113827708A (zh) 2014-06-16 2015-06-16 用于治疗麸质不耐受和由其引起的病症的组合物和方法

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US (3) US20160022785A1 (https=)
EP (2) EP3943104A1 (https=)
JP (2) JP6829077B2 (https=)
CN (2) CN106794228B (https=)
DK (1) DK3220946T3 (https=)
ES (1) ES2883347T3 (https=)
SI (1) SI3220946T1 (https=)
WO (1) WO2015192211A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015192211A1 (en) 2014-06-16 2015-12-23 Nepetx, Llc Compositions and methods for treating gluten intolerance and disorders arising therefrom
US10857214B2 (en) 2015-12-16 2020-12-08 Codexis, Inc. Compositions and methods for treating gluten intolerance and disorders arising therefrom
CN108504615B (zh) * 2018-03-30 2020-12-29 江南大学 一种产酸性蛋白酶的重组菌及其应用
WO2023220658A2 (en) * 2022-05-10 2023-11-16 Codexis, Inc. Recombinant neprosin polypeptides and methods of expression
CN115336666A (zh) * 2022-07-05 2022-11-15 熊子奕 猪笼草捕虫囊蛋白酶降低乳清蛋白致敏性的应用及方法
ES3008845A1 (es) 2023-09-22 2025-03-25 Consejo Superior Investigacion Proteína degradadora de gluten y usos de la misma

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012006384A2 (en) * 2010-07-07 2012-01-12 Trustees Of Boston University Rothia species gluten-degrading enzymes and uses thereof
US20140140980A1 (en) * 2012-11-21 2014-05-22 David Schriemer Treatment of gluten intolerance and related conditions

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK81193D0 (da) 1993-07-06 1993-07-06 Novo Nordisk As Enzym
JP3767831B2 (ja) 1995-06-14 2006-04-19 木村 健 ヘリコバクター・ピロリ除菌用組成物
JPH1149697A (ja) 1997-08-01 1999-02-23 Nisshin Flour Milling Co Ltd ストレス抑制剤及びストレス抑制用食品
JP2002503699A (ja) * 1998-02-23 2002-02-05 カルニボーラ・フォルシュングス−ゲーエムベーハー プロテインキナーゼの阻害を目的とする食肉植物の圧搾汁、消化液または抽出物の使用
FI980410A0 (fi) 1998-02-23 1998-02-23 Tapio Raivio Termoset
CN1217631C (zh) 2000-05-22 2005-09-07 奥勃斯医学技术股份有限公司 自膨胀扩展器
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7320788B2 (en) 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
AU2003215272B2 (en) 2002-02-14 2008-04-03 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
JP4415244B2 (ja) 2003-02-21 2010-02-17 グリコ栄養食品株式会社 小麦蛋白質にプロテアーゼを限定的に作用させて得られる食品素材
US7122035B2 (en) 2003-11-13 2006-10-17 Jerome Canady Bipolar surgical forceps with argon plasma coagulation capability
CN100384442C (zh) * 2004-01-13 2008-04-30 吴琼汉 一种中草药制剂及其制备方法和应用
US7628985B2 (en) 2004-04-26 2009-12-08 The Board Of Regents Of The Leland Stanford Junior University Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
US20060095096A1 (en) 2004-09-09 2006-05-04 Debenedictis Leonard C Interchangeable tips for medical laser treatments and methods for using same
WO2006096527A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Nucleic acids and proteins and methods for making and using them
EP1949093A2 (en) 2005-10-11 2008-07-30 Alvine Pharmaceuticals, Inc. Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
US20080115411A1 (en) 2006-11-16 2008-05-22 Ramsey Philip W Weed control system
US7645977B2 (en) 2006-11-17 2010-01-12 New Visual Media Group, L.L.C. Low cost dynamic insulated glazing unit
KR20090086416A (ko) 2006-12-04 2009-08-12 미츠비시 가스 가가쿠 가부시키가이샤 옥시메틸렌계 중합체를 포함하는 수지 재료의 접착 방법 및 구조체
WO2008115428A2 (en) 2007-03-16 2008-09-25 The Board Of Trustees Of The Leland Stanford Junior University A scaleable manufacturing process for cysteine endoprotease b, isoform 2
WO2008115411A1 (en) 2007-03-16 2008-09-25 The Board Of Trustees Of The Leland Stanford Junior University Combination enzyme therapy for digestion of dietary gluten
EP2229404A4 (en) 2007-12-10 2011-03-09 Univ Leland Stanford Junior ENZYMATIC POLYTHERAPY FOR GASTRIC DIGESTION OF FOOD GLUTEN IN PATIENTS WITH CELIAC DISEASE
EP2100900A1 (en) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
AU2009283157B2 (en) 2008-08-21 2015-02-26 Alvine Pharmaceuticals, Inc. Formulation for oral administration of proteins
JP2012505211A (ja) 2008-10-10 2012-03-01 アルヴィン ファーマシューティカルズ インコーポレーティッド チモーゲンの迅速な活性化を促進する剤形
CN101732504A (zh) * 2010-01-06 2010-06-16 宋晓翠 猪笼草和艾蒿、香蒲草制成的妇科药物及其制备方法
EP2531521B1 (en) 2010-02-02 2017-09-06 Amano Enzyme USA., Ltd. Use of proteases for gluten intolerance
US20130045195A1 (en) 2010-03-30 2013-02-21 Alvine Pharmaceuticals, Inc. Proteases for Degrading Gluten
US9023345B2 (en) 2011-03-01 2015-05-05 Novus International, Inc. Methods for improving gut health
CA2855469A1 (en) * 2011-04-22 2012-10-26 Paul Joseph FAERSTEIN Compositions and methods for nutritional supplementation
US8837173B2 (en) 2013-01-02 2014-09-16 Chicony Power Technology Co., Ltd DC to DC power converting device
EP2948170B1 (en) 2013-01-23 2020-08-19 Alvine Pharmaceuticals, Inc. Pharmaceutical compositions for treating celiac disease and gluten intolerance
WO2015192211A1 (en) * 2014-06-16 2015-12-23 Nepetx, Llc Compositions and methods for treating gluten intolerance and disorders arising therefrom
US10857214B2 (en) 2015-12-16 2020-12-08 Codexis, Inc. Compositions and methods for treating gluten intolerance and disorders arising therefrom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012006384A2 (en) * 2010-07-07 2012-01-12 Trustees Of Boston University Rothia species gluten-degrading enzymes and uses thereof
US20140140980A1 (en) * 2012-11-21 2014-05-22 David Schriemer Treatment of gluten intolerance and related conditions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pearls and pitfalls in the diagnosis of adult celiac disease;Freeman et al.;《Can J Gastroenterol》;20080331;第22卷(第3期);全文 *

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Publication number Publication date
JP2021073236A (ja) 2021-05-13
US20210220451A1 (en) 2021-07-22
EP3220946A4 (en) 2018-08-15
JP2017519763A (ja) 2017-07-20
EP3220946B1 (en) 2021-06-09
ES2883347T3 (es) 2021-12-07
JP6829077B2 (ja) 2021-02-10
US10960059B2 (en) 2021-03-30
EP3220946A1 (en) 2017-09-27
US20160022785A1 (en) 2016-01-28
CN106794228A (zh) 2017-05-31
CN113827708A (zh) 2021-12-24
EP3943104A1 (en) 2022-01-26
JP7369893B2 (ja) 2023-10-27
SI3220946T1 (sl) 2021-11-30
DK3220946T3 (da) 2021-08-02
WO2015192211A1 (en) 2015-12-23
US11723960B2 (en) 2023-08-15
WO2015192211A9 (en) 2016-02-25
US20190022194A1 (en) 2019-01-24

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