CN106757135A - A kind of method for producing the water thing of L- cysteine hydrochlorides one - Google Patents
A kind of method for producing the water thing of L- cysteine hydrochlorides one Download PDFInfo
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- CN106757135A CN106757135A CN201510797838.2A CN201510797838A CN106757135A CN 106757135 A CN106757135 A CN 106757135A CN 201510797838 A CN201510797838 A CN 201510797838A CN 106757135 A CN106757135 A CN 106757135A
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- cystine
- water
- water thing
- cysteine hydrochlorides
- filtering
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of method for producing the water thing of L- cysteine hydrochlorides one, the method belongs to amino acids production field；The raw material that the production method is used includes：CYSTINE, hydrochloric acid, activated carbon, water, react the operations such as rear decoloring, filtering, electrolysis, concentration, filtering, drying, crushing, packaging the water thing of L- cysteine hydrochlorides one is obtained by CYSTINE acid adding；The method has that simple production process, easy to operate, reaction condition be gentle, pollution-free waste discharge, the water thing of product L- cysteine hydrochlorides one is used for medicine, mainly as leukopenia and the medicine using the leukopenia caused by cancer therapy drug and radiopharmaceutical.
Description
Technical field
The invention belongs to amino acid manufacture field, more particularly to a kind of method with left-handed cystine as the water thing of raw material batch production L- cysteine hydrochlorides one.
Background technology
The water thing of L- cysteine hydrochlorides one, product appearance is white crystalline body or crystalline powder, there is tart flavour, water-soluble, ethanol；The water thing of L- cysteine hydrochlorides one is mainly used in field of medicaments：The medicine being made can clinically treat leukopenia and using the leukopenia caused by cancer therapy drug and radiopharmaceutical, it is heavy metal poisoning antidote, it is additionally operable to treatment toxic hepatitis, decrease of platelet, skin ulcer, and hepatonecrosis disease can be prevented, there are treatment tracheitis and resolve phlegm effect；As bread short-term training accelerator in terms of food, the local flavor of bread and food can be changed；Can be used for hair-waving essence, suncream, hair tonic perfume and hair conditioner of cosmetics etc. in terms of cosmetics.The technique of the water thing of production L- cysteine hydrochlorides one is more, the present invention is produced using one of which technique, the device with CYSTINE, hydrochloric acid, activated carbon, water be raw material material, with ceramic reactor, filter, electrolytic cell, concentration kettle, vacuum drier, pulverizer, packing machine as equipment, the operations such as rear decoloring, filtering, electrolysis, concentration, filtering, drying, crushing, packaging are reacted come finished product by acid adding.
The content of the invention
Present invention mainly solves problem be to provide a kind of method for producing the water thing of L- cysteine hydrochlorides one, the device is with ceramic reactor, filter, electrolytic cell, concentration kettle, vacuum drier, pulverizer, packing machine as equipment, with CYSTINE, hydrochloric acid, activated carbon, water as raw material, react the operations such as rear decoloring, filtering, electrolysis, concentration, filtering, drying, crushing, packaging by acid adding the water thing of L- cysteine hydrochlorides one is obtained.
The technical solution adopted by the present invention is：
（1）CYSTINE is sent into ceramic reactor, add five times of water of weight of CYSTINE, start agitator, rotating speed is 20 revs/min, CYSTINE and water are diluted to thick liquid, hydrochloric acid is added to slow in ceramic reactor, stop plus hydrochloric acid when adjusting the pH value in ceramic reactor for 1-1.2, stirring reaction 2-2.2 hours, now to addition catalyst activity charcoal in ceramic reactor, quantity is the 2-2.2% of CYSTINE weight, while insulated and stirred reaction carries out decoloring reaction in 0.5-0.6 hours when temperature is risen into 60 DEG C.
（2）It is cooled to normal temperature, by the material feeding filter filtering in ceramic reactor, the solid impurity discharge obtained after filtering is reclaimed, liquid portion is by sending into electrolytic tank electrolysis 10-10.5 hours, material feeding concentration kettle concentration after electrolysis is finished is 1/2nd of original liquid volume, material feeding filter after concentration is filtered liquid and discharges recovery, solid portion is dried by sending into vacuum drier, drying temperature is 70-75 DEG C, drying time is 3-3.5 hours, and drying obtains the water thing solid of L- cysteine hydrochlorides one after terminating.
（3）It is uniform powder that the water thing solid of the L- cysteine hydrochlorides one feeding pulverizer that will be obtained is crushed, and is then fed into packing machine, and finished product is obtained after product pulvis packaging is finished.
Further technical scheme of the invention is：
Described ceramic reactor is 4 tonnes.
4 tonnes of described concentration kettle, ceramic liner.
The beneficial effects of the invention are as follows：There is provided a kind of method for producing the water thing of L- cysteine hydrochlorides one, the method simple production process, easy to operate, reaction condition are gentle, pollution-free waste discharge, the water thing of product L- cysteine hydrochlorides one is used for medicine, mainly as leukopenia and the medicine using the leukopenia caused by cancer therapy drug and radiopharmaceutical.
Specific embodiment
Embodiment 1：
CYSTINE is sent into ceramic reactor, add five times of water of weight of CYSTINE, agitator is started, rotating speed is 20 revs/min, and CYSTINE and water are diluted into thick liquid, hydrochloric acid is added to slow in ceramic reactor, pH value in tune ceramic reactor stops plus hydrochloric acid when being 1, stirring reaction 2 hours, now to addition catalyst activity charcoal in ceramic reactor, quantity is the 2% of CYSTINE weight, while insulated and stirred reaction carries out decoloring reaction in 0.6 hour when temperature is risen into 60 DEG C.It is cooled to normal temperature, by the material feeding filter filtering in ceramic reactor, the solid impurity discharge obtained after filtering is reclaimed, liquid portion is by sending into electrolytic tank electrolysis 10 hours, material feeding concentration kettle concentration after electrolysis is finished is 1/2nd of original liquid volume, material feeding filter after concentration is filtered liquid and discharges recovery, solid portion is dried by sending into vacuum drier, drying temperature is 70 DEG C, drying time is 3.5 hours, and drying obtains the water thing solid of L- cysteine hydrochlorides one after terminating.It is uniform powder that the water thing solid of the L- cysteine hydrochlorides one feeding pulverizer that will be obtained is crushed, and is then fed into packing machine, and finished product is obtained after product pulvis packaging is finished.
Embodiment 2：
CYSTINE is sent into ceramic reactor, add five times of water of weight of CYSTINE, start agitator, rotating speed is 20 revs/min, CYSTINE and water are diluted to thick liquid, hydrochloric acid is added to slow in ceramic reactor, pH value in tune ceramic reactor stops plus hydrochloric acid when being 1.1, stirring reaction 2.1 hours, now to addition catalyst activity charcoal in ceramic reactor, quantity is the 2.1% of CYSTINE weight, while insulated and stirred reaction carries out decoloring reaction in 0.55 hour when temperature is risen into 60 DEG C.It is cooled to normal temperature, by the material feeding filter filtering in ceramic reactor, the solid impurity discharge obtained after filtering is reclaimed, liquid portion is by sending into electrolytic tank electrolysis 10.25 hours, material feeding concentration kettle concentration after electrolysis is finished is 1/2nd of original liquid volume, material feeding filter after concentration is filtered liquid and discharges recovery, solid portion is dried by sending into vacuum drier, drying temperature is 72.5 DEG C, drying time is 3.25 hours, and drying obtains the water thing solid of L- cysteine hydrochlorides one after terminating.It is uniform powder that the water thing solid of the L- cysteine hydrochlorides one feeding pulverizer that will be obtained is crushed, and is then fed into packing machine, and finished product is obtained after product pulvis packaging is finished.
Embodiment 3：
CYSTINE is sent into ceramic reactor, add five times of water of weight of CYSTINE, agitator is started, rotating speed is 20 revs/min, and CYSTINE and water are diluted into thick liquid, hydrochloric acid is added to slow in ceramic reactor, pH value in tune ceramic reactor stops plus hydrochloric acid when being 1.2, stirring reaction 2.2 hours, now to addition catalyst activity charcoal in ceramic reactor, quantity is the 2.2% of CYSTINE weight, while insulated and stirred reaction carries out decoloring reaction in 0.5 hour when temperature is risen into 60 DEG C.It is cooled to normal temperature, by the material feeding filter filtering in ceramic reactor, the solid impurity discharge obtained after filtering is reclaimed, liquid portion is by sending into electrolytic tank electrolysis 10.5 hours, material feeding concentration kettle concentration after electrolysis is finished is 1/2nd of original liquid volume, material feeding filter after concentration is filtered liquid and discharges recovery, solid portion is dried by sending into vacuum drier, drying temperature is 75 DEG C, drying time is 3 hours, and drying obtains the water thing solid of L- cysteine hydrochlorides one after terminating.It is uniform powder that the water thing solid of the L- cysteine hydrochlorides one feeding pulverizer that will be obtained is crushed, and is then fed into packing machine, and finished product is obtained after product pulvis packaging is finished.
Certainly, the present invention also has other implementation methods, and the improvement of any technology, principle and the technique done under without departing from spiritual background of the invention is within the scope of the present invention.
Claims (4)
1. a kind of method for producing the water thing of L- cysteine hydrochlorides one, the raw material for using includes：CYSTINE, hydrochloric acid, activated carbon, water, react the operations such as rear decoloring, filtering, electrolysis, concentration, filtering, drying, crushing, packaging the water thing of L- cysteine hydrochlorides one is obtained by CYSTINE acid adding, it is characterised in that：
（1）CYSTINE is sent into ceramic reactor, add five times of water of weight of CYSTINE, start agitator, rotating speed is 20 revs/min, CYSTINE and water are diluted to thick liquid, hydrochloric acid is added to slow in ceramic reactor, stop plus hydrochloric acid when adjusting the pH value in ceramic reactor for 1-1.2, stirring reaction 2-2.2 hours, now to addition catalyst activity charcoal in ceramic reactor, quantity is the 2-2.2% of CYSTINE weight, while insulated and stirred reaction carries out decoloring reaction in 0.5-0.6 hours when temperature is risen into 60 DEG C；
（2）It is cooled to normal temperature, by the material feeding filter filtering in ceramic reactor, the solid impurity discharge obtained after filtering is reclaimed, liquid portion is by sending into electrolytic tank electrolysis 10-10.5 hours, material feeding concentration kettle concentration after electrolysis is finished is 1/2nd of original liquid volume, material feeding filter after concentration is filtered liquid and discharges recovery, solid portion is dried by sending into vacuum drier, drying temperature is 70-75 DEG C, drying time is 3-3.5 hours, and drying obtains the water thing solid of L- cysteine hydrochlorides one after terminating；
（3）It is uniform powder that the water thing solid of the L- cysteine hydrochlorides one feeding pulverizer that will be obtained is crushed, and is then fed into packing machine, and finished product is obtained after product pulvis packaging is finished.
2. a kind of method for producing the water thing of L- cysteine hydrochlorides one as claimed in claim 1, it is characterised in that：Described ceramic reactor is 4 tonnes.
3. a kind of method for producing the water thing of L- cysteine hydrochlorides one as claimed in claim 1, it is characterised in that：4 tonnes of described concentration kettle, ceramic liner.
4. a kind of method for producing the water thing of L- cysteine hydrochlorides one as claimed in claim 1, it is characterised in that：Step（1）The usage amount of described catalyst activity charcoal is the 2.1% of raw material CYSTINE weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510797838.2A CN106757135A (en) | 2015-11-19 | 2015-11-19 | A kind of method for producing the water thing of L- cysteine hydrochlorides one |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510797838.2A CN106757135A (en) | 2015-11-19 | 2015-11-19 | A kind of method for producing the water thing of L- cysteine hydrochlorides one |
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| CN106757135A true CN106757135A (en) | 2017-05-31 |
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| CN201510797838.2A Pending CN106757135A (en) | 2015-11-19 | 2015-11-19 | A kind of method for producing the water thing of L- cysteine hydrochlorides one |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107699918A (en) * | 2017-09-12 | 2018-02-16 | 罗江晨明生物制品有限公司 | A kind of production technology of L cysteine hydrochlorides |
| CN110344077A (en) * | 2019-07-01 | 2019-10-18 | 吉林大学 | A method of by l-cysteine electrochemistry formated n-acetyl-L-cysteine |
-
2015
- 2015-11-19 CN CN201510797838.2A patent/CN106757135A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107699918A (en) * | 2017-09-12 | 2018-02-16 | 罗江晨明生物制品有限公司 | A kind of production technology of L cysteine hydrochlorides |
| CN107699918B (en) * | 2017-09-12 | 2019-07-02 | 罗江晨明生物制品有限公司 | A kind of production technology of L-cysteine hydrochloride |
| CN110344077A (en) * | 2019-07-01 | 2019-10-18 | 吉林大学 | A method of by l-cysteine electrochemistry formated n-acetyl-L-cysteine |
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Application publication date: 20170531 |
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