CN106754725A - A kind of Chimeric antigen receptor T cell and preparation method and application - Google Patents
A kind of Chimeric antigen receptor T cell and preparation method and application Download PDFInfo
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- CN106754725A CN106754725A CN201611214632.3A CN201611214632A CN106754725A CN 106754725 A CN106754725 A CN 106754725A CN 201611214632 A CN201611214632 A CN 201611214632A CN 106754725 A CN106754725 A CN 106754725A
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- cell
- antigen receptor
- chimeric antigen
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201611214632.3A CN106754725A (en) | 2016-12-26 | 2016-12-26 | A kind of Chimeric antigen receptor T cell and preparation method and application |
Applications Claiming Priority (1)
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CN201611214632.3A CN106754725A (en) | 2016-12-26 | 2016-12-26 | A kind of Chimeric antigen receptor T cell and preparation method and application |
Publications (1)
Publication Number | Publication Date |
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CN106754725A true CN106754725A (en) | 2017-05-31 |
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Family Applications (1)
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CN201611214632.3A Pending CN106754725A (en) | 2016-12-26 | 2016-12-26 | A kind of Chimeric antigen receptor T cell and preparation method and application |
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CN (1) | CN106754725A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107603995A (en) * | 2017-07-31 | 2018-01-19 | 北京普瑞金科技有限公司 | A kind of CD19 CART and its application |
CN107937428A (en) * | 2017-11-28 | 2018-04-20 | 马晓冬 | A kind of carrier construction method of integration microRNA and CAR functions |
CN108017716A (en) * | 2018-01-02 | 2018-05-11 | 赖沛龙 | Chimeric antigen receptor, slow virus carrier, expression cell and medicine comprising C5aR intracellular domain |
CN109468282A (en) * | 2018-11-22 | 2019-03-15 | 青岛协和华美医学诊断技术有限公司 | A kind of preparation method and application for the Chimeric antigen receptor T cell targeting CD19 |
CN111566219A (en) * | 2017-12-27 | 2020-08-21 | 环球生命科技咨询美国有限责任公司 | Methods and kits for viral vector isolation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104136458A (en) * | 2012-02-22 | 2014-11-05 | 宾夕法尼亚大学董事会 | Use of the cd2 signaling domain in second-generation chimeric antigen receptors |
CN104561069A (en) * | 2013-10-23 | 2015-04-29 | 深圳先进技术研究院 | Micro-annullus DNA recombinant plasmid containing recombinant chimeric antigen receptor gene expression box, micro-annullus DNA containing expression box and application |
CN105315375A (en) * | 2014-07-17 | 2016-02-10 | 科济生物医药(上海)有限公司 | Targeting CLD18A2 T lymphocyte, preparation method and applications thereof |
CN105906720A (en) * | 2016-05-16 | 2016-08-31 | 武汉汉密顿生物科技股份有限公司 | Targeting chimeric antigen receptor modified immune cell as well as preparation method and application thereof |
-
2016
- 2016-12-26 CN CN201611214632.3A patent/CN106754725A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104136458A (en) * | 2012-02-22 | 2014-11-05 | 宾夕法尼亚大学董事会 | Use of the cd2 signaling domain in second-generation chimeric antigen receptors |
CN104561069A (en) * | 2013-10-23 | 2015-04-29 | 深圳先进技术研究院 | Micro-annullus DNA recombinant plasmid containing recombinant chimeric antigen receptor gene expression box, micro-annullus DNA containing expression box and application |
CN105315375A (en) * | 2014-07-17 | 2016-02-10 | 科济生物医药(上海)有限公司 | Targeting CLD18A2 T lymphocyte, preparation method and applications thereof |
CN105906720A (en) * | 2016-05-16 | 2016-08-31 | 武汉汉密顿生物科技股份有限公司 | Targeting chimeric antigen receptor modified immune cell as well as preparation method and application thereof |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107603995A (en) * | 2017-07-31 | 2018-01-19 | 北京普瑞金科技有限公司 | A kind of CD19 CART and its application |
CN107937428A (en) * | 2017-11-28 | 2018-04-20 | 马晓冬 | A kind of carrier construction method of integration microRNA and CAR functions |
CN107937428B (en) * | 2017-11-28 | 2021-08-06 | 马晓冬 | Construction method of carrier integrating functions of microRNA and CAR |
CN111566219A (en) * | 2017-12-27 | 2020-08-21 | 环球生命科技咨询美国有限责任公司 | Methods and kits for viral vector isolation |
CN108017716A (en) * | 2018-01-02 | 2018-05-11 | 赖沛龙 | Chimeric antigen receptor, slow virus carrier, expression cell and medicine comprising C5aR intracellular domain |
WO2019134214A1 (en) * | 2018-01-02 | 2019-07-11 | 赖沛龙 | Chimeric antigen receptor comprising c5ar intracellular domain, lentiviral vector, expressing cell, and drug |
CN109468282A (en) * | 2018-11-22 | 2019-03-15 | 青岛协和华美医学诊断技术有限公司 | A kind of preparation method and application for the Chimeric antigen receptor T cell targeting CD19 |
CN109468282B (en) * | 2018-11-22 | 2019-06-18 | 青岛协和华美医学诊断技术有限公司 | A kind of preparation method and application for the Chimeric antigen receptor T cell targeting CD19 |
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Legal Events
Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20170824 Address after: 100161 Beijing city Fengtai District Wanfeng Road No. 308 Shunhe business office building room 8422 Applicant after: BEIJING PREGENE BIOTECHNOLOGY COMPANY,LTD. Address before: 100161 Beijing city Fengtai District Wanfeng Road No. 308 Shunhe business office building room 8422 Applicant before: BEIJING PREGENE BIOTECHNOLOGY COMPANY,LTD. Applicant before: Shenzhen Ka Di Biotechnology Co. Ltd. |
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TA01 | Transfer of patent application right | ||
CB02 | Change of applicant information |
Address after: Zi street Jinhui road Shenzhen city Guangdong province 518122 Pingshan District pit No. 14 Shenzhen Biomedical Innovation Industrial Park, building 1, 402 Applicant after: Shenzhen Purim biopharmaceutical Co., Ltd. Address before: 100161 Beijing city Fengtai District Wanfeng Road No. 308 Shunhe business office building room 8422 Applicant before: BEIJING PREGENE BIOTECHNOLOGY COMPANY,LTD. |
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CB02 | Change of applicant information | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |
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RJ01 | Rejection of invention patent application after publication |