CN106731093A - Bioactivity tissue fluid separating filter and its method of work - Google Patents
Bioactivity tissue fluid separating filter and its method of work Download PDFInfo
- Publication number
- CN106731093A CN106731093A CN201710136624.XA CN201710136624A CN106731093A CN 106731093 A CN106731093 A CN 106731093A CN 201710136624 A CN201710136624 A CN 201710136624A CN 106731093 A CN106731093 A CN 106731093A
- Authority
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- China
- Prior art keywords
- filter
- bioactivity
- point
- tissue fluid
- fluid separating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 23
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 abstract description 17
- 230000007547 defect Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 4
- 229960001866 silicon dioxide Drugs 0.000 description 4
- 239000011148 porous material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/085—Funnel filters; Holders therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/05—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements supported
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/50—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition
- B01D29/56—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in series connection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/76—Handling the filter cake in the filter for purposes other than for regenerating
- B01D29/86—Retarding cake deposition on the filter during the filtration period, e.g. using stirrers
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Prostheses (AREA)
Abstract
The present invention relates to a kind of bioactivity tissue fluid separating filter, including base, it is provided with the base and holds liquid funnel, described holding be provided with above liquid funnel at least one point of filter component, the bottom for holding liquid funnel is connected to holding vessel through pipeline, described point of filter component includes a point filter cylinder, and the described point of inner chamber of filter cylinder is sequentially set with agitating paddle, screen pack and porous support plate from top to down, and the drive link for driving agitating paddle to rotate is equipped with described point of filter cylinder；The invention further relates to a kind of method of work of bioactivity tissue fluid separating filter.The present invention overcomes the defect of the filtering of existing single-stage and multistage filtering, and screen pack is not easily blocked, and effectively, completely by filtering, residue in tissues is small, and product quality is high, simple operation for tissue, and filtered fluid not with air contact.
Description
Technical field
The present invention relates to a kind of bioactivity tissue fluid separating filter and its method of work.
Background technology
Need to carry out filtering and impurity removing matter to the tissue fluid after homogenate in bio-pharmaceuticals or related experiment, production is improved to reach
Product purity, Improving The Quality of Products.Required according to bio-pharmaceuticals GMP：Sterile working is wanted in purifying products filter process, it is impossible to
Polluted by inoculating microbe.
The filter plant that purifies existing at present mainly has two ways, and a kind of is that single-stage is filtered, and one kind is multiple mistake step by step
Filter.
Single-stage filtering carries out installing corresponding bore filter net according to purification target carries out disposable filtering purification, and filtering is carried
Pure procedure, because the granule foreign screen pack that is easily caused not of uniform size is blocked in tissue fluid, causes effectively tissue to lead to completely
Filtering, residue in tissues is big, causes deterioration in quality, and filtration time is long, efficiency is low.
Repeatedly filter step by step, the filter and multiple fluid reservoirs of multiple different pore sizes are prepared as needed, in filter process
In filtered step by step to the small filter in aperture from the big filter in aperture, in filter process, it is necessary to will from the big filter in aperture
Filtered fluid in fluid reservoir could be poured into and filtered in the small filter in aperture by filtrate again to after in fluid reservoir, be operated
Inconvenience, often, increase filtered fluid contacted with surrounding air, easily cause external source bacterium pollute.
The content of the invention
In view of the deficiencies in the prior art, the technical problems to be solved by the invention are to provide a kind of bioactivity tissue fluid point
Filter and its method of work, not only reasonable in design, and also it is efficiently convenient.
In order to solve the above-mentioned technical problem, the technical scheme is that：A kind of bioactivity tissue fluid separating filter, including
Base, is provided with the base and holds liquid funnel, and described holding be provided with above liquid funnel at least one point of filter component, described to hold
The bottom of liquid funnel is connected to holding vessel through pipeline, and described point of filter component includes a point filter cylinder, and the described point of inner chamber of filter cylinder is from upper
Under be sequentially set with agitating paddle, screen pack and porous support plate, be equipped with to drive agitating paddle to rotate in described point of filter cylinder
Drive link.
Preferably, the agitating paddle is arranged on the bottom outside of first sleeve, and the top center of the first sleeve is downward
The first connecting tube is provided with, the top center of the porous support plate sets up second coaxial with the first connecting tube and is connected
Pipe, the drive link passes through and sequentially passes through the second connecting tube, the first connecting tube and be threadedly coupled with the first connecting tube.
Preferably, the second sleeve pipe, second sleeve pipe and second are arranged with outside first connecting tube and the second connecting tube
Connecting tube is threadedly coupled.
Preferably, the screen pack is connected with the second sleeve pipe.
Preferably, the described point of silica gel pad for being provided with to seal between filter cylinder and porous support plate, described point of filter cylinder
With porous support plate through snapping connection.
Preferably, some described point of filter components coaxially are sequentially stacked from top to down, any two adjacent described point filter components it
Between be provided with to connect the shaft coupling of two adjacent drive links.
Preferably, some screen packs are sequentially reduced in aperture from top to down.
Preferably, the drive link connects with the associated electric motor for being used to drive it to rotate.
Preferably, the holding vessel is connected with minipump.
A kind of method of work of bioactivity tissue fluid separating filter, including the bioactivity tissue described in above-mentioned any one
Liquid separating filter, comprises the steps of：Treat that a point tissue solution for filter pours into a point filter component, it is molten through the tissue after undue filter component point filter
Liquid enters holding vessel through holding liquid funnel with pipeline successively.
Compared with prior art, the invention has the advantages that：
（1）Structure design of the present invention is simple, compact, reasonable, and a point filter component for different pore size of the present invention uses modularized design, i.e.,
Can be used alone, again can with other apertures point filter component is compatible constitutes the organic whole that filters step by step, point filtering component can be with
Different pore size screen pack is installed according to actual filtration demand；
（2）If blocking occurs in single point of filter component, the present invention can carry out quick-replaceable using buckle, can be by single point of filter
Component or multiple points of filter components carry out high-temperature sterilization together, and it is huge to solve other natural filtration equipment volumes, sterilization operation
Difficulty is installed and is simply easy to operation；
（3）The present invention overcomes the defect of existing single-stage filtering and multistage filtering, and screen pack is not easily blocked, and effectively tissue passes through completely
Filtering, residue in tissues is small, and product quality is high, simple operation, and filtered fluid not with air contact.
The present invention will be further described in detail with reference to the accompanying drawings and detailed description.
Brief description of the drawings
Fig. 1 is that the embodiment of the present invention has the multiple points of organigrams of filter component.
Fig. 2 is the local structure schematic diagram of embodiment of the present invention Fig. 1.
Fig. 3 is that the embodiment of the present invention has a point of organigram for filter component.
In figure：1- bases, 2- holds liquid funnel, and 3- points of filter component, 31- points of filter cylinder, 32- agitating paddles, 33- screen packs, 34- is more
Hole supporting plate, 35- drive links, 36- first sleeves, the sleeve pipes of 37- second, 4- pipelines, 5- holding vessels, 6- buckles, 7- shaft couplings, 8-
Motor, 9- minipumps.
Specific embodiment
It is that features described above of the invention and advantage can be become apparent, special embodiment below, and coordinate accompanying drawing, make detailed
Carefully it is described as follows.
As shown in Fig. 1 ~ 3, a kind of bioactivity tissue fluid separating filter, including base 1, it is provided with the base 1 and holds liquid
Funnel 2, the top for holding liquid funnel 2 is provided with least one point of filter component 3, and the bottom for holding liquid funnel 2 connects through pipeline 4
Holding vessel 5 is connected to, described point of filter component 3 includes a point filter cylinder 31, and the inner chamber of described point of filter cylinder 31 is sequentially set with from top to down to be stirred
Oar 32, screen pack 33 and porous support plate 34 are mixed, the biography for driving agitating paddle 32 to rotate is equipped with described point of filter cylinder 31
Lever 35, screen pack 33 is maintained static with porous support plate 34, and porous support plate 34 aperture more than screen pack 33 hole
Footpath.
In embodiments of the present invention, the agitating paddle 32 is arranged on the bottom outside of first sleeve 36, the first sleeve
36 top center is down-set the first connecting tube, and the top center of the porous support plate 34 has set up and connected with first
The second coaxial connecting tube of adapter, the drive link 35 passes through and sequentially passes through the second connecting tube, the first connecting tube and connect with first
Adapter threaded connection；First connecting tube is integrated with first sleeve 36 and is made, second connecting tube and porous support plate
34 are also integrated and are made, and first connecting tube is provided with internal thread, and second connecting tube is provided with external screw thread, the transmission
Screw thread is also correspondingly provided with bar 35.
In embodiments of the present invention, it is arranged with the second sleeve pipe 37 outside first connecting tube and the second connecting tube, described the
Two sleeve pipes 37 are threadedly coupled with the second connecting tube, and second sleeve pipe 37 effectively prevents filtered fluid from being leaked out to down along drive link 35
Filter component 3 or directly leak out to for one point and hold liquid funnel 2, strengthen sealing.
In embodiments of the present invention, the screen pack 33 is connected with the second sleeve pipe 37.
In embodiments of the present invention, the silicagel pad for sealing is provided between described point of filter cylinder 31 and porous support plate 34
Piece, described point of filter cylinder 31 is connected with porous support plate 34 through buckle 6；The base 1 with point filter component 3 porous support plate 34 it
Between be also equipped with the silica gel pad that seals, silica gel pad effectively prevents filtered fluid from permeating, the base 1 and a point filter component 3
Porous support plate 34 also connected through buckle 6, realize fast assembling-disassembling；If blocking occurs in single point of filter component, the present invention can be with
Quick-replaceable is carried out using buckle.
In embodiments of the present invention, some described point of filter components 3 are coaxially sequentially stacked from top to down, and any two is adjacent described
Be divided to filter component 3 between be provided with to connect the shaft coupling 7 of two adjacent drive links 35.
In embodiments of the present invention, some screen packs 33 are sequentially reduced in aperture from top to down, treat that point tissue of filter is molten
Liquid sequentially passes through some described point of filter components 3 under gravity.
In embodiments of the present invention, the drive link 35 is connected with the motor 8 for being used to drive it to rotate, the motor 8
It is arranged on base 1, the drive link 35 enters a point filter component 3 through liquid funnel 2 is held, and motor 8 works, in the work of shaft coupling 7
Under, the drive link 35 in every layer point of filter component 3 is driven to rotate simultaneously；The outlet-inclined impeller vane for holding liquid funnel 2 is arranged on and holds liquid
The bottom side of funnel 2.
In embodiments of the present invention, the holding vessel 5 is connected with minipump 9, and the minipump 9 plays handle
Tissue solution after filtering imports holding vessel 5, while playing acceleration tissue solution filtering.
In embodiments of the present invention, a kind of method of work of bioactivity tissue fluid separating filter, including above-mentioned any one
Described bioactivity tissue fluid separating filter, comprises the steps of：Treat that a point tissue solution for filter pours into a point filter component 3, through undue
Tissue solution after the 3 points of filters of filter component enters holding vessel 5 through holding liquid funnel 2 with pipeline 4 successively.
The present invention is not limited to above-mentioned preferred forms, and anyone can show that other are each under enlightenment of the invention
The bioactivity tissue fluid separating filter and its method of work of the form of kind.All impartial changes done according to scope of the present invention patent
With modification, should all belong to covering scope of the invention.
Claims (10)
1. a kind of bioactivity tissue fluid separating filter, it is characterised in that：Including base, it is provided with the base and holds liquid funnel,
Described holding be provided with above liquid funnel at least one point of filter component, and the bottom for holding liquid funnel is connected to storage through pipeline
Tank, described point of filter component includes a point filter cylinder, described point of inner chamber of filter cylinder be sequentially set with from top to down agitating paddle, screen pack and
Porous support plate, is equipped with the drive link for driving agitating paddle to rotate in described point of filter cylinder.
2. bioactivity tissue fluid separating filter according to claim 1, it is characterised in that：The agitating paddle is arranged on first
The bottom outside of sleeve pipe, the top center of the first sleeve is down-set the first connecting tube, the top of the porous support plate
Portion center sets up second connecting tube coaxial with the first connecting tube, and the drive link is passed through and sequentially passes through the second connection
Pipe, the first connecting tube are simultaneously threadedly coupled with the first connecting tube.
3. bioactivity tissue fluid separating filter according to claim 2, it is characterised in that：First connecting tube and second
The second sleeve pipe is arranged with outside connecting tube, second sleeve pipe is threadedly coupled with the second connecting tube.
4. bioactivity tissue fluid separating filter according to claim 3, it is characterised in that：The screen pack and the second sleeve pipe
It is connected.
5. bioactivity tissue fluid separating filter according to claim 1, it is characterised in that：Described point of filter cylinder and open support
It is provided with the silica gel pad for sealing between plate, described point of filter cylinder is with porous support plate through snapping connection.
6. bioactivity tissue fluid separating filter according to claim 1, it is characterised in that：Some described point of filter components are from upper
And lower coaxial order is stacked, any two it is adjacent it is described be divided to filter be provided with to connect the shaft coupling of two adjacent drive links between component
Device.
7. bioactivity tissue fluid separating filter according to claim 1, it is characterised in that：Some screen packs from upper and
Lower aperture is sequentially reduced.
8. bioactivity tissue fluid separating filter according to claim 1, it is characterised in that：The drive link be used to drive
Its associated electric motor for rotating connects.
9. bioactivity tissue fluid separating filter according to claim 1, it is characterised in that：The holding vessel and micro vacuum
Pump is connected.
10. a kind of method of work of bioactivity tissue fluid separating filter, it is characterised in that：It is any one including such as claim 1 ~ 9
Bioactivity tissue fluid separating filter described in, comprises the steps of：Treat that a point tissue solution for filter pours into a point filter component, through undue
Tissue solution after filter component point filter enters holding vessel through holding liquid funnel with pipeline successively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710136624.XA CN106731093A (en) | 2017-03-09 | 2017-03-09 | Bioactivity tissue fluid separating filter and its method of work |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710136624.XA CN106731093A (en) | 2017-03-09 | 2017-03-09 | Bioactivity tissue fluid separating filter and its method of work |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106731093A true CN106731093A (en) | 2017-05-31 |
Family
ID=58961834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710136624.XA Pending CN106731093A (en) | 2017-03-09 | 2017-03-09 | Bioactivity tissue fluid separating filter and its method of work |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106731093A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107328726A (en) * | 2017-07-07 | 2017-11-07 | 派生特（福州）生物科技有限公司 | The method that bursopoietin main active content is determined based on ultraviolet spectroscopy |
| CN108441445A (en) * | 2018-03-26 | 2018-08-24 | 郭庆 | A kind of medicine bacterium multi-stage separation screening technique |
| CN108485911A (en) * | 2018-03-26 | 2018-09-04 | 郭庆 | A kind of medicine bacterium multi-stage separation screening installation |
| CN110144290A (en) * | 2019-06-06 | 2019-08-20 | 广州承葛生物科技有限公司 | A kind of filter for the separation of intestines bacterium |
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| CN203750240U (en) * | 2014-03-13 | 2014-08-06 | 昆明理工大学 | Stirring and decompression filtering device with automatic feeding function |
| CN204022615U (en) * | 2014-07-30 | 2014-12-17 | 王俊锋泽 | A kind of water filtering device |
| CN206613237U (en) * | 2017-03-09 | 2017-11-07 | 派生特（福州）生物科技有限公司 | Bioactivity tissue fluid separating filter |
-
2017
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| CN2286645Y (en) * | 1997-01-29 | 1998-07-29 | 何子冀 | Multi-stage fine-filtering device |
| US20050226783A1 (en) * | 2001-12-18 | 2005-10-13 | Cheol-Soo Myung | Device for simultaneously collecting filtered water and filter paper |
| CN201120214Y (en) * | 2007-07-30 | 2008-09-24 | 华南师范大学 | Pressure reduction stage filter |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107328726A (en) * | 2017-07-07 | 2017-11-07 | 派生特（福州）生物科技有限公司 | The method that bursopoietin main active content is determined based on ultraviolet spectroscopy |
| CN108441445A (en) * | 2018-03-26 | 2018-08-24 | 郭庆 | A kind of medicine bacterium multi-stage separation screening technique |
| CN108485911A (en) * | 2018-03-26 | 2018-09-04 | 郭庆 | A kind of medicine bacterium multi-stage separation screening installation |
| CN108441445B (en) * | 2018-03-26 | 2021-07-02 | 江苏天瑞精准医疗科技有限公司 | Medical bacteria multistage separation screening method |
| CN110144290A (en) * | 2019-06-06 | 2019-08-20 | 广州承葛生物科技有限公司 | A kind of filter for the separation of intestines bacterium |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |
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| RJ01 | Rejection of invention patent application after publication |