CN106730365A - Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect - Google Patents
Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect Download PDFInfo
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- CN106730365A CN106730365A CN201710061410.0A CN201710061410A CN106730365A CN 106730365 A CN106730365 A CN 106730365A CN 201710061410 A CN201710061410 A CN 201710061410A CN 106730365 A CN106730365 A CN 106730365A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/06—Magnetotherapy using magnetic fields produced by permanent magnets
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Abstract
A kind of Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect, including N poles magnet and S poles magnet, are provided with microphone by magnetostatic field, be additionally provided with what is be sequentially connected in series：Amplifier, wave filter, Acquisition Processor and display, the signal input part of amplifier connect the signal output part of microphone, and the trigger signal output end of Acquisition Processor connects the signal input part of magnetic stimulator, the signal output part connection coil of magnetic stimulator.The output signal of magnetic stimulator is made up of marker and boost pulse on a timeline, and marker is realized by a high-frequency impulse, and the centre frequency of marker width is consistent with the measurement frequency range of microphone；The trigger signal output of Acquisition Processor is synchronous with the Neural stem cell signal output of magnetic stimulator, and the trigger collection moment of Acquisition Processor is identical with marker initial time.The present invention swashs tissue current distribution characteristic for monitoring electromagnetism, realizes the positioning of specific Neural Area and stimulates, and assessment monitoring effect of stimulation is significant.
Description
Technical field
The present invention relates to a kind of Neural stem cell electric current real-time monitoring device.It is more particularly to a kind of based on magnetosonic coupling effect
Neural stem cell electric current real-time monitoring device and monitoring method
Background technology
Electrophysiology is in critical role for the research aspect of nervous system structures, function.Particularly Neural stem cell method,
Used as the means of regulation nerve excitability, it applies quite varied, and the diagnosis and treatment of clinical disease are widely used at present, such as neural disease
Disease regulation, depression, treatment of obsession and epilepsy etc..Conventional Neural stem cell technology mainly produces sensing using magnetic stimulating coil
Magnetic field, forms induction field in the tissue, ultimately forms induced-current.When electric current is more than nervous excitation threshold value, then nerve is produced
Excitement, adjusts nervous activity, and then realize the purpose for the treatment of and diagnosis by the method.
But for electric current distribution situation in the tissue and indefinite, the high-resolution for CURRENT DISTRIBUTION in tissue is supervised
Survey and be imaged, there is no effective means to realize, the orientation problem to specific nerve is also in conceptual phase.To understand monitoring tissue electricity
Flow distribution characteristic, realizing the positioning of characteristic nerve stimulates, while assessing monitoring effect of stimulation, real-time regulation stimulation parameter has
Significance.
The content of the invention
The technical problems to be solved by the invention be to provide it is a kind of can realize characteristic nerve positioning stimulate based on magnetosonic
The Neural stem cell electric current real-time monitoring device and monitoring method of coupling effect.
The technical solution adopted in the present invention is：A kind of Neural stem cell electric current real-time monitoring dress based on magnetosonic coupling effect
Put, including for human body head provide provide magnetostatic field N poles magnet and S poles magnet, be provided with by the magnetostatic field for
Sound wave is converted into the microphone that electric signal realizes scanning simultaneously, is additionally provided with what is be sequentially connected in series：For to detecting
Amplifier that signal is amplified, retain marker for being filtered to the boost pulse frequency content in the signal after amplification
The wave filter of frequency content, the Acquisition Processor of the triggering collection for realizing signal and image reconstruction and for showing electric current point
The display of cloth image, wherein, the signal input part of the amplifier connects the signal output part of the microphone, the collection
The trigger signal output end of processor is connected to the signal input part of the magnetic stimulator for providing Neural stem cell electric current, the Neural stem cell
The signal output part of device is connected to the coil to human body head load energizing current.
The NS poles line direction of N poles magnet and S poles magnet, the line direction of the coil and the microphone end face
Normal direction is orthogonal two-by-two.
A kind of method of real-time of the Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect, magnetic stimulator
Output signal is made up of marker and boost pulse on a timeline, and the marker is realized by a high-frequency impulse, institute
The centre frequency for stating marker width is consistent with the measurement frequency range of microphone；The trigger signal output of Acquisition Processor and magnetic thorn
Swash the Neural stem cell signal output synchronization of device, the trigger collection moment of Acquisition Processor is identical with the marker initial time.
The time t of magnetic stimulator output signal is with space length l corresponding relations
L=tv
Wherein v is spread speed of the sound in sample, i.e. human brain tissue.
Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect of the invention, for monitoring electricity
Magnetic swashs tissue current distribution characteristic, realizes the positioning of specific Neural Area and stimulates, and assessment monitoring effect of stimulation, real-time regulation stimulates ginseng
Number is significant.
Brief description of the drawings
Fig. 1 is the overall structure diagram of Neural stem cell electric current real-time monitoring device of the present invention based on magnetosonic coupling effect；
Fig. 2 is signal waveforms of the invention.
In figure
1：Human body head 2：N poles magnet
3：S poles magnet 4：Microphone
5：Amplifier 6：Wave filter
7：Acquisition Processor 8：Display
9：Magnetic stimulator 10：Coil
Specific embodiment
The Neural stem cell electric current real-time monitoring based on magnetosonic coupling effect of the invention is filled with reference to embodiment and accompanying drawing
Put and be described in detail with monitoring method.
As shown in figure 1, the Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect of the invention, including for right
Human body head 1 provides the N poles magnet 2 and S poles magnet 3 of magnetostatic field, is provided with by the magnetostatic field for sound wave to be converted
Realize the microphone 4 of scanning simultaneously for electric signal, be additionally provided with what is be sequentially connected in series：For being put to the signal for detecting
Big amplifier 5, the frequency content for filtering reservation marker to the boost pulse frequency content in the signal after amplification
Wave filter 6, the Acquisition Processor 7 of the triggering collection for realizing signal and image reconstruction and for showing CURRENT DISTRIBUTION image
Display 8, wherein, the signal input part of the amplifier 5 connects the signal output part of the microphone 4, at the collection
The trigger signal output end for managing device 7 is connected to the signal input part of the magnetic stimulator 9 for providing Neural stem cell electric current, the Neural stem cell
The signal output part of device 9 is connected to the coil 10 to the load energizing current of human body head 1.
The NS poles line direction of N poles magnet 2 and S poles magnet 3, the line direction of the coil 10 and the end of the microphone 4
Face normal direction is orthogonal two-by-two.If magnet poles NS poles line direction is along-z directions, coil connecting line is in the x-direction, then described
The normal line of butt end direction of microphone 4 is y directions.
In Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect of the invention, the magnetic stimulator 9 be by
The WF1973 connection NF company HSA4101 power amplifiers of function generator NF companies are realized.The coil 10 can use diameter
2mm copper wire windings, are made diameter 70mm, and the wordline circle of 100 circle eight is realized.N poles magnet 2 and S poles magnet 3 are public by U.S. K＆J
Department DZ08-N52 is realized.The microphone 4 is realized by popularity MP201.The amplifier 5 is realized by AD companies AD624.The filter
Ripple device 6 is by NF companies.The Acquisition Processor 7 is realized by NI PXIe 1062Q and PXI5122.The display is public by Samsung
Department S24D360HL is realized.
Magnetic stimulator 9 in the present invention can also be realized by the rapid2 stimulators of Magstim companies.Coil it is also possible to use
Magstim companies 70mm, double coil coils are realized.
As shown in Fig. 2 of the invention using the real-time of the Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect
Monitoring method, the output signal of magnetic stimulator is made up of marker and boost pulse on a timeline, the marker by
One high-frequency impulse realizes that the centre frequency of the marker width is consistent with the measurement frequency range of microphone；Acquisition Processor
Trigger signal export, trigger collection moment and the mark of Acquisition Processor synchronous with the Neural stem cell signal output of magnetic stimulator
Note pulse initial time is identical.In embodiments of the invention, the marker can be by the signal period sinusoidal signal reality of 0.5 μ s
Existing, the boost pulse can be realized by the sine pulse of 10 μ s.
The time t of magnetic stimulator output signal is with space length l corresponding relations
L=tv
Wherein v is spread speed of the sound in sample, i.e. human brain tissue, is 1500 meter per seconds for soft tissue.
When Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect of the invention works, the t0 moment first produces
The signal period sinusoidal signal marker of 0.5 μ s, marker excitation produces magnetoacoustic signals response, magnetoacoustic signals response quilt
Receive, the sine pulse of the μ s of t1 moment 10 is output as boost pulse afterwards, carries out nerve stimulation.Due to marker and thorn
Sharp pulse be distributed in the tissue it is identical, therefore by detecting marker signal, you can realize what boost pulse was distributed in the tissue
Monitoring, and marker is shorter than boost pulse, the spatial resolution being distributed using marker monitoring current is high, can reach mm grades
Not.
Although being described to the preferred embodiments of the present invention above in conjunction with accompanying drawing, the invention is not limited in upper
The specific embodiment stated, above-mentioned specific embodiment is only schematical, is not restricted.This area it is common
Technical staff in the case of present inventive concept and scope of the claimed protection is not departed from, may be used also under enlightenment of the invention
To make many forms, these are belonged within protection scope of the present invention.
Claims (4)
1. a kind of Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect, including for providing human body head (1)
There is provided N poles magnet (2) and S poles magnet (3) of magnetostatic field, it is characterised in that be provided with by the magnetostatic field for sound wave to be turned
The microphone (4) that electric signal realizes scanning simultaneously is turned to, is additionally provided with what is be sequentially connected in series：For entering to the signal for detecting
The amplifier (5) that row amplifies, the frequency for filtering reservation marker to the boost pulse frequency content in the signal after amplification
The Acquisition Processor (7) of the wave filter (6), the triggering collection for realizing signal and image reconstruction of rate composition and for showing electricity
The display (8) of flow distribution image, wherein, the signal of the signal input part connection microphone (4) of the amplifier (5) is defeated
Go out end, the trigger signal output end of the Acquisition Processor (7) is connected to the letter of the magnetic stimulator (9) for providing Neural stem cell electric current
Number input, the signal output part of the magnetic stimulator (9) is connected to the coil to human body head (1) load energizing current
(10)。
2. a kind of Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect according to claim 1, its feature
It is, the NS poles line direction of N poles magnet (2) and S poles magnet (3), the line direction of the coil (10) and the wheat
Gram wind (4) normal line of butt end direction is orthogonal two-by-two.
3. the real-time monitoring side of the Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect described in a kind of claim 1
Method, it is characterised in that the output signal of magnetic stimulator is made up of marker and boost pulse on a timeline, the mark arteries and veins
Punching is realized that the centre frequency of the marker width is consistent with the measurement frequency range of microphone by a high-frequency impulse；At collection
The trigger signal output for managing device is synchronous with the Neural stem cell signal output of magnetic stimulator, the trigger collection moment of Acquisition Processor and institute
State marker initial time identical.
4. the real-time monitoring side of the Neural stem cell electric current real-time monitoring device based on magnetosonic coupling effect according to claim 3
Method, it is characterised in that the time t of magnetic stimulator output signal is with space length l corresponding relations
L=tv
Wherein v is spread speed of the sound in sample, i.e. human brain tissue.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710061410.0A CN106730365A (en) | 2017-01-26 | 2017-01-26 | Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect |
| CN201710553212.6A CN107260169B (en) | 2017-01-26 | 2017-07-07 | Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect |
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| CN201710061410.0A CN106730365A (en) | 2017-01-26 | 2017-01-26 | Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect |
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| CN201710553212.6A Active CN107260169B (en) | 2017-01-26 | 2017-07-07 | Neural stem cell electric current real-time monitoring device and monitoring method based on magnetosonic coupling effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301915A (en) * | 2019-05-14 | 2019-10-08 | 武汉闻道复兴智能科技有限责任公司 | A kind of bladder muscle electrical signal detection device and detection system |
| CN113101526A (en) * | 2021-04-12 | 2021-07-13 | 中国医学科学院生物医学工程研究所 | Noninvasive deep brain precise composite field stimulation device based on magnetoacoustic coupling effect |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI964387A0 (en) * | 1996-10-30 | 1996-10-30 | Risto Ilmoniemi | Foerfarande och anordning Foer kartlaeggning av kontakter inom hjaernbarken |
| CN101985058A (en) * | 2010-07-26 | 2011-03-16 | 香港脑泰科技有限公司 | Multi-functional transcranial magnetic stimulator |
| US9669226B2 (en) * | 2010-09-07 | 2017-06-06 | Empi, Inc. | Methods and systems for reducing interference in stimulation treatment |
| CN104783926B (en) * | 2014-01-20 | 2016-09-28 | 中国科学院声学研究所 | A kind of quickly multiple tracks synchronizes cochlear implant equipment performance assessment system |
| CN105251141A (en) * | 2015-10-10 | 2016-01-20 | 燕山大学 | Closed-loop transcranial magnetoacoustic stimulation device |
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2017
- 2017-01-26 CN CN201710061410.0A patent/CN106730365A/en not_active Withdrawn
- 2017-07-07 CN CN201710553212.6A patent/CN107260169B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301915A (en) * | 2019-05-14 | 2019-10-08 | 武汉闻道复兴智能科技有限责任公司 | A kind of bladder muscle electrical signal detection device and detection system |
| CN113101526A (en) * | 2021-04-12 | 2021-07-13 | 中国医学科学院生物医学工程研究所 | Noninvasive deep brain precise composite field stimulation device based on magnetoacoustic coupling effect |
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| Publication number | Publication date |
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| CN107260169B (en) | 2019-10-08 |
| CN107260169A (en) | 2017-10-20 |
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Application publication date: 20170531 |