CN106730198A - A kind of activin garlic breathing therapeutic equipment - Google Patents
A kind of activin garlic breathing therapeutic equipment Download PDFInfo
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- CN106730198A CN106730198A CN201611198770.7A CN201611198770A CN106730198A CN 106730198 A CN106730198 A CN 106730198A CN 201611198770 A CN201611198770 A CN 201611198770A CN 106730198 A CN106730198 A CN 106730198A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
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Abstract
A kind of activin garlic breathing therapeutic equipment for improving therapeutic effect, including casing, casing is provided with control panel, garlic volatilization room is provided with casing, garlic volatilization room connects with the venthole being located on casing, air distribution hole is provided with the bottom of garlic volatilization room, air distribution hole connects with the air pump of supply, the orifice plate placed and smash garlic to pieces is provided with garlic volatilization interior, the bottom of orifice plate is provided with heating dish, activin minim pipette is provided with casing, activin minim pipette extend into garlic volatilization interior and the liquid outlet of activin minim pipette is arranged on heating dish top, activin liquid-inlet is provided with casing, activin minim pipette connects with activin liquid-inlet, dropping funnel is provided with the middle part of activin minim pipette.Activin liquid is heated using heating dish, is formed after steam is sufficiently mixed to smashing the gas that garlic is volatilized to pieces, form compound allicin gas, active material can slow release out, by human body suction lung in, beneficial to the rehabilitation of patient.
Description
Technical field
The present invention relates to a kind of equipment that PUD D prevention and treatment are carried out using garlic, particularly a kind of activin is big
Garlic respiratory therapy.
Background technology
Inhaling therapeutical instrument, is to smash garlic to pieces in the prior art, is put into instrument, by air pump by having that garlic volatilizes
In effect composition suction lung, the preventing and treating of disease is carried out.It is disadvantageous in that garlic just has a large amount of gaseous volatilizations in process of smashing to pieces
Out, the service efficiency of garlic, inconvenient operation are influenceed.The gas volatilized by garlic oneself, its therapeutic effect is poor, and
The smell of generation is not easy to be received by most people, have impact on the popularization and application of the treatment technology.
The content of the invention
The technical problem to be solved in the present invention is directed to the deficiencies in the prior art, it is proposed that a kind of raising therapeutic effect swash
Cytokines garlic breathing therapeutic equipment.
The technical problem to be solved in the present invention is achieved through the following technical solutions, a kind of to improve swashing for therapeutic effect
Cytokines garlic breathing therapeutic equipment, including casing, casing are provided with control panel, and garlic volatilization room is provided with casing, and garlic is waved
Hair room connects with the venthole being located on casing, and air distribution hole, air distribution hole and the air pump for supplying are provided with the bottom of garlic volatilization room
Connect, be characterized in：The orifice plate placed and smash garlic to pieces is provided with garlic volatilization interior, the bottom of orifice plate is provided with heating dish, in case
Activin minim pipette is provided with vivo, and activin minim pipette extend into garlic volatilization interior and the liquid outlet of activin minim pipette sets
Put above heating dish, activin liquid-inlet is provided with casing, activin minim pipette connects with activin liquid-inlet, swash
Dropping funnel is provided with the middle part of cytokines minim pipette.
The technical problem to be solved in the present invention can also be come further to realize by the following technical programs, in garlic volatilization room
Sidepiece be provided with gas distributing chamber, be provided with oxygen generator in gas distributing chamber, the venthole phase on the escaping pipe of oxygen generator and casing
Connection.
The technical problem to be solved in the present invention can also be come further to realize by the following technical programs, in oxygen generator
Escaping pipe in the middle part of be provided with humidification device.
The technical problem to be solved in the present invention can also come further to realize by the following technical programs, activin minim pipette
It is upper that control liquid device is housed.
The technical problem to be solved in the present invention can also be come further to realize by the following technical programs, in described activation
Casing at plain liquid-inlet is provided with interface slot, is provided with the inwall of interface slot and coordinated with the bottleneck of dress activin liquid bottles
Screw thread, the central part of interface slot is provided with the spine for setting up and puncturing liquid bottle closure.
Compared with prior art, the present invention is heated the present invention using heating dish to activin liquid, forms steam pair
Smash to pieces after the gas that garlic volatilized is sufficiently mixed, form compound allicin gas, active material can slow release out,
In by human body suction lung, play a part of the malicious clearing lung-heat of smoke evacuation, growth of the allicin to cancer cell is inhibited, so favorably
The rehabilitation of patient Yu.
Brief description of the drawings
Fig. 1 is structure diagram of the invention.
Specific embodiment
A kind of activin garlic breathing therapeutic equipment for improving therapeutic effect, including casing 1, casing 1 are provided with chain of command
Plate, is provided with garlic volatilization room 5 in casing, garlic volatilization room 5 connects with the venthole 4 being located on casing, in garlic volatilization room
Bottom is provided with air distribution hole, and air distribution hole connects with the air pump 11 of supply, and the orifice plate placed and smash garlic to pieces is provided with garlic volatilization interior
14, the bottom of orifice plate 14 is provided with heating dish 13, and activin minim pipette 9 is provided with casing, and activin minim pipette 9 extend into garlic
The liquid outlet 12 of volatilization interior and activin minim pipette is arranged on the top of heating dish 13, activin liquid is provided with casing and is entered
Mouth 7, activin minim pipette connects with activin liquid-inlet, and dropping funnel 8 is provided with the middle part of activin minim pipette.Activin minim pipette
It is upper that control liquid device 10 is housed.
Sidepiece in garlic volatilization room is provided with gas distributing chamber, be provided with oxygen generator 2 in gas distributing chamber, and oxygen generator 2 goes out
Tracheae is connected with the venthole on casing.Humidification device 3 is provided with the middle part of the escaping pipe of oxygen generator.Liquid outlet 12 is
Copper product makes.
Interface slot is provided with casing at described activin liquid-inlet, is provided with the inwall of interface slot and swashed with dress
The screw thread that the bottleneck of cytokines liquid bottles coordinates, the central part of interface slot is provided with the spine for setting up and puncturing the sealing of medicinal liquid bottle 6.
The described bascule of orifice plate 14, facilitates disassembly, cleaning.Small basket structure can also be used, garlic volatilization room is hung over
Upper edge hole,
The activin is that distilled water adds plants essential oil to be prepared from, and can also be added（NH4）2SO4Or NH4The ammonium salts such as Cl, plant
Essential oil can be Rosa Damascana etc..
The activin formula of one of which implementation method is：0.1-8 mass parts are added dropwise in the distilled water of 100 mass parts
Plants essential oil；The ammonium salt of 1-5 mass parts can also be added in above-mentioned formula.
The compound allicin gas that activin reacts with garlic, is the general name of primary bioactive components in garlic, is many
Pi-allyl organic sulfur compound complex is planted, main component is containing 50%~80% diallyl trisulfide (DADS), 20%~50%
Diallyl disulfide (DAS) and 8% impurity（Such as acetone, ethanol）.Wherein, alliin is the precursor of allicin
Matter, in being present in garlic in the form of stablizing odorless, after the sour enzyme in garlic is activated, catalysis alliin forms allicin and is
Colorless oil.Garlic have multiple biological activities, and dynamic with antibacterial, sterilization, anti-oxidant, drop blood ester, hypotensive and preventing and treating
The effect of the angiocardiopathies such as pulse atherosclerosis, allicin is antitumor in antibacterial, antimycotic, and suppresses the work in immunological regulation
Dynamic existing related report.
Early in the 40's, Von Euler have found that alliin can suppress the Jensea tumour growths of rat.1960
Year, JA DIPAOIO and CCARRHTHERS had found that garlic have the effect for suppressing growth of tumour cell.The 70's found fresh
Growth of the garlic juice to the spontaneous mammary cancer of C3H and DDD mouse has inhibitory action.The 80's had been reported that garlic P.E
The growth of Morris liver cancer can be suppressed.The nineties, Wargovich
It was found that organosulfur compound contained in garlic can significantly inhibit murine fore-stomach carcinoma and the lung neoplasm that Bp or DNEA induces,
And the generation of the rat colon cancer and the cancer of the esophagus of DMH or NMBZA inductions.
In recent years, the compound allicin gas of activin and garlic reaction, principle active component diallyl sulfide
Antitumor action and its mechanism receive much attention.Epidemiology survey both domestic and external and experimental study show, activin and garlic
The compound allicin gas of reaction, to kinds of tumors such as stomach cancer, colon cancer, liver cancer, lung cancer, prostate cancer, breast cancer, leukaemia
There is obvious inhibiting effect[10].Research simultaneously to allicin Anticancer Effect and Mechanism is a lot, but its definite anticancer mechanism
Not yet it is fully apparent from.Lot of experiments shows that the compound allicin gas that activin reacts with garlic is not only disliked with prevention
Property tumorigenic effect, and the growth of inside and outside malignant cell can be suppressed, and its effect be probably multipath,
Mutiple Targets.
Allicin composite gas Anticancer Effect and Mechanism
Antioxidation
The state of oxidation of cell plays an important role in tumour develops, when various carcinogenic factors cause cell to produce excessively
Active oxygen and during the Scavenging activity more than cell, the oxidative damage of cell DNA molecule just into canceration originate because
Element.Internal experiment in vitro result of study is it has proven convenient that activin and the compound allicin gas of garlic reaction, can resist some poisonous substances
To the oxidative damage of body, sulfydryl and electrophilic group contained by its active ingredient have the work(of scavenging capacity oxygen radical
Energy.Thomas etc. thinks the compound allicin gas of activin and garlic reaction, in one of active ingredient DAS can suppress from
Three kinds of subcellular structures that female ACI mouse breast tissue is isolated（Microsome, mitochondria and nucleus）Middle stilbestrol
（DES）Oxidation, research confirms that DAS can effectively suppress cytogene caused by DES oxidations in breast tissue metabolism
Unstable and canceration.Domestic some researchs also tentative confirmation compound allicin gas of the activin with garlic reaction, Ke Nengtong
Reduction reactive oxygen species free radicals level is crossed, the activity of influence transcription factor NF-KB suppresses NF-KB paths, in causing tumour cell
Some gene expression doses change, and the effect of growth of cancer cells is suppressed so as to reach.LY Chung prove that alliin can be cleared up
Peroxide, allicin can suppress the formation of peroxide their researchs and show allyl disulfide, alliin, swashs
The compound allicin gas that cytokines is reacted with garlic, and allyl cysteine is the protective ingredient for preventing free radical from damaging, it
The different of oxidation-resistant form thereof
Suppress tumor cell proliferation
The compound allicin gas of activin and garlic reaction, to stomach cancer, colon cancer, liver cancer, lung cancer, prostate cancer, breast cancer,
The kinds of tumors such as oophoroma, sdenocarcinoma of stomach have obvious inhibiting effect, and it can substantially suppress tumour cell increasing under suitable concentration
It is raw, and inducing apoptosis of tumour cell, normal cell is then acted on without this.
The propagation of cell, division imbalance are tumorigenic bases, and the cell cycle is a complexity in order and is strictly adjusted
The process of control, can be divided into G0/G1 phases (DNA pre-synthesis phases), S phases (DNA synthesize phase), G2 phases cell generation cycle (after DNA synthesis
Phase) and the M phases (m period), in four cycles of cell growth, the G0/G1 phases block close with cell propagation and apoptosis
Correlation, makes damage dna be repaired before chromosome separation, it is impossible to which reparation person can not then enter cell generation cycle, therefore resistance
Only DNA damage after repair again be Apoptosis an important prerequisite.Cell cycle regulating obstacle, causes cell hyperplasia,
The even appearance of abnormal cell, so as to lead oncogenic generation.Research shows that many active ingredients of garlic can act on carefully
Some link in born of the same parents' cycle, and make be obstructed cell generation cycle, induce it that apoptosis occurs.
Hirsch etc.]Research finds that allicin can be by human breast carcinoma MCF-7 cells, endometrial carcinoma cell, colon cancer
HT-29 cells were prevented in G0/G1 and G2/M phases, effective inhibition of cell proliferation.Lan Hong et al. further study show that, activin
With garlic react compound allicin gas, BGC-823 Cells can be caused to be arrested in the G1 phases, may with activin with it is big
The compound allicin gas of garlic reaction, suppresses the expression of BGC-823 cell cyclinD1 albumen and increases p27kip1 albumen
Expression it is related.It is domestic there are some researches show：The compound allicin gas that activin reacts with garlic, acting on stomach cancer cell can change
Become the distribution of cell cycle, increase G2/M phase cell proportions, it is apoptosis-induced in dose dependent.It is detected simultaneously by cancer cell
Telomerase it is active suppressed, and depression effect and activin and garlic reaction compound allicin gas, action time and agent
After amount has dependence, telomerase activation to decline, cell mitogen is obstructed, and causes Apoptosis.External another some research discoveries,
The compound allicin gas that activin reacts with garlic, can also be thin by human colon carcinoma HCT-15 cells, human breast carcinoma MCF-7
Born of the same parents, endometrial carcinoma cell, colon cancer HT-29 cells were prevented in G2/M phases, effective inhibition of cell proliferation.
The compound allicin gas that activin reacts with garlic, inducing cell apoptosis
The influence of Telomerase
Telomerase is a kind of nucleoglucoprotein, is made up of microRNA and protein, and the major function of its RNA component is elongated end
The length of grain repetitive sequence, stabilization telomere.The shortening of the telomere that end is replicated determines the limited propagation of normal cell.Tumour cell
Most of performances telomerase activation high, and enable cell infinite multiplication.Telomerase activating in visual tumors cell can make
Cell development turns into the cancer cell of infinite multiplication, is the major reason that malignant tumour develops.Recent studies indicate that swashing
Cytokines and the compound allicin gas of garlic reaction, can effectively suppress the activity of tumour cell telomerase, induced tumor cell
G2/M phases are arrested in, cause apoptosis of tumor cells.The compound allicin gas that activin reacts with garlic, institute's induced tumor is thin
Born of the same parents' apoptosis, it is believed that lower tumour cell telomerase activation with it relevant.Reason is that tumour cell is replicated after telomerase activation declines
During telomere be gradually shortened, cell mitogen is obstructed, it is impossible to carries out further division growth, causes Apoptosis.This
One of the compound allicin gas for being probably activin with garlic reaction, antineoplastic action mechanism.
Influence to caspase protein expressions
Discovered in recent years caspase (caspase) family plays an important role in Apoptosis.Antiapoptotic signals are passed
The key led is the activation of caspase.Caspase families are present in mammalian cell, are and elegans cell death egg
A white Ced23 similar albuminoid enzyme, hitherto it is found that 16 members.All of caspase is with inactive proenzyme shape
Formula is present, and caspase cascade reactions will be produced once activation, ultimately results in Apoptosis.According to the length of N ends front domain, can be by
Caspase points is regulation and control and effect caspase.Caspase3 belongs to effect caspase, is so far with shorter N ends front domain
It was found that all caspase family members in Ced23 homology sopranos, and 2 of caspase not coactivations
Approach (caspase 8 and the activation of zymogen approach of caspase 9) is both needed to the participation of caspase3, therefore caspase 3
It is considered as the key protein enzyme in mammalian apoptosis.Oommen S etc. have found that activin is compound with garlic reaction
Allicin gas, effect tumour cell can cause caspase -3, caspase -8, the activation of caspase -9 and poly
(ADP-ri2bose) polymerase degrades.
Influence to bcl-2, bax protein expression
Bcl-2 families play an important role in apoptosis regulation, and its family member has including many amino acid sequences
The albumen of very strong homology, such as suppresses apoptotic proteins bcl-2, bcl-xl, pro apoptotic protein bax, bad etc..It is existing to grind
Study carefully the reduction of the increase and/or bax expression for proving bcl-2 expression, it is all closely related with tumour cell abnormality proliferation.
Carefully the result of study such as bright is proved Xu, the compound allicin gas that activin reacts with garlic, lymphocyte after treatment
Increasing apoptosis it is many, the positive lymphocyte number of bcl-2 expression is reduced, and Bax positive cell numbers have no substantially change.Illustrate activation
The compound allicin gas that element reacts with garlic, can be by reducing the expression of bcl-2 albumen come the apoptosis of induction of lymphocyte.
But it is the expression which kind of approach to suppress bcl-2 albumen by, then as activin and the compound allicin gas of garlic reaction
Need further research.
Influence to second signal system cAMP, PKC approach
CAMP is the product that ATP is catalyzed through adenyl cyclase, is the second messenger of many hormones in vivo, and its is main
Function is activated protein kinase A, by the phosphorylation of some protein, and then influences the activity of endogenous endonuclease, is come
Realize its physiological effect.When cAMP concentration is raised, can effectively inducing cell apoptosis.CAMP or a kind of effective induction
Differentiation agent, the reduction of intracellular cAMP levels is the immediate cause for causing canceration.And the level for recovering intracellular cAMP is to lead
Cause the direct mechanism of cancer eliminating.So cAMP is an important step in Apoptosis path.CAMP levels are raised and can lured
Tumour cell is led to develop to apoptosis direction.
Protein kinase C is a kind of Ca2+, phospholipid dependent protein kinases, participate in the regulation and control of many cellular activities.Activation
PKC can make the serine of multiple protein and threonine residues phosphorylation, the transmission of influence regulation intracellular biological information.In regulation
Play an important roll in cell metabolism, differentiation, propagation or even canceration.
The PKC of activation can suppress the Apoptosis that cAMP, glucocorticoid or hormone TCR are induced.Research discovery, cell
When interior PKC contents increase, cAMP levels are reduced, Apoptosis is suppressed, normal cell canceration;And work as intracellular PKC contents drop
Low, when cAMP levels are raised, then tumor cell proliferation is suppressed, and apoptosis rate increases, and grade of malignancy is low.Activin and garlic reaction
Compound allicin gas, may cause Apoptosis initiating gene fas and apoptosis by second signal system cAMP, PKC approach
Promoting gene bax expression increases, and the expression of apoptosis suppressor bcl -2 is reduced, and improves apoptosis rate[24]。
Some protein kinase pathways are that regulation cell is bred and apoptotic signal is it is well known that in reality in various model systems
Show in the data tested, suppress the compound allicin gas that protein kinase blocking greatly reduces activin and garlic reaction, lure
The ability of guided cell apoptosis.Bax and AIF expressions are caused to decline additionally, suppressing PKA signal pathways.PKA participates in swashing
The compound allicin gas that cytokines is reacted with garlic, inducing cell apoptosis process and Bax expression and apoptosis inducing factor are to pass through
PKA mediation path in regulation ags cell.
Additionally, the compound allicin gas that also activin reacts with garlic, suppresses macrophage and withers in poor nutrition condition
The correlative study died, research shows, in lean nutritional status to activin and the compound allicin gas of garlic reaction, carries out pre- place
Reason, to being checked for the Apoptosis of peritoneal macrophage, Apoptosis speed depends on using iodate staining analysis
Flow cytometer, DNA fragmentation, and caspase-3 methods.Show that activin is anti-with garlic by DNA fragmentation and iodate staining analysis
The compound allicin gas answered, makes the macrophage reduction of malnutritive induction.The compound allicin that activin reacts with garlic
Gas, the one-level Bax protein expressions of the macrophage for having processed, from mitochondria release cytochromes alcohol quantity and
The activity of caspase-3 is also low compared with than in a undressed macrophage of lean nutritional status.Additionally, in a poor nutrition
Situation, MEK（Mitogen activated protein kinases/extracellular signal-regulated kinase）Inhibitor inhibits activin and garlic
The compound allicin gas of reaction, inducing cell apoptosis and activin and the compound allicin gas of garlic reaction, improve
The phosphorylation of ERK1/2.Activin and the compound allicin gas of garlic reaction, influence the Apoptosis of macrophage, influence
The expression of gene participating in apoptosis.Mitochondria is risen in Apoptosis by discharging cytochromes-C and apoptosis induction factor
Key effect, the reduction in mitochondrial membrane potential is caused.During Apoptosis, mitochondrial membrane potential is by various anti-
Bcl-2 albumen（Bcl-2 and Bcl-xl）With a series of regulation of albumen such as apoptosis Bcl-2 albumen.Also indicate that, activin with it is big
The compound allicin gas of garlic reaction, suppresses the expression of apoptogene, Bax expression.In general, in lean nutritional status, activation
Element and the compound allicin gas of garlic reaction, reduce the activity of caspase-3.It is reported that in many tumour cells,
The activation of MEK/ERK approach can promote oncogene to synthesize and activation Raf/MEK/ERK signal pathways.In various cell lines
In, the suppression of MEK/ERK signal paths can cause Apoptosis.Under study for action, suppress the ability of reduction MEK, protect activin
The compound allicin gas reacted with garlic, to cell from apoptosis, so as to increase the phosphorylation of ERK.This shows, MEK/ERK
Approach participates in the compound allicin gas of activin and garlic reaction, the process that inducing cell apoptosis suppress.
Block carcinogenic synthesis
Activin and the compound allicin gas of garlic reaction, can prevent polycyclic aromatic hydrocarbons (PAH) and nitrosamines chemical factor carcinogenic,
The mutagenicity for blocking chemical factors has been reported.Nitrite be synthesize strong carcinogen nitrosamine precursor, activin with
The compound allicin gas of garlic reaction, it is possible to decrease content of nitrite in stomach, and then influence the synthesis of nitrosamine.Garlic can drop
Content of nitrite in low stomach, so as to influence the synthesis of nitrosamine, and then reduces the probability for getting a cancer of the stomach[37].Activin and garlic
The compound allicin gas of reaction, can block Escherichia coli, enterococcus to diethylnitrosamine, the synthesis of dibutyl nitrosamine
Facilitation, and block Escherichia coli reduction nitrate for nitrite process.Activin is compound big with garlic reaction
Allicin gas, can also suppress the growth of carcinogenicity mould-fusarium moniliforme.Diethylstilbestrol (DES) can cause human or animal
The research such as cancer, Green shows that the compound allicin gas that activin reacts with garlic can directly suppress the metabolism of DES, hinder
Only DNA adds the formation with thing, so as to prevent the generation of the tumour of estrogen induction.Additionally, containing many electron rich knots in garlic
The molecule of structure (S0 mono-, a SS mono-, a C=C mono-), can be combined, with electrophilic ultimate carcinogen so as to play antimutagenic effect.
Aromatic amine and heterocyclic amine material by that can be produced after the metabolic conversion of human body including the toxicity including carcinogenesis,
Acetylation is one of important step of such metabolism conversion, is catalyzed by N. acetyltransferases (NAT) and completed.Occur
Acetoxyl group aromatic amino-derivative produced by acetylation on oxygen atom contains the Nitrogen ion of high reaction activity, easily
DNA compounds are combined to form with DNA, causes DNA mutation, cause cell carcinogenesis.Chung etc. is analyzed with liquid chromatogram and PCR methods
NAT activity and NAT mRNA are expressed on colon cancer cell after being processed through DAS, and experiment demonstrates DAS for the 1st time can be by suppressing to tie
The activity of NAT and gene expression reduction tumor susceptibility in colon-cancer cell.
To the sensitization of antineoplastic
During chemotherapy of tumors, cancer therapy drug also has killing to make while killing tumor cell, to normal proliferating cells
With, thus influence the curative effect of chemotherapy.Drug on tumor cell is killed to greatest extent, and the toxicity of normal cell is subtracted
Minimum imagination is arrived less increasingly to draw attention.
The MDR that the overexpression of P- glycoprotein causes is the main cause for influenceing chemotherapy of tumors curative effect, and P- glycoprotein can
Drug concentration is reduced, and its function regulator can then recover sensitiveness of the multidrug resistance cell to chemotherapeutics.Arora
Research discovery, non-toxic dose DAS（8.75×10(-3)mol/L）Increased vincristine thin with other vincristine class medicines
Cellular toxicity is acted on.DAS is measured by the P- P-glycoprotein expressions of mdr cell by Western blot and immunocytochemical method
It is reduced to normal level.And experiment in vivo also demonstrates that DAS can effectively suppress the P- of vincristine induction in rat hepatoma cell
The overexpression of glycoprotein.The above-mentioned characteristic prompting activin of DAS and the compound allicin gas of garlic reaction, can be used as new
Multidrug resistance non-toxic conditioning agent, with other chemotherapy drugs in combination applications in chemotherapy of tumors, to improve tumour cell
To the sensitiveness of medicine, heighten the effect of a treatment.
Ha Minwen etc. by studying the compound allicin gas that activin and garlic react, to SGC-7901 MGC-
The influence of 803 and SGC-7901 cell cycles and its it is used in combination with cycle-specific agent, enhancing cancer therapy drug is to tumour
The lethal effect of cell.Using the activin and the compound allicin gas of garlic reaction of various concentrations in this research, make employment
After gastric carcinoma cell lines MGC-803 and SGC-7901, the growth of cell proliferation inhibition rate measurement result tumor cells showed is subject to bright
It is aobvious to suppress.The activin of same concentrations and the compound allicin gas of garlic reaction, act on cultured cells, using fluidic cell
Instrument is detected and Switzerland-Ji's nurse Sa dyeing is in its form of light Microscopic observation, it is found that the cell cycle is arrested in the M phases.Cell cycle exists
There is important effect in the adjusting and controlling growth of tumour cell, the infinite multiplication of tumour cell has been prevented by changing the cell cycle
Paid close attention to by people.
The compound allicin gas of activin and garlic reaction, for antineoplaston remain problem and prospect
It is existing largely about activin and the compound allicin gas of garlic reaction both at home and abroad so far, suppress in vitro culture and swell
Tumor cell proliferation, apoptosis-induced, the inhibitory cell cycle research, but activin and the compound allicin gas of garlic reaction, press down
The mechanism of action of tumour processed is extremely complex, and effect link and action pathway are many, and its definite mechanism of action is also
Need further further investigated.Activin and garlic reaction compound allicin gas, for antineoplastic research in, in vivo
Zoopery is also little, because the non-physiologic of external malignant tumor cell culture, the result of in vitro study cannot be directly used to
It is clinical.Due to the complexity of human body, the clinical compound allicin gas for reacting activin and garlic is controlled for antineoplastic
Treatment need further system research in drug dose, the course for the treatment of and application method.With the continuous development and exploitation of garlic preparation
And domestic and foreign scholars are on a molecular scale to activin and the compound allicin gas of garlic reaction, active ingredient and the machine of acting on
The research of system, the compound allicin gas of activin and garlic reaction, antitumaous effect application clinically will be more and more wider
It is general, curative effect can be increased with other chemotherapeutic use in conjunction, reduce drug resistance.From existing retrospect analysis from documents, activin with
The compound allicin gas of garlic reaction, has good prospect as a kind of low toxicity side effect, inexpensive antineoplastic.
Claims (5)
1. a kind of activin garlic breathing therapeutic equipment, including casing, casing is provided with control panel, garlic is provided with casing and is waved
Hair room, garlic volatilization room connects with the venthole being located on casing, and air distribution hole is provided with the bottom of garlic volatilization room, air distribution hole with
The air pump of supply connects, it is characterised in that：The orifice plate placed and smash garlic to pieces is provided with garlic volatilization interior, the bottom of orifice plate is provided with
Heating dish, is provided with activin minim pipette in casing, and activin minim pipette extend into garlic volatilization interior and activin dropping liquid
The liquid outlet of pipe is arranged on heating dish top, and activin liquid-inlet, activin minim pipette and activin liquid are provided with casing
Body import connects, and dropping funnel is provided with the middle part of activin minim pipette.
2. activin garlic breathing therapeutic equipment according to claim 1, it is characterised in that：In the sidepiece of garlic volatilization room
Gas distributing chamber is provided with, oxygen generator is provided with gas distributing chamber, the escaping pipe of oxygen generator is connected with the venthole on casing.
3. activin garlic breathing therapeutic equipment according to claim 2, it is characterised in that：In the outlet of oxygen generator
Humidification device is provided with the middle part of pipe.
4. activin garlic breathing therapeutic equipment according to claim 1, it is characterised in that：It is equipped with activin minim pipette
Control liquid device.
5. activin garlic breathing therapeutic equipment according to claim 1, it is characterised in that：In described activin liquid
Casing at import is provided with interface slot, and the spiral shell coordinated with the bottleneck of dress activin liquid bottles is provided with the inwall of interface slot
Line, the central part of interface slot is provided with the spine for setting up and puncturing liquid bottle closure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611198770.7A CN106730198A (en) | 2016-12-22 | 2016-12-22 | A kind of activin garlic breathing therapeutic equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611198770.7A CN106730198A (en) | 2016-12-22 | 2016-12-22 | A kind of activin garlic breathing therapeutic equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106730198A true CN106730198A (en) | 2017-05-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611198770.7A Pending CN106730198A (en) | 2016-12-22 | 2016-12-22 | A kind of activin garlic breathing therapeutic equipment |
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| Country | Link |
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| CN (1) | CN106730198A (en) |
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| CN110237377A (en) * | 2019-06-10 | 2019-09-17 | 江苏华唐大康医疗科技有限公司 | A kind of garlic aspiration enters therapeutic equipment |
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