CN106729679A - The syringe of reciprocating promotes instrument - Google Patents
The syringe of reciprocating promotes instrument Download PDFInfo
- Publication number
- CN106729679A CN106729679A CN201510803727.8A CN201510803727A CN106729679A CN 106729679 A CN106729679 A CN 106729679A CN 201510803727 A CN201510803727 A CN 201510803727A CN 106729679 A CN106729679 A CN 106729679A
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- China
- Prior art keywords
- syringe
- catch bar
- instrument
- connector
- plunger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N2021/8405—Application to two-phase or mixed materials, e.g. gas dissolved in liquids
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Low dose of water-in-oil vaccine emulsion process is very uncontrollable.When a kind of emulsion is prepared, manually promote plunger mixture is flowed into opposite side syringe by connector from side syringe, so promote the method for completing emulsification to be difficult to obtain the emulsion of uniform quality repeatedly.The invention provides a kind of syringe pushing meanss, including：Fixing device for fixing syringe, for alternately promoting two pushing meanss of syringe plunger, and a drive system.The present invention has the advantage that for preparing antigen emulsion instead of manual type：1st, the motive force homogeneous constant of plunger is promoted every time；2nd, the time consistency of each pushing syringe plunger；3rd, can accurately control to promote taken time uniformity every time, liquid uniform force in syringe, the speed by connector is consistent every time, the speed uniform, controllable of such two kinds of liquid mixing, the emulsion of uniform quality is readily available, is not influenceed by different operating person's different operating batch.
Description
Technical field
The present invention relates to a kind of device, for two syringe plungers of connection of reciprocating, being especially suitable at the uniform velocity two syringe plungers of reciprocating makes wherein liquid be mixed with the device of bioactivity antigen emulsion.
Background technology
The immunization therapy of tumour antigen is the most popular research direction of current biomedicine field, and various new antigens and new vaccine adjuvant are developed for treating various tumours and other diseases.When immune induction is carried out by using a kind of antigen, antigen is injected together with adjuvant, adjuvant can play a part of to promote immune response.In this case, adjuvant is oil ingredient, for example mineral oil, needs for adjuvant and antigen and water to be mixed into emulsion before the injection.Low dose water-in-oil vaccine emulsification at present（Antigen aqueous phase solution mixes with oil phase adjuvant）Process is very uncontrollable.When a kind of emulsion is prepared manually, mixture is set to be flowed into opposite side syringe by connector from side syringe by reciprocating plunger, because preparation process is typically manual, operating personnel are difficult to control the strength and driving velocity of each promotion, this method is difficult to obtain the emulsion of uniform quality, influences the administration quality of medicine, and because the number of times for needing to promote is more, speed, increases the burden that emulsion prepares personnel.Therefore, in order to realize the automation of liquid mixed process in two syringes, we have proposed a device for automatic pushing syringe.The device includes：For fixing two fixing devices of syringe, for alternately promoting two pushing meanss of syringe plunger, and a promotion program setting system.
The content of the invention
The present apparatus is applied to syringe-connector-injector system., it is necessary to two syringes equipped with different liquids are connected with connector before liquid married operation is carried out.Concrete operations are as follows：The desired amount of antigenic solution first is drawn with a syringe, syringe is connected with connector either end and is screwed, then pushing syringe plunger, the bubble in exhaustjet device and connector（Liquid is full of connector）, take another syringe and draw appropriate adjuvant, wherein bubble is drained, the syringe is connected with connector and is screwed.After the completion of syringe-connector-syringe three connection, you can left and right pushing syringe plunger carries out emulsification procedure.It is manually operated it is difficult to ensure that the driving velocity and the uniformity of motive force in each cycle.In the preparation of emulsion, no matter manually operated or instrument is prepared automatically, when a powered side plunger, liquid is flowed in another syringe in syringe, opposite side syringe plunger can be driven to be moved toward same direction, and without the pulling that exerted a force to it, it is to avoid the inconsistent air for causing of push-pull speed enters system.Promote every time and all liquid in the syringe of side is pushed into opposite side syringe completely.It is once a cycle that syringe-plunger of connector-injector system two is respectively promoted.According to the requirement of driving velocity, the drive system of this instrument sets two programs：Cycle and fast cycle at a slow speed, the present apparatus can provide promote at a slow speed, it is quick promote, promote at a slow speed+three kinds of promotion patterns are quickly promoted to complete liquid mixing.Each several part device of the present invention includes：For fixing two fixing devices of syringe, for alternately promoting two pushing meanss of syringe plunger, and a drive system.Their working method is as follows：Touch-screen sets promotion program, and touch-screen is connected to PLC drivers by data wire, and PLC drivers connect motor by data wire, and motor drives catch bar to be moved reciprocatingly according to setting program.When this instrument is designed, what is considered first is the determination of each setting position, that is, system motion path determination.Depending on the installation site and motion path of catch bar are according to syringe plunger position, so the position of syringe should first be determined.Syringe is fixed on operating desk by syringe fixed seat.Length and mutual alignment according to syringe-connector-injector system determine pre-installed position of the syringe fixed seat on operating desk.There is syringe fixing groove in syringe fixed seat, syringe is embedded in fixing groove.Fixing groove is the fixing groove that can select corresponding size according to the size of different syringes according to the size design of syringe.There is locating dowel in the position of operating desk pre-installation fixed seat, the number of locating dowel is 2-4, has the location hole corresponding with locating dowel position with the one side that operating desk is contacted in fixed seat, and the location hole of fixed seat is enclosed within locating dowel during installation, convenient dismounting.The mentality of designing of syringe plunger pushing meanss is as follows：After fixing the position of syringe, the foreseen movement path of syringe plunger is also substantially stationary, according to plunger foreseen movement path, when liquid in syringe is pushed into offside syringe completely, the position of Work Promote bar is the near-end of catch bar groove, the distal end of catch bar groove should be greater than the position of offside catch bar, according to relevant position, catch bar groove be cut out on operating desk.Catch bar top is extend out on operating desk from catch bar groove, the height of the height higher than syringe plunger on catch bar top.It is syringe fixed seat between two catch bar grooves.Under operating desk plane, two catch bar bottoms are separately mounted to the both sides on same drawing plate, the distance between two catch bars, that is, drawing plate length, both sides syringe plunger is all pulled to distance during maximum capacity after being fixed equal to syringe-connector-injector system.Because, when liquid mixes, the capacity of the no more than single branch syringe of the summation of liquid capacity in two syringes, otherwise, the liquid leakage when side liquid is pushed completely to opposite side syringe.So overall length when syringe-connector-injector system works adds connector length not over the maximum length of two syringes.The position of catch bar and syringe plunger and connector on the same line, during ensureing that catch bar promotes plunger, motive force vertically forward, rather than lateral syringe sidewall.It is moving horizontally for drawing plate on two motion essences of catch bar.Drawing plate is arranged on stretching board mount, and stretching board mount is also the track of drawing plate motion.The drive system of this instrument is made up of motor and motor driver, in this instrument, as module.Motor driver drive motor rotates, and motor connects with module, module rotation is driven, so as to above-mentioned pushing meanss carry out straight line reciprocate.The external presentation of the timer for managing the driving time cycle of dipper crowding gear is touch-screen, can set cycle time and the cycle times that emulsification is promoted by touch-screen, so simple to operate easy to learn.The setting range of cycle time is 8-30 seconds at a slow speed, and the setting range of cycle times is 0-99 times；The setting range of fast cycle time is 1.0-3.0 seconds, and the setting range of cycle times is 0-99 times.Whole instrument is shaped as cuboid.Above, on a face with operating desk vertical connection, this face is the front of this instrument to the installation site of touch-screen to operating desk.Except touch-screen, front is also provided with various controlling switches：Power switch, start switch, reset switch, emergency stop switch, shutdown switch, each switch i.e. corresponding indicator lamp.Power switch can also be arranged on the side or below of instrument with outlet.In addition, this instrument is also mounted with safety guard and dust cap on operating desk, and these positions are made up of transparent material, convenient observation operation, again for emulsification procedure creates a closed environment, beneficial to the bio-safety requirement kept in emulsion preparation process and purity requirements.Slide rail is installed on the both sides side long of safety guard, dust cap moves to realize switching manipulation on slide rail.One handle is housed on dust cap.After the promotion EP (end of program) of setting, it is seen that mixing liquid is creamy white.Syringe-connector-injector system is taken out from fixed seat, remove the syringe equipped with mixing liquid, by syringe needle in syringe jacket, one glass of water is taken, promotes plunger to ooze a few drop mixing liquids on the water surface, it is seen that first rounded particle is suspended in water liquid, emerge afterwards in round spot shape, surrounding will not also fly away without oil slick, and such mixing liquid is the successful emulsion of emulsification.The present invention has the advantage that for preparing antigen emulsion instead of manual type：1st, the motive force homogeneous constant of plunger is promoted every time；2nd, the time consistency of each pushing syringe plunger；3rd, can accurately control to promote taken time uniformity every time, liquid uniform force in syringe, the speed by connector is consistent every time, the speed uniform, controllable of such two kinds of liquid mixing, the emulsion of uniform quality is readily available, is not influenceed by different operating person's different operating batch.Brief description of the drawings Fig. 1 is present invention work top view.Fig. 2 is present invention work top view（Plus dust cap）.Fig. 3 is fixed seat top view of the present invention（Remove syringe）.Fig. 4 is fixed seat structure figure of the present invention.Fig. 5 is Facad structure of the present invention.Fig. 6 is inventive touch screen schematic diagram.Fig. 7 is internal structure schematic diagram of the present invention.Description of reference numerals 1- connectors,2- syringes,3- syringe fixed seats,4- catch bars,5- catch bar grooves,11- transparent dust-proof lids,12- dust cap handles,51- syringe fixed seat locating dowels,52- fixed seats position,41- syringe fixing grooves,42- fixed seat location holes,13- transparent safety covers,14- touch-screens,15- non-slip feets,16- reset switches,17- metal shells,18- power switches,19- emergency stop switch,20- shutdown switches,21- starts switch,22- dust cap slide rails,31- catch bar drawing plates,32- stretches board mount,33- modules,34- outlet specific embodiments are as shown in Figure 1,This instrument top view is visible,Operating desk is one piece of metal flat,Two strip hollow outs 5 are catch bar groove thereon,The as space of catch bar.Region is syringe fixing device between catch bar groove, wherein equipped with two syringe fixed seats 3, syringe can be completely embedded into the fixing groove 41 of fixed seat（See Fig. 4）.Two syringes are connected by connector 1.As shown in Fig. 2 there is a transparent dust-proof lid 11 above the operating desk of instrument, pull handle 12 passes through slide rail 22（Fig. 5）Can push-and-pull open or shut dust cap, be conducive to keep emulsion preparation process in bio-safety requirement and purity requirements.As shown in Figure 3 and Figure 4, syringe fixed seat 3 is dismountable, and fixed seat carries out positioning 52 by the way that the correspondence of fixed seat location hole 42 is inserted in fixed seat locating dowel 51.Corresponding fixed seat is loaded onto according to various sizes of syringe.As shown in Figure 5 and Figure 6, after syringe-connector-injector system is fixed, after dust cap 11 is shut, whether outward winding power switch 18 and confirmation emergency stop switch 19 are opened（If down state, then select button ejects it）, power supply indicator lighted, and touch-screen is lighted, cycle time at a slow speed and number of times, fast cycle time and number of times are set on the touchscreen, after parameter setting is good, is pressed and is started switch 21, catch bar 4 starts to move reciprocatingly along catch bar groove 5, and the liquid in syringe is promoted back and forth.After the completion of promotion, catch bar 4 can be automatically stopped in original position, and instrument can send " ticking " prompt tone, press reset switch 16, and prompt tone is eliminated.Dust cap 11 is opened, syringe is taken out.Such as need to stop operation in emulsion process, press emergency stop switch 19, power supply breaks, and catch bar stops immediately.To right rotation emergency stop switch 19, emergency stop switch resets, and power supply indicator is bright, and catch bar is slowly returned to initial position.Shutdown switch 20 can suspend emulsification procedure.16th, 20,21 is also simultaneously indicator lamp.The setting range of cycle time is 8-30 seconds at a slow speed, and the setting range of cycle times is 0-99 times；The setting range of fast cycle time is 1.0-3.0 seconds, and the setting range of cycle times is 0-99 times.Fig. 7 is the internal structure schematic diagram of instrument, and this instrument uses common 220V alternating currents.（Need to connect wires, prevent electrostatic from producing）.
Claims (19)
1. a kind of syringe of reciprocating promotes instrument, it is characterised in that the device includes：For fixing two fixing devices of syringe, for alternately promoting two pushing meanss of syringe plunger, and a drive system.
2.According to claim 1 The syringe of described reciprocating promotes instrument, it is characterised in thatThe device working method is as follows：Touch-screen sets promotion program, and touch-screen is connected to PLC drivers by data wire, and PLC drivers connect motor by data wire, and motor drives catch bar to be moved reciprocatingly according to setting program.
3. the syringe of reciprocating according to claim 1 promotes instrument, it is characterised in that for fixing two fixing devices of syringe, that is, fixed seat, and positioning, convenient dismounting are combined by the location hole in the locating dowel on operating desk and fixed seat.
4. fixing device according to claim 3, it is characterised in that have syringe fixing groove in fixed seat, syringe can be embedded in fixing groove.
5. fixing device according to claim 3, it is characterised in that fixing groove according to syringe size design, the fixing groove of the size of different syringes from corresponding size.
6. the syringe of reciprocating according to claim 1 promotes instrument, it is characterised in that pushing meanss include the drawing plate of catch bar and connection catch bar.
7. pushing meanss according to claim 6, it is characterised in that drawing plate is arranged on stretching board mount, stretching board mount is also the track of drawing plate motion, is moving horizontally for drawing plate on two motion essences of catch bar.
8. pushing meanss according to claim 6, it is characterized in that, under operating desk plane, two catch bar bottoms are separately mounted to the both sides on same drawing plate, the distance between two catch bars, namely the length of drawing plate, both sides syringe plunger is all pulled to distance during maximum capacity after being fixed equal to syringe-connector-injector system.
9. pushing meanss according to claim 6, it is characterized in that, when liquid in syringe is pushed into offside syringe completely, the position of Work Promote bar is the near-end of catch bar groove, the distal end of catch bar groove should be greater than the position of offside catch bar, according to relevant position, catch bar groove is cut out on operating desk.
10. pushing meanss according to claim 6, it is characterised in that catch bar top is extend out on operating desk from catch bar groove, the height of the height higher than syringe plunger on catch bar top is syringe fixed seat between two catch bar grooves.
The syringe of 11. reciprocatings according to claim 1 promotes instrument, it is characterized in that, the drive system of the instrument is made up of motor and motor driver, in this instrument, as module, motor driver drive motor rotation, motor connects with module, module rotation is driven, so as to above-mentioned pushing meanss carry out straight line reciprocate.
The syringe of 12. reciprocatings according to claim 1 promotes instrument, it is characterized in that, the external presentation of the timer for managing the driving time cycle of dipper crowding gear is touch-screen, can set the program that emulsification is promoted, including cycle time and cycle times by touch-screen.
13. drive devices according to claim 12, it is characterised in that according to the requirement of driving velocity, the drive system of this instrument sets two programs：Cycle and fast cycle at a slow speed, it is possible to provide promote at a slow speed, it is quick promote, promote at a slow speed+quick promote three kinds of promotion patterns.
14. drive devices according to claim 12, it is characterised in that the setting range of cycle time is 8-30 seconds at a slow speed, the setting range of cycle times is 0-99 times；The setting range of fast cycle time is 1.0-3.0 seconds, and the setting range of cycle times is 0-99 times.
The syringe of 15. reciprocatings according to claim 1 promotes instrument, it is characterised in that whole instrument is shaped as cuboid, and, above, touch-screen is in front for operating desk.
16. except touch-screen, and front is also provided with various controlling switches：Power switch, start switch, reset switch, emergency stop switch, shutdown switch, each switch is also corresponding indicator lamp.
The syringe of 17. reciprocatings according to claim 1 promotes instrument, it is characterised in that this instrument is mounted with safety guard and dust cap on operating desk, and a handle is housed on dust cap, and safety guard and dust cap are made up of transparent material.
A kind of 18. method of preparing emulsion, the desired amount of antigenic solution is drawn with a syringe, syringe is connected with connector either end and is screwed, then pushing syringe plunger, the bubble in exhaustjet device and connector（Liquid is full of connector）, take another syringe and draw appropriate adjuvant, drain wherein bubble, the syringe is connected with connector and is screwed, after the completion of syringe-connector-syringe three connection, you can two syringes are respectively embedded into fixing groove, setting promotion program, reciprocating emulsification procedure is carried out with the instrument.
A kind of 19. emulsion evaluation methods, after the promotion EP (end of program) of setting, it can be seen that mixing liquid is creamy white, syringe-connector-injector system is taken out from fixed seat, remove the syringe equipped with mixing liquid, by syringe needle in syringe jacket, take one glass of water, promotion plunger oozes a few drop mixing liquids on the water surface, it can be seen that liquid first rounded particle is suspended in water, emerge afterwards in round spot shape, around without oil slick, also will not fly away, such mixing liquid is the successful emulsion of emulsification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803727.8A CN106729679A (en) | 2015-11-20 | 2015-11-20 | The syringe of reciprocating promotes instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803727.8A CN106729679A (en) | 2015-11-20 | 2015-11-20 | The syringe of reciprocating promotes instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106729679A true CN106729679A (en) | 2017-05-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510803727.8A Pending CN106729679A (en) | 2015-11-20 | 2015-11-20 | The syringe of reciprocating promotes instrument |
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| CN (1) | CN106729679A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108458904A (en) * | 2018-03-14 | 2018-08-28 | 北京建筑大学 | Gas sampling system |
| CN109142666A (en) * | 2018-08-03 | 2019-01-04 | 中国葛洲坝集团易普力股份有限公司 | A kind of emulsion matrix pumps simulator and analog detection method repeatedly |
| WO2021012875A1 (en) * | 2019-07-24 | 2021-01-28 | 南方科技大学 | Mixing apparatus |
| CN113631100A (en) * | 2019-03-22 | 2021-11-09 | 巴德股份有限公司 | Sealant delivery device for pulmonary treatment procedures and systems and methods for preparing same |
| US11766645B2 (en) | 2018-12-28 | 2023-09-26 | Biotechnology Institute, I Mas D, S.L. | Fluid mixing device and mixing method |
-
2015
- 2015-11-20 CN CN201510803727.8A patent/CN106729679A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108458904A (en) * | 2018-03-14 | 2018-08-28 | 北京建筑大学 | Gas sampling system |
| CN109142666A (en) * | 2018-08-03 | 2019-01-04 | 中国葛洲坝集团易普力股份有限公司 | A kind of emulsion matrix pumps simulator and analog detection method repeatedly |
| US11766645B2 (en) | 2018-12-28 | 2023-09-26 | Biotechnology Institute, I Mas D, S.L. | Fluid mixing device and mixing method |
| CN113631100A (en) * | 2019-03-22 | 2021-11-09 | 巴德股份有限公司 | Sealant delivery device for pulmonary treatment procedures and systems and methods for preparing same |
| WO2021012875A1 (en) * | 2019-07-24 | 2021-01-28 | 南方科技大学 | Mixing apparatus |
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Application publication date: 20170531 |