CN106728768A - It is a kind of to treat Chinese and western medicinal composition of hyperglycaemia and preparation method thereof - Google Patents
It is a kind of to treat Chinese and western medicinal composition of hyperglycaemia and preparation method thereof Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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Abstract
The invention discloses a kind of Chinese and western medicinal composition for treating hyperglycaemia, the Chinese and western medicinal composition of the treatment hyperglycaemia is according to the primary raw material of weight portion：8 20 parts of the red sage root, 15 17 parts of glutinous rehmannia, 0.5 0.9 parts of the wind-weed, 4 17 parts of 5 hydroxyl color amine, 18 25 parts of dehydroevodiamine, 11 15 parts of phellinus ketone G, 49 parts of wilforine, 7 12 parts of garlic Li Lu alkali, 5 16 parts of scutellarin methyl esters.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of hyperglycaemia, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Chinese and western medicinal composition for treating hyperglycaemia.
Background technology
When blood sugar is higher than normal range (NR) when medically (in 8 hours sugar-free and any containing sugared food intake) on an empty stomach (on an empty stomach
Blood sugar normal value 4.0-6.1mmol/L) it is referred to as hyperglycaemia, if two hours blood glucoses are higher than 7.8mmol/L after the meal, it is also possible to referred to as
Hyperglycaemia.Diabetes are a kind of endocrine system diseases with carbohydrate metabolism disturbance as cardinal symptom, and pathogenesis is pancreas islet in patient's body
Plain hyposecretion or insulin receptor dysfunction, clinical manifestation on an empty stomach or postprandial blood sugar raise, glycosuria and hyperlipidemia, its
The incidence of disease is just in the trend for rising year by year.Although hyperglycaemia is not a kind of disease, also not exclusively it is equal to diabetes, hyperglycaemia
There is inevitable inner link with diabetes, clinically hyperglycaemia easy induced Diabetic really, and suffer from hyperglycaemia for a long time
It is also possible to that eyes, kidney, blood vessel, heart, nerve etc. can be damaged.
Still lack the specific drug for the treatment of diabetes at present.The medicine of western medical treatment diabetes mainly includes orally-taken blood sugar reducing class medicine
Thing and insulin, oral hypoglycemic drug is including sulfonylureas, biguanides, prandial glucose regulator etc..Although the above medicine
There is certain curative effect to the treatment of diabetes, but its effect is not it is obvious that some drugs on patients also have poison in clinic
Side effect, the side effect of such as biguanides most serious is to cause lactic acidosis, and the death rate is 50% after generation, unsuitable long-term
Take.
The content of the invention
It is an object of the invention to provide a kind of Chinese and western medicinal composition for treating hyperglycaemia, with solving above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese and western medicinal composition for treating hyperglycaemia, be according to the primary raw material of weight portion：Red sage root 8-20 parts, glutinous rehmannia
15-17 parts, wind-weed 0.5-0.9 parts, serotonine 4-17 parts, dehydroevodiamine 18-25 parts, 11-15 parts of phellinus ketone G, thunder
Public rattan time 4-9 parts of alkali, 7-12 parts of garlic Li Lu alkali, 5-16 parts of scutellarin methyl esters.
As further scheme of the invention：The Chinese and western medicinal composition of the treatment hyperglycaemia, according to the main of weight portion
Raw material is：Red sage root 9-15 parts, glutinous rehmannia 15-17 parts, wind-weed 0.5-0.9 parts, serotonine 8-13 parts, dehydroevodiamine 21-
23 parts, 11-15 parts of phellinus ketone G, wilforine 4-9 parts, 9-11 parts of garlic Li Lu alkali, 9-14 parts of scutellarin methyl esters.
As further scheme of the invention：The Chinese and western medicinal composition of the treatment hyperglycaemia, according to the main of weight portion
Raw material is：12 parts of the red sage root, 16 parts of glutinous rehmannia, 0.7 part of the wind-weed, 11 parts of serotonine, 22 parts of dehydroevodiamine, phellinus ketone G 13
Part, 6 parts of wilforine, 10 parts of garlic Li Lu alkali, 12 parts of scutellarin methyl esters.
A kind of preparation method of the Chinese and western medicinal composition for treating hyperglycaemia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, the red sage root, glutinous rehmannia, the wind-weed, serotonine, dehydrogenation are weighed by above-mentioned metering ratio
Rutaecarpin, phellinus ketone G, wilforine, garlic Li Lu alkali, scutellarin methyl esters, sieving, machinery add ultra-pure water after mixing,
Place in pharmacy mixer, mix 4-8min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control is in 4-8
DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of hyperglycaemia.
As further scheme of the invention：Mix 6min in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of hyperglycaemia, so as to reach comprehensive rehabilitation
Purpose, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Chinese and western medicinal composition for treating hyperglycaemia, be according to the primary raw material of weight portion：8 parts of the red sage root, 15 parts of glutinous rehmannia,
0.5 part of the wind-weed, 4 parts of serotonine, 18 parts of dehydroevodiamine, 11 parts of phellinus ketone G, 4 parts of wilforine, garlic Li Lu alkali 7
Part, 5 parts of scutellarin methyl esters.
A kind of preparation method of the Chinese and western medicinal composition for treating hyperglycaemia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, the red sage root, glutinous rehmannia, the wind-weed, serotonine, dehydrogenation are weighed by above-mentioned metering ratio
Rutaecarpin, phellinus ketone G, wilforine, garlic Li Lu alkali, scutellarin methyl esters, sieving, machinery add ultra-pure water after mixing,
Place in pharmacy mixer, mix 4min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control are wrapped at 4 DEG C
Dress obtains final product the Chinese and western medicinal composition for the treatment of hyperglycaemia.
Embodiment 2
A kind of Chinese and western medicinal composition for treating hyperglycaemia, be according to the primary raw material of weight portion：9 parts of the red sage root, 15 parts of glutinous rehmannia,
0.5 part of the wind-weed, 8 parts of serotonine, 21 parts of dehydroevodiamine, 11 parts of phellinus ketone G, 4 parts of wilforine, garlic Li Lu alkali 9
Part, 9 parts of scutellarin methyl esters.
A kind of preparation method of the Chinese and western medicinal composition for treating hyperglycaemia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, the red sage root, glutinous rehmannia, the wind-weed, serotonine, dehydrogenation are weighed by above-mentioned metering ratio
Rutaecarpin, phellinus ketone G, wilforine, garlic Li Lu alkali, scutellarin methyl esters, sieving, machinery add ultra-pure water after mixing,
Place in pharmacy mixer, mix 4min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control are wrapped at 4 DEG C
Dress obtains final product the Chinese and western medicinal composition for the treatment of hyperglycaemia.
Embodiment 3
A kind of Chinese and western medicinal composition for treating hyperglycaemia, be according to the primary raw material of weight portion：12 parts of the red sage root, glutinous rehmannia 16
Part, 0.7 part of the wind-weed, 11 parts of serotonine, 22 parts of dehydroevodiamine, 13 parts of phellinus ketone G, 6 parts of wilforine, garlic multitude
10 parts of reed alkali, 12 parts of scutellarin methyl esters.
A kind of preparation method of the Chinese and western medicinal composition for treating hyperglycaemia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, the red sage root, glutinous rehmannia, the wind-weed, serotonine, dehydrogenation are weighed by above-mentioned metering ratio
Rutaecarpin, phellinus ketone G, wilforine, garlic Li Lu alkali, scutellarin methyl esters, sieving, machinery add ultra-pure water after mixing,
Place in pharmacy mixer, mix 6min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control are wrapped at 6 DEG C
Dress obtains final product the Chinese and western medicinal composition for the treatment of hyperglycaemia.
Embodiment 4
A kind of Chinese and western medicinal composition for treating hyperglycaemia, be according to the primary raw material of weight portion：15 parts of the red sage root, glutinous rehmannia 17
Part, 0.9 part of the wind-weed, 13 parts of serotonine, 23 parts of dehydroevodiamine, 15 parts of phellinus ketone G, 9 parts of wilforine, garlic multitude
11 parts of reed alkali, 14 parts of scutellarin methyl esters.
A kind of preparation method of the Chinese and western medicinal composition for treating hyperglycaemia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, the red sage root, glutinous rehmannia, the wind-weed, serotonine, dehydrogenation are weighed by above-mentioned metering ratio
Rutaecarpin, phellinus ketone G, wilforine, garlic Li Lu alkali, scutellarin methyl esters, sieving, machinery add ultra-pure water after mixing,
Place in pharmacy mixer, mix 8min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control are wrapped at 8 DEG C
Dress obtains final product the Chinese and western medicinal composition for the treatment of hyperglycaemia.
Embodiment 5
A kind of Chinese and western medicinal composition for treating hyperglycaemia, be according to the primary raw material of weight portion：20 parts of the red sage root, glutinous rehmannia 17
Part, 0.9 part of the wind-weed, 17 parts of serotonine, 25 parts of dehydroevodiamine, 15 parts of phellinus ketone G, 9 parts of wilforine, garlic multitude
12 parts of reed alkali, 16 parts of scutellarin methyl esters.
A kind of preparation method of the Chinese and western medicinal composition for treating hyperglycaemia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, the red sage root, glutinous rehmannia, the wind-weed, serotonine, dehydrogenation are weighed by above-mentioned metering ratio
Rutaecarpin, phellinus ketone G, wilforine, garlic Li Lu alkali, scutellarin methyl esters, sieving, machinery add ultra-pure water after mixing,
Place in pharmacy mixer, mix 8min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control are wrapped at 8 DEG C
Dress obtains final product the Chinese and western medicinal composition for the treatment of hyperglycaemia.
Pharmacology test
1st, acute toxicity test
It is experiment with Chinese and western medicinal composition obtained in the embodiment of the present invention 3, it is continuous in 24h using gastric infusion mode
Administration 3 times, per minor tick 6h, is administered 300mg/kg doses every time, and daily accumulation medicine total amount reaches 900mg medicines/kg, equivalent to
90 times of people's quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, and its is average
Body weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung, kidney,
Brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This hair
Bright Chinese and western medicinal composition is without acute toxic reaction.
2nd, long term toxicity test
It is experiment with Chinese and western medicinal composition obtained in the embodiment of the present invention 3, using gastric infusion mode, by Chinese and Western of the present invention
Drug composition is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 100,200,300mg medicines/
Kg/d, 10,20,30 times equivalent to clinical dosage.After gastric infusion 24 weeks, general status, blood of the medicine of the present invention to animal
, without obvious influence, Systematic anatomy, organ coefficient and histopathological examination do not find yet for liquid index, blood parameters
Abnormal pathologic changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Chinese and western medicinal composition of the present invention is in long term toxicity test
In, do not find overt toxicity reaction and delayed toxicity reaction.It can be seen that, Chinese and western medicinal composition non-toxic reaction of the present invention is long-term to use
Medicine is safe and reliable.
3rd, clinical test
The hyperglycemic patients that in June, 2015 accepts for medical treatment in December, 2015；Totally 200 patients, wherein, male 100, women
100；Age 22-75 Sui, average age 42.6 years old；Course of disease 1-10, average 4.5 years.
The Chinese and western medicinal composition of the preparation of the embodiment of the present invention 3 is given, according to 100mg/kg/ days, 5 days as one therapeutic course (treatment
Two courses for the treatment of) carry out symptom follow-up record；Clinical efficacy criterion is that (1) effective diabetic symptom and complication disappear substantially
Lose, Hemorheology 5, fibrinolytic system 2 improved, fasting blood-glucose is less than 110mg/dl, twenty-four-hour urine sugar less than 5g or
Drop-out value is more than 50% before blood sugar urinary sugar is relatively treated；(2) effectively diabetic symptom and complication substantially mitigates, Hemorheology and
4 or 4 improvement derived above of fibrinolytic system, fasting blood-glucose is less than 150mg/dl, and twenty-four-hour urine sugar is less than 10g or blood sugar urinary sugar
Drop-out value is more than 30% before relatively treating；(3) invalid diabetic symptom and complication are not improved, or even aggravation.
Treatment results：200 patients, 162 recoveries from illness, 20 are effective, and 8 are effectively, 10 invalid, total effective rates
95.0%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (5)
1. a kind of Chinese and western medicinal composition for treating hyperglycaemia, it is characterised in that the primary raw material according to weight portion is：Red sage root 8-20
Part, glutinous rehmannia 15-17 parts, wind-weed 0.5-0.9 parts, serotonine 4-17 parts, dehydroevodiamine 18-25 parts, phellinus ketone G 11-
15 parts, wilforine 4-9 parts, 7-12 parts of garlic Li Lu alkali, 5-16 parts of scutellarin methyl esters.
2. it is according to claim 1 treatment hyperglycaemia Chinese and western medicinal composition, it is characterised in that the treatment hyperglycaemia
Chinese and western medicinal composition, be according to the primary raw material of weight portion：Red sage root 9-15 parts, glutinous rehmannia 15-17 parts, wind-weed 0.5-0.9 parts, 5- hydroxyls
8-13 parts of primary colours amine, dehydroevodiamine 21-23 parts, 11-15 parts of phellinus ketone G, wilforine 4-9 parts, garlic Li Lu alkali 9-11
Part, 9-14 parts of scutellarin methyl esters.
3. it is according to claim 1 and 2 treatment hyperglycaemia Chinese and western medicinal composition, it is characterised in that the treatment blood high
The Chinese and western medicinal composition of sugar, be according to the primary raw material of weight portion：12 parts of the red sage root, 16 parts of glutinous rehmannia, 0.7 part of the wind-weed, 5- hydroxyl colors
11 parts of amine, 22 parts of dehydroevodiamine, 13 parts of phellinus ketone G, 6 parts of wilforine, 10 parts of garlic Li Lu alkali, scutellarin methyl esters
12 parts.
4. a kind of preparation method of the Chinese and western medicinal composition for the treatment of hyperglycaemia as described in claim 1-3 is any, its feature exists
In concretely comprising the following steps：
First, in pharmaceutical grade clean area, the red sage root, glutinous rehmannia, the wind-weed, serotonine, dehydrogenation Wu Zhu are weighed by above-mentioned metering ratio
Cornel alkali, phellinus ketone G, wilforine, garlic Li Lu alkali, scutellarin methyl esters, sieving, machinery add ultra-pure water after mixing, and place
In pharmacy mixer, mix 4-8min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control are wrapped at 4-8 DEG C
Dress obtains final product the Chinese and western medicinal composition for the treatment of hyperglycaemia.
5. the preparation method of the Chinese and western medicinal composition for the treatment of hyperglycaemia according to claim 4, it is characterised in that specific step
Mixing 6min in rapid.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903236A (en) * | 2006-08-04 | 2007-01-31 | 朱海芸 | Medicine composition having activity of anti-diatebes |
| CN103877111A (en) * | 2014-03-25 | 2014-06-25 | 云南植物药业有限公司 | Herba erigernotis-flavone medicinal composition and preparation method thereof |
-
2016
- 2016-12-17 CN CN201611171913.5A patent/CN106728768A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903236A (en) * | 2006-08-04 | 2007-01-31 | 朱海芸 | Medicine composition having activity of anti-diatebes |
| CN103877111A (en) * | 2014-03-25 | 2014-06-25 | 云南植物药业有限公司 | Herba erigernotis-flavone medicinal composition and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 谢文英: "《常见中草药：彩色精华版》", 31 August 2016, 陕西科学技术出版社 * |
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Application publication date: 20170531 |