CN106727660A - Lift composition and its application of body immunity - Google Patents
Lift composition and its application of body immunity Download PDFInfo
- Publication number
- CN106727660A CN106727660A CN201611046135.7A CN201611046135A CN106727660A CN 106727660 A CN106727660 A CN 106727660A CN 201611046135 A CN201611046135 A CN 201611046135A CN 106727660 A CN106727660 A CN 106727660A
- Authority
- CN
- China
- Prior art keywords
- composition
- body immunity
- polysaccharide
- lentinan
- lifting body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The present invention provides composition and its application of lifting body immunity, comprising Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan, wherein Phellinus polysaccharide, Inonotue obliquus, and the weight ratio of coriolan and lentinan is (450~480)：(400~450)：(800~830)：(650~700).The composition of lifting body immunity of the invention has effect of strong scavenging hydroxyl etc., can be used for preparing various cosmetics, health products and antineoplastic.
Description
Technical field
The invention belongs to Medicines and Health Product field, it is related to a kind of composition for lifting body immunity and its application.
Background technology
Polysaccharide (polysaccharide) is that the ketone group containing or aldehyde that are formed are connected by glycosidic bond by the monose of more than 10
The polyhydroxylated polymer and its derivative of base, it is distributed widely in nature, is particularly present in the cell membrane of plant and microorganism
In.Recently as people's further carrying to the separation of polysaccharide compound, purifying, structural analysis and compound mensuration means
Height, there is new understanding to the biological function of polysaccharide compound, and such as polysaccharide is transported in cell recognition, intercellular substance, exempted from
The research that epidemic disease is adjusted and the aspect such as antitumor is acted on causes the extensive attention of people, wherein what is extracted from edible fungus is more
Sugar, more shows immunological regulation and antineoplastic important function, so that for seeking antitumor medicine illustrates good prospect.With
The change of environment for human survival, the change of Model of Nutrition, the change of medical model and world's spectrum of disease, pure chemistry medicine is
Through not adapting to the need for people prevent and cure diseases, recover one's original simplicity, back to nature, advocate natural drug and natural compound nutritional into
The integration factor of contemporary trend, food and natural drug, must exist with a kind of rigorous compound or compound state.
They are not individually individual in nature, are organic colonies, and these molecules are woven into a complexity to each other
Stereochemical structure, be embedded in the material on complicated structure, including proteins,vitamins,minerals etc. even thousands of kinds answer
Miscellaneous combination.They deal with Protean requirement and resist " all kinds of diseases and ailments " and embody magical function.Even to current bioscience
Cannot also be fully described and understand it.It is more important as not only having complete, high content and high-quality normal nutrition in fungi
Be the physiological activator for having many steady chemical structures, function distinguished.These active material configurations are complicated, and species is various,
Effect differs, and single β-polysaccharide just has hundreds of, and triterpenes is also gone up and hundred kinds, also alkaloid, adenosine class, vitamin etc..This
It is a little to be combined into the excellent type for being grouped into natural " monarch ", serve the effect for preventing and treating various diseases.
Edible fungi polysaccharide has sp act mostly, and different edible fungi polysaccharides its structures is also differed, and has difference to human body
Treatment and opsonic action.These polysaccharide have very strong graftable activity, and Ecology grafting is carried out according to " monarch " pharmacology
Polysaccharide-based because, with more fully diagnosis and treatment based on an overall analysis of the illness and the patient's condition effect, that is, suit the medicine to the illness again to disease, from outward appearance to inner essence, full side is carried out to disease
Position conditioning, until rehabilitation.At present, the synergy research about complex polysaccharide has caused the interest of scholars, but compound
The effect of polysaccharide is not to exist complement each other, refinforce each other between the simple addition of single polysaccharide component, each composition, it is also possible to
Mutually exclusive relation, it is added, collaboration or antagonism can not be ignored.Because polysaccharide can produce collaboration, addition after compound
Or antagonism interaction and cause curative effect improve or reduce, using which kind of mode be combined compatibility develop complex polysaccharide
In play conclusive effect, this respect is explored and is not only necessary, is also very valuable.
The content of the invention
A kind of at least one deficiency in order to overcome prior art of the invention, there is provided composition for lifting body immunity,
To realize combining the purpose that lower complex polysaccharide reaches the clearance rate of hydroxy radical maximum herein.
To achieve these goals, the present invention uses following technical scheme：
The composition of body immunity is lifted, comprising Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan, its
The weight ratio of middle Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan is (450~480)：(400~450)：(800
~830)：(650~700).
Further, the weight ratio of Phellinus polysaccharide in the composition, Inonotue obliquus, coriolan and lentinan is
(460~470)：(410~430)：(800~810)：(655~680).
Preferably, the weight ratio of Phellinus polysaccharide in the composition, Inonotue obliquus, coriolan and lentinan is
4.66：4.22：8.09：6.64.
Further, composition described in the composition also includes excipient.Excipient of the present invention, the excipient
Be refer to increase the stability of invention formulation, pH value, permeability, bioavilability and transparency etc., without producing secondary work
With, the additional material in addition to main ingredient that does not affect the treatment, including but not limited to adhesive, filler, disintegrant, lubricant, anti-
Rotten agent, antioxidant, flavouring, aromatic, cosolvent, emulsifying agent, solubilizer, osmotic pressure regulator, colouring agent etc..
The present invention also provides application of the composition of above-mentioned lifting body immunity in health products are prepared.It is of the invention multiple
Closing polysaccharide composition has the good result of scavenging hydroxyl, and with strengthen immunity and antitumous effect, can be used for
Prepare the health products of various strengthen immunities.
The present invention also provides application of the composition of above-mentioned lifting body immunity in cosmetics are prepared.
Complex polysaccharide composition of the invention has the good result of scavenging hydroxyl, can add in various cosmetics
In, or composition needed for adding other cosmetics based on this complex polysaccharide composition, it is made cosmetics.
The present invention also provides application of the composition of above-mentioned lifting body immunity in antineoplastic is prepared.
When antineoplastic is prepared into, described pharmaceutical composition can be made the composition of lifting body immunity of the invention
Into suitable for being administered orally, being injected intravenously the various pharmaceutical dosage forms such as administration sublingual administration.Specifically used form includes tablet, particle
Agent, pill, capsule, lozenge, aqueous suspension or oil suspending agent, tincture, dispersible pulvis, solution, emulsion, suspending agent and other are suitable
Suitable form.
Available carrier includes glucose, lactose, dextrin, microcrystalline cellulose, Arabic gum, gelatin, mannitol, starch
Paste, magnesium stearate, talcum, silica gel and other carriers suitable for producing preparation with solid, semi-solid or liquid form.Separately
Auxiliary reagent, stabilizer, thickener can be used outward, can also be come from one or more flavor enhancement, colouring agent, antistaling agent etc.
The pharmaceutical preparation of good palatability is provided.Preferably, selection microcrystalline cellulose, dextrin, lactose, magnesium stearate are used as excipient substance.
Compared with prior art, the present invention has advantages below：
Screening by science of the invention, repetition test proves that the composition of lifting body immunity of the invention is permitted four
There is synergy between kind composition, its Immune-enhancing effect and antitumor action are significantly improved.Rational compatibility is played each other
The effect of complementing each other between medicine, can significantly improve curative effect.
Found by experiment, same dose level, four kinds of single polysaccharide Scavenging action to hydroxyl free radical sums are
57.13%, and the Scavenging action to hydroxyl free radical of the composition of lifting body immunity of the invention is 78.41%.
It is that above and other objects of the present invention, feature and advantage can be become apparent, preferred embodiment cited below particularly,
It is described in detail below.
Specific embodiment
Embodiment 1
The composition of body immunity is lifted, its composition includes：
The weight ratio of Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan is 9：8：16：13.
Wherein above-mentioned polyose is commercially available, it is desirable to be the purified product of corresponding polyose, its purity requirement
More than 99%.
Embodiment 2
The composition of body immunity is lifted, its composition includes：
The weight ratio of Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan is 92：82：160：131.
Embodiment 3
The composition of body immunity is lifted, its composition includes：
The weight ratio of Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan is 4.66：4.22：8.09：6.64.
The composition solution of lifting body immunity is made of this formula, it is preferred that Phellinus is added in every liter of solution many
Sugared 4.66g, Inonotue obliquus 4.22g, coriolan 8.09g and lentinan 6.64g.
Found by experiment, under various concentrations when four kinds of polysaccharide are individually tested, four kinds of polysaccharide clearance rate sums
Complex polysaccharide is much smaller than, such as in 2.6g/L, four kinds of polysaccharide clearance rate sums are 13.15%, and complex polysaccharide is 16.9%；
During 5.2g/L, four kinds of polysaccharide clearance rate sums are 22.6%, when complex polysaccharide is then 44.12,22g/L, four kinds of polysaccharide clearance rates
Sum is 57.13%, and complex polysaccharide is 78.41%.
Embodiment 4
The composition of body immunity is lifted, its composition includes：
The weight ratio of Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan is 47：43：81：68.
Embodiment 5
The composition of body immunity is lifted, its composition includes：
The weight ratio of Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan is 48：45:83：70.
The above is the preferred embodiment of the present invention, it is noted that for the those of ordinary skill of this technology neighborhood
For, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (7)
1. the composition of body immunity is lifted, it is characterised in that the composition includes Phellinus polysaccharide, Inonotue obliquus, cloud
The weight ratio of sesame polysaccharide and lentinan, wherein Phellinus polysaccharide, Inonotue obliquus, coriolan and lentinan for (450~
480)：(400~450)：(800~830)：(650~700).
2. it is according to claim 1 lifting body immunity composition, it is characterised in that Phellinus is more in the composition
The weight ratio of sugar, Inonotue obliquus, coriolan and lentinan is (460~470)：(410~430)：(800~810)：
(655~680).
3. it is according to claim 1 lifting body immunity composition, it is characterised in that Phellinus is more in the composition
The weight ratio of sugar, Inonotue obliquus, coriolan and lentinan is 4.66：4.22：8.09：6.64.
4. it is according to claim 1 lifting body immunity composition, it is characterised in that described in the composition combine
Thing also includes excipient.
5. application of the composition of the lifting body immunity as described in claim 1-3 any one in health products are prepared.
6. application of the composition of the lifting body immunity as described in claim 1-3 any one in cosmetics are prepared.
7. as described in claim 1-3 any one lifting body immunity composition in antineoplastic is prepared should
With.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611046135.7A CN106727660B (en) | 2016-11-22 | 2016-11-22 | Promote composition and its application of body immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611046135.7A CN106727660B (en) | 2016-11-22 | 2016-11-22 | Promote composition and its application of body immunity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106727660A true CN106727660A (en) | 2017-05-31 |
| CN106727660B CN106727660B (en) | 2019-11-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611046135.7A Active CN106727660B (en) | 2016-11-22 | 2016-11-22 | Promote composition and its application of body immunity |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101695513A (en) * | 2009-10-28 | 2010-04-21 | 上海永神生物科技有限公司 | Composition with anti-tumor effect and application thereof |
| CN104382929A (en) * | 2014-11-25 | 2015-03-04 | 高秀媛 | Medicine for removing blood garbage and vivotoxin and preparation method thereof |
| CN104473144A (en) * | 2014-12-04 | 2015-04-01 | 褚兰坤 | Health food with anti-tumor effect and preparation process of health food |
| CN104840481A (en) * | 2015-04-15 | 2015-08-19 | 威海御膳坊生物科技有限公司 | Composite fungal polysaccharide product |
| WO2016040940A1 (en) * | 2014-09-12 | 2016-03-17 | Austin, Frank | Occidiofungin formulations and uses thereof |
-
2016
- 2016-11-22 CN CN201611046135.7A patent/CN106727660B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101695513A (en) * | 2009-10-28 | 2010-04-21 | 上海永神生物科技有限公司 | Composition with anti-tumor effect and application thereof |
| WO2016040940A1 (en) * | 2014-09-12 | 2016-03-17 | Austin, Frank | Occidiofungin formulations and uses thereof |
| CN104382929A (en) * | 2014-11-25 | 2015-03-04 | 高秀媛 | Medicine for removing blood garbage and vivotoxin and preparation method thereof |
| CN104473144A (en) * | 2014-12-04 | 2015-04-01 | 褚兰坤 | Health food with anti-tumor effect and preparation process of health food |
| CN104840481A (en) * | 2015-04-15 | 2015-08-19 | 威海御膳坊生物科技有限公司 | Composite fungal polysaccharide product |
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| Publication number | Publication date |
|---|---|
| CN106727660B (en) | 2019-11-12 |
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