CN106727360A - A kind of diacerein solid dispersion preparation and preparation method thereof - Google Patents
A kind of diacerein solid dispersion preparation and preparation method thereof Download PDFInfo
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- CN106727360A CN106727360A CN201710082461.1A CN201710082461A CN106727360A CN 106727360 A CN106727360 A CN 106727360A CN 201710082461 A CN201710082461 A CN 201710082461A CN 106727360 A CN106727360 A CN 106727360A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The present invention relates to field of medicine preparations, a kind of diacerein solid dispersion preparation and preparation method thereof is specifically disclosed.Diacerein solid dispersion preparation of the present invention includes diacerein, PVP, specific lubricant and specific disintegrant and diluent.The result of extraction of invention formulation, bioavilability and stability, beneficial to the industrialized production of diacerein solid dispersion preparation.
Description
Technical field
The present invention relates to field of medicine preparations, and in particular to a kind of diacerein solid dispersion preparation and its preparation side
Method.
Background technology
1st, pharmacological action and clinical effect
Diacerein is the primary inhibitor of osteoarthritis IL-1.Confirmed through cell experiment and zoopery, the pharmacology of this product is made
With mainly having（1）This product can induce Chondrogenesis, with analgesic, anti-inflammatory and antipyretic effect；（2）Do not suppress prostaglandin and into；
（3）Play the role of to delay disease process to osteoarthritis.Pharmacokinetic shows, in animal and human body, oral is double
Vinegar it is auspicious because enter body circulation before through the Viability metabolite Rhein of deacetylation.Health adult's single oral administration reaches
Peak time is about 2.4 hours, and plasma protein binding rate is more than 99%, and plasma half-life is about 4.2 hours, the apparent biological profit of this product
Expenditure is 35%-56%., mainly through RE, fraction is also through bile excretion for metabolite Rhein.
The toxicological effect experiment of this product shows that the maximal tolerance dose of mouse and rat single-dose exceedes people's dosage
190 and 410 times, the maximal tolerance dose of dog exceedes 600 times of people's dosage（Calculated by body surface area dosage）.It is subacute, slow
Property and fetotoxicity experiment, fertility test, perinatal period and postpartum toxicity test, carcinogenic and teratology testing shows diacerein
With good security.
This product indication clinically is for treating degenerative joint disease（Osteoarthritis and relevant disease）；State
Interior research display, this product can significantly improve the symptoms such as the pain that osteoarthritis and relevant disease cause and joint function disturbance.Clothes
Effective with starting after 2-4 weeks, performance in 4-6 weeks is obvious.If continuous treatment is discontinued for 3 months later, curative effect is at least sustainable 1 month
（Carry-over effect）.
2nd, clinical practice
Usage and dosage is, orally.240mg-480mg (1-2), 3 times a day, or follows the doctor's advice.According to patient's state of an illness, connect
It is continuous to take for 4-12 weeks, if necessary in doctor's long-term treatment（It is not shorter than 3 months）：It is daily 1-2 times, 1 every time, take after the meal.By
May cause laxativeness in take diacerein first 2 weeks, it is therefore proposed that treatment first 4 weeks daily 1, clothes after dinner
With.After patient is adapted to medicine, dosage just should increase to that 2 times a day, after the meal orally.When doctor should determine treatment according to curative effect
Between, but the course for the treatment of should not be shorter than 3 months.In clinical trial, patient once continuously took this product 2 years and without any safety problem.If controlling
Needing to share other medicines in treatment carries out long-term treatment, should carry out within every 6 months once including the comprehensive blood including liver biochemistry enzyme
Liquid and urine test.Because this product works slowly（It is effective in 2-4 weeks after treatment）And good gastrointestinal toleration, it is proposed that giving
First 2-4 weeks of medicine can be with other anodyne or non-steroid anti-inflammatory drug use in conjunction.
Diacerein is not useable for less than 15 years old children, because this age group does not carry out any clinical trial.More than 70 years old,
And with serious renal insufficiency（CCr rate 10-30ml/min）Gerontal patient, must dosage halve or follow the doctor's advice.
Take improvement intestinal transport and（Or）During the medicine of intestinal contents property, taboo takes this medicine.To improve the biology profit of diacerein
Expenditure should avoid and meanwhile take containing aluminium hydroxide and（Or）The medicine of magnesium hydroxide.Can increase using anti-after taking diacerein
Raw element and（Or）Chemotherapeutic patient suffers from the possibility of enterocolitis, because antibiotic and chemotherapy can influence enteron aisle
Flora.Unexpected or spontaneous excessive use diacerein can cause diarrhoea.Without special solution.If diarrhoea continues, doctor need to be asked
Treatment.Internal fluid and electrolyte balance need to be repeatedly detected during emergent management.
The content of the invention
It is an object of the invention to provide a kind of diacerein solid dispersion preparation and preparation method thereof, the present invention is provided
Following technical scheme：
A kind of diacerein solid dispersion particles agent, including diacerein, PVP and lubricant；
The lubricant is selected from talcum powder, magnesium stearate, silica, sodium stearyl fumarate, lauryl sodium sulfate
Plant or two or more.
In certain embodiments of the present invention, the lubricant can be further selected from talcum powder, magnesium stearate, titanium dioxide
One kind in silicon, sodium stearyl fumarate, lauryl sodium sulfate, two or three；Further, the lubricant is optional
From：
Two kinds of lauryl sodium sulfate and magnesium stearate；
Two kinds of lauryl sodium sulfate and talcum powder；
Two kinds of silica and magnesium stearate；Or three kinds of lauryl sodium sulfate, silica and magnesium stearate.
Wherein, do not limited for the ratio between various lubricants, but in certain embodiments of the present invention, 12
Ratio between sodium alkyl sulfate and magnesium stearate, silica is 1:1:4, the ratio between lauryl sodium sulfate and talcum powder
Example is 1:2.
In certain embodiments of the present invention, in parts by weight, all formulations include 20-100 parts of diacerein,
50-200 parts of PVP and 2-6 parts of lubricant；The weight portion can use any conventional unit of weight table in a concrete fashion
Show, such as microgram, milligram, gram, kilogram, two, jin, kilogram, for example, specific manifestation shape of the granule with mg as weight portion
Formula, including 20-100mg diacereins, 50-200mg PVPs and 2-6mg lubricants.
In certain embodiments of the present invention, the PVP further selected from 30 POVIDONE K 30 BP/USP 25, PVP K30 or
30 POVIDONE K 30 BP/USP 90.
In certain embodiments of the present invention, the composition of the granule further can be as follows：
Granule filling capsule shells of the present invention are capsule preparations, therefore present invention also offers a kind of diacerein solid
Dispersion capsule, including granule of the present invention and capsule shells.
Present invention also offers the preparation method of the granule, diacerein, PVP and partial lubrication agent are mixed
Solid dispersions are prepared by melt extrusion method, rest lubricant is then added and is obtained the granule；Or double vinegar are auspicious
Cause and PVP are dissolved in organic solvent, and solid dispersions, addition profit are prepared by solvent evaporated method or spray drying process
The granule is obtained after lubrication prescription；
Wherein, when being prepared by melt extrusion method, the partial lubrication agent refers not only to an a kind of part for lubricant, but also
Refer to a certain lubricant during various lubricants, preferably prepared by melt extrusion method with silica containing various lubricants,
It is the partial lubrication agent with silica.
Additionally, the present invention also provides a kind of diacerein solid dispersions tablet, including diacerein, PVP, lubrication
Agent, disintegrant and diluent；
The lubricant is selected from talcum powder, magnesium stearate, silica, sodium stearyl fumarate, lauryl sodium sulfate
Plant or two or more；
The disintegrant is selected from PVPP, Ac-Di-Sol, sodium carboxymethyl starch, low substituted hydroxy-propyl fiber
One or more in element；
The diluent be selected from microcrystalline cellulose, starch, pregelatinized starch, lactose, mannitol, dextrin in one or two with
On.
In certain embodiments of the present invention, the PVP further selected from 30 POVIDONE K 30 BP/USP 25, PVP K30 or
30 POVIDONE K 30 BP/USP 90.
In certain embodiments of the present invention, the composition of the tablet further can be as follows：
Mode one：
| Component | Weight portion |
| Diacerein | 50 |
| PVP K30 | 100 |
| Microcrystalline cellulose 102 | 50 |
| Ac-Di-Sol | 20 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 232 |
Mode two：
| Component | Weight portion |
| Diacerein | 25 |
| PVP K30 | 100 |
| Microcrystalline cellulose 102 | 50 |
| Ac-Di-Sol | 20 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 172 |
Mode three：
| Component | Weight portion |
| Diacerein | 100 |
| PVP K30 | 200 |
| Microcrystalline cellulose 102 | 50 |
| Ac-Di-Sol | 20 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 382 |
Present invention also offers the preparation method of the tablet, diacerein and PVP are dissolved in organic solvent, and pass through
Solvent evaporated method or spray drying process prepare solid dispersions, are subsequently adding lubricant, disintegrant and diluent mixing pressure
Piece, obtains the tablet；Or diacerein, PVP and partial lubrication agent mixing are prepared into solid by melt extrusion method
Dispersion, then adds disintegrant, diluent and rest lubricant mixed pressuring plate, obtains the tablet；
Wherein, when being prepared by melt extrusion method, the partial lubrication agent refers not only to an a kind of part for lubricant, but also
Refer to a certain lubricant during various lubricants, preferably prepared by melt extrusion method with silica containing various lubricants,
It is the partial lubrication agent with silica.
Specific embodiment
The invention discloses a kind of diacerein solid dispersion preparation and preparation method thereof, method is as follows：
1st, melt extrusion method
Take the diacerein and PVP of recipe quantity, add partial lubrication agent, mix, to put and extrude the mixing in double screw extruder
Thing, in extrusion, deaerates, through two to turning calender roller, by the extrudate to melt to extruded tube applying vacuum through row
Calendering, then to cooling before grinding, obtains solid dispersions.
2nd, spray drying process
By the diacerein of recipe quantity, PVP, (acetone in organic solvent is dissolved in：Methyl alcohol v/v=1:1-2), spray drying,
85-90 DEG C of EAT, air quantity 20-25kg/hr, atomizing pressure 0.5-0.75bar, atomization gas flow 1.5-2.0kg/hr is supplied
Liquid stream 4.5-5.0ml/min, the spray-dried powders for obtaining are vacuum dried 24 hours at putting 45-60 DEG C, obtain solid dispersion
Body.
3rd, solvent evaporated method
By the diacerein of recipe quantity, PVP, (acetone in organic solvent is dissolved in：Absolute ethyl alcohol v/v=2:1st, acetone：Dichloro
Methane v/v=3:1st, methyl alcohol：Dichloromethane v/v=4:1 or acetone：Methyl alcohol v/v=3:1) in solvent, the water at 55-60 DEG C
Bath, vacuum 0.07-0.08MPa is recovered under reduced pressure organic solvent, after being in thick, continues reduced vacuum and dries 1-3h, is transferred to
In vacuum drying chamber, 40-65 DEG C dries the crushing of 80 mesh sieves excessively after 48h, obtains solid dispersions.
With reference to embodiment, the present invention is expanded on further.
Embodiment 1：Diacerein solid dispersions tablet
Prescription：
| Component | Weight portion |
| Diacerein | 50 |
| PVP K30 | 100 |
| Microcrystalline cellulose 102 | 50 |
| Ac-Di-Sol | 20 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 232 |
Preparation process：Solvent evaporated method
Diacerein, the PVP K30 of recipe quantity will be taken, acetone is dissolved in：Methyl alcohol (1:3) in solvent, in water-bath at 60 DEG C
Decompression volatilization, vacuum 0.07-0.08MPa is recovered under reduced pressure organic solvent, after being in thick, continues reduced vacuum and dries 1h,
It is transferred in vacuum drying chamber, 40 DEG C dry the crushing of 80 mesh sieves excessively after 48h, obtain solid dispersions.
Obtained solid dispersions are added microcrystalline cellulose pH102, Ac-Di-Sol, 12 of recipe quantity
Sodium alkyl sulfate, silica, mixing, direct tablet compressing.
Embodiment 2：Diacerein solid dispersions tablet
Prescription：
| Component | Weight portion |
| Diacerein | 100 |
| PVP K30 | 200 |
| Microcrystalline cellulose 102 | 50 |
| Ac-Di-Sol | 20 |
| Lauryl sodium sulfate | 10 |
| Talcum powder | 2 |
| Piece weight | 387 |
Preparation process：Solvent evaporated method
Diacerein, the PVP K30 of recipe quantity are taken, methyl alcohol is dissolved in：Dichloromethane (4:1) in solvent, the water-bath at 60 DEG C,
Vacuum 0.07-0.08MPa, is recovered under reduced pressure organic solvent, after being in thick, continues reduced vacuum and dries 1h, is transferred to vacuum
In drying box, 40 DEG C dry the crushing of 80 mesh sieves excessively after 48h, obtain solid dispersions.
Obtained solid dispersions are added microcrystalline cellulose pH102, PVPP, the dodecyl sulphate of recipe quantity
Sodium, talcum powder, mixing, direct tablet compressing.
Embodiment 3：Diacerein solid dispersions tablet
Prescription：
| Component | Weight portion |
| Diacerein | 25 |
| PVP K30 | 100 |
| Microcrystalline cellulose 102 | 50 |
| Ac-Di-Sol | 20 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 207 |
Preparation process：Solvent evaporated method
By the diacerein of recipe quantity, PVP K30, acetone is dissolved in：Dichloromethane (3:1) in solvent, the water-bath at 55 DEG C,
Vacuum 0.07-0.08MPa, is recovered under reduced pressure organic solvent, after being in thick, continues reduced vacuum and dries 3h, is transferred to vacuum
In drying box, 60 DEG C dry the crushing of 80 mesh sieves excessively after 48h, obtain solid dispersions.
Obtained solid dispersions are added pregelatinized starch, low-substituted hydroxypropyl cellulose, the dodecyl of recipe quantity
Sodium sulphate, silica, mixing, direct tablet compressing.
Embodiment 4：Diacerein solid dispersions tablet
Prescription：
| Component | Weight portion |
| Diacerein | 10 |
| PVP K30 | 100 |
| Lactose | 45 |
| Sodium carboxymethyl starch | 25 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 197 |
Preparation process：Spray drying process
By the diacerein of recipe quantity, PVP K30, acetone is dissolved in：Methyl alcohol (1:1) in solvent, spray drying, EAT
85 DEG C, air quantity 25kg/hr, atomizing pressure 0.5bar, atomization gas flow 1.5kg/hr, feed flow flow 4.5ml/min, the spray for obtaining
Mist dried powder is vacuum dried 24 hours at being placed in 45 DEG C, obtains solid dispersions.
Lactose, sodium carboxymethyl starch, lauryl sodium sulfate, the silica of solid dispersions addition recipe quantity will be obtained,
Mixing, direct tablet compressing.
Embodiment 5：Diacerein solid dispersion particles agent
Prescription：
| Component | Weight portion |
| Diacerein | 25 |
| PVP K30 | 100 |
| Microcrystalline cellulose 102 | 50 |
| Ac-Di-Sol | 20 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 107 |
Preparation method：Solvent evaporated method
By the diacerein of recipe quantity, PVP K30, acetone is dissolved in：Absolute ethyl alcohol (2:1) in solvent, microcrystalline cellulose is added
Element 102, Ac-Di-Sol dissolving, the water-bath at 60 DEG C, vacuum 0.07-0.08MPa is recovered under reduced pressure organic molten
Agent, after being in thick, continues reduced vacuum and dries 3h, is transferred in vacuum drying chamber, and 65 DEG C dry 80 mesh sieve powder excessively after 48h
It is broken, obtain solid dispersions.
Obtained solid dispersions are added microcrystalline cellulose 102, Ac-Di-Sol, the dodecane of recipe quantity
Base sodium sulphate and silica, mixing, packing obtain final product granule.
Embodiment 6：Diacerein solid dispersions capsule
Prescription：
| Component | Weight portion |
| Diacerein | 50 |
| PVP K30 | 100 |
| Microcrystalline cellulose 102 | 45 |
| Ac-Di-Sol | 25 |
| Lauryl sodium sulfate | 10 |
| Silica | 2 |
| Piece weight | 232 |
Preparation method：Spray drying process
By the diacerein of recipe quantity, 30 POVIDONE K 30 BP/USP 90, acetone is dissolved in：Methyl alcohol (1:2) in solvent, spray drying, EAT
90 DEG C, air quantity 20kg/hr, atomizing pressure 0.75bar, atomization gas flow 2.0kg/hr, feed flow flow 5.0ml/min are obtained
Spray-dried powders are vacuum dried 24 hours at being placed in 60 DEG C, obtain solid dispersions.
Obtained solid dispersions are added eicosyl sodium sulphate, the magnesium stearate of recipe quantity, mixing obtains particle
Agent, pours into 3# capsules as capsule preparations.
Claims (9)
1. a kind of diacerein solid dispersion particles agent, it is characterised in that including diacerein, PVP and lubricant；
The lubricant is selected from talcum powder, magnesium stearate, silica, sodium stearyl fumarate, lauryl sodium sulfate
Plant or two or more.
2. granule according to claim 1, it is characterised in that the lubricant is selected from talcum powder, magnesium stearate, titanium dioxide
One kind in silicon, sodium stearyl fumarate, lauryl sodium sulfate, two or three.
3. granule according to claim 1, it is characterised in that in parts by weight, including 20-100 parts of diacerein, 50-
200 parts of PVPs and 2-6 parts of lubricant.
4. the preparation method of granule described in claim 1, it is characterised in that by diacerein, PVP and partial lubrication agent
Mixing prepares solid dispersions by melt extrusion method, then adds rest lubricant and obtains the granule；Or will be double
Vinegar it is auspicious because and PVP be dissolved in organic solvent, solid dispersions are prepared by solvent evaporated method or spray drying process, add
Plus the granule is obtained after lubricant；
The lubricant is selected from talcum powder, magnesium stearate, silica, sodium stearyl fumarate, lauryl sodium sulfate
Plant or two or more.
5. preparation method according to claim 4, it is characterised in that in parts by weight, each parts by weight of raw materials is 20-100 parts
Diacerein, 50-200 part PVP and 2-6 parts of lubricant.
6. a kind of diacerein solid dispersions capsule, it is characterised in that including granule described in claim 1-3 any one
And capsule shells.
7. a kind of diacerein solid dispersions tablet, it is characterised in that including diacerein, PVP, lubricant, disintegrant
And diluent；
The lubricant is selected from talcum powder, magnesium stearate, silica, sodium stearyl fumarate, lauryl sodium sulfate
Plant or two or more；
The disintegrant is selected from PVPP, Ac-Di-Sol, sodium carboxymethyl starch, low substituted hydroxy-propyl fiber
One or more in element；
The diluent be selected from microcrystalline cellulose, starch, pregelatinized starch, lactose, mannitol, dextrin in one or two with
On.
8. tablet according to claim 7, it is characterised in that the lubricant is selected from talcum powder, magnesium stearate, titanium dioxide
One kind in silicon, sodium stearyl fumarate, lauryl sodium sulfate, two or three；
Characterized in that, in parts by weight, including 20-100 parts of diacerein, 50-200 parts of PVP, 2-6 parts of lubricant, 6-
10 portions of disintegrants and 20-80 parts of diluent.
9. the preparation method of tablet described in claim 7, it is characterised in that diacerein and PVP are dissolved in organic solvent
In, and solid dispersions are prepared by solvent evaporated method or spray drying process, it is subsequently adding lubricant, disintegrant and dilution
Agent mixed pressuring plate, obtains the tablet；Or mix by melt extrusion method preparation diacerein, PVP and partial lubrication agent
Solid dispersions are obtained, disintegrant, diluent and rest lubricant mixed pressuring plate is then added, the tablet is obtained；
The lubricant is selected from talcum powder, magnesium stearate, silica, sodium stearyl fumarate, lauryl sodium sulfate
Plant or two or more；
It is fine that the disintegrant is selected from PVPP, Ac-Di-Sol, sodium carboxymethyl starch or low substituted hydroxy-propyl
Dimension element；
The diluent be selected from microcrystalline cellulose, starch, pregelatinized starch, lactose, mannitol, dextrin in one or two with
On.
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| CN201710082461.1A CN106727360A (en) | 2017-02-16 | 2017-02-16 | A kind of diacerein solid dispersion preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710082461.1A CN106727360A (en) | 2017-02-16 | 2017-02-16 | A kind of diacerein solid dispersion preparation and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107982253A (en) * | 2017-12-06 | 2018-05-04 | 佛山市腾瑞医药科技有限公司 | A kind of Zaltoprofen solid dispersion preparation and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395484A (en) * | 2000-01-12 | 2003-02-05 | 梅迪多姆实验室股份有限公司 | Substances for use in treating psoriasis |
| CN106176618A (en) * | 2016-09-18 | 2016-12-07 | 佛山市弘泰药物研发有限公司 | A kind of Roflumilast solid dispersion preparation and preparation method thereof |
-
2017
- 2017-02-16 CN CN201710082461.1A patent/CN106727360A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395484A (en) * | 2000-01-12 | 2003-02-05 | 梅迪多姆实验室股份有限公司 | Substances for use in treating psoriasis |
| CN106176618A (en) * | 2016-09-18 | 2016-12-07 | 佛山市弘泰药物研发有限公司 | A kind of Roflumilast solid dispersion preparation and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107982253A (en) * | 2017-12-06 | 2018-05-04 | 佛山市腾瑞医药科技有限公司 | A kind of Zaltoprofen solid dispersion preparation and preparation method thereof |
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Application publication date: 20170531 |
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