CN106725990B - Intravenous self-administration intubation tube - Google Patents
Intravenous self-administration intubation tube Download PDFInfo
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- CN106725990B CN106725990B CN201611242899.3A CN201611242899A CN106725990B CN 106725990 B CN106725990 B CN 106725990B CN 201611242899 A CN201611242899 A CN 201611242899A CN 106725990 B CN106725990 B CN 106725990B
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- hose
- silica
- lateral openings
- administration
- connector
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A kind of intravenous self-administration intubation tube, including gasket, hard conduit, connector, coherent mass and hose, the L-shaped bending of hard conduit have vertical part and the horizontal part；Connector is set to the middle part in theaforesaid vertical portion；Connector above-mentioned and hard conduit are bonded on the end face of gasket by coherent mass, and vertical portion above-mentioned then vertical gasket setting；Hose one end and aforementioned levels portion are tightly connected, and the other end is then insertion end and end forms flush end opening, it is characterised in that the insertion end of the hose offers lateral openings at flush end opening rear, which is obliquely installed from back to front.Compared with the prior art, the advantages of the present invention are as follows: it is not easy incrustation blocking and leakage, while substantially prolonging service life.
Description
Technical field
The present invention relates to a kind of intravenously administrable instrument more particularly to a kind of medicine-feeding canulas, belong to medical equipment technical field.
Background technique
Intravenous self administration is one of most widely used animal model in drug habit research.In the model, animal
Behavior is touched by active pressing board or nose, obtains from jugular vein and enters intracorporal drug, complete effective intravenous self administration behavior.
Meanwhile intravenous self administration experiment generally lasted for as even some months in several weeks.Therefore, success rate, the stabilization of venous cannula operation
Property and maintained during can animal grow in effect self administration behavior using degree and seem even more important.Venous cannula is performed the operation
Guarantee the experiment basis that intravenous self administration is completed, and good and lasting venous channel be guarantee animal carry out it is permanently effective to
The essential condition of medicine.Intravenous self administration experiment generally lasted for as even some months in several weeks, because furthermore venous cannula perform the operation at
Power, stability and seem even more important using degree.Jugular vein intubation operation is the experiment for guaranteeing intravenous self administration and completing
Basis, and good and lasting venous channel is to guarantee that animal carries out the essential condition of permanently effective administration.
Intravenous self administration can be realized on many animals, including rat, mouse, primate, cat, dog etc., rat are
Carry out common a kind of experimental animal when physiology, pharmacology, Pharmacokinetics research.Meanwhile rat volume it is moderate and
Postoperative faster recovery also becomes animal the most commonly used in intravenous self administration experiment.But rat jugular vein blood vessel
Relatively thin, intubation difficulty is big, is easy to cause intubation time longer, to extend operating time, or even cause rat excessive blood loss or
It is dead.The unreasonable design and postoperative clean level of surgical catheters be not high, is easy to cause catheter blockage, increases zoogenetic infection wind
Danger, leads to fistulae and the failure of an experiment.In summary, it is ensured that successfully completed in the short time rat jugular vein intubation operation and it is longer
Effective self administration behavior is maintained in time, the preparation of conduit and intubation procedure are particularly important.
Basic accessory needed for jugular vein intubation operation is conduit, and it partially mainly includes back or head that conduit, which implants,
Portion.Wherein, intubation operation in back is divided into back piece and without two kinds of back piece again.Using the intubation technique of back piece can be with referenced patent number
The Chinese utility model patent " protective device of rat femoral intubation outer body " of ZL200520013524.0.But it exists
The deficiencies of troublesome in poeration, required the device is complicated, larger to rat wound.And the jugular vein intubation operation without back piece is because of its operation
Simplicity, required device simple is few to rat wound, and is widely used, currently, conduit needed for the jugular vein without back piece is performed the operation is exhausted
Most of is all the finished product of import, but the shortage of its fancy price and domestic factor, significantly limits this kind of conduit
Application at home.
For this purpose, the applicant is in being previously disclosed a kind of improved " intravenous self-administration intubation tube " (Authorization Notice No. CN
202036363U), see patent ZL 201120009256.0.Although the intubation of the patent disclosure, which has, manufactures convenient, material
It is easy to get, the lower advantage of manufacturing cost.But exist following insufficient:
First, only front opening, gives medicine or has led to pipe, it, can be another due to the effect of suction after extracting delivery tube
A bit of blood is sucked out in one open end, and so again and again, the open end in blood vessel can be more and more narrow, finally results in blocking and leakage
Liquid；
Second, will lead to flush end opening front in this way since silicone tube is foreign matter and gradually form a scab, so as to cause given drug
Or the outflow of heparin direction, which results in leakages；
Third, can gradually unclamp after being surgical ligation, when being administered in this way, due to direction active force, silicone tube can be made gradually
It retreats, finally pops up socket, influence administration process；
Fourth, shorter using validity period, the case where which generally maintains 4-6 days just to will appear blocking, leakage, and itself
It is 14 days that the maintenance phase, which is administered, so the intubation of side will at least maintain 7-10 days.
Therefore, existing medicine-feeding canula needs to improve.
Summary of the invention
It is a kind of long using validity period the technical problem to be solved by the present invention is to provide for the above-mentioned state of the art
Intravenous self-administration intubation tube.
Another technical problem to be solved by this invention is to provide one kind for the above-mentioned state of the art and be not easy to form a scab
Intravenous self-administration intubation tube.
Another technical problem to be solved by this invention is to provide one kind for the above-mentioned state of the art and be not easy to plug
With the intravenous self-administration intubation tube of leakage.
The technical scheme of the invention to solve the technical problem is: intravenous self-administration intubation tube, including
Gasket；
Hard conduit, L-shaped bending have vertical part and the horizontal part；
Connector, set on the middle part in theaforesaid vertical portion；
Connector above-mentioned and hard conduit are bonded on the end face of gasket by coherent mass, and vertical portion above-mentioned is then hung down
Straight gasket setting；And
Hose, one end and aforementioned levels portion are tightly connected, and the other end is then insertion end and end forms flush end opening,
It is characterized in that the insertion end of the hose offers lateral openings at flush end opening rear, the lateral openings are after
Turn forward setting.
Further, the lateral openings are multiple, and are staggered and are opened in the insertion end of hose.
Being successively arranged between the lateral openings rear can the first silica-gel sphere in implantable intravascular and for fixing hose
The second silica-gel sphere, aforementioned second silica gel bulb diameter be greater than the first silica gel bulb diameter.First silica-gel sphere is convenient in implantable intravascular,
First silica-gel sphere rear ligatures, it is ensured that the second hose will not move back pop-up socket.Second silica-gel sphere is placed in outside socket, main
It is used to fix the second hose, will not pull out or promote the second hose due to the wriggling of muscle in this way, the division of labor is clear, each to take charge of
Its duty.
The hose is located at the breeze way that the first silica-gel sphere rear has energy pitch of the laps, and ligation is in second after the breeze way pitch of the laps
Silica-gel sphere front position and can prevent the second silica-gel sphere loosen.The breeze way of pitch of the laps is replaced in the recovery of muscle layer and wriggling
The stress for silica-gel sphere, the power pulled in this way are not transferred on the second silica-gel sphere, it is ensured that the fixed solid effect of the second silica-gel sphere, from
Without will affect the second hose in blood vessel, avoid being drawn out.
Convenient for assembly, in the second hose that the hose includes the first hose and is connect with the first hose, also, first
The internal diameter of hose is adapted with the internal diameter of the outer diameter of vertical portion and the second hose, and the lateral openings peace end opening is opened
On the second hose.
Further, the coherent mass includes smooth support portion and the uprights that are raised in the middle part of support portion, and described
The lower end of connector be then located in uprights, the horizontal part is then located in support portion.
The vertical portion end of the hard conduit is further equipped with a conduit cap, and administration when opens conduit cap, has been administered
It is loaded onto after finishing, prevents foreign matter from entering in pipe.
Compared with the prior art, the advantages of the present invention are as follows: when administration and siphunculus, it can exclude at lateral openings
Blood, will not form a scab in this way；When administration, since medical fluid rushes lateral openings outflow, one power of hose, such pipe can be given
It will receive forward component, under this force, hose would not move backward；Again, lateral openings can be used as backup
Opening, flush end opening blood can make flush end opening blocking, but due to flush end opening lateral openings between be flooded with medical fluid,
Since the effect blood of pressure can only slowly be spread, incrustation speed in this way is very slow, in addition, daily siphunculus and administration, and laterally
Opening can not form a scab, and can be used as backup opening.Reliability improves, and is greatly prolonged to bring using validity period.
Detailed description of the invention
Fig. 1 is 1 structural schematic diagram of embodiment.
Fig. 2 is 1 three-dimensional cutaway view of embodiment.
Fig. 3 is the exploded view of connector, coherent mass and hard conduit in Fig. 1.
Fig. 4 is schematic diagram after embodiment 1 is performed the operation.
Fig. 5 is embodiment 1 and comparative example using effect comparison diagram.
Fig. 6 is 2 structural schematic diagram of embodiment.
Specific embodiment
The present invention will be described in further detail below with reference to the embodiments of the drawings.
Embodiment 1, as shown in Figure 1, Figure 2, Figure 3 and Figure 4, intravenous self-administration intubation tube include gasket 1, hard conduit 4, connect
Connector 3, coherent mass 2 and hose, gasket 1 be round plastic polypropylene material, have mesh, the L-shaped bending of hard conduit 4,
With vertical portion 41 and horizontal part 42.
Connector 3 is set to the middle part of vertical portion 41, has external screw thread；41 end of vertical portion of hard conduit 4 is further equipped with
Conduit cap (in figure without display) forms internal screw thread in conduit cap, matches with the external screw thread of connector 3, and administration when opens
Conduit cap is loaded onto after administration.
Connector 3 and hard conduit 4 are bonded on the end face of gasket 1 by coherent mass 2, and then vertical gasket 1 is set for vertical portion 41
It sets；Coherent mass 2 includes smooth support portion 22 and the uprights 21 for being raised in 22 middle part of support portion, and the lower end of connector 3 is then
In uprights 21, horizontal part 42 is then located in support portion 22.
Hose one end and horizontal part 42 are tightly connected, and the other end is then insertion end and end forms flush end opening 61, hose
Silicone tube can be used.Hose in the present embodiment includes the first hose 5 and the second hose 6 for connecting with the first hose 5, and
And first the internal diameter of hose 5 be adapted with the internal diameter of the outer diameter of vertical portion 41 and the second hose 6, lateral openings 62 and flush end
Opening 61 is opened on the second hose 6.
The insertion end of second hose 6 offers a lateral openings 62 at 61 rears of flush end opening, and the lateral openings 62 are certainly
After turn forward setting, i.e., consistent with opening direction and liquid flow direction, the main consideration following of design in this way:
Firstly, can exclude the blood at lateral openings when administration and siphunculus, will not form a scab in this way；
It,, can be soft to second since medical fluid rushes lateral openings outflow when administration secondly, according to hydromechanical principle
6 one power of pipe, such pipe will receive forward component, and under this force, the second hose 6 would not move backward；
Again, lateral openings 62 can be used as the opening of backup, and the blood of flush end opening 61 can make 61 blocking of flush end opening,
But due to being flooded with medical fluid 100 (heparin or being administered object) between flush end opening 61 and lateral openings 62, due to the effect of pressure
Blood can only slowly be spread, and incrustation speed in this way is very slow, and in addition, daily siphunculus and administration, lateral openings 62 are can not to tie
Scab, it can be used as backup opening.
Second hose 6 is located at the first silica-gel sphere 71 being successively arranged in energy implantable intravascular between 62 rear of lateral openings and uses
In the second silica-gel sphere 72 of fixed hose, 72 diameter of the second silica-gel sphere is greater than 71 diameter of the first silica-gel sphere.Second hose 6 is located at the
One silica-gel sphere, 71 rear has the breeze way 63 of energy pitch of the laps, and ligation is in 72 front position of the second silica-gel sphere after 63 pitch of the laps of breeze way
And the second silica-gel sphere 72 can be prevented to loosen.
Using small one and large one two silica-gel spheres, size is combined.First silica-gel sphere 71 its diameter is straight relative to vein blood vessel
Diameter is smaller, convenient for being ligatured in implantable intravascular at 71 rear of the first silica-gel sphere, it is ensured that the second hose 6 will not move back pop-up and insert
Mouthful.Second silica-gel sphere 72 is placed in outside socket, is mainly used for fixing the second hose 6, will not be pulled out in this way due to the wriggling of muscle
Or promote the second hose 6.
As shown in connection with fig. 5, administration process:
An osculum is opened in rat left/right chest, struts opening with scissors, and with scissors blunt separation skin and muscle layer, with
It is used all over back poling；With scissors separation muscle layer (moving towards separation along jugular vein 10), until seeing blood vessel, then in blood vessel two
It is segmented with scissors side；Blood vessel, and the muscle layer with arrow operation surgical forceps below the blood vessel are clamped with Smooth forceps, and with non-absorbing
Property suture wire tag.
Open back separates skin and muscle layer, is implanted into gasket 1, and clamp the second hose 6 with curved needle holders, passes through
Subcutaneously；Jugular vein 10 is erected with blunt nosed curved tweezer, an osculum is opened with fine shearing, the second hose 6 is cut into an angle such as Fig. 1 institute
Show, and is inserted into along blood vessel.
10 second silica-gel sphere of jugular vein, 72 two sides suture, by the breeze way 63 of the second hose 6 around a circle, in the second silica-gel sphere
72 two sides also ligature, pay attention to elastic moderate (administration is in general, power is moderate).The breeze way of pitch of the laps is in the extensive of muscle layer
It is multiple and when wriggling, substitute the second silica-gel sphere 72 and stress, the power pulled in this way is not transferred on the second silica-gel sphere 72, really
The fixed solid effect of the second silica-gel sphere 72 is protected, to will not influence the second hose 6 in blood vessel, avoids being drawn out.
Comparative example is ligatured using Patent No. ZL201120009256.0, and using silica-gel sphere two sides, due to muscle layer
Restore and wriggle, can be loosened at ligation, such silicone tube, which will pop up, to be come.
Fig. 5 is the contrast effect figure carried out after four groups of tests.According to formula: S=disposably succeeds number of elements/participation experiment always
Number of rats obtains following two groups of successful coefficients.
| Before improvement | 0.11 | 0.28 | 0.21 | 0.00 |
| After improvement | 0.63 | 0.71 | 0.91 | 0.88 |
From in attached drawing it can be seen that the present embodiment 1 in successful intubation greatly improve, meanwhile, also extended using validity period
Very much.
Lateral openings 62 in the present embodiment are 2, and are staggered in the insertion end for being opened in the second hose 6.Other structures
Reference implementation example 1, due to lateral openings 62 increase, incrustation and blocking a possibility that it is smaller.But the intensity of the second hose 6 is
Decline.
Claims (4)
1. a kind of intravenous self-administration intubation tube, including
Gasket；
Hard conduit, L-shaped bending have vertical part and the horizontal part；
Connector, set on the middle part in theaforesaid vertical portion；
Connector above-mentioned and hard conduit are bonded on the end face of gasket by coherent mass, and vertical portion above-mentioned then vertical pad
Piece setting；And
Hose, one end and aforementioned levels portion are tightly connected, and the other end is then insertion end and end forms flush end opening,
It is characterized in that the insertion end of the hose offers lateral openings at flush end opening rear, the lateral openings are from back to front
It is obliquely installed；
The lateral openings are multiple, and are staggered and are opened in the insertion end of hose；
The lateral openings rear is successively arranged can the first silica-gel sphere in implantable intravascular and for fixing hose and being placed in slotting
The second silica-gel sphere outside mouthful, aforementioned second silica gel bulb diameter are greater than the first silica gel bulb diameter；
The hose is located at the breeze way that the first silica-gel sphere rear has energy pitch of the laps, and ligation is in the second silica gel after the breeze way pitch of the laps
Ball front position and can prevent the second silica-gel sphere loosen.
2. intravenous self-administration intubation tube according to claim 1, it is characterised in that the hose include the first hose and
The second hose being connect with the first hose, also, the internal diameter of the internal diameter of the first hose and the outer diameter of vertical portion and the second hose is equal
It is adapted, the lateral openings peace end opening is opened on the second hose.
3. intravenous self-administration intubation tube according to claim 1, it is characterised in that the coherent mass includes smooth branch
Support part and the uprights being raised in the middle part of support portion, and the lower end of the connector is then located in uprights, the water
Flat portion is then located in support portion.
4. intravenous self-administration intubation tube according to claim 1, it is characterised in that the vertical portion end of the hard conduit
It is further equipped with a conduit cap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611242899.3A CN106725990B (en) | 2016-12-29 | 2016-12-29 | Intravenous self-administration intubation tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611242899.3A CN106725990B (en) | 2016-12-29 | 2016-12-29 | Intravenous self-administration intubation tube |
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| Publication Number | Publication Date |
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| CN106725990A CN106725990A (en) | 2017-05-31 |
| CN106725990B true CN106725990B (en) | 2019-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611242899.3A Active CN106725990B (en) | 2016-12-29 | 2016-12-29 | Intravenous self-administration intubation tube |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496049A (en) * | 2017-09-29 | 2017-12-22 | 深圳北京大学香港科技大学医学中心 | A kind of jugular vein long term administration indwelling pipe device and its application method |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234406A (en) * | 1992-04-06 | 1993-08-10 | The Regents Of The University Of California | Method and system for continuous spinal delivery of anesthetics |
| WO1997039789A1 (en) * | 1996-04-22 | 1997-10-30 | Medtronic, Inc. | Two-stage angled venous cannula |
| DE19949590A1 (en) * | 1998-10-14 | 2000-06-21 | Cardiothoracic Sys Inc | Cannula comprising flexible and inflexible tube sections with joints, use in various surgical procedures, e.g. Cardiopulmonary Bypass (CPB) |
| EP1825872A3 (en) * | 2006-02-23 | 2007-10-03 | Levitronix LLC | A pump-inflow-cannula, a pump-outflow-cannula and a blood managing system |
| US8403911B2 (en) * | 2008-04-22 | 2013-03-26 | Becton, Dickinson And Company | Systems and methods for improving catheter hole array efficiency |
| JP2012517271A (en) * | 2009-02-09 | 2012-08-02 | ヴェインフロー インコーポレイテッド | Intravenous cannula |
| CN202036363U (en) * | 2011-01-11 | 2011-11-16 | 宁波大学 | Intravenous self-administration intubation tube |
| US20160073937A1 (en) * | 2014-09-11 | 2016-03-17 | Becton, Dickinson And Company | Blood sampling system for improving draw success and reducing hemolysis |
| CN204813852U (en) * | 2015-07-31 | 2015-12-02 | 温州医科大学附属第一医院 | Making devices of toy right side heart pipe intubate |
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