CN106725572A - Low dosage digital X-ray image shelter - Google Patents

Low dosage digital X-ray image shelter Download PDF

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Publication number
CN106725572A
CN106725572A CN201611271084.8A CN201611271084A CN106725572A CN 106725572 A CN106725572 A CN 106725572A CN 201611271084 A CN201611271084 A CN 201611271084A CN 106725572 A CN106725572 A CN 106725572A
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image
vehicle
signal
ray image
ray
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CN106725572B (en
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高欣
梁志远
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Priority to CN201611271084.8A priority Critical patent/CN106725572B/en
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Priority to PCT/CN2017/117799 priority patent/WO2018121411A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44—Constructional features of apparatus for radiation diagnosis
    • A61B6/4411—Constructional features of apparatus for radiation diagnosis the apparatus being modular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4064—Arrangements for generating radiation specially adapted for radiation diagnosis specially adapted for producing a particular type of beam
    • A61B6/4085—Cone-beams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/90—Means for process control, e.g. cameras or sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60P—VEHICLES ADAPTED FOR LOAD TRANSPORTATION OR TO TRANSPORT, TO CARRY, OR TO COMPRISE SPECIAL LOADS OR OBJECTS
    • B60P3/00—Vehicles adapted to transport, to carry or to comprise special loads or objects
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/00—2D [Two Dimensional] image generation
    • G06T11/003—Reconstruction from projections, e.g. tomography
    • G06T11/005—Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/10—Formation of a green body
    • B22F10/12—Formation of a green body by photopolymerisation, e.g. stereolithography [SLA] or digital light processing [DLP]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/10—Formation of a green body
    • B22F10/18—Formation of a green body by mixing binder with metal in filament form, e.g. fused filament fabrication [FFF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/31—Calibration of process steps or apparatus settings, e.g. before or during manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7532—Artificial members, protheses
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10081—Computed x-ray tomography [CT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
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  • Automation & Control Theory (AREA)
  • General Physics & Mathematics (AREA)
  • Transportation (AREA)
  • Mechanical Engineering (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Pulmonology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
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  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The invention discloses a kind of low dosage digital X-ray image shelter, it is related to a kind of three-dimensional CT image reconstruction model based on compressed sensing.Sampling can be by the time and spatially continuous signal is changed into one group of discrete over time and space sequence of values, sampled using Nyquist Shannon sampling thheorems, when sample frequency is more than 2 times of (set up in practical application is 5~10 times) primary signal highest frequencies, can completely retain all information in primary signal.The appearance of compressed sensing technology can as much as possible reduce sample frequency on the premise of CT reconstruction qualities are ensured, the purpose of dose of radiation is reduced to reach.

Description

Low dosage digital X-ray image shelter
Technical field
The present invention relates to a kind of medical apparatus and instruments, it is more particularly related to a kind of low dosage digital X-ray shadow Image space cabin.
Background technology
The particularity of ruthlessness, military mission for war, disaster relief it is multiple, the quick treatment of the sick and wounded is proposed Requirements at the higher level.Currently, my army health support units at different levels must be relied on new equipment, there is provided quick, safety treatment.Make Wartime or non-military task health support reach such ability, and the task of top priority is that a new generation to be allowed defends diligent equipment and ensures under battle conditions Demand " seamless link ".In recent years, my army defends diligent change system digitlization, the level of IT application and improves constantly, field operation shelter, hospital The a collection of advanced duty equipment of defending such as ship, train hospital is come out one after another, and is realized mobile field hospital and is interconnected with central hospital of the entire PLA Intercommunication, remote medical consultation with specialists, recover to army, keep and improve its combat capabilities to serve important effect.
But, used as checking tool --- radiodiagnosis car important during duty is equipped is defended, it is right that existing weaponry and equipment cannot but meet The first aid demand of the wounded.Particularly during field operation or the disaster relief, for the quick diagnosis and emergency aid and treatment of craniocerebral injury, existing X Mobile x ray clinic can only provide 2 d fluoroscopy images, it is impossible to provide three-dimensional structure imaging, not only bad for Accurate Diagnosis, and It is unfavorable for that the three dimensions of focus in treatment is accurately positioned.In addition in existing XCY2002-1/200 types field X-ray diagnosis car X-ray detection system still uses film making pattern, does not use digital detector, seriously reduces the operating efficiency of system. The electric power system of this kind of x-ray diagnosis car still uses 380V power supplys, need to be by external 30kW power station trailers for it is powered, in heavy rain Weather increases danger of hazardous electrical discharges, while being also unfavorable for the arduous condition transport in field.
Furthermore, in operation, it may be necessary to diversified to treat patient with instrument and prosthese.In some applications In, emergency can be high.For example, as the soldier that treatment be wound, the condition of the injury is generally serious and needs to process as early as possible.Additionally, In military and non-military application, medical practitioner may perform the operation for requiring using instrument and/or replacing prosthese.These are held Dealer may be limited to space or can be brought into the quantity and type of the equipment at scene.
The fast pace of modern war and disaster relief is kept up with, and meets the demand higher of the rescue and treatment of the wounded, my army needs Medical field equipment with more best performance, wherein the X-ray medical image shelter that can provide multi-modality imaging function will be very big Improve the ability of health support.
The content of the invention
For case above, intend developing a new X-ray medical image shelter, the shelter can not only provide traditional X Actinoscopy X image and routine take the photograph piece, and it can also provide CT image informations, can carry out quick three-dimensional to any position of whole body Structure imaging simultaneously can provide 3D printing, and it will substitute the need to sending or storing the dummy of substantial amounts of operation instrument and customization Ask.This can be reduced to the perform the operation shipment and delivery cost in place and the reparation implant of reduction establishment operation or the time of instrument.
Present invention mainly solves be using compressive sensing theory overcome the shortcomings of lack sampling cause rebuild effect it is undesirable, For low-dose CT imaging is provided a method that, so as to reduce the dose of radiation that patient in CT examination is received as much as possible.By Flat panel detector is usually in the detector of Cone-Beam CT, compared to two-dimensional ct, its detector quantity is presented the growth of geometry multiple, The data volume of three-dimensional reconstruction image also accordingly increases, and thus results in and be related to the amount of calculation of corresponding observing matrix to increase sharply in the algorithm, The calculating time lengthens significantly.Using different projection angles, the orthogonal characteristic of CT projection patterns under the conditions of different detectors, I Parallel processing is carried out to the computing that is related to observing matrix, the time required for substantially reducing the iterative algorithm computing, while Solve observing matrix excessive, it is difficult to the problem of storage, reduce system resource occupation rate.
It is suitable for the instrument of OP and/or the device of prosthese and process present invention generally provides for production.This hair It is bright that a kind of image shelter with three-dimensional (3D) print capacity is provided, its will substitute to send or store substantial amounts of operation instrument and The demand of the dummy of customization.This can be reduced to the shipment and delivery cost in operation place and reduce the reparation implantation for creating operation The time of thing or instrument.Shelter can include scanner, computer, 3D printer and the original for printing operation instrument or prosthese Material.Thus instant invention overcomes when can printing speed Medical Devices, instrument and prosthese at the scene when, to transport and/or The demand of substantial amounts of Medical Devices, instrument and prosthese is stored at medical facilities.This device and method will allow only to need 3D fast freights to beat Print can rapid build movement Surgicenter.
The method of the present invention and equipment will allow direct virtual private net (VPN) Image Sharing, so that doctor at the scene Life can receive image, and cooperate to assist them to obtain appropriate implant/prosthese and for specific with other doctors The difficult of operation solves design.Because various difficult trauma situations generally show that its own is in the position of tool challenge (e.g., on the battlefield or region of war of military operation), so this is highly profitable.Device and method of the invention contribute to suffering from Person provides the nursing of highest standard.
Device and method of the invention can also access the data of storage and Medical Devices, instrument and the related information of prosthese Storehouse.It can also have make the implant of customization at the scene with scanning and Method of printing and create can help when needed The lifesaving of patient and the ability of therapeutic equipment.By all these characteristics, the disclosure can reduce the fortune of necessary surgical equipment Weight is sent, the time of the last implantation of lifesaving medical treatment implantable devices is reduced, and operating room is created within a few hours.Raw material Can supply and deliver by pre-packaged proprietary mode.
To be easy to description, term " prosthese " and " multiple prostheses " used in the present invention are used to indicate the class of implant Type, bone alternative, tissue alternative, prosthese or even can design and create in a device and with disclosed method it is whole Individual organ.Thus, as used in the present invention, term " prosthese " may indicate that facial implant (bone or the soft tissue plant of customization Enter), facial fracture and reparation, microtia support, eye prosthese, ose implant, upper jaw prosthese, palate prosthese, in it is false every prosthese, calvarium Body, mandibular alternative (bone collection printed matter), maxilla alternative, the soft tissue implant (Zone Full of body of customization Including but not limited to airway stent, intravascular stent, transplanting, percutaneous or operated vessels block equipment), hand/limbs implant/vacation Body, articular replacement (such as Minor articulus of wrist/refer to), large joint alternative (e.g., hip, knee, shoulder), backbone body alternative, long bone is replaced Change thing (femur, shin bone, fibula, radius, ulna, humerus), thoracic cavity alternative, pelvis defect repair, large joint alternative can not The dummy (e.g., refer to, other appendages, four limbs, corrective or obturation) of implantation, its combination, or other suitable implants.
In order to realize these purposes of the invention and further advantage, there is provided a kind of multifunctional digital X ray image Shelter, including：
Vehicle-mounted cone-beam CT imaging system, vehicle-mounted Cone-Beam CT rail structure, vehicle-mounted X-ray image information processing system, three-dimensional are beaten Print machine and 220V onboard power systems.
Preferably, the vehicle-mounted cone-beam CT imaging system of the image shelter is using the cone-beam CT imaging based on flat panel detector Pattern, using top slide rail structure, by cone-beam CT imaging system hang in shelter top and make its as needed it is scanning bed not It is imaged with position.Cone-beam CT imaging system carries out 360 ° of rotation exposures centered on slip ring, by cone-beam CT reconstruction technology, Three-dimensionalreconstruction is carried out to imaging object, imaging object three-dimensional internal structural information is obtained, on the display device display image；To beating Print machine sends image；And instrument or prosthese are printed according to the image on printer.
Preferably, the vehicle-mounted cone-beam CT imaging system includes：
Frame, it is vertically erected in the mobile device of CT scanner；Cage-type rotary part, including the first rotation accessory, The seamed edge of the second rotation accessory and the connection first rotation accessory and the second rotation accessory, the first rotation accessory passes through Floating bearing is rotatably arranged in the frame, and the cage-type rotary part and frame are circular ring, circle ring center's conduct The scanning holes of CT scanner；Imaging system, it has the X being arranged on along axle Central Symmetry on the second rotation accessory homonymy wall Ray source component and detector assembly, the X-ray source component are fixed on the second rotation accessory with the detector assembly, described Detector assembly correspondence receives the emergent ray from the X-ray source component；And be inclined on the first rotation accessory Turbine assembly, the gear wheel for engaging is fixedly installed on the one side different from the described first rotation accessory of frame, described first The axis of rotation accessory, frame, gear wheel and the second rotation accessory overlaps, and turbine assembly drives the cage-type rotary portion by motor Part rotates in a circumferential direction around gear wheel, and cable connects power supply and the imaging system by the cage-type rotary part；Wherein, the X Using pencil-beam as outgoing beam, the imaging system is rotated a circle right to complete ray source component with dynamic volume scan mode The scanning imagery process of object.
Preferably, the vehicle-mounted X-ray image information processing system is the three-dimensional CT image algorithm for reconstructing based on compressed sensing：
Algorithm (TV minimization by Augmented are minimized using the TV of augmentation Lagrange and alternating direction Lagrangian and Alternating direction ALgorithms, TVAL3) be then with compressive sensing theory be the back of the body Scape, with reference to augmentation Lagrangian method and alternating direction method, a kind of optimal of image reconstruction is carried out to the data for projection after lack sampling Change method.Using compressed sensing reconstruction general type and two dimensional image gradient-structure the characteristics of, select total variation (Total Variation, TV) is minimized as object function, carries out the solution of optimization problem：
Wherein x is 3-D view to be reconstructed, and b is the data for projection obtained by lack sampling, and A is observing matrix, DiX is referred to The discrete gradient of ith pixel on reconstruction image x.The formula regularization part is equidistant TV norms, can also equally use non-equidistant TV norms --- TVa(x)=∑i||Dix||1Object function is solved carries out problem reduction.
Further object function is transformed, by introducing shrink functions wiInstead of image gradient, while obtaining it Related Augmented Lagrangian Functions：
vi, λ is Lagrange multiplier.Wherein for reconstruction image x, we have used gradient descent method and have been iterated more Newly.Substitute into the parameter obtained by last iteration so that Augmented Lagrangian Functions LA(wi, x, vi, λ) and it is changed into one on x two Equation of n th order n, its pressure gradient expression formula is as follows：
By selecting suitable iteration step length, then the general framework of alternating direction method (ADM) is substituted into, to above-mentioned object function It is iterated, it is possible to realize constantly approaching for true reconstruction image.Specific iterative step is as follows：
And different TV norms are directed to, its corresponding shrink function representations form is also different, for equidistant TV norms Speech：
For non-equidistant TV norms：
Preferably, three-dimensional printer includes：Image acquisition equipment, the autoclaving for the output sterilizing for 3D printer The scanner of device or miscellaneous equipment and checking printed product.Same offer of the invention uses its method.Using 3 D-printing The long-range image acquisition equipment of image acquisition equipment and three-dimensional printer in machine, or by access have it is relative The database of prestored digital image data and obtain the image of desired operation instrument or prosthese.Image be then communicated to printer with Printing.By this way, the disclosure provides the device and method of the hypervelocity prototype of the dummy/instrument for application of performing the operation.One The application for planting the suitable fast freight container for the disclosure is in military affairs, because its permission creates mobile military affairs doctor within a few houres Treat facility.Three-dimensional printer can be prepositioned before its needs.To describe in more detail below other application and Characteristic.
Device and method of the invention are discussed in the environment of three-dimensional (3D) printing.3D printing may include but be not limited to：It is all Such as method：Fused glass pellet, melt filament (filament) making, automatic mortar injection forming (robocasting), electron beam without Molding work, direct metal laser sintering, electronic torch melting (melting), selective laser melting, selective thermal sintering, selection Property 3D printing laser sintered, based on gypsum, laminated solid mass manufacture, Stereolithography (stereolithography) and numeral Light treatment.Also can be using the process of " decrement " manufacture.In this embodiment, same as above, image acquisition equipment will send to be expected Prosthese image to computer.There are amendment or the final image without amendment to be sent to maker.Maker uses decrement side Method next life maternity leave body, wherein prosthese can be cut by solid implantable material to dig.Decrement method may include that lathe process is false Body, is cut, punching press with laser, water or air knife cutting element, is ground or is carved.
By " being used in operation ", it is intended that prosthese and/or instrument in identical OP or with obtain Take the position identical surgery location of the image that prosthese is based on and print or make.It is currently available that equipment or method may indicate that " rapid prototyping ", but this typically mean when obtain specific part image when, then by it during it can need several weeks Send so as to remote printing.Using term " hypervelocity prototype " and " in operation ", the present invention is set to be different from these processes.In the present invention Method in, required prosthese can be provided during OP.One of most unique aspect of the invention is come for patient Say, the scanning of patient and the treatment of image, and the printing of dummy or other implantable equipment can be anaesthetized in single Lower completion.
Software program or algorithm can be embedded on computer, and can cause acquired image will in monitor or Shown on other displays.Software program can allow doctor, technician, either with or without the input from patient oneself When, the image of scanning is customized to desired setting or characteristic.Final image (as being applicable, the image being customized) and then is sent out Printer or maker are sent to create.As previously discussed, printer or maker are in fast freight appearance together with computer one In device.This time quantum needed for the prosthese that production is used in OP is greatly reduced.
In one embodiment, image acquisition equipment, computer and printer or maker are placed on 3 D-printing jointly In machine.In another embodiment, computer, printer, sterilizing installation and checking scanner can be placed in shelter jointly. No matter which kind of mode, the device and method of the disclosure be oriented so that hypervelocity prototype for may, so as to eliminate or significantly reduce obtain The amount of delay of prosthese or instrument needed for obtaining.Depending on the particular type of medical procedure, the printer after final image is obtained Or the time cycle of maker offer prosthese can change.The scope of the time cycle can be small to 24 from ten minutes When, or any subrange therebetween.Time cycle can also be or any son therebetween from 30 minutes to 12 hours Scope.
When three-dimensional printer of the invention is used in operation application, the actual operation program to patient can be in shelter Interior generation.The present invention is it is also contemplated that OP can be in the generation of the outside of shelter, so that shelter is used as produced prosthese or hand The make-up room of art instrument.Shelter can be used to print desired instrument or prosthese, and be packed to be delivered to other Facility or position.If desired, packaging can be completed with sterilization method.As non-limiting example, 3 D-printing of the invention Machine can be deployed in the ground of existing hospital facility.User can print desired instrument or prosthese, and fast freight container can be with It is packaged in sterilization packaging.The place by OP is implemented is arrived in user and then the part transport that can be packed.
On Military Application, soldier is currently afield stablized, and evacuate to the second place (e.g., after the war) with do into One step medical treatment and nursing.Method using being discussed in the invention, the operation of further determining property can occur in soldier by task region of war Before withdrawing, this might mean that saving their life, eyesight or four limbs.Using digital X-ray image shelter of the invention and The database of the data related to operation instrument and prosthese for having stored, device and method of the invention can be produced to have and are finished The complete operating room of type instrument is abandoned, it can be by the method for the invention by quick (＜ 24 hours) and cheap Build.Therefore, for doctor and anesthetist, it is necessary to the only stock for being provided to build instrument will be setting from database Meter and the raw material for printing.These can be used for building from implant and scalpel to tracheal catheter that is flexible or strengthening, Any object of tracheostomy tube or airway stent.Finally, bought under the method that is currently available that implant or prosthese into Originally can be high.Device and method for printing the specific implant of patient of the invention, will save the big reward for writing or painting of army Gold, because it will eliminate the demand to becoming the implantable dummy of big stock that is unpasteurized and causing traumatic infection.
Other applications for being suitable for shelter of the invention are probably in devastated.Along with such as hurricane or earthquake Natural calamity, it is traditional or be currently available that power system and medical services may be interrupted.In this condition, the present invention Digital X-ray image shelter can by deployment be used for emergency scene medical rescue.Digital X-ray image shelter of the invention Can be used in existing medical facilities (such as policlinic), the space of the medical facilities may be of great value and with additional flexible Property, with perform can be or can not be facility standard capability part operation.The digital X-ray in the application of the invention The use of image shelter can also be conducive to vacateing existing memory space in these facilities, and it can be used for stock's customization or non-fixed The implant of system.
Device and method including database of the invention, can provide the means for changing the mode for supporting to build hospital. Cost savings needed for offer will be made the doctor at scene that required equipment and dummy can be used by this, think that patient carries For more preferable nursing quality.
Printer of the invention or maker can also eliminate vacation in device and method are currently available that and implantable The time of the sterilizing correlation of body.At present, when doctor after printing time delay when implantable prosthese is received, exist and gone out with prosthese The related additional period of bacterium, its cost for further increasing program and the risk to patient.However, using equipment of the invention and Method, the time is significantly reduced or is completely eliminated.Printer that device and method of the invention are provided or maker can be with Sterilized prosthese soon to use is provided.In the case where prosthese is produced via the lathe process of computer guiding, The processing of prosthese will be likely to remain that sterilizing, but lathe process process can be rapider than printing, so sterilizing is used Additional period should not be long.
The material for being suitable for prosthese of the invention may be different.Material can include the poly- breast checked and approved for implantable devices Acid and acronitrile-butadiene-styrene.The other materials of anticipation may include rubber, photo-curable polymer, metal, ceramics and The entity of implantable immersion antibiotic.
In addition to the implantation prosthese being suitable in patient's body, device and method of the invention can be that doctor and patient carry For surgical planning model and cutting guide.For example, doctor can hold the model of bone or skull, and formulate where and will implement to cut The plan of mouth or resected bone.Doctor can also equally to the tender or guardian's explanation of patient or patient.
Although as described above, shelter of the invention or other suitable modular receptacles can be used in Military Application 3 D-printing, but it is also envisioned that other application.Shelter of the invention can be used for wherein at various positions its mobility for Easily medical treatment and/or the useful any application of laboratory services are provided.For example, in power infrastructures and possible into equipment The natural calamity region being interrupted, the medical centre in the region has been endangered, or other are on the nonessential region of war in war In remote areas.3 D-printing aspect of the invention is particularly advantageous, but shelter of the invention also can be comprising other medical treatment dresses Standby, instrument is prefabricated the prosthese made or print.
Brief description of the drawings
Fig. 1 is X-ray medical image shelter perspective imaging modes schematic diagram of the invention.
Fig. 2 is the vehicle-mounted cone-beam CT imaging system in the present invention.
Fig. 3 is exemplary to provide many image frame treatment.
Fig. 4 is 3 D-printing process provided in an embodiment of the present invention.
Specific embodiment
As shown in figure 3, the processing unit 1 of present embodiment and endoscope 2 (mirror body), light supply apparatus 3, display device 4, X X-ray apparatus 5 is connected, and the endoscope 2 is generated endoscope with importeding into subject to being shot in vivo for subject The image pickup part 21 of picture signal, the light supply apparatus 3 generation illumination light L and before being supplied to endoscope 2 via light guide cables 22 End, the display device 4 is by having used liquid crystal or organic EL (Electro Luminescence：Electroluminescent) the structure such as display Into, the X-ray apparatus 5 generation radioscopic image signal, and 1 pair of endoscopic images signal from the input of endoscope 2 of the processing unit Implement the image procossing of regulation and also the radioscopic image signal to being input into from X-ray apparatus 5 implement the image procossing of regulation, And image corresponding with synthesized image signal is shown in display device 4, the synthesized image signal is after being arranged image procossing Endoscopic images signals and X-ray signal and be synthesized into.Processing unit 1 makes synthesized image signal be shown in display dress Put in 4 display picture, the synthesized image signal will be displayed with the picture of image corresponding with radioscopic image signal and show The picture of endoscopic images signal the two pictures are represented as major-minor picture.Processing unit 1 is to endoscope 2, light supply apparatus 3 And the action of display device 4 is controlled.
Processing unit 1 have input unit 11, control unit 12, image processing part 13, display control unit 14, output section 15, with And storage part 16.
Input unit 11 is realized using operation equipments such as mouse, keyboard and touch panels, and receives various configured informations Input.Specifically, input unit 11 receives the information of the subject that endoscope 2 and X-ray apparatus 5 are checked and (such as ID, goes out Raw date, name etc.), the identification information (such as ID and the corresponding project of inspection) of endoscope 2, the identification volume of X-ray apparatus 5 Number and the various configured informations such as the scope of examination input.
Control unit 12 is realized using CPU etc..The treatment action in each portion of the control process device 1 of control unit 12.Control unit 12 by carrying out transmission of configured information or data of each structure for processing unit 1 etc. come the action of control process device 1. Control unit 12 is connected via each cable with image pickup part 21, each structure position of light supply apparatus 3 and display device 4, so that also right The action of image pickup part 21, light supply apparatus 3 and expression device 4 is controlled.
Image processing part 13 is according to the control of control unit 12, the endoscopic images signal generated to image pickup part 21 and from X The signal transacting that the radioscopic image signal of the input of x-ray apparatus 5 is specified.Image processing part 13 have remaining white test section 13a, Region-of-interest cut-out portion 13b (region-of-interest configuration part and cut-out portion), zoom portion 13c, endoscopic images processing unit 13d, And combining unit 13e.Radioscopic image signal is with the operating personnel image part for manifesting subject of interest and is arranged at The picture signal of the remaining white part around image part.Remaining white part is brightness or the uniform homogeneous area of color.
Remaining white test section 13a detects radioscopic image by detecting the brightness of radioscopic image signal or the change of color Remaining white part in signal.
Remaining white portion in radioscopic image signals of the region-of-interest cut-out portion 13b according to more than detected by white test section 13a Point, initial region-of-interest corresponding with the image part in radioscopic image signal is set, and cut from radioscopic image signal Go out the initial region-of-interest of the setting.
Zoom portion 13c corresponds to the radioscopic image of the expression device 5 as the expression object of radioscopic image signal Represent picture size, and generate zoom in or out close by note region cut-out portion 13b cut out from radioscopic image signal it is initial Picture signal obtained from region-of-interest, as the region-of-interest picture signal for representing initial region-of-interest.
Endoscopic images processing unit 13d is carried out comprising the black subtraction of optics to the endoscopic images signal being input into from endoscope 2 Treatment, Gain tuning treatment, the treatment of the synchronization process of picture signal, gamma correction, white balance (WB) adjustment treatment, color moment Battle array calculation process, color reproduction treatment and edge enhancement treatment etc. are in interior various image procossings.
Combining unit 13e is generated and is exported synthesized image signal, and the synthesized image signal is arranged by zoom portion 13c The region-of-interest picture signal that is generated and the endoscopic images signal after treatment is implemented simultaneously by endoscopic images processing unit 13d It is synthesized into.
Synthesized image signal that display control unit 14 is exported according to combining unit 13e and generate for being shown in display device 4 Display picture signal, and after the display picture signal of generation is converted into analog signal from data signal, will turn The picture signal of the analog signal after changing is changed to the forms such as high-resolution mode and exports give expression device 4.In addition, there is also aobvious Showing device 4 has a case that a part for the effect of display control unit 14.
Output section 15 is realized using loudspeaker or printer etc., and the output section 15 is defeated according to the control of control unit 12 Go out the information relevant with the display processing of endoscopic images signal and radioscopic image signal.
Storage part 16 realized using volatile memory or nonvolatile memory, and the storage part 16 be stored with for Make the various programs of processing unit 1, endoscope 2 and light supply apparatus 3 action.Storage part 16 temporarily stores the place of processing unit 1 Information in reason.Storage part 16 can also use storage card installed from the outside of processing unit 1 etc. to constitute.
Reference picture 3, shows 3 D-printing process (100) of the invention.First, user can use optical scanner Equipment (101), medical imaging devices (102), tactile touch image (103) or the instrument or anatomical data that pass through foregoing storage Database (104) and obtain image.Then image is downloaded and processed by computer (105).Alternatively, computer can to Family or doctor's display image are further manipulating (106).After this step, printer is then sent images to print (107).Checking scanner can alternatively verify the product correctness (108) of final printing.Optionally as well, finally print Product can also be sterilized using sterilizing installation, such as autoclave (109).
Between download step (105) and step display (106), there can also be optional step (105a).Because image is obtained Take the defect in technology, when body part or instrument are scanned, be there may be in final image missing information, gap or " hole ".To be incomplete and thus unaccommodated if the image is sent to printer or maker.In step (105a) Period, image can be compared with for the prosthese or the normal data of instrument that can be stored in database.Acquired figure Any gap as in can be filled.
Label declaration
1：Processing unit；2：Endoscope；3：Light supply apparatus；4：Display device；5：X-ray apparatus；11：Input unit；12：Control Portion processed；13：Image processing part；13a：Remaining white test section；13b：Region-of-interest cut-out portion；13c：Zoom portion；13d：Inside peep Mirror image processing part；13e：Combining unit；14：Display control unit；15：Output section；16：Storage part；21：Image pickup part.
X ray image shelter of the invention can also be used for during wherein mobility is not the application of first concern point.Example Such as, existing hospital facility may need the ability of printing speed instrument or prosthese, and it may have no ability to or not have at present Space do so.X ray image shelter of the invention can be easily deployed on the ground of existing hospital facility, for example, exist In the unused area on the ground of parking lot, garage parking, roof or facility.Regardless of whether the ability is needed, regardless of whether in the presence of Existing utility, the fast freight container of the disclosure can be disposed.
Although embodiment of the present invention is disclosed as above, it is not restricted to listed in specification and implementation method With, it can be applied to various suitable the field of the invention completely, for those skilled in the art, can be easily Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, the present invention is not limited In specific details and shown here as the legend with description.

Claims (8)

1. a kind of low dosage digital X-ray image shelter, it is characterised in that：Including
Synthetic image imaging system, vehicle-mounted Cone-Beam CT rail structure, vehicle-mounted X-ray image information processing system, three-dimensional printer and 220V onboard power systems.
2. low dosage digital X-ray image shelter according to claim 1, it is characterised in that：The synthetic image imaging System includes vehicle-mounted cone-beam CT imaging system and endoscope, and the vehicle-mounted cone-beam CT imaging system is used based on flat panel detector Cone-beam CT imaging pattern, the endoscope is generated interior peeping to being shot in vivo for subject with importeding into subject The image pickup part of mirror picture signal, it is the vehicle-mounted X-ray image information processing system and endoscope, light supply apparatus, display device, vehicle-mounted Cone-beam CT imaging system is connected.
3. low dosage digital X-ray image shelter according to claim 1, it is characterised in that：The vehicle-mounted cone-beam CT imaging System generates radioscopic image signal, and the vehicle-mounted X-ray image information processing system to the endoscopic images that are input into from endoscope Signal implements the image procossing of regulation and also the radioscopic image signal to being input into from vehicle-mounted cone-beam CT imaging system implements regulation Image procossing, and image corresponding with synthesized image signal is shown in display device, the synthesized image signal is to be arranged Endoscopic images signal and X-ray signal after image procossing are simultaneously synthesized into.
4. low dosage digital X-ray image shelter according to claim 3, it is characterised in that：At vehicle-mounted X-ray image information Reason system has input unit, control unit, image processing part, display control unit, output section and storage part.
5. low dosage digital X-ray image shelter according to claim 4, it is characterised in that：Input unit receives endoscope The information (such as ID, birthdate, name etc.) of the subject checked with vehicle-mounted cone-beam CT imaging system, endoscope Identification information (such as ID and the corresponding project of inspection), the identiflication number of vehicle-mounted cone-beam CT imaging system and scope of examination etc. are each Plant the input of configured information.
6. low dosage digital X-ray image shelter according to claim 4, it is characterised in that：Control unit is by entering the hand-manipulating of needle Transmission of configured information or data of each structure to vehicle-mounted X-ray image information processing system etc. come control vehicle-mounted X-ray image believe The action of processing system is ceased, control unit connects via each cable and image pickup part, each structure position of light supply apparatus and display device Connect, so that also the action to image pickup part, light supply apparatus and display device is controlled.
7. low dosage digital X-ray image shelter according to claim 4, it is characterised in that：Image processing part is according to control The control in portion processed, the endoscopic images signal generated to image pickup part and the X ray picture from the input of vehicle-mounted cone-beam CT imaging system As the signal transacting that signal is specified, image processing part have remaining white test section, region-of-interest cut-out portion, zoom portion, Endoscopic images processing unit and combining unit, radioscopic image signal are with operating personnel's shadow for manifesting subject of interest As part and the picture signal of the remaining white part being arranged at around image part, remaining white part is that brightness or color are uniformly equal Even region.
8. low dosage digital X-ray image shelter according to claim 4, it is characterised in that：The vehicle-mounted X-ray image letter Breath processing system is the three-dimensional CT image algorithm for reconstructing based on compressed sensing min x T V ( x ) = Σ i | | D i x | | 2 s . t . b = A x , Wherein x is 3-D view to be reconstructed, and b is the data for projection obtained by lack sampling, and A is observing matrix, D1X refers to reconstruction image The discrete gradient of the upper ith pixels of x.
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