CN106699590A - Production method of industrial grade glycine - Google Patents
Production method of industrial grade glycine Download PDFInfo
- Publication number
- CN106699590A CN106699590A CN201510789316.8A CN201510789316A CN106699590A CN 106699590 A CN106699590 A CN 106699590A CN 201510789316 A CN201510789316 A CN 201510789316A CN 106699590 A CN106699590 A CN 106699590A
- Authority
- CN
- China
- Prior art keywords
- production method
- methyl alcohol
- industrial grade
- hour
- filter cake
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01C—AMMONIA; CYANOGEN; COMPOUNDS THEREOF
- C01C1/00—Ammonia; Compounds thereof
- C01C1/16—Halides of ammonium
- C01C1/164—Ammonium chloride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a production method of industrial grade glycine. The production method comprises following steps: liquid ammonia is added into a urotropin solution, liquid chloroacetic acid is added dropwise at the same time, pH value is controlled to be 6.5, reaction is carried out for 2 to 3h at 60 to 70 DEG C, the temperature is maintained to be constant for half an hour, and an obtained mixture is cooled to be lower than 40 DEG C, and is added into methyl alcohol at a temperature lower than 30 DEG C dropwise, wherein the weight amount of methyl alcohol is three times of that of chloroacetic acid; thermal insulation and crystallization are carried out for 0.5 to 1h at 30 DEG C, centrifugation is carried out so as to remove a mother liquid; methyl alcohol is used for washing obtained filter cake and removing ammonium chloride; finished product glycine with a content of higher than 98.5% is obtained via drying of the filter cake, a mother liquid is recycled via rectification so as to recycle methyl alcohol with a purity higher than 90%, and an obtained rectification solution is subjected to evaporation and cooling so as to obtain by product ammonia chloride. The production method is simple; operation is convenient; and the production method is friendly to the environment.
Description
Technical field
The present invention relates to a kind of production method of industrial grade glycine.
Background technology
The production method of existing industrial grade glycine is complicated, and not easy to operate, yield is low, and environmental pollution is big.
The content of the invention
It is an object of the invention to provide a kind of production method of easy, easy to operate, the environmentally friendly industrial grade glycine of method.
Technical solution of the invention is：
A kind of production method of industrial grade glycine, it is characterized in that：Liquefied ammonia is passed through in methenamine solution, while drop
Plus liquid chloroacetic acid, reacted 2~3 hours at control pH6.5,65 ± 5 DEG C of temperature, half an hour is incubated, it is cooled to
Less than 40 DEG C, it is added drop-wise in less than 30 DEG C of methyl alcohol, methanol usage is 3 times of monoxone weight, is incubated at 30 DEG C
Partial crystallization half an hour~mono- hour, centrifugal drying goes mother liquor, again with methanol washing filter cake to remove ammonium chloride, and filter cake is dried
The finished product amion acetic acid of content more than 98.5%, mother liquor using rectifying reclaim more than 90% methyl alcohol, rectifying kettle liquid steam
Hair, cooling, obtain by-product ammonium chloride.
The inventive method is easy, easy to operate, the feature of environmental protection is good.
With reference to embodiment, the invention will be further described.
Specific embodiment
A kind of production method of industrial grade glycine, liquefied ammonia is passed through in methenamine solution, while liquid chloroacetic acid is added dropwise,
Reacted 2~3 hours at control pH6.5,65 ± 5 DEG C of temperature, be incubated half an hour, be cooled to less than 40 DEG C, be added drop-wise to
In less than 30 DEG C of methyl alcohol, methanol usage is 3 times of monoxone weight, and partial crystallization half an hour~mono- is incubated at 30 DEG C
Hour, centrifugal drying goes mother liquor, again with methanol washing filter cake to remove ammonium chloride, and filter cake dries to obtain content more than 98.5%
Finished product amion acetic acid, mother liquor using rectifying reclaim more than 90% methyl alcohol, rectifying kettle liquid evaporation, cooling, obtain
By-product ammonium chloride.
Claims (3)
1. a kind of production method of industrial grade glycine, it is characterized in that：Liquefied ammonia is passed through in methenamine solution, while liquid is added dropwise
Monoxone, reacts 2~3 hours at control pH6.5,65 ± 5 DEG C of temperature, is incubated half an hour, is cooled to less than 40 DEG C,
It is added drop-wise in less than 30 DEG C of methyl alcohol, partial crystallization half an hour~mono- hour is incubated at 30 DEG C, centrifugal drying removes mother liquor, then uses
Methyl alcohol washs filter cake, removes ammonium chloride, and filter cake dries to obtain finished product amion acetic acid, mother liquor using rectifying reclaim more than 90%
Methyl alcohol, rectifying kettle liquid evaporation, cooling, obtain by-product ammonium chloride.
2. the production method of a kind of industrial grade glycine according to claim 1, it is characterised in that the methanol usage is chloroethene
3 times of sour weight.
3. a kind of production method of industrial grade glycine according to claim 1, it is characterised in that the finished product ammonia after the drying
Guanidine-acetic acid obtains content more than 98.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510789316.8A CN106699590A (en) | 2015-11-16 | 2015-11-16 | Production method of industrial grade glycine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510789316.8A CN106699590A (en) | 2015-11-16 | 2015-11-16 | Production method of industrial grade glycine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106699590A true CN106699590A (en) | 2017-05-24 |
Family
ID=58932962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510789316.8A Pending CN106699590A (en) | 2015-11-16 | 2015-11-16 | Production method of industrial grade glycine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106699590A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115991657A (en) * | 2022-08-23 | 2023-04-21 | 山东民基新材料科技有限公司 | Co-production method of glycine and ammonium chloride |
-
2015
- 2015-11-16 CN CN201510789316.8A patent/CN106699590A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115991657A (en) * | 2022-08-23 | 2023-04-21 | 山东民基新材料科技有限公司 | Co-production method of glycine and ammonium chloride |
| CN115991657B (en) * | 2022-08-23 | 2024-03-19 | 山东民基新材料科技有限公司 | Co-production method of glycine and ammonium chloride |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104151128A (en) | Preparation method of isolongifolene | |
| CN101492394B (en) | Method of preparing Octocrilene | |
| CN103254090A (en) | Production method of industrial grade glycine | |
| CN106916138B (en) | A kind of synthetic method of methane-disulfonic acid methylene ester | |
| CN105541657A (en) | Method for preparing adipic acid dihydrazide | |
| CN106699590A (en) | Production method of industrial grade glycine | |
| CN104892444B (en) | A kind of method of synthetic D-pHPG methyl esters | |
| CN103102326A (en) | Preparation method of rubber accelerator NOBS (N-(oxidiethylene)-2-benzothiazolyl sulfenamide) | |
| CN104072369B (en) | A kind of technique preparing Diisopropyl malonate | |
| CN104529935A (en) | Method for synthesizing high-purity ethyl 2-(3-aldehyde-4-isobutyloxyphenyl)-4-methylthiazole-5-formate | |
| CN107868013A (en) | The production method of industrial grade glycine | |
| CN108203388A (en) | The production method of industrial grade glycine | |
| CN103896781A (en) | Preparation method of benzyltriethylammonium chloride | |
| CN103435069A (en) | Method for realizing continuous production of ammonium hydrogen fluoride | |
| CN104744239A (en) | Preparation method of hydroxyacetic acid | |
| CN103435441B (en) | The method of dimethyl malonate production wastewater treatment and resource reclaim | |
| CN107602341A (en) | A kind of method from epoxy height boiling extraction trichloropropane | |
| CN104418759A (en) | Method for preparing glycine through alcohol phase synthesis, chromatographic separation, MVR evaporative crystallization | |
| CN106431821B (en) | The method for being dehydrated the comprehensive utilization and by-product sodium bisulfate of dilute sulfuric acid and byproduct sodium chloride | |
| CN102659697B (en) | Method for preparing energy-saving and environment-friendly triazole sodium | |
| CN106800510A (en) | The production method of dimethyl succinate | |
| CN111153794A (en) | Method for synthesizing ethyl palmitate by using dodecyl trimethyl ammonium chloride-based eutectic solvent catalyst | |
| CN104672105A (en) | Method for preparing L-3-(3,4-dimethoxyphenyl)-2-amino-2-methyl propionitrile hydrochloride | |
| CN104262190B (en) | A kind of production technique of Environmental Protective Water-paint aggregate | |
| CN104045514A (en) | Synthetic method for 2-butyne-1-ol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170524 |