CN1066947C - Qinglong capsule and preparing method thereof - Google Patents
Qinglong capsule and preparing method thereof Download PDFInfo
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- CN1066947C CN1066947C CN97101463A CN97101463A CN1066947C CN 1066947 C CN1066947 C CN 1066947C CN 97101463 A CN97101463 A CN 97101463A CN 97101463 A CN97101463 A CN 97101463A CN 1066947 C CN1066947 C CN 1066947C
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Abstract
The present invention relates to a Qinglong capsule and a preparation method thereof. The Qinglong capsule is prepared from the following medicines of the proportion in a prescription: 40 to 60 grams of sea horse, 20 to 40 grams of donkey kidney, 20 to 40 grams of dog kidney, 90 to 110 grams of tuber onion seed, 90 to 110 grams of epimedium herb, 90 to 110 grams of tremolite or tremolite asbestos, 40 to 60 grams of psoralea fruit, 40 to 60 grams of common curculigo rhizome, 40 to 60 grams of cornus, 40 to 60 grams of medicinal indianmulberry root, 40 to 60 grams of prepared rhizome of rehmannia, 40 to 60 grams of barbary wolfberry fruit, 40 to 60 grams of mulberry fruit, 40 to 60 grams of dodder seed, 40 to 60 grams of lotus stamen, 40 to 60 grams of gordon euryale seed and 40 to 60 grams of white nut. The preparation method comprises: the sea horse, the psoralea fruit, the cornus and the epimedium herb are mixed and ground into fine powder in reserve, the other medicines are decocted with water of 1 to 10 times the medicines for two times, each time needs 1 to 3 hours, and the filter liquor is concentrated into extractum; the fine powder is added in the extractum, the fine powder and the extractum are uniformly mixed, dried, pulverized, sieved and subpackaged to obtain the Qinglong capsule.
Description
The present invention is medicine and the processing technique that belongs to treatment renal deficiency type sexual impotence.
The renal deficiency type sexual impotence is one of common frequently-occurring disease of male at present, and each age group becomes generation is arranged per capita, and its cause of disease is various; But sings and symptoms is consistent substantially; Though this sick not threat to life causes people's cultural life to have a strong impact on.Traditional medical treatment is a principal agent with rare Chinese medicines such as Cornu Cervi Pantotrichums mainly, but its price is too expensive.
The objective of the invention is to propose a kind of capsule (its trade name is a Green Dragon capsule) and production method thereof for the treatment of sexual impotence, utilize the medicine of natural animal-plant, develop cheaply, the health product of strengthening yang and invigorating kidney effect are arranged at man's renal deficiency type sexual impotence.
The present invention is with pure natural animals and plants medicine, by proportioning through being processed into Green Dragon capsule; It is characterized in that: by Hippocampus, Testis Et penis Equi, Testis et Pentis Canis, Semen Allii Tuberosi, Herba Epimedii, Actinolitum, Fructus Psoraleae, Rhizoma Curculiginis, Fructus Corni, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Mori, Semen Cuscutae, Stamen Nelumbinis, Semen Euryales, Semen Ginkgo, its proportioning of thousand is: Hippocampus 40-60g, Testis Et penis Equi 20-40g, Testis et Pentis Canis 20-40g, Semen Allii Tuberosi 90-110g, Herba Epimedii 90-110g, Actinolitum 90-110g, Fructus Psoraleae 40-60g, Rhizoma Curculiginis 40-60g, Fructus Corni 40-60g, Radix Morindae Officinalis 40-60g, Radix Rehmanniae Preparata 40-60g, structure Fructus Lycii 40-60g, Fructus Mori 40-60g, Semen Cuscutae 40-60g, Stamen Nelumbinis 40-60g, Semen Euryales 40-60g, Semen Ginkgo 40-60g; Its processing method is with the Hippocampus in the raw material, Fructus Psoraleae, Fructus Corni, that the Herba Epimedii mixed powder is broken into fine powder is standby, and its raw material is added the water that 1-10 doubly measures, mix decocting, extract secondary, each 1-3 hour, gradation is filtered, merging filtrate in the time of 80-90 ℃, is condensed into the extractum that relative density is 1.10-1.40, add mixing behind standby Hippocampus, Fructus Psoraleae, Fructus Corni, the Herba Epimedii fine powder, the 70-90 mesh sieve is crossed in dry under 80 ℃ of temperature, pulverizing, divides the capsule of packing into.
The pharmacology of each medicine of the present invention:
Hippocampus, Testis Et penis Equi, Testis et Pentis Canis are monarch drug, Hippocampus sweet-salty, warm in nature wherein, and the function kidney invigorating and YANG supporting claims it " to go into the kidney channel gate of vitality, specially kind Xing Yang " " book on Chinese herbal medicine is newly organized ".The two is all the in love product of flesh and blood Testis Et penis Equi, Testis et Pentis Canis, can YIN nourishing and YANG strengthening, and the Testis Et penis Equi salty in the mouth is warm in nature, and the strong muscle of kidney tonifying, " Sichuan Chinese medicinal herbal " claim its " the sexual impotence erectile problem is controlled in the nourishing kidney tonifying YANG "; But the tonifying YANG of Testis et Pentis Canis warming the kidney, " Japan hanako materia medica " claim its energy " tonifying YANG, warm waist knee joint, tonify deficiency labor ".The three is shared, the nourishing kidney tonifying YANG.In the side again minister with Herba Epimedii, Radix Rehmanniae Preparata; The power of Herba Epimedii sweet in the mouth kidney invigorating and YANG supporting principal drug assistance warm in nature, Shennong's Herbal cloud: " main sexual impotence is hindered extremely, pains in the penis "; Radix Rehmanniae Preparata sweet in the mouth slightly warm in nature is filled out marrow but the YIN nourishing benefit is smart, and " pearl sac " said, Radix Rehmanniae Preparata " the main gas kidney nourishing water of enriching blood, benefit is Kidney-Yin ".Can make the unlikely damage the moon of monarch drug tonifying YANG with it for medicine, to reach equilibrium between yin and yang.
All the other medicines are adjuvant drug;
Structure Fructus Lycii, Fructus Mori enriching yin and nourishing kidney are to help the power of Radix Rehmanniae Preparata; Wherein structure Fructus Lycii sweet in the mouth is flat, nourishing kidney tonifying liver, Collective Notes to the Canon of Materia medica cloud its " nourishing the essence and strengthening QI is felt vagina by force "; The Fructus Mori sweet in the mouth is cold in nature, the kidney tonifying YIN nourishing, and " the southern regions of the Yunnan Province book on Chinese herbal medicine " claims its " kidney tonifying dirty and controlling nocturnal emission with astringent drugs ".This two medicine is gone into Radix Rehmanniae Preparata is shared more can bring into play tonifying YANG and the effect of non-impairment of YIN.
Semen Allii Tuberosi, Radix Morindae Officinalis, Rhizoma Curculiginis, Semen Cuscutae, Fructus Psoraleae, Actinolitum are played the power of the merit of kidney invigorating and YANG supporting with principal drug assistance altogether.Wherein the Semen Allii Tuberosi sweet in the mouth is warm in nature, the kidney warming controlling nocturnal emission with astringent drugs, tonifying YANG.The energy of " the southern regions of the Yunnan Province book on Chinese herbal medicine " meaning " Xing Yangdao controls sexual impotence for invigorating the liver and kidney, warm waist knee joint ".The Actinolitum salty in the mouth is warm in nature, specially in warming the kidney to invigorate YANG.Say in the Shennong's Herbal Actinolitum " main metrorrhagia and metrostaxis ... loss of fecundity, sexual impotence does not rise ".The Rhizoma Curculiginis acrid in the mouth is ripe, the kidney warming, tonifying YANG, bone and muscle strengthening." book on Chinese herbal medicine justice " claims " Rhizoma Curculiginis is the special medicine of YANG invigorating the kidney warming ".Radix Morindae Officinalis sweet in the mouth slightly warm in nature, kidney-replenishing, bone and muscle strengthening; Shennong's Herbal claims it can control " sexual impotence does not rise ", tonifying the kidney to consolidate the essence; Say in " property of medicine opinion " that it " controls men and women's cold caused by deficiency, sperm adding and marrow healthing ".The Fructus Psoraleae acrid in the mouth is warm in nature, reinforcing the kidney and supporting YANG, warm spleen controlling nocturnal emission with astringent drugs, " Kaibao Bencao " cloud its " main five kinds of strain and seven kinds of impairment, the bone marrow wound loses, the former and married woman's vim and vigour induced abortion of the cold essence of kidney ".
Help Fructus Corni, Stamen Nelumbinis, Semen Euryales, Semen Ginkgo again and help the famous medicine tonifying the kidney to consolidate the essence again.But Fructus Corni sour in the mouth the kidney invigorating arresting seminal emission warm in nature, " property of medicine opinion " are said its " it is indefinite to end month water, the kidney invigorating gas, emerging vagina, lacquer marrow ".Stamen Nelumbinis sweet in the mouth, adstringency are put down, but the kidney tonifying arresting seminal emission." book on Chinese herbal medicine covers an aromatic plant metioned in ancient books " calls it " Gu kidney tonifying, arresting seminal emission is marrow ".Stamen Nelumbinis sweet in the mouth, adstringency are put down, energy supplementing the kidney to control the nocturnal, spleen invigorating, and " book on Chinese herbal medicine is asked grass " calls its " puckery reinforces the kidney, and loses band and make, and incontinence of urine all heals ".Semen Ginkgo sweet in the mouth, adstringency are put down, and the solid part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of convergence, and " book on Chinese herbal medicine is new again " is referred to as " QI invigorating nourishes heart, the kidney tonifying YIN nourishing ".
To Green Dragon capsule drug effect, carried out following experiment: one, the kidney invigorating experiment by white mice; Two, tonifying YANG experiment; Wherein the kidney invigorating experiment: select 60 of Kunming kind male white mouses for use, with Green Dragon capsule and contrast medicine YANSHENG HUBAO YE, hydrocortisone; Experiment influence to the animal of suffering from a deficiency of the kidney: select female rat for use from breast; With Green Dragon capsule, contrast medicine YANSHENG HUBAO YE, the plain injection of propanoic acid cover ball.Test for tonifying YANG: select healthy male rat for use; Medication is the same; Confirm by above experimentation: (1) this compound recipe can make the moving autonomic activities number of times of insufficiency of kidney-YANG increase, and has tangible anti-low temperature fatigue resistance.(2) this compound recipe also is significantly increased effect to the castrated rats weight of reproductive organs.(3) this compound recipe also has a significant effect to the castrated rats penile erectile function, and its erection is obviously shortened incubation period.(4) this compound recipe promotes the ability of male rat copulation in addition, shortens the effect that Piao catches ejaculation latency.
To Green Dragon capsule rat long term toxicity test: select rat for use, use Green Dragon capsule, to rat carry out general situation, body weight, routine blood test, liver function, vitals are observed and the pathologic group inspection.Through every experiment confirm, Green Dragon capsule gives the rat oral gavage administration after 60 days, general state, and growth promoter, every indexs such as routine blood test, liver, renal function there is no abnormal change; Administration group and matched group relatively P all＞0.05, difference is not remarkable, naked eyes and histopathology observe there is no unusual, therefore show this medicine take safe and reliable, no obvious toxic-side effects.
The acute toxicity test of Green Dragon capsule in order to estimate Green Dragon capsule in clinical application safety, experimentizes with the Kunming white mice, if by adult maximum dosage (every day three times, each 4) calculate, its result is 312.5 times of normal dose, so that this medicine can be thought is safe.More than three experiments and the evidence that provides is provided by Heilongjiang Traditional Chinese Medicine university Chinese medicine research department.
The clinical observation of Green Dragon capsule for treating renal deficiency type sexual impotence;
Began in 1994 the insufficiency of kidney-YANG patient is carried out clinical observation;
(1) selection meets patient's 215 examples of diagnostic criteria, and 164 examples are Green Dragon capsule for treating group, and 50 examples are the YANSHENG HUBAO YE matched group; The Green Dragon capsule for treating group age is 32-60 year, average out to 42 years old; YANSHENG HUBAO YE matched group age 30-60 year, 40 years old mean age.
(2) concrete treatment: give Green Dragon capsule every day 3 times to the treatment group, each 4; Matched group is given YANSHENG HUBAO YE secondary every day, each 20ml.Two groups of equal hungry area usefulness, one month is the course of treatment, takes 1-3 the course of treatment continuously.The patient must not take other Yang invigorating medicine or hormone medicine during treating, and observes toxicity and the untoward reaction of patient to this medicine.Clinical effectiveness: clinical efficacy is judged; Cure in the recent period; Treatment back symptom and sign all disappear, and endophallus erected greater than 90 ° in 3 months, and property change chance can success more than 75%.The symptom, sign of suffering from a deficiency of the kidney obviously improved, and presses integration and reduces more than 50% before than treatment, and treatment back erection is greater than 90 °, and 50% of property change chance can success.The symptom, sign of suffering from a deficiency of the kidney all take a favorable turn, and integration reduces more than 30% before than treatment, and erection has improvement, property change chance successful 25% or more.
Clinical observation result;
The clinical observation result table:
| Group | The example number | Cure in the recent period (%) | Produce effects number (%) | Significant figure (%) | Invalid number (%) | Total effective rate (%) |
| Administration group matched group | 165 50 | 12 (7.3) 3 (6.0) | 99 (60.0) 27 (54.0) | 38 (23.0) 11 (22.0) | 16 (9.7) 9 (15) | 90.3 52.0 |
Clinical observation result shows that Green Dragon capsule has better therapeutic effect to impotence due to deficiency of the kidney, and total effective rate is 90.3%, compares with the matched group YANSHENG HUBAO YE, and there is significant difference P＜0.05.
Through clinical 165 routine renal deficiency type sexual impotence are treated with Green Dragon capsule, patient's sings and symptoms all has clear improvement, and sexual function is recovered that better action is arranged, and is the comparatively satisfied compound preparation of a curative effect; Viewing duration does not find that it has any toxic and side effects.This clinical material is provided by attached second hospital of Heilongjiang University of Chinese Medicine.
The present invention compared with prior art has following advantage:
(1) this medicine can play nourishing kidney-yin altogether, the effect of the gas that reinforces the kidney, invigorating kidney-YANG, can be used for treating seminal fluid loss, deficiency of the kidney yin table, the overstrain internal injury, dizziness and fatigue, muscles and bones is unable, soreness of the waist and knees, sexual impotence is out of fashion to wait disease.
(2) active drug of Green Dragon capsule for treating impotence due to deficiency of the kidney, total effective rate are 90.2%, contrast YANSHENG HUBAO YE total effective rate 80.5%.This medicine has a better role to the sings and symptoms of kidney type sexual impotence, can promote the chance of patient's erection and increase success rate of sexual intercourse simultaneously effectively, has sex hormone function.Find that under observation this medicine recovers to have outside the direct effect to sexual function, most of patients self-induction muscle power strengthens, and is energetic, shows that this medicine still has constitutional effect, and clothes can slow down aging for a long time.This medicine is without any side effects, and liver, renal function are had no effect.
Description of drawings:
Figure is a process chart of the present invention.
Embodiments of the invention:
The present invention is the animals and plants medicine with pure natural, is processed into Green Dragon capsule by proportioning; This medicine, is processed from strand by proportioning by Hippocampus, Testis Et penis Equi, Testis et Pentis Canis, Semen Allii Tuberosi, Herba Epimedii, Actinolitum, Fructus Psoraleae, Rhizoma Curculiginis, Fructus Corni, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Mori, structure Fructus Lycii, Semen Cuscutae, Stamen Nelumbinis, Semen Euryales, Semen Ginkgo.
Embodiment 1:
The present invention takes following prescription:
Hippocampus 40g, Testis Et penis Equi 20g, Testis et Pentis Canis 20g, Semen Allii Tuberosi 90g, Herba Epimedii 90g, Actinolitum 90g, Fructus Psoraleae 40g, Rhizoma Curculiginis 40g, Fructus Corni 40g, Radix Morindae Officinalis 40g, Radix Rehmanniae Preparata 40g, structure Fructus Lycii 40g, Fructus Mori 40g, Semen Cuscutae 40g, Stamen Nelumbinis 40g, Semen Euryales 40g, Semen Ginkgo 40g.
Hippocampus in the above-mentioned prescription, Fructus Psoraleae, Fructus Corni, Herba Epimedii mixed powder are broken into fine powder, standby; Described all the other recipe ingredients are added the water of 6 times of amounts, mix decocting, extract secondary, each 2.5 hours, gradation was filtered, and merging filtrate is condensed into the extractum (80 ℃ of heat are surveyed) of relative density 1.35.Add Hippocampus, BUSHENZHI, Fructus Corni, Herba Epimedii mixing fine powders, mixing, 70 ℃ of dryings, dry thing is pulverized, and crosses 80 mesh sieves, divides in 1000 capsules of packing into, gets final product.
Embodiment 2:
The present invention takes following prescription:
Hippocampus 50g, Testis Et penis Equi 30g, Testis et Pentis Canis 30g, Semen Allii Tuberosi 100g, Herba Epimedii 100g, Actinolitum 100g, Fructus Psoraleae 50g, Rhizoma Curculiginis 50g, Fructus Corni 50g, Radix Morindae Officinalis 50g, Radix Rehmanniae Preparata 50g, Fructus Lycii 50g, Fructus Mori 50g, Semen Cuscutae 50g, Stamen Nelumbinis 50g, Semen Euryales 50g, Semen Ginkgo 50g.
Hippocampus in the above-mentioned prescription, Fructus Psoraleae, Fructus Corni, Herba Epimedii mixed powder are broken into fine powder, standby; Described all the other recipe ingredients are added the water of 6 times of amounts, mix decocting, extract secondary, each 2.5 hours, gradation was filtered, and merging filtrate is condensed into the extractum (80 ℃ of heat are surveyed) of relative density 1.35; Add Hippocampus, Fructus Psoraleae, Fructus Corni, Herba Epimedii mixing fine powders, mixing, 70 ℃ of dryings, dry thing is pulverized, and crosses 80 mesh sieves, divides in 1000 capsules of packing into, gets final product.
Claims (2)
1, the capsule of treatment sexual impotence, it is characterized in that: per thousand is to make with the raw material of following consumption: Hippocampus 40-60g, Testis Et penis Equi 20-40g, Testis et Pentis Canis 20-40g, Semen Allii Tuberosi 90-110g, Herba Epimedii 90-110g, Actinolitum 90-110g, Fructus Psoraleae 40-60g, Rhizoma Curculiginis 40-60g, Fructus Corni 40-60g, Radix Morindae Officinalis 40-60g, Radix Rehmanniae Preparata 40-60g, structure Fructus Lycii 40-60g, Fructus Mori 40-60g, Semen Cuscutae 40-60g, Stamen Nelumbinis 40-60g, Semen Euryales 40-60g, Semen Ginkgo 40-60g.
2, as the capsular production method of treatment sexual impotence according to claim 1, it is characterized in that: the Hippocampus in the raw material, Fructus Psoraleae, Fructus Corni, that the Herba Epimedii mixed powder is broken into fine powder is standby, its raw material is added the water that 1-10 doubly measures, mix and decoct, extract two not good liquors, each 1-3 hour, filter respectively, merging filtrate in the time of 80-90 ℃, is condensed into the extractum that relative density is 1.10-1.40, add mixing behind standby Hippocampus, Fructus Psoraleae, Fructus Corni, the Herba Epimedii fine powder, the 70-90 mesh sieve is crossed in dry under 80 ℃ of temperature, pulverizing, divides the capsule of packing into.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97101463A CN1066947C (en) | 1997-03-12 | 1997-03-12 | Qinglong capsule and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN97101463A CN1066947C (en) | 1997-03-12 | 1997-03-12 | Qinglong capsule and preparing method thereof |
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| Publication Number | Publication Date |
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| CN1192912A CN1192912A (en) | 1998-09-16 |
| CN1066947C true CN1066947C (en) | 2001-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN97101463A Expired - Fee Related CN1066947C (en) | 1997-03-12 | 1997-03-12 | Qinglong capsule and preparing method thereof |
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| CN104055082A (en) * | 2013-03-22 | 2014-09-24 | 丁卫华 | Dietotherapy health care composition capable of tonifying kidney |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084747A (en) * | 1992-12-09 | 1994-04-06 | 辽宁中山科工贸总公司 | The Chinese medicine mixture prepares Zhuangyangshengjingdan (strong medicine) and method thereof |
| CN1107345A (en) * | 1994-07-17 | 1995-08-30 | 贺鑫世 | Healthy Chinese medicine and its preparing process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084747A (en) * | 1992-12-09 | 1994-04-06 | 辽宁中山科工贸总公司 | The Chinese medicine mixture prepares Zhuangyangshengjingdan (strong medicine) and method thereof |
| CN1107345A (en) * | 1994-07-17 | 1995-08-30 | 贺鑫世 | Healthy Chinese medicine and its preparing process |
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| CN1192912A (en) | 1998-09-16 |
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