CN106693081A - Method for preparing nuclear magnetic resonance development material and application - Google Patents
Method for preparing nuclear magnetic resonance development material and application Download PDFInfo
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- CN106693081A CN106693081A CN201611065167.1A CN201611065167A CN106693081A CN 106693081 A CN106693081 A CN 106693081A CN 201611065167 A CN201611065167 A CN 201611065167A CN 106693081 A CN106693081 A CN 106693081A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/128—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
Abstract
The invention belongs to the field of biomedicine and discloses a method for preparing a nuclear magnetic resonance development material. According to the method, mixed solution of a high polymer material and a material having nuclear magnetic resonance specificity response is prepared into a blocky or film solid composite material through solution casting. According to the method, a device is simple in process and good in repeatability and can be produced in a large scale. The prepared nuclear magnetic resonance development material reserves mechanical property and biological characteristics of the high polymer material, and achieves an effect of development under nuclear magnetic resonance. An image remarkably different from human body peripheral tissues can be obtained under nuclear magnetic resonance, and information such as the shape and in vivo position of an implanted material is obtained through zero-damage MRI detection, so as to achieve the goal of tracking and learning about patient conditions. The method can be widely applied in a cranial nerve decompression gasket, a pelvic floor composite gasket, a lower eyelid substitute material, a hernia repair piece, an artificial chest wall, heart patches and postoperative anti-adhesion membranes.
Description
Technical field
The present invention relates to biomedical sector, more particularly, to it is a kind of can magnetic resonance imaging material preparation method
And application.
Technical background
Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) or magnetic resonance imaging or nuclear magnetic resonance show
Seem a kind of clinical medicine detection technique lossless to human body.Body implanting material is largely used to as a kind of medical equipment
Medical field, macromolecular material is the important source material of existing body implanting material.Due to atomic nucleus type, electron outside nucleus shielding effect
The presence of factor should be waited, certain frequency, the radio-frequency pulse of certain energy are only capable of acting on the atomic nucleus of precession frequency matching.It is based on
The characteristics of human body, the signal of nuclear magnetic resonance is derived mainly from the proton in hydrone and fat molecule.Macromolecular material is comprising big
Amount non-hydrogen atom, and wherein hydrogen atom is huge with the external electrical environmental difference of lipid with respect to water proton, will not be by RF pulse-to-pulse
Impulse is sent out, or its relaxation time is only several ms, less than NMR signal acquisition time.Thus, insert internal high score
Sub- material, the complete no signal generally under nuclear magnetic resonance, or by tissue fluid infiltrate so that with surrounding tissue indifference, cause postoperative
It is difficult to observe the macromolecular material of implantation state in vivo, made troubles to further treatment and diagnosis.Therefore, tool is prepared
Have can magnetic resonance imaging material, be particularly important for extending material implanted application.
The characteristics of MRI possesses the different relaxation times using people's substance in vivo, human body can be obtained by applying radiofrequency signal
Nuclear magnetic resonance image, differentiation is reached with this, the purpose of tissue state is judged.The information content that MRI is provided not only is more than
Other many imaging techniques in Medical Imaging, and different from existing imaging technique.Therefore, its diagnosis tool to disease
There are very big potential advantages.It can directly make the body tomographic image of cross section, sagittal plane, coronal-plane and various sections, without electricity
From radiation, there is no harmful effect to body.MRI is to detection intracerebral hematoma, brain outer hemotoncus, brain tumor, intracranial aneurysm, arteriovenous
The cranium brain common disease such as vascular malformation, cerebral ischemia, intraspinal tumor, syringomyelia and hydromyelia is highly effective, while right
The diagnosis of the diseases such as intervertebral disc of lumbar vertebra processus aboralis, primary carcinoma of liver is also very effective.Due to signal intensity, acquisition mode and atomic nucleus
The limitation of abundance, medical nmr equipment can only detect the signal of hydrogen atom in human body, and signal essentially from water proton with
Lipid.And insert internal macromolecular material, the complete no signal generally under nuclear magnetic resonance, or by tissue fluid infiltrate so that with
Surrounding tissue indifference, causes the postoperative macromolecular material state in vivo for being difficult observation implantation, to further treatment and
Diagnosis is made troubles.Therefore, prepare have can magnetic resonance imaging material, seem outstanding for extending material implanted application
For important.
The content of the invention
In order to improve the problem that existing body implanting material can not be imaged under nuclear magnetic resonance, the present invention provides one kind can core
The preparation method of Magnetic Resonance Imaging composite, the method is by macromolecular material and the material with nuclear magnetic resonance specificly-response
The mixed solution of material is prepared into block or film or fibrous solids composite, and the method preparation process is simple, equipment is ripe,
It is easy to industrialized production.
What another object of the present invention was to provide prepared by a kind of above method can magnetic resonance imaging composite.The material was both
Macromolecular material mechanical property in itself and biological characteristics are remained, the imaging results under nuclear magnetic resonance are realized again,
There are the specific signals different from tissue under different NMRS sequences, image can be produced under nuclear magnetic resonance.
Still a further object of the present invention be to provide it is a kind of it is above-mentioned can magnetic resonance imaging composite application.
The purpose of the present invention is realized by subordinate's technical scheme.
It is a kind of can magnetic resonance imaging composite preparation method, comprise the following steps：
S1. macromolecular material is dissolved in organic solvent at -10~80 DEG C, compound concentration is the high score of 1~30wt%
Sub- solution, stirs, and is subsequently adding with nuclear magnetic resonance specificly-response material and dispersant, is uniformly mixing to obtain after ultrasound
Mixed solution；
S2. by step S1 gained mixed solution pour into controllable temperature mould or be laid on controllable temperature flat board, temperature be 20~
80 DEG C, through solvent volatilization curing molding, being obtained can magnetic resonance imaging composite.
Preferably, macromolecular material described in step S1 and the mass ratio with nuclear magnetic resonance specificly-response material are 1：
(10-5~1.5), nuclear magnetic resonance specificly-response material is 1 with the mass ratio of dispersant：(1.5~104)。
The macromolecular material is natural macromolecular material, synthesis macromolecular material or natural macromolecular material high with synthesis
The mixture of molecular material.
The natural macromolecular material is PLA, polycaprolactone, PGA, polylactide, polyglycolic acid, transparent
One or more of matter acid, fibrin, silk-fibroin, polyethylene glycol, shitosan, collagen or gelatin；
It is described synthesis macromolecular material be polyethylene, polypropylene, polyvinyl chloride, polystyrene, polymethyl methacrylate,
Polyamide, makrolon, polyformaldehyde, polybutylene terephthalate, PET, cellulose acetate, methyl
It is cellulose, ethyl cellulose, hydroxyethyl cellulose, cyanethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, thin
Fungin, HES, CMS, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylonitrile, polyethylene glycol breast
It is sour block copolymer, PEG-PCL block copolymer, polyethylene glycol vinylpyrrolidone block copolymer, poly-
Polystyrene-polybutadiene block copolymer, SBS, polystyrene-poly (ethene-
Butylene)-polystyrene block copolymer, styrene-isoprene/butadiene-styrene block copolymer or polystyrene-poly
One or more of butadiene-polystyrene block copolymer.
Preferably, it is europium compound, gadolinium compound, terbium to have nuclear magnetic resonance specificly-response material described in step S1
In compound, dysprosium compound, manganese compound, ferrimagnet, polyalcohol, glyceride, sterol compound or aliphatic acid it is a kind of with
On.
It is further preferable that the europium compound is europium oxide, Europium chloride, nano europium oxide or nanometer Europium chloride；The gadolinium
Compound be gadolinium diethyl pentetic acid chelate, gadolinium oxide, gadolinium chloride, gadolinium oxalate, nano oxidized gadolinium, nanometer gadolinium chloride or
Nanosized oxalate；The terbium compound is terbium oxide, terbium chloride, nano oxidized terbium or nanometer terbium chloride；The dysprosium compound is
Dysprosia, dysprosium chloride, nano oxidized dysprosium or nanometer dysprosium chloride；The manganese compound is mangano-manganic oxide, manganese chloride, citric acid chela
Close manganese, ethylenediamine tetra-acetic acid manganese, nano manganic manganous oxide or nanometer manganese chloride；The ferrimagnet is super-paramagnetism nano oxygen
Change iron, magnetic ferroferric oxide, sodium ferrite, citric acid chelated iron, amino acid iron or the adjacent phenylacetic acid iron of ethylenediamine two；It is described many
First alcohol is ethylene glycol, propane diols or glycerine；The glyceride is that glycerin monostearate, bi-tristearin or three are stearic
Acid glyceride；The sterol compound is cholesterine, sitosterol, stigmasterol, ergosterol or wool steroid；The aliphatic acid is the moon
Cinnamic acid, myristic acid, palmitic acid, stearic acid, arachidic acid, lignoceric acid, linoleic acid, leukotrienes, arachidonic acid, eicosapentaenoic
Acid or DHA.
Preferably, organic solvent described in step S1 is dichloromethane, chloroform, dichloroethanes, tetrachloroethanes, propylene
Sour methyl esters, tetrahydrofuran, methyltetrahydrofuran, N,N-dimethylformamide, DMAC N,N' dimethyl acetamide, dimethyl sulfoxide (DMSO), second
Ether, petroleum ether, acetone, formic acid, acetic acid, trifluoroacetic acid, carbon tetrachloride, dimethylbenzene, toluene, phenol, chlorobenzene, nitrobenzene, pentane,
N-hexane, hexahydrotoluene, 1-METHYLPYRROLIDONE, methyl phenyl ethers anisole, methyl alcohol, ethanol, 1- propyl alcohol, 2- propyl alcohol, n-butyl alcohol, 2- fourths
One or more of alcohol, amylalcohol, N-methylmorpholine-N- oxides, methyl chloride imidazole salts or cresols；
Preferably, dispersant described in step S1 is glycerin monostearate, bi-tristearin, three glycerol stearates
Ester, linear paraffin, its chemical general formula are CnH2n+2, wherein n=3~60, barium stearate, zinc stearate, polyethylene glycol, poly- the third three
Any one in alcohol or HPMA.
Preferably, the speed for being stirred described in step S1 is 200~2000rpm, and the power of the ultrasound is 10~50W,
The frequency of ultrasound is 20~80MHz, and the time of ultrasound is 1~5h.
Prepared by a kind of above method magnetic resonance imaging composite and its can be combined at depressurize pad, basin bottom of cranial nerve
Application in sticking patch, lower eyelid alternative materials, hernia repair piece, artificial breast wall, cardiac patch, postoperative anti-adhesion membrane.
Preferably, it is described can magnetic resonance imaging composite be block or film-form.
Compared with prior art, the present invention has the advantages that：
1. macromolecular material is blended system by the present invention using solution casting method with having nuclear magnetic resonance specificly-response material
It is standby can magnetic resonance imaging material.By allocating component raw material and proportioning, and different moulds or press mold technique are utilized, can obtained
With different IPs Magnetic Resonance, different shape and thickness can magnetic resonance imaging material.The letter of the method apparatus and process
It is single, it is easy to which that plastotype is reproducible to meet the requirement to being implanted into material shape, can carry out scale of mass production.
2. the present invention prepare can magnetic resonance imaging composite both remained macromolecular material mechanical property in itself
And biological characteristics, the imaging results under nuclear magnetic resonance are realized again.Can be obtained under nuclear magnetic resonance and be substantially distinguished from people
The image of body surrounding tissue, obtains the information such as shape and the internal position of implantation material.Can be detected by not damaged MRI and be planted
Enter the information such as object location and face shaping change, to realize tracking and understanding the purpose of the sufferer state of an illness.Can be in cranial nerve pressure-reducing pad
Obtained in piece, basin bottom composite patch, lower eyelid alternative materials, hernia repair piece, artificial breast wall, cardiac patch, postoperative anti-adhesion membrane
Widely apply.
3. the present invention is by the way that from different, with nuclear magnetic resonance specificly-response material, obtaining has different nuclear magnetic resonance
The magnetic resonance imaging material of response signal and intensity, make can magnetic resonance imaging body implantation material efficiently solve in human body
The problem of implantation material information can not be obtained due to existing macromolecule implantation material and surrounding tissue no signal difference, operation is planted
Can meet between material and tissue after entering at the same realize clear resolved materials and surrounding organized optimum contrast
Need and application purpose.
Brief description of the drawings
Fig. 1 is the photo in kind of the PEG/GMS composites of preparation in embodiment 2.
Fig. 2 is PET/GdCl in embodiment 33The photo in kind and its nuclear magnetic resonance T2 weighted imaging figures of/PEG composites
(T2WI)。
Fig. 3 is the photo in kind of the nano oxidized gadoliniums of the SEBS//GTS film-form composites of preparation in embodiment 4.
Specific implementation method
It is explained further the present invention with reference to embodiments, but embodiment does not do any type of limit to the present invention
It is fixed.
Embodiment 1 prepares polypropylene (PP)/Europium chloride (EuCl3)/polyglycerol composite
S1. 200rpm stirs in 24g PP being dissolved in into 56g DMFs (DMF) at 30 DEG C, then
Add 0.005g EuCl3With 1g polyglycerols, ultrasound 4h, 300rpm are uniformly mixing to obtain PP/EuCl under 30MHz, 20W3/ poly-
Glycerine mixed solution.
S2. by gained PP/EuCl in S13/ polyglycerol mixed solution is poured into 50 DEG C of mould, solvent flashing, shaping
After obtain PP/EuCl3/ polyglycerol composite.
Embodiment 2 prepares polyethylene glycol (PEG)/glycerin monostearate (GMS) composite
S1. 400rpm stirs in 200g PEG being dissolved in into 450g dichloromethane at 60 DEG C, is subsequently adding 300g
GMS, ultrasound 2h, 500rpm are uniformly mixing to obtain PET/GMS mixed solutions under 30MHz, 20W.
S2. gained PET/GMS mixed solutions in S1 are poured into 25 DEG C of mould, PET/ is obtained after solvent flashing, shaping
GMS composites.
If Fig. 1 is the photo in kind of PEG/GMS composites, the material is shown in figure for white solid, the length of side is about
The rectangular block shape material of 2.5cm.
Embodiment 3 prepares PET (PET)/gadolinium chloride (GdCl3)/polyethylene glycol (PEG) composite wood
Material
S1. 1000rpm stirs in 40g PET being dissolved in into 140g dichloromethane and 140g trifluoroacetic acids at 35 DEG C,
It is subsequently adding 0.02g GdCl3With 5g PEG, the ultrasound 2.5h under 45MHz, 23W, 1500rpm stirs, and obtains PET/
GdCl3/ PEG mixed solutions.
S2. by gained PET/GdCl in S13Mixed solution is poured into 30 DEG C of mould, is obtained after solvent flashing, shaping
PET/GdCl3/ PEG composites.
If Fig. 2 is PET/GdCl3The photo in kind (Fig. 2 left) of/PEG composite material test samples and its in left figure black line
Shown in section nuclear magnetic resonance T2WI images (Fig. 2 right).During test, PET/GdCl3/ PEG composites are loaded on a diameter of
In the vial of 2cm, bottle external environment be water, packing material in bottle, and by water be full of residual volume.Glass can not provide signal,
A black annulus (low signal) is shown as in Fig. 2 right sides (nuclear magnetic resonance T2WI).Water in bottle and signal intensity one shown in the outer water of bottle
Cause, equal gray；Material is in low signal (black) under nuclear magnetic resonance T2WI images in bottle.
Embodiment 4 prepares polystyrene-poly (Ethylene/Butylene)-polystyrene block copolymer (SEBS)/nano oxidized
Gadolinium/glyceryl tristearate (GTS) composite
S1. 2000rpm stirs in 100g SEBS being dissolved in into 620g tetrahydrofurans at 5 DEG C, is subsequently adding 0.001g
Nano oxidized gadolinium and 10g GTS, the ultrasound 5h under 20MHz, 10W, rear 2000rpm be uniformly mixing to obtain the nano oxidized gadoliniums of SEBS//
GTS mixed solutions.
S2. the nano oxidized gadoliniums of gained SEBS//GTS mixed solutions in S1 are laid on 80 DEG C of metal plates, solvent flashing,
The nano oxidized gadoliniums of SEBS//GTS composites are obtained after shaping.
If Fig. 3 is the photo in kind of the nano oxidized gadoliniums of SEBS//GTS film-form composites, show that the material is in figure
Bright circular membrane.
Embodiment 5 prepares polypropylene (PP)/super-paramagnetism nano iron oxide (SPIO)/polyethylene glycol (PEG) composite
S1. 1500rpm stirs in 30g PP being dissolved in into 140g DMFs (DMF) at 45 DEG C, so
0.001g SPIO and 10g PEG are added afterwards, and ultrasound 1h, rear 1500rpm are uniformly mixing to obtain PP/SPIO/ under 50MHz, 50W
PEG mixed solutions.
S2. gained PP/SPIO/PEG mixed solutions in S1 are poured into 50 DEG C of mould, is obtained after solvent flashing, shaping
PP/SPIO/PEG composites.
Embodiment 6 prepares bacteria cellulose (BC)/nano manganic manganous oxide/polyethylene glycol (PEG) composite
S1. 400rpm stirs in 3g BC being dissolved in into 97g N-methylmorpholine-N- oxides (NMMO) at -10 DEG C,
0.01g nano manganic manganous oxides and 15g PEG are subsequently adding, the ultrasound 3h under 30MHz, 30W, rear 1200rpm stirs, obtains
To BC/ nano manganic manganous oxides/PEG mixed solutions.
S2. gained BC/ nano manganic manganous oxides/PEG mixed solutions in S1 are laid on 20 DEG C of metal plates, are volatilized molten
BC/ nano manganic manganous oxides/PEG composites are obtained after agent, shaping.
Embodiment 7 prepares cellulose acetate (CA)/bi-tristearin (GDS)/polyethylene glycol (PEG) composite
S1. 15g PET are dissolved in 28gN at 25 DEG C, 1800rpm is stirred in dinethylformamide (DMF) and 57g acetone
Mix uniform, be subsequently adding 5g GDS and 5g PEG, the ultrasound 3.5h under 40MHz, 15W, 2000rpm stirs, and obtains CA/
GDS/PEG mixed solutions.
S2. gained CA/GDS/PEG mixed solutions in S1 are laid on 40 DEG C of metal plates, are obtained after solvent flashing, shaping
CA/GDS/PEG composites.
Embodiment 8 prepares shitosan (CS)/dysprosium chloride (DyCl3)/glyceryl tristearate (GTS) composite
S1. 600rpm stirs in 1g CS being dissolved in into 20g formic acid, is subsequently adding 0.002g DyCl3With 1g GTS,
Ultrasound 3h under 42MHz, 10W, 1200rpm stir, and obtain CS/DyCl3/ GTS mixed solutions.
S2. by gained CS/DyCl in S13/ GTS mixed solutions are laid on 65 DEG C of glass plates, after solvent flashing, shaping
To CS/DyCl3/ GTS composites.
Above-described embodiment is the present invention preferably implementation method, but embodiments of the present invention are not by above-described embodiment
Limitation, it is other it is any without departing from Spirit Essence of the invention and the change, modification, replacement made under principle, combine and simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. it is a kind of can magnetic resonance imaging composite preparation method, it is characterised in that comprise the following steps：
S1. macromolecular material is dissolved in organic solvent at -10~80 DEG C, compound concentration is that the macromolecule of 1~30wt% is molten
Liquid, is stirred, and is subsequently adding with nuclear magnetic resonance specificly-response material and dispersant, and mixing is uniformly mixing to obtain after ultrasound
Solution；
S2. step S1 gained mixed solutions are poured into controllable temperature mould or are laid on controllable temperature flat board, temperature is 20~80 DEG C,
Through solvent volatilization curing molding, being obtained can magnetic resonance imaging composite.
2. according to claim 1 can magnetic resonance imaging composite preparation method, it is characterised in that institute in step S1
It is natural macromolecular material, synthesis macromolecular material or natural macromolecular material and synthesis macromolecular material to state macromolecular material
Mixture；
The natural macromolecular material is PLA, polycaprolactone, PGA, polylactide, polyglycolic acid, hyalomitome
One or more of acid, fibrin, silk-fibroin, polyethylene glycol, shitosan, collagen or gelatin；
The synthesis macromolecular material is polyethylene, polypropylene, polyvinyl chloride, polystyrene, polymethyl methacrylate, polyamides
Amine, makrolon, polyformaldehyde, polybutylene terephthalate, PET, cellulose acetate, Methyl cellulose
Element, ethyl cellulose, hydroxyethyl cellulose, cyanethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, bacterium are fine
Dimension element, HES, CMS, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylonitrile, polyethylene glycol-polylactic acid are embedding
Section copolymer, PEG-PCL block copolymer, polyethylene glycol vinylpyrrolidone block copolymer, polyphenyl second
Alkene-butadiene block copolymer, SBS, polystyrene-poly (ethene-fourth
Alkene)-polystyrene block copolymer, styrene-isoprene/butadiene-styrene block copolymer or polystyrene-poly fourth
One or more of diene-polystyrene block copolymer.
3. according to claim 1 can magnetic resonance imaging composite preparation method, it is characterised in that institute in step S1
It is 1 that macromolecular material is stated with the mass ratio with nuclear magnetic resonance specificly-response material：(10-5~1.5), the nuclear magnetic resonance is special
Different in nature responsive materials are 1 with the mass ratio of dispersant：(1.5~104)。
4. according to claim 1 can magnetic resonance imaging composite preparation method, it is characterised in that institute in step S1
It is europium compound, gadolinium compound, terbium compound, dysprosium compound, manganese compound, iron to state with nuclear magnetic resonance specificly-response material
One or more of magnetic material, polyalcohol, glyceride, sterol compound or aliphatic acid.
5. according to claim 4 can magnetic resonance imaging composite preparation method, it is characterised in that the europium chemical combination
Thing is europium oxide, Europium chloride, nano europium oxide or nanometer Europium chloride；The gadolinium compound is chelated for gadolinium diethyl pentetic acid
Thing, gadolinium oxide, gadolinium chloride, gadolinium oxalate, nano oxidized gadolinium, nanometer gadolinium chloride or nanosized oxalate；The terbium compound is oxidation
Terbium, terbium chloride, nano oxidized terbium or nanometer terbium chloride；The dysprosium compound is dysprosia, dysprosium chloride, nano oxidized dysprosium or nanometer
Dysprosium chloride；The manganese compound is mangano-manganic oxide, manganese chloride, citric acid Chelated Manganese, ethylenediamine tetra-acetic acid manganese, nanometer four are aoxidized
Three manganese or nanometer manganese chloride；The ferrimagnet is super-paramagnetism nano iron oxide, magnetic ferroferric oxide, sodium ferrite, lemon
Lemon acid chelated iron, amino acid iron or the adjacent phenylacetic acid iron of ethylenediamine two；The polyalcohol is ethylene glycol, propane diols or glycerine；
The glyceride is glycerin monostearate, bi-tristearin or glyceryl tristearate；The sterol compound is courage
Sterol, sitosterol, stigmasterol, ergosterol or wool steroid；The aliphatic acid is laurate, myristic acid, palmitic acid, tristearin
Acid, arachidic acid, lignoceric acid, linoleic acid, leukotrienes, arachidonic acid, eicosapentaenoic acid or DHA.
6. according to claim 1 can magnetic resonance imaging composite preparation method, it is characterised in that institute in step S1
The organic solvent stated is dichloromethane, chloroform, dichloroethanes, tetrachloroethanes, methyl acrylate, tetrahydrofuran, methyl four
Hydrogen furans, N,N-dimethylformamide, DMAC N,N' dimethyl acetamide, dimethyl sulfoxide (DMSO), ether, petroleum ether, acetone, formic acid, second
Acid, trifluoroacetic acid, carbon tetrachloride, dimethylbenzene, toluene, phenol, chlorobenzene, nitrobenzene, pentane, n-hexane, hexahydrotoluene, N- first
Base pyrrolidones, methyl phenyl ethers anisole, methyl alcohol, ethanol, 1- propyl alcohol, 2- propyl alcohol, n-butyl alcohol, 2- butanol, amylalcohol, N-methylmorpholine-N- oxygen
One or more of compound, methyl chloride imidazole salts or cresols.
7. according to claim 1 can magnetic resonance imaging composite preparation method, it is characterised in that institute in step S1
Dispersant is stated for glycerin monostearate, bi-tristearin, glyceryl tristearate, linear paraffin, its chemical general formula is
CnH2n+2, appointing wherein in n=3~60, barium stearate, zinc stearate, polyethylene glycol, polyglycerol or HPMA
Meaning is a kind of.
8. according to claim 1 can magnetic resonance imaging composite preparation method, it is characterised in that institute in step S1
The speed of stirring is stated for 200~2000rpm, the power of the ultrasound is 10~50W, and the frequency of ultrasound is 20~80MHz, ultrasound
Time be 1~5h.
9. it is a kind of according to claim any one of 1-8 methods described prepare can magnetic resonance imaging composite, its feature exists
In, it is described can magnetic resonance imaging composite be block or film-form.
10. according to claim 9 can magnetic resonance imaging composite cranial nerve depressurize pad, basin bottom composite patch,
Application in lower eyelid alternative materials, hernia repair piece, artificial breast wall, cardiac patch, postoperative anti-adhesion membrane.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569694A (en) * | 2017-09-15 | 2018-01-12 | 杨润 | A kind of dept. of radiology's tumor imaging agent and preparation method thereof |
| CN111155197A (en) * | 2020-01-10 | 2020-05-15 | 华南理工大学 | Magnetic fiber material and preparation method and application thereof |
| CN111632155A (en) * | 2020-06-01 | 2020-09-08 | 西南大学 | Preparation method of sericin-gadolinium pH responsive targeted tumor nuclear magnetic resonance contrast agent |
| CN112063839A (en) * | 2020-08-04 | 2020-12-11 | 福建省连城锰矿有限责任公司 | Process for preparing manganese sulfate by manganese sulfide wet method |
| CN112587723A (en) * | 2020-11-19 | 2021-04-02 | 南京医科大学 | In-situ rapid-forming magnetic hydrogel for repairing urinary system and preparation method thereof |
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| CN116590806A (en) * | 2023-04-12 | 2023-08-15 | 华南理工大学 | Binary fatty acid eutectic composite fiber capable of magnetic resonance imaging and preparation and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569694A (en) * | 2017-09-15 | 2018-01-12 | 杨润 | A kind of dept. of radiology's tumor imaging agent and preparation method thereof |
| CN111155197A (en) * | 2020-01-10 | 2020-05-15 | 华南理工大学 | Magnetic fiber material and preparation method and application thereof |
| CN111155197B (en) * | 2020-01-10 | 2021-01-19 | 华南理工大学 | Magnetic fiber material and preparation method and application thereof |
| CN111632155A (en) * | 2020-06-01 | 2020-09-08 | 西南大学 | Preparation method of sericin-gadolinium pH responsive targeted tumor nuclear magnetic resonance contrast agent |
| CN111632155B (en) * | 2020-06-01 | 2023-01-24 | 西南大学 | Preparation method of sericin-gadolinium pH responsive targeted tumor nuclear magnetic resonance contrast agent |
| CN112063839A (en) * | 2020-08-04 | 2020-12-11 | 福建省连城锰矿有限责任公司 | Process for preparing manganese sulfate by manganese sulfide wet method |
| CN112063839B (en) * | 2020-08-04 | 2021-12-28 | 福建省连城锰矿有限责任公司 | Process for preparing manganese sulfate by manganese sulfide wet method |
| CN112587723A (en) * | 2020-11-19 | 2021-04-02 | 南京医科大学 | In-situ rapid-forming magnetic hydrogel for repairing urinary system and preparation method thereof |
| WO2023000371A1 (en) * | 2021-07-23 | 2023-01-26 | 中国科学院深圳先进技术研究院 | Bone repair scaffold, and preparation method therefor and use thereof |
| CN116590806A (en) * | 2023-04-12 | 2023-08-15 | 华南理工大学 | Binary fatty acid eutectic composite fiber capable of magnetic resonance imaging and preparation and application thereof |
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