CN106692230A - Preparation method of herba lysimachiae granules - Google Patents
Preparation method of herba lysimachiae granules Download PDFInfo
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- CN106692230A CN106692230A CN201710157190.1A CN201710157190A CN106692230A CN 106692230 A CN106692230 A CN 106692230A CN 201710157190 A CN201710157190 A CN 201710157190A CN 106692230 A CN106692230 A CN 106692230A
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- desmodium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a preparation method of herba lysimachiae granules. The preparation method comprises the steps of adopting herba lysimachiae as a raw material; adopting water (90 to 95 DEG C) for forcedly and dynamically recycling extracting for three times; vacuum concentrating an extracting solution to obtain a herba lysimachiae extract; adding appropriate pharmaceutic adjuvant and appropriate amount of flavoring agent for highly dispersing, and then preparing to form mixed dry extract powder through a vacuum low-temperature continuous drying technology; adding ethyl alcohol for stirring and mixing to obtain the granules. According to the preparation method adopted by the invention, the contents of quercetin and kaempferide in the herba lysimachiae granules can be remarkably improved, and the increased range achieves 250 percent; the dosage of the commercially available herba lysimachiae granules for every time can be reduced by not less than 70 percent, so that the patient adaptability is greatly improved; the operation cost can be reduced by not less than 1/3, the energy consumption can be reduced by not less than 40 percent, and the modernization of a traditional Chinese medicine can be fully reflected.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, and in particular to a kind of to prepare money grass particle by raw material of desmodium
Preparation method.
Background technology
Desmodium is《Pharmacopoeia of People's Republic of China》（Version one in 2015）Kind is recorded, is that Ofthe Primulaceae is passed by one's way
Yellow (Lysimachia christinae Hance's) dries herb, and the harvesting of the season of summer and autumn two removes impurity, dries.Desmodium taste
It is sweet, it is salty, it is slightly cold, Return liver, courage, kidney, bladder warp, with removing dampness through diuresis and removing jaundice, inducing diuresis for treating strangurtia, the effect of removing toxicity for detumescence, for damp and hot Huang
Subcutaneous ulcer, courage is swollen hypochondriac pain, urolithiasis, heat gonorrhea, difficulty and pain in micturition, carbuncle swells furunculosis, snake bite and insect sting.The thatched cottage proved recipe transcript of Sichuan hundred, the Qing Dynasty according to legend
Qianlong yearses（1736-1795）, there is desmodium to treat the record of " yellow sand walks subcutaneous ulcer ", the application at least having for more than 200 years so far is gone through
Shi Liao, is described as controlling the key medicine of calculus.Nearly 50 years, domestic scholars were to the chemical composition of desmodium, pharmacological action and clinical practice
Many researchs are carried out.Initial analysis desmodium contains phenolic constituent, flavonoids, glucoside, tannin, volatile oil, amino acid, courage
The compositions such as alkali, sterol, potassium chloride, lactone；The pharmacological action of desmodium：1. invigorating gallbladder and removing gall-stone effect.2. diuresis and stone expeling effect.③
Antiinflammatory action.
It is at present that the money grass particle that single raw material is made uses traditional decocting process with desmodium, is concentrated to give leaching
Cream, adds a large amount of auxiliary materials（Medicinal extract is than auxiliary material up to 1:6）Carry out granulation production and obtain finished product, there are problems：
Existing money grass particle《National drug Chinese medicine standard》（Internal medicine liver and gall fascicle）Production technology is to take desmodium 2000g
Add water to cook three times, 2 hours for the first time, second 1 hour, third time 30 minutes, collecting decoction stood 12-24 hours, takes
Supernatant is filtered, and filtrate is concentrated into relative density for 1.10-1.30（55℃）Thick paste, plus cane sugar powder 828.9g, appropriate dextrin,
Mix, be made particle, dry, be made 1000g, obtain final product, granule finished product content is to be not less than 0.8mg/ bags.The technique is present
Prepare particle difficult, supplementary product consumption is excessive, and 10g is taken each serving used in amounts, and granule content is relatively low, only 0.8mg/ bags, causes
A large amount of sugar avoiding patients are unwilling to take, even sugar avoiding patient is not taken, also because dose is excessive（Each 10g）, it is unwilling
Take, but because granule content is relatively low, active constituent content is less, and curative effect is weakened.
Chinese patent 201410509753.5 discloses a kind of preparation method of sugar type granules, than a kind of upper desmodium
Although grain preparation method improves, but still rests on using traditional decocting process, is used after extract solution is concentrated
Medicinal extract and the direct granulating process of auxiliary material, have banned a large amount of sucrose in above-mentioned money grass particle technique, can be applied to avoid sugar
Patient, there is certain progress, but it is excessive still to there is auxiliary material proportion addition（With medicinal extract ratio up to 5: 1）, dose is excessive, content
It is too low, only 0.9mg/ bags.
Chinese patent 201410352824.5 discloses a kind of preparation method of money grass particle, using water boiling and extraction,
Extract liquid to be concentrated through Three-effect concentration device, obtain medicinal extract, and desmodium particle preparation work is obtained with sucrose, dextrin granulation
Skill.More foregoing preparation technology increases, but it is excessive still not change supplementary product consumption（With medicinal extract ratio up to 6.64:1）, still deposit
It is too low in content（Only 0.8mg/ bags）Phenomenon.
Desmodium flavones ingredient, crude drug detects that flavone component content is 0.1% with Quercetin and Kaempferol；And pass through
Extraction is prepared into money grass particle, is only 0.8mg/ bags with Quercetin and Kaempferol detection flavone component content, it can be seen that, have
Modernized as desired by research lifting desmodium granule preparing process, improve formulation content, reduce supplementary product consumption, especially solved
The need for the application of vast sugar avoiding patient is so as to fit modern Chinese herbal medicine.
Preparation method of the present invention can significantly improve the content of Quercetin and Kaempferol in money grass particle, improve
Amplitude is up to 250%；Commercially available money grass particle can be reduced and each take dosage more than 70%, patient's compliance is greatly improved；
Operating cost more than 1/3, reducing energy consumption more than 40% can be saved, and the modernization of Chinese medicine can be fully demonstrated.
The content of the invention
For deficiencies of the prior art, it is low, granulation difficulty that the present invention solves desmodium granular preparation content
Problem, and after overcoming and removing sucrose in technique, is difficult the bad problem of granulation, melting, there is provided a kind of desmodium granule
Preparation method, adapts to modernization Chinese medicine needs.
Above-mentioned technical problem is solved, the present invention is adopted the following technical scheme that：A kind of preparation method of money grass particle, it is special
Levy and be, it by desmodium medicinal extract, suitable pharmaceutic adjuvant and appropriate flavouring through high degree of dispersion after, it is continuous by vacuum and low temperature
Drying machine is made mixing dry extract, adds ethanol, and stirring mixing is made particle；Concretely comprise the following steps：
（1）Desmodium medicinal extract：Desmodium medicinal extract is extracted using pressure dynamic circulation；Concrete operations mode is to take desmodium medicinal material
400 weight portions, add water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic circulation to extract 2
Hour, add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour, add water for the third time 2 times and measure, force dynamic circulation to extract 30
Minute, merge extract solution, stand 12~24 hours；Supernatant is taken, is filtered, it is relatively close at 50~55 DEG C that filtrate is concentrated into temperature
Spend 75~130 weight portion medicinal extract for 1.10~1.25；
（2）By step（1）Gained medicinal extract adds suitable pharmaceutic adjuvant and appropriate flavouring, is uniformly dispersed with homogenizer,
Through vacuum and low temperature continuous drier（Vacuum -0.04~-0.10MPa, 50~70 DEG C of temperature of charge, the mesh of grinding particle size 80）Obtain
Dry extract；
（3）By step（2）The dry extract of gained, adds ethanol, softwood processed to cross 12 eye mesh screens, be made wet granular, less than 70 DEG C
Dry, obtain final product 30~60 weight portion particles.
The present invention during granule Study on Forming, once using directly by extract dry gained dry extract, and
Addition dextrin, the auxiliary material such as sodium carboxymethylcellulose are pelletized, as a result the addition of auxiliary material need in 2 times of dry extract amounts ability
Particle is made, granulation is difficult；Using first using sodium carboxymethylcellulose, polyvinylpyrrolidone k-30, without or a small amount of outer attach
Plus pelletized after dextrin, mannitol high degree of dispersion, can obtain preferable particle, granulation is easily, it was demonstrated that the dispersion preparation process has
The characteristics of having easy-formation.The present invention realizes continuous feed and discharging by vacuum and low temperature continuous drier, and product is whole true
Dried during empty, closed environment, property is gentle, drying capacity is strong, in production capacity, the linkage flowing water of dry granulation can be realized
Change operation, yield is up to 100kg/ lab scales.And with Conventional processing methods such as one-step palletizings, yield maximum can reach 50kg/ hours,
Production capacity of the present invention is significantly improved, and operating cost saves 1/3, energy consumption reduction by more than 40%.
Compared to existing technology, the present invention has the advantages that：
1st, the present invention carries out forcing dynamic circulation to be extracted by 90-95 DEG C of hot water, and using the macromolecule material of high degree of dispersion
System, and the continuous drying technology of vacuum and low temperature, obtain a kind of Chinese herbal granules for meeting modernization application in TCM feature.It is logical
Preparation technology of the present invention is crossed, Quercetin and kaempferia galamga cellulose content are improved to 2mg/ bags by original 0.8mg/ bags, and content improves
250%, main active is greatly improved.
2nd, the present invention solves the problems, such as that dry extract is not easy granulation by the high degree of dispersion preparation method, accords with dosage
The requirement of modernization process is closed, is overcome after removing sucrose in technique, be difficult the bad problem of granulation, melting.
3rd, present invention obviates the application of a large amount of auxiliary materials, auxiliary material more than 90% is saved, is reduced each serving consumption up to more than 70%
（It is changed into below 3g/bag from former 10g/ bags）；Sucrose is also not used simultaneously, while the modernization of Chinese medicine is embodied, to diabetes etc.
Vast sugar avoiding patient provides another money grass particle without sucrose.
4th, using new auxiliary material and modern dry technology, make Chinese herbal granules is reduced to below 3g each serving consumption 10g,
Dose reduces more than 70%, greatly improves the compliance of patient.
5th, the present invention uses the continuous drying technology of vacuum and low temperature, under vacuum conditions continuous feed and discharging, product yield
Up to more than 99%, operating cost is dried than medicinal extract granulation, boiling one-step palletizing is dried and saves 1/3, energy consumption reduction by more than 40%.
Brief description of the drawings
Fig. 1 is that embodiment sample 1 is relatively schemed with the hydroscopicity curve ratio of sample 2.
Specific embodiment
The present invention is described in further detail with reference to specific embodiment.It should be understood, however, that, these embodiments
It is only used for specifically describing in more detail and is used, and is not to be construed as limiting the present invention in any form.
A kind of preparation method of money grass particle, comprises the following steps：
1st, desmodium medicinal extract：Using forcing dynamic circulation to be extracted, concrete operations mode is to take desmodium medicinal material 400 to desmodium medicinal extract
Weight portion, adds water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic circulation to extract 2 small
When, add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour, add water for the third time 2 times and measure, force dynamic circulation to extract 30 points
Clock, merges extract solution；12~24 hours are stood, supernatant is taken, filtered；Filtrate is concentrated into temperature relative density at 50~55 DEG C
It is 1.10~1.25 75~130 weight portion medicinal extract；
2nd, step 1 gained medicinal extract is added into suitable pharmaceutic adjuvant and appropriate flavouring, is uniformly dispersed with homogenizer, through true
Empty low temperature continuous drier（Vacuum -0.04~-0.10MPa, 50~70 DEG C of temperature of charge, the mesh of grinding particle size 80）Obtain dry leaching
Cream powder；
3rd, by the dry extract of step 2 gained, ethanol, softwood processed is added to cross 12 eye mesh screens, be made wet granular, less than 70 DEG C are done
It is dry, obtain final product 30~60 weight portion particles.
Following examples use preparation method of the present invention：
Embodiment 1
Desmodium 400g, adds water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic circulation
Extract 2 hours；Add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour；Third time adds water 2 times and measures, and forces dynamic circulation
Extract 30 minutes；Merge extract solution, stand 12 hours, take supernatant, filter, filtrate is concentrated into temperature relative density at 55 DEG C
It is 1.10 75g medicinal extract, solid content is 30g；0.9g polyvinylpyrrolidones and Aspartame 0.6g are added, high-speed stirring is used
The machine of mixing stirs, through vacuum and low temperature continuous drier（Vacuum -0.09MPa, 60 DEG C of temperature of charge）Obtain dry extract, powder
It is broken；75% ethanol is added, is pelletized, cross 12 eye mesh screens, be made wet granular, 65 DEG C of dryings obtain final product 31.2g particles, are distributed into 20 bags.
Embodiment 2
Desmodium 4000g, adds water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic to be followed
Ring is extracted 2 hours；Add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour；Third time adds water 2 times and measures, and forces dynamic to be followed
Ring is extracted 30 minutes；Merge extract solution, stand 12 hours, take supernatant, filter, it is relatively close at 55 DEG C that filtrate is concentrated into temperature
The 1298g medicinal extract for 1.10 is spent, solid content is 498g；0.5g sodium carboxymethylcelluloses and Steviosin 2.5g are added, with height
Fast mixer stirs, through vacuum and low temperature continuous drier（Vacuum -0.09MPa, 60 DEG C of temperature of charge, grinding particle size 80
Mesh）Obtain dry extract；75% ethanol is added, is pelletized, cross 12 eye mesh screens, be made wet granular, 65 DEG C of dryings obtain final product 500g particles,
It is distributed into 200 bags, every bag of 2.5g.
Embodiment 3
Desmodium 100kg, adds water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic to be followed
Ring is extracted 2 hours；Add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour；Third time adds water 2 times and measures, and forces dynamic to be followed
Ring is extracted 30 minutes；Merge extract solution, stand 24 hours, take supernatant, filter, it is relative when surveying for 55 DEG C that filtrate is concentrated into temperature
Density is 1.25 18.75kg medicinal extract, and solid content is 12.5kg；Add 125g polyvinylpyrrolidones k-30 and A Siba
Sweet 125g, is stirred with homogenizer, through vacuum and low temperature continuous drier（Vacuum -0.04MPa, 70 DEG C of temperature of charge,
The mesh of grinding particle size 80）Dry extract is obtained, in wet granulator, 75% ethanol is added, granulation is crossed 12 eye mesh screens, is made wet
Grain, 70 DEG C of ebullated bed fluidized dryings obtain final product 12.5kg particles, are distributed into 5000 bags, every bag of 2.5g.
Embodiment 4
Desmodium 120kg, adds water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic to be followed
Ring is extracted 2 hours；Add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour；Third time adds water 2 times and measures, and forces dynamic to be followed
Ring is extracted 30 minutes；Merge extract solution, stand 12 hours, take supernatant, filter, filtrate is concentrated into temperature and determines phase at 50 DEG C
It is 1.20 30kg medicinal extract to density, solid content is 12kg；Add 120g sodium carboxymethylcelluloses, dextrin 6kg and stevia rebaudianum
Plain 60g, is stirred with homogenizer, through vacuum and low temperature continuous drier（Vacuum -0.098MPa, 50 DEG C of temperature of charge,
The mesh of grinding particle size 80）Dry extract is obtained, 75% ethanol is added, granulation is crossed 12 eye mesh screens, is made wet granular, 65 DEG C of dryings, i.e.,
18kg particles are obtained, 6000 bags, every bag of 3g are distributed into.
Embodiment 5
Desmodium 120Kg, adds water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic to be followed
Ring is extracted 2 hours；Add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour；Third time adds water 2 times and measures, and forces dynamic to be followed
Ring is extracted 30 minutes；Merge extract solution, stand 12~24 hours, take supernatant, filter, filtrate is concentrated into temperature in 55 DEG C of phases
It is 1.10 38.4kg medicinal extract to density, solid content is 11.9kg, adds 119g polyvinylpyrrolidones, mannitol 6kg
With Steviosin 60g, stirred with homogenizer；Through vacuum and low temperature continuous drier（Vacuum -0.09MPa, temperature of charge
70 DEG C, the mesh of grinding particle size 80）Dry extract is obtained, 75% ethanol is added, 12 eye mesh screens are crossed in granulation, are made wet granular, and 70 DEG C are done
It is dry, 18kg particles are obtained final product, 6000 bags are distributed into, every bag of weight is 3g.
Embodiment 6
This example further proves that this technology can greatly improve former desmodium particle agent content by contrast test.
By preparing two categories below sample, and with reference to the method for inspection of desmodium granular mass standard, different samples are detected
Content.Sample 1 is the sample obtained by the preparation method of above-mentioned embodiment 5, and sample 2 is now to press《National drug Chinese medicine mark
It is accurate》（Internal medicine liver and gall fascicle）The sample of technique productions.
Quercetin and Kaempferol assay result table in the money grass particle of table one
According to above-mentioned comparative test result, from result of the test, it can be clearly seen that, using preparation technology of the invention, can be bright
The aobvious content for improving Quercetin and Kaempferol in every bag of money grass particle, improves degree up to 250%, it was demonstrated that preparation method of the present invention
With notable superiority.
The measure of hydroscopicity：
This example passes through the technology of high degree of dispersion and presses《National drug Chinese medicine standard》（Internal medicine liver and gall fascicle）Technique productions
Sample is contrasted, and further illustrating this preparation technology can reduce the hygroscopicity of granule.
The assay method of hydroscopicity：The glass desicator that one bottom fills supersaturated sodium chloride solution is placed in 25 DEG C of constant temperature
Constant temperature places 48 h in incubator, makes its internal relative humidity be 75%.Respectively take sample 1（Sample 1 is by above-mentioned embodiment
The sample that 4 preparation methods are obtained）, sample 2（Sample 2 is by existing《National drug Chinese medicine standard》（Internal medicine liver and gall fascicle）Technique
The sample of production）About 2 g money grass particles are divided in having dried to the measuring cup bottom of constant-quality, are uncapped and are placed in drier
12 more than h make sample 1 and sample 2 reach dehumidification balance, standby.It is placed in after the accurately weighed quality of measuring bottle that will be equipped with medicine
In stating glass desicator, in 4,8,12,24,36,48, the h of 6O, 72,84,96,108,120,144,168 timings it is accurately weighed, put down
Row does 3 parts, and calculates Moisture percentage.
Hydroscopicity=(the moisture absorption prodrug silty amount of medicinal powder quality one after moisture absorption)/moisture absorption prodrug silty amount
Result of the test：
1st, Moisture percentage
2nd, Moisture percentage interpretation of result
The above results are drawn into sucting wet curve, with the time as abscissa, hydroscopicity is ordinate, as a result sees Fig. 1.
It is that sample 2 is more than sample 1 from the size order of the visible hydroscopicity of accompanying drawing 1, i.e., using the money prepared by the present invention
Grass particle can substantially reduce the hygroscopicity of particle.
To sum up, the dispersion by forcing the continuous drying technique of dynamic circulation water leaching, low temperature and height of the invention
System is prepared into money grass particle, solves that existing desmodium granule content is too low, supplementary product consumption is excessive and uses less auxiliary material
The not easy-formation that causes, granulation, particle are difficult because of the serious problem of the auxiliary material hygroscopicity such as sucrose, so as to improve money grass particle
Modernization.The preparation method for being used can significantly improve the content of Quercetin and Kaempferol in money grass particle, increase rate
Up to 250%；Commercially available money grass particle can be reduced and each take dosage more than 70%, patient's compliance is greatly improved；Can section
About operating cost more than 1/3, reducing energy consumption more than 40%, and the modernization of Chinese medicine can be fully demonstrated.
Claims (5)
1. a kind of preparation method of money grass particle, it is characterised in that it is by desmodium medicinal extract, suitable pharmaceutic adjuvant and appropriate
After flavouring is through high degree of dispersion, mixing dry extract is made by vacuum and low temperature continuous drier, adds ethanol, stirring mixes,
It is made particle；Concretely comprise the following steps：
（1）Desmodium medicinal extract：Desmodium medicinal extract is extracted using pressure dynamic circulation；Concrete operations mode is to take desmodium medicinal material
400 weight portions, add water（90-95℃）Force dynamic circulation to be extracted three times, add water for the first time 6 times and measure, force dynamic circulation to extract 2
Hour；Add water for the second time 4 times and measure, force dynamic circulation to be extracted 1 hour；Third time adds water 2 times and measures, and forces dynamic circulation to extract 30
Minute；Extract solution is then combined with, 12~24 hours are stood；Supernatant is taken, is filtered, filtrate is concentrated into temperature in 50~55 DEG C of phases
It is 1.10~1.25 75~130 weight portion medicinal extract to density；
（2）By step（1）Gained medicinal extract adds suitable pharmaceutic adjuvant and appropriate flavouring, is uniformly dispersed with homogenizer,
Through vacuum and low temperature continuous drier（Vacuum -0.04~-0.10MPa, 50~70 DEG C of temperature of charge, the mesh of grinding particle size 80）Obtain
Dry extract；
（3）By step（2）The dry extract of gained, adds ethanol, softwood processed to cross 12 eye mesh screens, be made wet granular, less than 70 DEG C
Dry, obtain final product 30~60 weight portion particles.
2. the preparation method of money grass particle according to claim 1, it is characterised in that：Step（1）The phase of middle gained medicinal extract
It is 1.10~1.25 to density（50℃）, medicinal extract is 75~130 weight portions, and solid content is in 30~50 weight portions.
3. the preparation method of money grass particle according to claim 1 or claim 2, it is characterised in that：Step（1）Middle pharmaceutic adjuvant is
The sodium carboxymethylcellulose and polyvinylpyrrolidone of 1~3% medicinal extract solid content weight（K30）, add further according to being made total amount and calculating
Plus 0~dextrin and mannitol auxiliary material of 30 weight portions.
4. the preparation method of money grass particle according to claim 1 or claim 2, it is characterised in that：Step（2）In flavouring choosing
From Aspartame, Steviosin, consumption is medicinal extract solid content weight 0.5-2%.
5. the preparation method of money grass particle according to claim 1 or claim 2, it is characterised in that：Step（3）In particle for wet
Legal system grain is obtained, and in wet granulator, adds 75% ethanol, and Granulation time is 2 minutes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554332A (en) * | 2021-12-17 | 2023-01-03 | 吉林省正和药业集团股份有限公司 | Lysimachia christinae hance tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953883A (en) * | 2010-10-22 | 2011-01-26 | 重庆科瑞制药有限责任公司 | Chinese medicinal granules for treating calculosis and preparation method thereof |
| CN104224867A (en) * | 2014-09-28 | 2014-12-24 | 重庆和平制药有限公司 | Sugarless herba lysimachiae granules and preparation method thereof |
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| CN104224867A (en) * | 2014-09-28 | 2014-12-24 | 重庆和平制药有限公司 | Sugarless herba lysimachiae granules and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554332A (en) * | 2021-12-17 | 2023-01-03 | 吉林省正和药业集团股份有限公司 | Lysimachia christinae hance tablet and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN106692230B (en) | 2020-04-17 |
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