CN106691459A - Noninvasive blood glucose testing device based on human-eye iris reflection aqueous humor near infrared spectrum - Google Patents
Noninvasive blood glucose testing device based on human-eye iris reflection aqueous humor near infrared spectrum Download PDFInfo
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Abstract
The invention discloses a noninvasive blood glucose testing device based on human-eye iris reflection aqueous humor near infrared spectrum. The noninvasive blood glucose testing device comprises a halogen tungsten lamp, a band-pass filter, a gazing target, a near infrared spectrometer, a data processing module, a human-eye aqueous humor glucose content near infrared spectrum predicting mathematic model module and an LED screen. Continuous near infrared light beams generated by the halogen tungsten lamp pass the band-pass filter and are obliquely injected into human eyes; the continuous near infrared light beams pass human corneas and are subjected to aqueous humor transmission and iris reflection, and the emergent near infrared light contains the glucose content information in aqueous humor; the near infrared spectrometer collects and analyzes the emergent near infrared light to obtain the spectrum data information of the emergent near infrared light and transmits the spectrum data information into the data processing module; the data processing module preprocesses the spectrum data information and transmits the preprocessed data into the human-eye aqueous humor glucose content near infrared spectrum predicting mathematic model to obtain an accurate blood glucose value, and the accurate blood glucose value is displayed on the LED screen. The noninvasive blood glucose testing device has the advantages that the signal-to-noise ratio of the incident signals of the near infrared spectrometer is increased, and the accuracy of blood glucose testing is increased.
Description
Technical field
The invention belongs to biological tissue's parameter detecting field, it is related to a kind of noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum.
Background technology
Diabetes are a kind of metabolic diseases being characterized with hyperglycaemia caused due to defect of insulin secretion or biological action obstacle.It is one of most important Chronic Non-Communicable Diseases of current threat global human health.At present, most of self-monitoring blood glucose meters use minimally invasive blood sugar detecting method, and the method both brought pain and also increases infection risk to patient.
Chinese patent 201519152.1 discloses one kind《Noninvasive system for detecting blood sugar》, including light source module, light conduction module, light detection module and data processing module, the system both can also carry out blood sugar test using by the way of transmission by the way of reflecting.The positions such as existing Non-invasive detection instrument more options finger, ear-lobe, palm are used as detection object, although the position includes blood glucose constituents information, but because its structural constituent is complicated, and influenceed larger by body temperature, function of human body state etc., thus certainty of measurement it is difficult to ensure that.
The Wolfgang of German Wurzburg universities
Schrader etc. exists《Non-invasive glucose determination in
the human eye 》Using aqueous humor as detection object in one text, noninvasive system for detecting blood sugar is established, it selects the light being reflected back from lens surface as detection spectrum, but because crystalline volume reflectivity is very low, therefore the spectral signal signal to noise ratio for obtaining is relatively low, accuracy of detection is greatly affected.
Existing noninvasive dynamics monitoring device is bulky, and accuracy of detection is relatively low, and cost is costly.
The content of the invention
It is an object of the invention to provide a kind of noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum, overcome damage of the minimally invasive detection of tradition to patients fingers, on the premise of Non-invasive detection, by the use of the simple aqueous humor of structural constituent as detection object, the precision of detection is improve.
The technical solution for realizing the object of the invention is：A kind of noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum, including halogen tungsten lamp, bandpass filter, fixation object, near infrared spectrometer, data processing module, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module and LED screen；Bandpass filter is arranged on the light-emitting window of halogen tungsten lamp, fixation object is located at human eye front, halogen tungsten lamp and near infrared spectrometer are respectively positioned on human eye diagonally forward,, respectively positioned at the both sides of fixation object, near infrared spectrometer, data processing module, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module and LED screen are sequentially connected for halogen tungsten lamp and near infrared spectrometer；Halogen tungsten lamp produces continuous near-infrared light beam, it is changed near infrared light of the wavelength in the range of 1500 ~ 1800 nm after being filtered through bandpass filter, human eye is incided with incline direction, incident iris after being transmitted through the cornea and aqueous humor of human eye, again through the reflection of people's eye iris, by aqueous humor region, the glucose content information in aqueous humor is included in the near infrared light of outgoing second；Near infrared spectrometer is collected to the near infrared light of outgoing, and analysis obtains its spectroscopic data information, then is sent to data processing module；Data processing module is pre-processed to spectroscopic data information, and pretreated data are sent into people's aqueous humor glucose content near infrared spectrum mathematical prediction model module, obtains accurate blood glucose value, and shown in LED screen.
The wave-length coverage of described halogen tungsten lamp is 600 ~ 2500 nm, and the centre wavelength of bandpass filter is 1650
Nm, a width of 150 nm of half-peak.
The data processing module carries out pretreatment and comprises the following steps to spectroscopic data information：The optimum choice of noise filtering, normalized and spectral region.
The method for building up of people's aqueous humor glucose content near infrared spectrum mathematical prediction model is as follows in people's aqueous humor glucose content near infrared spectrum mathematical prediction model module：
Step 1：Artificial anterior chamber's model is set up, artificial aqueous humor solution is injected into artificial anterior chamber's model, to be filled with artificial anterior chamber's model of artificial aqueous humor solution as calibration set；
Step 2：Using the near infrared spectrum data comprising glucose content information in artificial aqueous humor solution that near infrared spectrometer is returned from the correction artificial anterior chamber's model of concentrated collection；
Step 3：Near infrared spectrum data to measuring is pre-processed；
Step 4：With through the near infrared spectrum data of the artificial aqueous humor solution after Pretreated spectra is associated actual glucose content in artificial aqueous humor solution using PLS by pretreated near infrared spectrum data, the fitting of institute's established model and predictive ability are evaluated with complete cross-verification proof method, so as to set up the mathematical prediction model of glucose content in the human eye based near infrared light spectrum information.
Artificial anterior chamber's model includes organic glass contact mirror and quartzy flat board in the step 1, and lucite contact lense imitates cornea, and quartzy flat board imitates iris, and deployed artificial aqueous humor solution is filled between lucite contact lense and quartzy flat board.
The artificial aqueous humor liquor capacity filled between the lucite contact lense and quartzy flat board is 50 ~ 80 μ L, and the inner surface distance from the inner surface of quartzy flat board to lucite contact lense is 3.00 ~ 3.35 mm.
Artificial aqueous humor solution is substrate with 0.9% physiological saline in the step 1, and the pH value of artificial aqueous humor solution is 8, and concentration of glucose is 1 ~ 30 mmol/L, and concentration interval is 1
Mmol/L, the covariance of each component material concentration is 0.
The sample mode of the near infrared spectrometer of the step 2 is reflection, and spectral scanning range is 1500 ~ 1800
Nm, resolution ratio is 2 nm, to each the sample multiple scanning three times in calibration set, is averaged as sample near infrared spectrum.
Pretreatment includes noise filtering, normalized, data screening, the optimum choice of spectral region, centralization and standardization in the step 3.
The Spectral range of selection is pre-processed in the step 3 for 1500 ~ 1800 nm, 17 smoothing processings, 4 number of principal components.
The present invention compared with prior art, its remarkable advantage：
（1）With human eye as detection object, using the simple excellent optical medium of people's aqueous humor this structural constituent, using Ray obliquity incidence cornea, returned by iris reflex after aqueous humor, and again pass by aqueous humor outgoing, it is greatly increased compared to the signal to noise ratio from crystalline lens front surface reflection, outgoing near infrared light spectrum signal.
（2）In the selection of analysis wave band, select the wave band of 1500 ~ 1800 nm as main analysis peak, be different from the full spectral coverage analysis of 800 ~ 2500 general nm, it is possible to increase the precision of spectrum analysis, it is ensured that the accuracy of blood sugar test.
（3）The mode of Non-invasive detection can eliminate infection risk compared to minimally invasive detection, mitigate the sense of discomfort of detection.
Brief description of the drawings
Fig. 1 is the structural representation of the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum of the invention.
Fig. 2 is the index path of the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum of the invention.
Fig. 3 is the Establishing process figure of people's aqueous humor glucose content near infrared spectrum mathematical prediction model of the invention.
Fig. 4 is the artificial anterior chamber's illustraton of model in people's aqueous humor glucose content near infrared spectrum mathematical prediction model of the invention.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
With reference to Fig. 1 and Fig. 2, a kind of noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum, including halogen tungsten lamp 1, bandpass filter 2, fixation object 3, near infrared spectrometer 4, data processing module 5, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 6 and LED screen 7.Bandpass filter 2 is arranged on the light-emitting window of halogen tungsten lamp 1, fixation object 3 is located at human eye front,, respectively positioned at the both sides of fixation object 3, near infrared spectrometer 4, data processing module 5, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 6 and LED screen 7 are sequentially connected for halogen tungsten lamp 1 and near infrared spectrometer 4.Halogen tungsten lamp 1 produces continuous near-infrared light beam, and wavelength is changed into 1500 ~ 1800 after being filtered through bandpass filter 2
Near infrared light in the range of nm, human eye is injected into incline direction, incident iris after being transmitted through the cornea and aqueous humor of human eye, by after the reflection of people's eye iris, for the second time by aqueous humor region, comprising the glucose content information in aqueous humor in the near infrared light of outgoing.Near infrared spectrometer 4 is collected to the near infrared light of outgoing, and analysis obtains its spectroscopic data information, and is sent to data processing module 5.Data processing module 5 is pre-processed to spectroscopic data information, by pretreated data feeding people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 6, obtains accurate blood glucose value, and shown in LED screen 7.
The wave-length coverage of described halogen tungsten lamp 1 is 600 ~ 2500 nm, and the centre wavelength of bandpass filter 2 is 1650 nm, a width of 150 nm of half-peak.
The data processing module 5 carries out pretreatment and comprises the following steps to spectroscopic data information：The optimum choice of noise filtering, normalized and spectral region.
With reference to Fig. 3 and Fig. 4, the method for building up of people's aqueous humor glucose content near infrared spectrum mathematical prediction model is as follows in people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 5：
Step 1：Artificial anterior chamber's model is set up, artificial aqueous humor solution is injected into artificial anterior chamber's model, to be filled with artificial anterior chamber's model of artificial aqueous humor solution as calibration set；
Step 2：Using the near infrared spectrum data comprising glucose content information in artificial aqueous humor solution that near infrared spectrometer is returned from the correction artificial anterior chamber's model of concentrated collection；
Step 3：Near infrared spectrum data to measuring is pre-processed；
Step 4：With through the near infrared spectrum data of the artificial aqueous humor solution after Pretreated spectra is associated actual glucose content in artificial aqueous humor solution using PLS by pretreated near infrared spectrum data, the fitting of institute's established model and predictive ability are evaluated with complete cross-verification proof method, so as to set up the mathematical prediction model of glucose content in the human eye based near infrared light spectrum information.
Artificial anterior chamber's model includes organic glass contact mirror and quartzy flat board in the step 1, and lucite contact lense imitates cornea, and quartzy flat board imitates iris, and deployed artificial aqueous humor solution is filled between lucite contact lense and quartzy flat board.
The artificial aqueous humor liquor capacity filled between the lucite contact lense and quartzy flat board is 50 ~ 80 μ L, and the inner surface distance from the inner surface of quartzy flat board to lucite contact lense is 3.00 ~ 3.35 mm.
Artificial aqueous humor solution is substrate with 0.9% physiological saline in the step 1, and the pH value of artificial aqueous humor solution is 8, and concentration of glucose is 1 ~ 30 mmol/L, and concentration interval is 1
Mmol/L, the covariance of each component material concentration is 0.
The sample mode of the near infrared spectrometer of the step 2 is reflection, and spectral scanning range is 1500 ~ 1800
Nm, resolution ratio is 2 nm, to each the sample multiple scanning three times in calibration set, is averaged as sample near infrared spectrum.
Pretreatment includes noise filtering, normalized, data screening, the optimum choice of spectral region, centralization and standardization in the step 3.
The Spectral range of selection is pre-processed in the step 3 for 1500 ~ 1800 nm, 17 smoothing processings, 4 number of principal components.
Embodiment 1
With reference to Fig. 1 and Fig. 2, a kind of noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum of the present invention, including halogen tungsten lamp 1, bandpass filter 2, fixation object 3, near infrared spectrometer 4, data processing module 5, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 6 and LED screen 7.Bandpass filter 2 is arranged on the light-emitting window of halogen tungsten lamp 1, fixation object 3 is located at human eye front,, respectively positioned at the both sides of fixation object 3, near infrared spectrometer 4, data processing module 5, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 6 and LED screen 7 are sequentially connected for halogen tungsten lamp 1 and near infrared spectrometer 4.Halogen tungsten lamp 1 produces continuous near-infrared light beam, it is changed near infrared light of the wavelength in the range of 1500 ~ 1800 nm after being filtered through bandpass filter 2, human eye is injected into incline 45° angle direction, incident iris after being transmitted through the cornea and aqueous humor of human eye, by after the reflection of people's eye iris, by aqueous humor region, the glucose content information in aqueous humor is included in the near infrared light of outgoing second.Near infrared spectrometer 4 is collected to the near infrared light of outgoing, and analysis obtains its spectroscopic data information, and is sent to data processing module 5.Data processing module 5 is pre-processed to spectroscopic data information, by pretreated data feeding people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 6, obtains accurate blood glucose value, and shown in LED screen 7.
The wave-length coverage of described halogen tungsten lamp 1 is 600 ~ 2500 nm, and the centre wavelength of bandpass filter 2 is 1650 nm, a width of 150 nm of half-peak.
The data processing module 5 carries out pretreatment and comprises the following steps to spectroscopic data information：The optimum choice of noise filtering, normalized and spectral region.
With reference to Fig. 2, from halogen tungsten lamp 1 as near-infrared light source, its advantage is mainly including wavestrip wide ranges, stable luminescent property, long service life etc..The bandpass filter 2 that centre wavelength is 1650 nm is inserted after the light source of halogen tungsten lamp 1, selection wavelength enters human eye for the light of 1500 ~ 1800 nm.By after convergent lens group, with 45 ° of angle oblique incidence cornea, incident ray by being radiated at iris surface after cornea and aqueous humor, by the reflection of iris, again by aqueous humor and by cornea outgoing.In Fig. 2 human eye partial enlargement block diagrams, L represents the incident ray for inclining 45° angle, A represents the light reflected through anterior surface of cornea, and B represents the light reflected from posterior surface of cornea after being transmitted through anterior surface of cornea, and C represents the light from iris reflex after being transmitted through cornea and aqueous humor.According to reflection law and Pu-mulberry Er Shi（Purkinje-Sanson）Picture, only enters line convergence, and use collecting fiber by the light i.e. light C of aqueous humor twice to what is be reflected back from iris surface.It is the accuracy for ensureing testing result, being relatively fixed for position of human eye in detection process is realized using luminous fixation object 3.
With reference to Fig. 3 and Fig. 4, the method for building up of people's aqueous humor glucose content near infrared spectrum mathematical prediction model is as follows in people's aqueous humor glucose content near infrared spectrum mathematical prediction model module 5：
Step 1：Artificial anterior chamber's model is set up, artificial aqueous humor solution is injected into artificial anterior chamber's model, to be filled with artificial anterior chamber's model of artificial aqueous humor solution as calibration set；
Step 2：Using the near infrared spectrum data comprising glucose content information in artificial aqueous humor solution that near infrared spectrometer is returned from the correction artificial anterior chamber's model of concentrated collection；
Step 3：Near infrared spectrum data to measuring is pre-processed；
Step 4：With through the near infrared spectrum data of the artificial aqueous humor solution after Pretreated spectra is associated actual glucose content in artificial aqueous humor solution using PLS by pretreated near infrared spectrum data, the fitting of institute's established model and predictive ability are evaluated with complete cross-verification proof method, so as to set up the mathematical prediction model of glucose content in the human eye based near infrared light spectrum information.
Artificial anterior chamber's model includes organic glass contact mirror and quartzy flat board in the step 1, and lucite contact lense imitates cornea, and quartzy flat board imitates iris, and deployed artificial aqueous humor solution is filled between lucite contact lense and quartzy flat board.
The artificial aqueous humor liquor capacity filled between the lucite contact lense and quartzy flat board is 60 μ L, and the inner surface distance from the inner surface of quartzy flat board to lucite contact lense is 3.13 mm.
Artificial aqueous humor solution is substrate with 0.9% physiological saline in the step 1, and the pH value of artificial aqueous humor solution is 8, and concentration of glucose is 1 ~ 30 mmol/L, and concentration interval is 1
Mmol/L, the covariance of each component material concentration is 0.
The sample mode of the near infrared spectrometer of the step 2 is reflection, and spectral scanning range is 1500 ~ 1800
Nm, resolution ratio is 2 nm, to each the sample multiple scanning three times in calibration set, is averaged as sample near infrared spectrum.
Pretreatment includes noise filtering, normalized, data screening, the optimum choice of spectral region, centralization and standardization in the step 3.
The Spectral range of selection is pre-processed in the step 3 for 1500 ~ 1800 nm, 17 smoothing processings, 4 number of principal components.
The method that the present invention passes through human eye iris reflex, near infrared spectrum of the collection comprising glucose content information in aqueous humor, and the Mathematical Modeling that spectroscopic data substitution has been built, so as to calculate the blood-sugar content of human body.Package unit compact conformation, stability is high, and the accurate detection to blood sugar is realized on the premise of to human zero damage, there is larger application prospect.
Claims (10)
1. a kind of noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum, it is characterised in that：Including halogen tungsten lamp（1）, bandpass filter（2）, fixation object（3）, near infrared spectrometer（4）, data processing module（5）, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module（6）And LED screen（7）；Bandpass filter（2）It is arranged on halogen tungsten lamp（1）Light-emitting window, fixation object（3）Positioned at human eye front, halogen tungsten lamp（1）And near infrared spectrometer（4）It is respectively positioned on human eye diagonally forward, halogen tungsten lamp（1）And near infrared spectrometer（4）Fixation object is located at respectively（3）Both sides, near infrared spectrometer（4）, data processing module（5）, people's aqueous humor glucose content near infrared spectrum mathematical prediction model module（6）And LED screen（7）It is sequentially connected；Halogen tungsten lamp（1）Continuous near-infrared light beam is produced, through bandpass filter（2）It is changed near infrared light of the wavelength in the range of 1500 ~ 1800 nm after optical filtering, human eye is incided with incline direction, incident iris after being transmitted through the cornea and aqueous humor of human eye, then through the reflection of people's eye iris, by aqueous humor region, the glucose content information in aqueous humor is included in the near infrared light of outgoing second；Near infrared spectrometer（4）Near infrared light to outgoing is collected, and analysis obtains its spectroscopic data information, then is sent to data processing module（5）；Data processing module（5）Spectroscopic data information is pre-processed, pretreated data are sent into people's aqueous humor glucose content near infrared spectrum mathematical prediction model module（6）, accurate blood glucose value is obtained, and in LED screen（7）Upper display.
2. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 1, it is characterised in that：Described halogen tungsten lamp（1）Wave-length coverage be 600 ~ 2500 nm, bandpass filter（2）Centre wavelength be 1650 nm, a width of 150 nm of half-peak.
3. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 1, it is characterised in that：The data processing module（5）Pretreatment is carried out to spectroscopic data information to comprise the following steps：The optimum choice of noise filtering, normalized and spectral region.
4. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 1, it is characterised in that：People's aqueous humor glucose content near infrared spectrum mathematical prediction model module（6）The method for building up of middle people's aqueous humor glucose content near infrared spectrum mathematical prediction model is as follows：
Step 1：Artificial anterior chamber's model is set up, artificial aqueous humor solution is injected into artificial anterior chamber's model, to be filled with artificial anterior chamber's model of artificial aqueous humor solution as calibration set；
Step 2：Using the near infrared spectrum data comprising glucose content information in artificial aqueous humor solution that near infrared spectrometer is returned from the correction artificial anterior chamber's model of concentrated collection；
Step 3：Near infrared spectrum data to measuring is pre-processed；
Step 4：With through the near infrared spectrum data of the artificial aqueous humor solution after Pretreated spectra is associated actual glucose content in artificial aqueous humor solution using PLS by pretreated near infrared spectrum data, the fitting of institute's established model and predictive ability are evaluated with complete cross-verification proof method, so as to set up the mathematical prediction model of glucose content in the human eye based near infrared light spectrum information.
5. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 4, it is characterised in that：Artificial anterior chamber's model includes organic glass contact mirror and quartzy flat board in the step 1, and lucite contact lense imitates cornea, and quartzy flat board imitates iris, and deployed artificial aqueous humor solution is filled between lucite contact lense and quartzy flat board.
6. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 5, it is characterised in that：The artificial aqueous humor liquor capacity filled between the lucite contact lense and quartzy flat board is 50 ~ 80 μ L, and the inner surface distance from the inner surface of quartzy flat board to lucite contact lense is 3.00 ~ 3.35
mm。
7. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 4, it is characterised in that：Artificial aqueous humor solution is substrate with 0.9% physiological saline in the step 1, and the pH value of artificial aqueous humor solution is 8, and concentration of glucose is 1 ~ 30 mmol/L, and concentration interval is 1 mmol/L, and the covariance of each component material concentration is 0.
8. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 4, it is characterised in that：The sample mode of the near infrared spectrometer of the step 2 is reflection, and spectral scanning range is 1500 ~ 1800 nm, and resolution ratio is 2 nm, to each the sample multiple scanning three times in calibration set, is averaged as sample near infrared spectrum.
9. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 4, it is characterised in that：Pretreatment includes noise filtering, normalized, data screening, the optimum choice of spectral region, centralization and standardization in the step 3.
10. the noninvasive dynamics monitoring device based on human eye iris reflex aqueous humor near infrared spectrum according to claim 4, it is characterised in that：The Spectral range of selection is pre-processed in the step 3 for 1500 ~ 1800 nm, 17 smoothing processings, 4 number of principal components.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107374646A (en) * | 2017-07-31 | 2017-11-24 | 中国科学院半导体研究所 | Blood sugar detection apparatus and method, electronic installation based near infrared technology |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589122A (en) * | 2001-09-20 | 2005-03-02 | 视觉路径公司 | Non-invasive blood glucose monitoring by interferometry |
| CN103908264A (en) * | 2012-12-28 | 2014-07-09 | 财团法人工业技术研究院 | Non-invasive glucose monitoring device |
| CN104048939A (en) * | 2014-06-05 | 2014-09-17 | 中国肉类食品综合研究中心 | Near infrared rapid detection method for blood sugar content in live pig blood |
-
2015
- 2015-08-11 CN CN201510486516.6A patent/CN106691459A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589122A (en) * | 2001-09-20 | 2005-03-02 | 视觉路径公司 | Non-invasive blood glucose monitoring by interferometry |
| CN103908264A (en) * | 2012-12-28 | 2014-07-09 | 财团法人工业技术研究院 | Non-invasive glucose monitoring device |
| CN104048939A (en) * | 2014-06-05 | 2014-09-17 | 中国肉类食品综合研究中心 | Near infrared rapid detection method for blood sugar content in live pig blood |
Non-Patent Citations (1)
| Title |
|---|
| WOLFGANG SCHRADER等: "Non-invasive glucose determination in the human eye", 《JOURNAL OF MOLECULAR STRUCTURE》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107374646A (en) * | 2017-07-31 | 2017-11-24 | 中国科学院半导体研究所 | Blood sugar detection apparatus and method, electronic installation based near infrared technology |
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