CN106668960A - Biological membrane inhibiting microstructure - Google Patents
Biological membrane inhibiting microstructure Download PDFInfo
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- CN106668960A CN106668960A CN201611188936.7A CN201611188936A CN106668960A CN 106668960 A CN106668960 A CN 106668960A CN 201611188936 A CN201611188936 A CN 201611188936A CN 106668960 A CN106668960 A CN 106668960A
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- Prior art keywords
- holes
- micro structure
- biomembrane
- base material
- antibacterial
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a biological membrane inhibiting microstructure. The biological membrane inhibiting microstructure contains a base material and a hydrophilic layer, wherein a plurality of holes are formed in the surface of the base material and extend towards the thickness direction of the base material, and the hydrophilic layer is arranged on the surface of the base material and the hole walls of the plurality of holes. The biological membrane inhibiting microstructure has the advantage that a biological membrane is not easily formed even after microorganisms such as bacteria are attached to the biological membrane inhibiting microstructure.
Description
Technical field
The invention relates to a kind of suppress biomembrane micro structure, refer in particular to one kind and be applied to surfaces of medical devices, make antibacterial
Even if after Deng microorganism attachment thereon, being also difficult to form biomembranous micro structure.
Background technology
The mechanism of biofilm formation, existing research is mainly found to be the quorum sensing between antibacterial (Quorum Sensing),
When antibacterial is because of cumulative amount or excessive breeding, gram negative bacteria will produce acyl homoserine lactones (Acyl-
Homoserine lactones, AHLs), gram positive bacteria will produce automatic induction peptide (Autoinducing peptides,
) etc. AIPs inducing hormone, stimulates antibacterial to produce extracellular polymeric and forms biomembrane.Although presently, there are many effective sterilizations and suppression
The mode of bacterium, but major part belongs to and uses in vitro, if being applied in human body or wound, it would still be possible to zest or cell toxicant
Property, therefore sterilization and the antibacterial mode of in human body to be applied to or wound, it is only capable of taking the mode of antibiotic therapy mostly.
But, formed after biomembrane once antibacterial, minimum inhibitory concentration now (minimum inhibitory concentration,
MIC) will be significantly increased, form 400 to 1000 times of the bacterial antibiotic repellence even free bacteria after biomembrane, because
This, clinically the hardly possible antibiotic by such high concentration is used in human body, although this be why in modern hospital all
There is good infection control flow process, the poor excessive risk sufferer of resistance treats the patient of respiratory organ pipe for example with invasive,
Nosocomial infection may still occur, main cause is breeding on pipeline surface of the antibacterial in human body and forms biomembrane and amount reproduction
Afterwards, it is difficult to which the antibiotic of general dosage is eliminated, and causes the complication such as pneumonia.
Therefore, if being avoided that, antibacterial freely accumulates in a large number, breeds in surfaces of medical devices, you can reduces antibacterial and forms biology
The probability of film.Known reduction antibacterial forms biomembranous mode, for example, can be coated with anti-sticky coating or shape in surfaces of medical devices
Into the nanostructured of low-surface-energy, antibacterial is set to be difficult attachment accumulation.Even if thus, the such as operating room of the high risk environment in hospital
Or still there is the risk of nosocomial infection in intensive care unit, even if being primarily due to reduce the chance that antibacterial is attached to medical device,
But as long as there is a small amount of antibacterial to be attached to surfaces of medical devices, at short notice, such as escherichia coli can be double through 20 to 30 minutes
Times breed, and in breeding certain amount after, still can produce can drug resistance biomembrane and cause patient to infect.
The content of the invention
Biomembranous problem, the purpose of the present invention are formed in view of cannot effectively suppress bacterial reproduction in above-mentioned conventional art
Exactly suppression biomembrane micro structure that is a kind of novel and meeting industry applications is being provided, to overcoming the difficulty of existing product
Point.
To reach above-mentioned purpose, the present invention provides a kind of suppression biomembrane micro structure, and it includes base material, the surface of the base material
Extend to base material thickness direction with a plurality of holes, and a plurality of holes；And hydrophilic layer, the hydrophilic layer is arranged at the base material
Surface and a plurality of holes hole wall on.
In the suppression biomembrane micro structure of one embodiment of the invention, a plurality of holes run through or not through the base material
Two relative surfaces.
In the suppression biomembrane micro structure of another embodiment of the present invention, a plurality of holes are in the row in base material thickness direction
Row mode is to be parallel to each other or interlaced.
In the suppression biomembrane micro structure of another embodiment of the present invention, the aperture of a plurality of holes is 0.2 μm to 3 μ
m。
In the suppression biomembrane micro structure of another embodiment of the present invention, the depth of a plurality of holes is 2 μm to 90 μm.
In the suppression biomembrane micro structure of another embodiment of the present invention, in a plurality of holes between adjacent holes between
Every being between 0.1 μm to 2 μm.
In the suppression biomembrane micro structure of another embodiment of the present invention, the depth-to-width ratio of a plurality of holes is 10 to 45,
Preferably 10 to 30.
In the suppression biomembrane micro structure of another embodiment of the present invention, the base material is flexible substrate.
In the suppression biomembrane micro structure of another embodiment of the present invention, electrostatic attraction agent is included in a plurality of holes.
In the suppression biomembrane micro structure of another embodiment of the present invention, antibacterial is included in a plurality of holes.
Compared with prior art, the present invention suppresses biomembrane micro structure by hole is formed on base material, spatially to limit
Aggregation quantity of the system into the free bacteria in hole so as to be difficult to, by quorum sensing, produce enough hormones, and then avoid shape
Biomembrane on two dimensional surface even Three-dimensional thickness direction.
Description of the drawings
Fig. 1 is the schematic diagram of the suppression biomembrane micro structure of one embodiment of the invention.
Fig. 2 is the schematic side view of the suppression biomembrane micro structure of one embodiment of the invention.
Fig. 3 is the side view of the suppression biomembrane micro structure of further embodiment of this invention.
Fig. 4 is the hole arrangement mode schematic diagram of the suppression biomembrane micro structure of another embodiment of the present invention.
Fig. 5 is the schematic diagram of the suppression biomembrane micro structure of another embodiment of the present invention.
Specific embodiment
Effect to make inventive features of the invention, content and advantage and its to be reached is more readily apparent, hereby by the present invention
Coordinate schema, and describe as follows, and the schema used in it in detail with the expression-form of embodiment, its purport be only signal and
Aid in illustrating book to be used, the actual proportions and precisely configuration after may not implementing for the present invention, therefore should not be with regard to the ratio of appended schema
Example first chats bright with configuration relation deciphering, the scope of the claims limited the invention in actual enforcement, conjunction.
Please refer to shown in Fig. 1 and Fig. 2, the present invention provides a kind of suppression biomembrane micro structure 1, and it includes base material 2, base
The surface 2a of material has a plurality of holes 3, and hole 3 extends to the thickness direction of base material 2；And hydrophilic layer 4, hydrophilic layer 4 arranges
On the surface 2a of base material 2 and the hole wall 3a of a plurality of holes 3.Because a plurality of holes 3 belong to one-dimensional on the thickness direction of base material 2
Direction extends, and a plurality of holes 3 are all independently do not communicate each other, and hydrophilic layer 4 can then make one internal body fluid and be easier to infiltration
In entering hole 3.Therefore when the minority in body fluid does not enter plurality of holes by the free bacteria that the known sterilization mode such as antibiotic is eliminated
Behind hole 3, only be all in single hole 3 in one-dimensional square and adjacent free bacteria produce communication switching；Again because of space limit
The aggregation quantity of free bacteria is made, and it is difficult to by quorum sensing, produced enough hormones and form two dimensional surface even
Biomembrane on Three-dimensional thickness direction, thus free bacteria be easier to by human autoimmune's system or the antibiotic for being applied with
Medicine is eliminated, and its probability survived in vivo and continue to breed is greatly reduced.
As shown in Fig. 2 in the suppression biomembrane micro structure 1 of one embodiment of the invention, a plurality of holes 3 do not run through base material
2 relative two surface 2a (for example, the upper and lower surface on thickness direction), makes the side surface for not having hole 3 can
The surface of known medical device or pipeline is directly arranged at, with the effect for suppressing biofilm formation.
Fig. 3 is refer to, in the suppression biomembrane micro structure 1 of further embodiment of this invention, a plurality of holes 3 run through base material
2 relative two surface 2a, when making suppression biomembrane micro structure 1 be applied to the medical device with invasive pipeline, for example
All can preferably penetrate in hole 3 as the tube wall of pipeline, the fluid of the side of tube wall two.
Please also refer to Fig. 1 and Fig. 4, in the suppression biomembrane micro structure 1 of another embodiment of the present invention, a plurality of holes
3 is to be parallel to each other or interlaced hole arrangement mode in the arrangement mode of the thickness direction of base material 2, when a plurality of holes 3 in
The arrangement mode of the thickness direction of base material 2 for it is interlaced when, can make in the case of thinner thickness using base material 2, still can tie up
Hold higher hole depth.
Fig. 5 is refer to, in the suppression biomembrane micro structure 1 of another embodiment of the present invention, the aperture W of a plurality of holes 3
For 0.2 μm to 3 μm.Depth D of a plurality of holes 3 is 2 μm to 90 μm.Interval S in a plurality of holes 3 between adjacent holes 3
For 0.1 μm to 2 μm.Because of the size of known antibacterial, for example, often result in the coccus class of infection, such as mycoplasm hyopneumoniae, staphylococcus aureuses
Equal diameter is 0.3 μm to 1 μm, the width of bacillus class such as escherichia coli, bacillus pyocyaneus etc. for 0.2 μm extremelyLength is
0.5 μm to 5 μm, therefore can be by being intended to suppress the target bacteria size for being likely to result in infection, selectivity is using aperture W than antibacterial
Width is suitable or slightly larger, and the interval S between adjacent holes 3 is less than the suppression biomembrane micro structure 1 of antibacterial width, you can make thin
Bacterium is difficult to stay in and suppresses the surface 2a of biomembrane micro structure 1, and enters in a plurality of holes 3.A plurality of holes 3 for example can mat
Formed by modes such as impressing, etching pore-creating, the depth-to-width ratio for making hole 3 is 10 to 45, preferably 10 to 30.If depth-to-width ratio is too low,
Even if suppress biomembrane micro structure 1 to possess a plurality of holes 3, but a plurality of holes 3 are simultaneously not enough for the space of holding of antibacterial, when
When accumulating excessive antibacterial and making a plurality of holes 3 inaccessible, antibacterial still may form biomembrane in the surface 2a of base material 2.Therefore
Only allow antibacterial into one-dimensional linear array and in the case that hole 3 has high depth-to-width ratio, the antibacterial into a plurality of holes 3 is by nothing
Method is assembled in a large number and forms biomembrane.
In the suppression biomembrane micro structure of another embodiment of the present invention, base material 2 is flexible substrate, is beneficial to and is processed into
The top layer of medical device or pipeline.
In the suppression biomembrane micro structure of another embodiment of the present invention, electrostatic attraction agent is included in a plurality of holes 3, it is quiet
Electric attraction agent can for example adopt metal cation, can mat electrostatic charge attract electronegative antibacterial, enter antibacterial to provide driving force
One step is easily entered and is stranded in hole, and is difficult to be gathered in substrate surface.
In the suppression biomembrane micro structure of another embodiment of the present invention, comprising existing known anti-in a plurality of holes 3
Microbial inoculum, when a small amount of antibacterial enters a plurality of holes 3, that is, is eliminated with further.
The embodiment of the above technological thought only to illustrate the invention and feature, its purpose makes to be familiar with this skill
Personage will appreciate that present disclosure and implement according to this, when can not with restriction the present invention the scope of the claims, i.e., generally according to
Impartial change or modification that disclosed spirit is made, should cover in the scope of the claims of the present invention.
Claims (10)
1. it is a kind of to suppress biomembrane micro structure, it is characterised in that the suppression biomembrane micro structure is included：
Base material, the surface of the base material has a plurality of holes, and a plurality of holes extend to base material thickness direction；And
Hydrophilic layer, the hydrophilic layer is arranged on the hole wall of the surface of the base material and a plurality of holes.
2. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that a plurality of holes run through or do not run through
Relative two surface of the base material.
3. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that a plurality of holes are in the thickness of the base material
The arrangement mode in direction is to be parallel to each other or interlaced.
4. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that the aperture of a plurality of holes is 0.2 μm
To 3 μm.
5. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that the depth of a plurality of holes be 2 μm extremely
90μm。
6. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that in a plurality of holes between adjacent holes
At intervals of 0.1 μm to 2 μm.
7. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that the depth-to-width ratio of a plurality of holes be 10 to
45。
8. it is as claimed in claim 7 to suppress biomembrane micro structure, it is characterised in that the depth-to-width ratio of a plurality of holes be 10 to
30。
9. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that the base material is flexible substrate.
10. it is as claimed in claim 1 to suppress biomembrane micro structure, it is characterised in that antibacterial is included in a plurality of holes
Or electrostatic attraction agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611188936.7A CN106668960B (en) | 2016-12-20 | 2016-12-20 | Biofilm-inhibiting microstructure material and medical equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611188936.7A CN106668960B (en) | 2016-12-20 | 2016-12-20 | Biofilm-inhibiting microstructure material and medical equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106668960A true CN106668960A (en) | 2017-05-17 |
| CN106668960B CN106668960B (en) | 2019-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611188936.7A Active CN106668960B (en) | 2016-12-20 | 2016-12-20 | Biofilm-inhibiting microstructure material and medical equipment |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010514A (en) * | 2010-11-02 | 2011-04-13 | 东南大学 | Method and device for preparing nano silver- and porous structure-containing medical high molecular material |
| US20130045266A1 (en) * | 2011-08-16 | 2013-02-21 | Chungbuk National University Industry Academic Cooperation Foundation | Method for preparing polymeric biomaterials having immobilized drug delivery system comprising bioactive molecules loaded particle carrier |
| CN204364238U (en) * | 2014-12-10 | 2015-06-03 | 明基材料有限公司 | Wound dressing |
-
2016
- 2016-12-20 CN CN201611188936.7A patent/CN106668960B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010514A (en) * | 2010-11-02 | 2011-04-13 | 东南大学 | Method and device for preparing nano silver- and porous structure-containing medical high molecular material |
| US20130045266A1 (en) * | 2011-08-16 | 2013-02-21 | Chungbuk National University Industry Academic Cooperation Foundation | Method for preparing polymeric biomaterials having immobilized drug delivery system comprising bioactive molecules loaded particle carrier |
| CN204364238U (en) * | 2014-12-10 | 2015-06-03 | 明基材料有限公司 | Wound dressing |
Non-Patent Citations (1)
| Title |
|---|
| 高丽松等: "《21世纪科技与教育发展大观 上》", 31 December 2001, 北京：中国人事出版社 * |
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| CN106668960B (en) | 2019-12-20 |
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Effective date of registration: 20201209 Address after: 241000 No.106 Huajin South Road, high tech Development Zone, Yijiang District, Wuhu City, Anhui Province Patentee after: BENQ MATERIALS (WUHU) Co.,Ltd. Patentee after: BENQ MATERIALS Co.,Ltd. Patentee after: BenQ Materials Corp. Address before: Chunhui Road Industrial Park in Suzhou city of Jiangsu Province, No. 13 215121 Patentee before: BENQ MATERIALS Co.,Ltd. Patentee before: BenQ Materials Corp. |