CN106668571A - Composition for inhibiting tumor cells - Google Patents
Composition for inhibiting tumor cells Download PDFInfo
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- CN106668571A CN106668571A CN201510740798.8A CN201510740798A CN106668571A CN 106668571 A CN106668571 A CN 106668571A CN 201510740798 A CN201510740798 A CN 201510740798A CN 106668571 A CN106668571 A CN 106668571A
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Abstract
The invention provides a composition utilizing natural materials. The composition comprises extracts of cypress wood, Cinnamomum kanehirae, Calocedrus formosana, Cinnamomum camphora, citronella, lindera glauca, cassia bark, Lengxiangshan, tea tree, Eucalyptus, Cryptomeria fortunei and acacia rachii, and the extracts are mixed in a specific ratio to form the tumor cell inhibition composition having an inhibition effect on tumor cell growth.
Description
Technical field
The present invention is with regard to a kind of plant extract from obtained by plant material, according to the group that certain proportion is allocated
Compound, said composition has the function of suppressing growth of tumour cell.
Background technology
Nearly 10 years malignant tumours all be located at the 10 big causes of the death first of, wherein lung cancer, liver cancer and colorectal cancer it
No matter death rate men and women is all first 3, the death rate is arranged the 4th, 5 and is respectively breast cancer and pancreas for women
Dirty cancer, and the male sex is then carcinoma of mouth and cancer of the esophagus, no matter both at home and abroad doctor and researcher all endeavour
Generation or the hyperplasia of tumour cell how are avoided or reduce in research.
Pulmonary fibrosis refers to that lung tissue is affected by inflammation, makes alveolar be replaced by fibrous matter, makes original
This soft lung tissue becomes hard, follows the string, and gradually loses the energy of contraction, diastole and gas exchanges
Power, makes patient have the phenomenons such as shortness of breath, chest tightness pain or dry cough, cannot can breathe when serious, ultimately results in
Respiratory failure.
Above-mentioned disease has now medicine or mode to be treated or suppressed, and so, the grade medicine is mostly changed
Learn synthesis or utilize radiotherapy, so over the course for the treatment of many patients have side effect generation, often
Symptom produced by side effect more makes patient uncomfortable than disease itself, and this is a big shortcoming.
Chinese juniper wood (Chamaecyparisformosensis), is one kind of aiphyllium in coniferals Cupressaceae, in pin
Very important status is accounted in the number of sheets, it is wooden hard because Chinese juniper wood delicate fragrance is without pungent taste, it is not apt to rot or damage by worms
Etc. characteristic, Chinese juniper wood is further worked out containing superior suppression typhoid fever bacterium, Escherichia coli, tinea alba bacterium and gold
Staphylococcus aureus etc., with antiinflammation.
Cinnamomum kanehirai (Cinnamomumkanehirai), belongs to canella, and the tall and straight strength show of tree performance, is landscape
The excellent seeds of trees, its wood property is excellent, is also the upper of woodcut skill product and furniture with unique perfume
Good material；Often length has an Antrodia camphorata to cinnamomum kanehirai, Antrodia camphorata contain three note class compounds, super oxygen disproportionation ferment,
Gland is sweet, polysaccharides, multiple proteins, multivitamin etc., with it is antitumor, increase immunity, drop
The function such as blood sugar and norcholesterol, the at present correlative study about Antrodia camphorata focuses mostly in Antrodia camphorata, still
Show that the woody body of Cinnamomum kanahirai hay or its extract have clear and definite antineoplastic action without research.
Taiwan Xiao Nan (Calocedrusformosana), is that the Taiwan of the evergreen megaphanerophyte of Cupressaceae Xiao's Phoebe is peculiar
Kind, having special aroma, quality is fine and close, and lines is graceful, and it is antimycotic, anti-that research shows that its extract has
Oxidation and anti-inflammatory isoreactivity, the research for only closing Xiao Nan compositions is more based on branches and leaves extract, for
The research of wood heartwood extract is less, there is no correlative study to show that the extract of Xiao Nanmu has and clearly presses down
The effect of cancer cell processed.
Research in recent years finds have many plants (as described above) in the Nature with anti-inflammatory or anti-oxidant
Have and improve the function of permeability of cell membrane etc. the distillation extraction thing of function, especially plant, can allow cell
Required nutrient and oxygen is able to smoothly enter intracellular, and the waste produced by cell is discharged into cell
Outward, lift the ability of cell metabolism, such cell thus the activation that secures good health, order in a organized way,
Organ and immune functional rehabilitation are normal, there is provided the immunity of human body itself, resistance and from
Body repair ability.
Patent No. I407995 discloses the preparation method of a plant extract liquor body and combinations thereof solution, wherein
Plates are cut into including by plant material planing wood, the main stove of stove kiln distillation is put into, and are put into timber igniting
Burning, and sets cut point, after the various plant material vapor reaction times are reached, then Jing coolings with
The distillation extraction thing of the various plants of output by separating；Using extract obtained in patent No. I407995 method
Either essential oil layer or water layer (hydrosol), with the essential oil obtained by the general machine way of distillation and hydrosol not
Together, it is characterised in that contained than general machine using extract obtained in the inventive method (essential oil or hydrosol)
The more rich compound of the extract (essential oil or hydrosol) of way of distillation gained.
Also, though those plants distinctly have the functions such as anti-oxidant, anti-inflammatory, research at present is to those plants
Thing folk prescription can treat those diseases still for unknown, and the extract of folk prescription plant effect is not on tumour is suppressed
Good, it is impossible to extensively application, this is two big shortcomings.
Applicant is in view of the disappearance of known suppression technology, being that invention is a kind of utilizes composite natral material, can press down
System, the symptom for reducing or slowing down disease, to the disappearance for improving above-mentioned prior art.
The content of the invention
The main object of the present invention, is to provide a kind of (the TGLON combinations of natural plant extraction compositions
Thing), the constituent has the function of adjusting or increase cell metabolism, and with suppression tumour cell life
Long function.
In order to achieve the above object, it is a feature of the present invention that：Planted using the different growths of the low middle High aititude in Taiwan
The principle of thing, designs The Greatest Love of Nature compound plants extraction compositions (TGLON
Composition), it is combined into a suppression tumor cell composition according to special ratios using following plant extracts；Its
Composition includes：Chinese juniper wood, Cinnamomum kanahirai hay, Xiao Nan, cinnamomum camphora, lemongrass, lindera glauca, Chinese cassia tree, cold fragrant China fir, tea
Tree, You Jiali trees, cryptomeria and acacia rachii extract.
It is another feature that, front plant extract of taking off is obtained using patent No. I407995 method
Hydrosol；Using hydrosol obtained in patent No. I407995 method it is characterized in that：Compared to general hydrosol,
Wherein containing more rich compound group into.
By TGLON compositions Jing after serial dilution, respectively with breast cancer cell (MCF-7), HCC
(HepG2) and lung fibroblast (MRC-5) cultivate 72 hours, followed by ELISA Reader (540nm)
The survival rate of the grade cell line is analyzed, Jing results show, had when said composition is diluted to into about 40 times
More than 50% Cell growth inhibition effect.
Description of the drawings
Fig. 1 tests percentage relation figure for the present invention to breast cancer cell strain relative survival rate.
Fig. 2 is the present invention to suppressing breast cancer cell strain test suppression percentage linear regression curves figure.
Fig. 3 tests percentage relation figure for the present invention to lung fibroblast strain relative survival rate.
Fig. 4 is the present invention to suppressing lung fibroblast strain test suppression percentage linear regression curves figure.
Fig. 5 tests percentage relation figure for the present invention to hepatoma cell strain relative survival rate.
Fig. 6 is the present invention to suppressing hepatoma cell strain test suppression percentage linear regression curves figure.
Fig. 7 is the constituent analysis figure of the present composition.
Fig. 8 is the Chinese juniper wood hydrosol constituent analysis figure of present component.
Fig. 9 is the Cinnamomum kanahirai hay hydrosol constituent analysis figure of present component, does not indicate less than 0.05% composition.
Figure 10 is the Xiao Nan hydrosol constituent analysis figures of present component, does not indicate less than 0.05% composition.
Figure 11 is the cinnamomum camphora hydrosol constituent analysis figure of present component, does not indicate less than 0.05% composition.
Figure 12 is the lemongrass hydrosol constituent analysis figure of present component, does not indicate less than 0.05% composition.
Figure 13 is the lindera glauca hydrosol constituent analysis figure of present component, does not indicate less than 0.05% composition.
Figure 14 is the Chinese cassia tree hydrosol constituent analysis figure of present component.
Figure 15 is the cold fragrant China fir hydrosol constituent analysis figure of present component.
Figure 16 is the tea tree hydrosol constituent analysis figure of present component.
Figure 17 is the You Jiali tree hydrosol constituent analysis figures of present component, does not indicate less than 0.05% composition.
Figure 18 is the cryptomeria hydrosol constituent analysis figure of present component, does not indicate less than 0.05% composition.
Figure 19 is the acacia rachii hydrosol constituent analysis figure of present component.
Specific embodiment
For ease of your juror the suppression tumor cell composition of this case is had further understanding with
Solution, hereby coordinates schema for embodiment, describes in detail as follows.
One suppression tumor cell composition (TGLON compositions) of the present invention, the suppression tumour cell combination
Plant extract of the thing comprising following colony：Chinese juniper wood, Cinnamomum kanahirai hay, Xiao Nan, cinnamomum camphora, lemongrass, lindera glauca,
Chinese cassia tree, cold fragrant China fir, tea tree, You Jiali trees, cryptomeria and acacia rachii；The grade plant material is utilized and is divided
The active ingredient of plant is extracted from technology, wherein isolation technics can be：It is the way of distillation, solvent extraction, cold
Milling process, carbon dioxide supercritical extraction method and absorption process etc.；TGLON compositions itself have adjustment
Or the function of increase cell metabolism, and with the function of suppression growth of tumour cell.
Further illustrate, the plant extract of the present invention is to use the hydrosol obtained by the way of distillation, more enters one
Step explanation, is the hydrosol obtained by patent No. I407995 method, is obtained using patent No. I407995 method
Hydrosol it is characterized in that：Compared to general hydrosol, wherein containing more rich compound group into.
The another original for beginning to possess complete curative effect using the low middle High aititude difference growing plant mixing in Taiwan of the invention
Reason, is further the suppression tumor cell composition, the weight of mixing by the hydrosol mixing of above-mentioned plant
Percentage is：Chinese juniper wood hydrosol account for 40%～50%, Cinnamomum kanahirai hay hydrosol account for 10%～20%, Xiao Nan hydrosols account for 10%～20%,
Cinnamomum camphora hydrosol accounts for 8%～10%, lemongrass hydrosol and accounts for 8%～10%, lindera glauca hydrosol and accounts for 6%～8%, Chinese cassia tree hydrosol
Account for 6%～8%, cold fragrant China fir hydrosol and account for 4%～6%, tea tree hydrosol and account for 2%～4%, You Jiali tree hydrosols and account for
2%～4%, cryptomeria hydrosol account for 2%～4% and acacia rachii hydrosol account for 2%～4%.
Further with the suppression tumor cell composition to breast cancer cell (MCF-7), lung fibroblast
And HCC (HepG2) carries out tumor cell survival experiment (MIRC-5).
Embodiment 1
In the present embodiment, first the suppression tumor cell composition is subsequently added into different multiples dilution
The culture into breast cancer cell strain (MCF-7), recycles MTT colorimetric methods, carries out said composition to breast cancer cell
Strain growth inhibition test, observes whether said composition has the effect of suppression, its suppression to breast cancer cell strain growth
Why is concentration processed.
First, the good breast cancer cell strain of upgrowth situation is seeded to into 96 micropore square positions, per hole cell number about
3,000cells, it is placed in 5%CO2, cultivate to overnight in 37 DEG C of incubators, add the suppression tumour thin every other day
Born of the same parents' composition, it is first degerming with 0.22 μm of membrane filtration before said composition is added, then carry out 2 with sterilized water
Times serial dilution, takes the said composition after dilution and acutely adds in celliferous 96 micropore, finally after concussion
Concentration is respectively：40960X、20480X、10240X、5120X、2560X、1280X、640X、320X、
160X, 80X, 40X, 20X and 10X, in 5%CO2, cultivate 72 hours in 37 DEG C of incubators,
MTT (5mg/mL) solution of 1/10 cumulative volume is added after 72 hours in each micropore, in 5%CO2、
Cultivate 4 hours in 37 DEG C of incubators, then remove the mixing liquid in micropore, add 100 μ l DMSO
In every micropore, with the intracellular bluish violet crystal (formazan) of dissolution, further 96 micropore square positions are put
Data are read in ELISA reader (540nm) and analyze.
Refer to table 1 and Fig. 1, shown in 2, said composition has to breast cancer cell growth and substantially suppress survival
Effect, when extension rate is 80 times, its inhibition up to 50%, in 10 times of extension rate extremely
When 40 times, said composition may be up to more than 98% for the inhibition that breast cancer cell grows.
Referring again to shown in Fig. 2, according to said composition concentration (Y-axis), suppression percentage corresponding thereto
Than the data of (X-axis) so that a regression formula can be obtained after two-dimensional linear regression analysis：
Y=160.02-1.8222X+0.0043X2, to bring X=50 into regression formulas and calculate Y=80, the value as should
Composition is for 503nhibiting concentration (50%Inhibition Concentration, the IC of breast cancer cell strain50) it is about 80
Times diluted concentration.
The composition of the present invention of table 1. is to breast cancer cell strain (MCF-7) growth inhibition test
Embodiment 2
In the present embodiment, first the suppression tumor cell composition is subsequently added into different multiples dilution
The culture into lung fibroblast strain (MRC-5), recycles MTT colorimetric methods, carries out said composition fine to lung
Dimension cell strain growth suppresses test, observes whether said composition has the effect of Developing restraint to lung fibroblast,
Why is its inhibition concentration.
First, the good lung fibroblast strain of upgrowth situation is seeded to into 96 micropore square positions, per hole cell
Number about 3,000cells, is placed in 5%CO2, cultivate to overnight in 37 DEG C of incubators, add the suppression to swell every other day
Oncocyte composition, it is first degerming with 0.22 μm of membrane filtration before said composition is added, then entered with sterilized water
2 times of serial dilutions of row, take after the said composition after dilution is acutely shaken and add in celliferous 96 micropore,
Ultimate density is respectively：40960X、20480X、10240X、5120X、2560X、1280X、640X、
320X, 160X, 80X, 40X, 20X and 10X, in 5%CO2, cultivate 72 in 37 DEG C of incubators
Hour, MTT (5mg/mL) solution of 1/10 cumulative volume is added after 72 hours in each micropore, in 5%
CO2, cultivate 4 hours in 37 DEG C of incubators, then remove the mixing liquid in micropore, add 100 μ l
DMSO in every micropore, with the intracellular bluish violet crystal (formazan) of dissolution, further by 96 micropores
Square position is placed in ELISA reader (540nm) and reads data and analyze.
Refer to table 2 and Fig. 3, shown in 4, said composition has to lung fibroblast strain substantially suppress survival
Effect, extension rate be 40 times when, its inhibition up to more than 50%, in extension rate 10
When again to 20 times, said composition may be up to more than 97% for the inhibition that lung fibroblast grows.
Referring again to shown in Fig. 4, according to said composition concentration (Y-axis), suppression percentage corresponding thereto
Than the data of (X-axis) so that a regression formula can be obtained after two-dimensional linear regression analysis：
Y=83.595-0.787X+0.0008X2, to bring X=50 into regression formulas and calculate Y=46, the value as should
503nhibiting concentration of the composition for lung fibroblast strain (MRC-5) (50%Inhibition Concentration,
IC50) it is about 46 times of diluted concentrations.
The composition of the present invention of table 2. is to lung fibroblast strain (MRC-5) growth inhibition test
Embodiment 3
In the present embodiment, first the suppression tumor cell composition is subsequently added into different multiples dilution
The culture into hepatoma cell strain (HepG2), recycles MTT colorimetric methods, carries out said composition to HCC
Strain growth inhibition test, observes whether said composition has the effect of Developing restraint to hepatoma cell strain, its suppression
Why is concentration processed.
First, the good hepatoma cell strain of upgrowth situation is seeded to into 96 micropore square positions, per hole cell number about
3,000cells, it is placed in 5%CO2, cultivate to overnight in 37 DEG C of incubators, add the suppression tumour thin every other day
Born of the same parents' composition, it is first degerming with 0.22 μm of membrane filtration before said composition is added, then carry out 2 with sterilized water
Times serial dilution, takes the said composition after dilution and acutely adds in celliferous 96 micropore, finally after concussion
Concentration is respectively：40960X、20480X、10240X、5120X、2560X、1280X、640X、320X、
160X, 80X, 40X, 20X and 10X, in 5%CO2, cultivate 72 hours in 37 DEG C of incubators,
MTT (5mg/mL) solution of 1/10 cumulative volume is added after 72 hours in each micropore, in 5%CO2、
Cultivate 4 hours in 37 DEG C of incubators, then remove the mixing liquid in micropore, add 100 μ l DMSO
In every micropore, with the intracellular bluish violet crystal (formazan) of dissolution, further 96 micropore square positions are put
Data are read in ELISA reader (540nm) and analyze.
Refer to table 3 and Fig. 5, shown in 6, said composition has the effect for substantially suppressing survival to hepatoma cell strain
Really, when extension rate is 160 times, its inhibition up to more than 50%, in 10 times of extension rate extremely
When 40 times, said composition may be up to more than 97% for the inhibition of liver cancer cell growth.
Referring again to shown in Fig. 6, according to said composition concentration (Y-axis), suppression percentage corresponding thereto
The data of (X-axis) after two-dimensional linear regression analysis can obtain a regression formula：
Y=0.0367X2- 10.128X+66.72, brings X=50 into regression formulas and calculates Y=253, and the value as should
503nhibiting concentration (50%Inhibition Concentration, IC of the composition for hepatoma cell strain (HepG2)50)
About 253 times diluted concentrations.
The composition of the present invention of table 3. is to hepatoma cell strain (HepG2) growth inhibition test
Embodiment 4
Refer to Fig. 7, by can confirm in above-described embodiment said composition have suppress growth of tumour cell work(
Can, then the suppression tumor cell composition is carried out GC/MS analyses, chemistry contained therein by inventor
Composition includes：1,8- eucalyptols (1,8-Cineole), camphor (Camphor), borneol (Borneol), 4- terpenes
Alcohol (Terpinen-4-ol), alpha-terpineol (α-Terpineol), (-)-myrtenol ((-)-Myrtenol), cis-
Myrtanol (cis-Myrtanol), australene (α-Pinene), amphene (Camphene), sabinene
(Sabinene), laurene (Myrcene), 1,4- eucalyptols (1,4-Cineole), α-terpinene (α-Terpinene),
Cymene (Cymene), limonene (Limonene), γ-terpinene (γ-Terpinene), α-terpinolene
(α-Terpinolen), fenchanol (α-Fenchol), citronellal (Citronellal), citronellol
(Citronellol)、:Nerol (Nerol), safrole (Safrole), α-terpinyl acetate (α-Terpinyl
Acetate), beta-elemene (β-Elemene), α-himachalene (α-Cedrene), β-cedrene (β
- Cedrene), α-amorphene (α-Amorphene), β-selinene (β-Selinene), γ -2- needle junipers
Alkene (γ -2-Cadinene), α-Java Cananga Oil alkene (α-Muurolene), γ-cadinene (γ-Cadinene), δ -
Cadinene (δ-Cadinene), β-cadinene (β-Cadinene), elemol (α-Elemol), cedrol
(Cedrol), α-cubebene (α-Cubebene), γ-cineol (γ-Eudesmol), β-cineol (β
- Eudesmol), tau- Yilans oleyl alcohol (tau-Muurolol).
Fig. 8-19 are referred to, inventor analyzes respectively the suppression tumor cell composition further with GC/MS
In each plant hydrosol composition, be not shown in schema less than 0.05% composition.
It is above-listed to describe system's illustrating for the possible embodiments of the present invention in detail, but the embodiment is simultaneously
Be not used to limit the scope of the claims of the present invention, all equivalence enforcements without departing from carried out by skill spirit of the present invention or
Change, in being intended to be limited solely by the scope of the claims of this case.
Claims (8)
1. it is a kind of to suppress tumor cell composition, it is characterised in that wherein said composition includes the plant extract of following colony plant：Chinese juniper wood, Cinnamomum kanahirai hay, Xiao Nan, cinnamomum camphora, lemongrass, lindera glauca, Chinese cassia tree, cold fragrant China fir, tea tree, You Jiali trees, cryptomeria and acacia rachii.
2. the plant extract of tumor cell composition is suppressed as claimed in claim 1, it is characterised in that it is using the hydrosol obtained by the way of distillation.
3. it is as claimed in claim 2 to suppress tumor cell composition, it is characterised in that wherein said composition contains：The Chinese juniper wood hydrosol of 40% ~ 50% percentage by weight, the Cinnamomum kanahirai hay hydrosol of 10% ~ 20% percentage by weight, the Xiao Nan hydrosols of 10% ~ 20% percentage by weight, the cinnamomum camphora hydrosol of 8% ~ 10% percentage by weight, the lemongrass hydrosol of 8% ~ 10% percentage by weight, the lindera glauca hydrosol of 6% ~ 8% percentage by weight, the Chinese cassia tree hydrosol of 6% ~ 8% percentage by weight, the cold fragrant China fir hydrosol of 4% ~ 6% percentage by weight, the tea tree hydrosol of 2% ~ 4% percentage by weight, the You Jiali tree hydrosols of 2% ~ 4% percentage by weight, the cryptomeria hydrosol of 2% ~ 4% percentage by weight and the acacia rachii hydrosol of 2% ~ 4% percentage by weight.
4. it is as claimed in claim 3 to suppress tumor cell composition, it is characterised in that wherein said composition can suppress breast cancer cell to grow.
5. tumor cell composition is suppressed as claimed in claim 3, it is characterised in that wherein said composition can liver cancer cell growth.
6. it is as claimed in claim 3 to suppress tumor cell composition, it is characterised in that wherein said composition can suppress lung fibroblast to grow.
7. it is as claimed in claim 3 to suppress tumor cell composition, it is characterised in that wherein the grade hydrosol is the product of stove kiln first gained of the way of distillation.
8. the suppression tumor cell composition as described in any one of claims 1 to 3, it is characterised in that wherein said composition includes：1,8- eucalyptols (1,8-Cineole)、Camphor (Camphor)、Borneol (Borneol)、4- terpenols (Terpinen-4-ol)、Alpha-terpineol (α-Terpineol)、(-)-myrtenol ((-)-Myrtenol)、Cis- myrtanols (cis-Myrtanol)、Australene (α-Pinene)、Amphene (Camphene)、Sabinene (Sabinene)、Laurene (Myrcene)、1,4- eucalyptols (1,4-Cineole)、α-terpinene (α-Terpinene)、Cymene (Cymene)、Limonene (Limonene)、γ-terpinene (γ-Terpinene)、α-terpinolene (α-Terpinolen)、Fenchanol (α-Fenchol)、Citronellal (Citronellal)、Citronellol (Citronellol)、:Nerol (Nerol), safrole (Safrole), α-terpinyl acetate (α-Terpinyl
acetate)、Beta-elemene (β-Elemene)、α-himachalene (α-Cedrene)、β-cedrene (β-Cedrene)、α-amorphene (α-Amorphene)、β-selinene (β-Selinene)、γ -2- cadinenes (γ -2-Cadinene)、α-Java Cananga Oil alkene (α-Muurolene)、γ-cadinene (γ-Cadinene)、δ-cadinene (δ-Cadinene)、β-cadinene (β-Cadinene)、Elemol (α-Elemol)、Cedrol (Cedrol)、α-cubebene (α-Cubebene)、γ-cineol (γ-Eudesmol)、β-cineol (β-Eudesmol)、Tau- Yilans oleyl alcohol (tau-Muurolol).
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| CN114364391A (en) * | 2019-07-08 | 2022-04-15 | 吉亚生技控股股份有限公司 | Compositions and methods for ameliorating or inhibiting gastrointestinal distress |
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| CN109364045A (en) * | 2018-10-21 | 2019-02-22 | 郑州大学第附属医院 | A kind of inhibitor of heat shock protein 90 and the application in terms of liver cancer treatment |
| CN109364045B (en) * | 2018-10-21 | 2020-08-21 | 郑州大学第一附属医院 | Heat shock protein 90 inhibitor and application thereof in liver cancer treatment |
| CN114364391A (en) * | 2019-07-08 | 2022-04-15 | 吉亚生技控股股份有限公司 | Compositions and methods for ameliorating or inhibiting gastrointestinal distress |
| CN114364391B (en) * | 2019-07-08 | 2023-08-11 | 吉亚生技控股股份有限公司 | Compositions and methods for improving or inhibiting gastrointestinal distress |
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