CN106667951A - Preparation method of intestine soluble capsule material - Google Patents
Preparation method of intestine soluble capsule material Download PDFInfo
- Publication number
- CN106667951A CN106667951A CN201611073641.5A CN201611073641A CN106667951A CN 106667951 A CN106667951 A CN 106667951A CN 201611073641 A CN201611073641 A CN 201611073641A CN 106667951 A CN106667951 A CN 106667951A
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- China
- Prior art keywords
- parts
- preparation
- intestine
- capsule material
- stirring
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Abstract
The invention discloses a preparation method of an intestine soluble capsule material. The preparation method comprises the following steps: firstly, stirring and mixing gelatin, polyvinyl acetate and one part of glycerol at the temperature of 40 to 45DEG C till the mixture becomes uniform; secondly, stirring and mixing hydroxy propyl cellulose, polyoxyethylene and water at normal temperature until the mixture becomes uniform; thirdly, stirring and mixing pectin and the other part of glycerol at the temperature of 10 to 20DEG C until the mixture becomes uniform; fourthly, stirring and mixing mixtures obtained from the first step to the third step separately at normal temperature until the mixtures become uniform, and forming by using a dropping method to obtain a capsule. The capsule material prepared by the preparation method disclosed by the invention is uniform and stable in property; used raw materials are mild in performance; the use amount of the gelatin is relatively low; the intestine soluble capsule material is well absorbed by intestine; by means of the intestine soluble capsule material, the damage to the intestine of a patient can be effectively reduced.
Description
Technical field
The present invention relates to the technical field of medicinal materials, the more particularly to technical field of capsule for medicine material.
Background technology
Some drugs need to be taken by patient in forms such as powder, molecules, are to solve it to take difficulty, capsule for medicine
Thus produce.In capsule for medicine can be sealed in powder or granular medicament, by patient swallow in the form of entirety, thereafter in intestines
Digested absorption in road, although this absorpting form avoids the stimulation of drugs on patients's stomach and damages, but while increased
The load of Intestinal Mucosal Injury in Patients Undergoing and the stimulation to Intestinal Mucosal Injury in Patients Undergoing.
The content of the invention
It is an object of the invention to propose a kind of enteric solubility glue,medicinal capsule material that can effectively reduce the stimulation to Intestinal Mucosal Injury in Patients Undergoing
The preparation method of material.
Technical scheme is as follows：
A kind of preparation method of enteric capsulation material, comprises the following steps：
(1) by gelatin, polyvinyl acetate, a part of glycerine is uniformly mixed at 40~45 DEG C；
(2) by hydroxypropyl cellulose, polyoxyethylene, water is uniformly mixed at normal temperatures；
(3) by pectin, another part glycerine is uniformly mixed at 10~20 DEG C；
(4) mixture that step (1)~(3) respectively obtain is uniformly mixed at normal temperatures, is molded using dropping preparation method
For capsule.
Preferably：In parts by mass, in above-mentioned steps each raw material in parts by mass, including：10~25 parts of gelatin, poly-vinegar
1.5~5 parts of vinyl acetate, 2~2.5 parts of hydroxypropyl cellulose, totally 7~10 parts of glycerine, 7~20 parts of water, polyoxyethylene 1.5~
2.5 parts, 5~10 parts of pectin.
It is also preferred that：The polyoxyethylated molecular weight is 3000~8000.
Obtained capsule material property of the invention is homogeneous, stable, and the material performance for using is gentle, and gelatin usage amount is relatively
Low, intestinal absorption is good, can effectively reduce the damage to Intestinal Mucosal Injury in Patients Undergoing.
Specific embodiment
Embodiment 1
A kind of preparation method of enteric capsulation material is comprised the following steps：
(1) by 10 parts of gelatin, 1.5 parts of polyvinyl acetate, 2 parts of glycerine is uniformly mixed at 40~45 DEG C；
(2) by 2 parts of hydroxypropyl cellulose, molecular weight is 3,000 1.5 parts of polyoxyethylene, and 7 parts of water stirs at normal temperatures mixed
Close uniform；
(3) by 5 parts of pectin, 5 parts of glycerine is uniformly mixed at 10~20 DEG C；
(4) mixture that step (1)~(3) respectively obtain is uniformly mixed at normal temperatures, is molded using dropping preparation method
For capsule.
Embodiment 2
A kind of preparation method of enteric capsulation material is comprised the following steps：
(1) by 25 parts of gelatin, 5 parts of polyvinyl acetate, 5 parts of glycerine is uniformly mixed at 40~45 DEG C；
(2) by 2.5 parts of hydroxypropyl cellulose, molecular weight is 8,000 2.5 parts of polyoxyethylene, and 20 parts of water is stirred at normal temperatures
It is well mixed；
(3) by 10 parts of pectin, 5 parts of glycerine is uniformly mixed at 10~20 DEG C；
(4) mixture that step (1)~(3) respectively obtain is uniformly mixed at normal temperatures, is molded using dropping preparation method
For capsule.
Claims (3)
1. a kind of preparation method of enteric capsulation material, it is characterised in that：Comprise the following steps：
(1) by gelatin, polyvinyl acetate, a part of glycerine is uniformly mixed at 40~45 DEG C；
(2) by hydroxypropyl cellulose, polyoxyethylene, water is uniformly mixed at normal temperatures；
(3) by pectin, another part glycerine is uniformly mixed at 10~20 DEG C；
(4) mixture that step (1)~(3) respectively obtain is uniformly mixed at normal temperatures, using dropping preparation method glue is shaped to
Capsule.
2. the preparation method of enteric capsulation material according to claim 1, it is characterised in that：Each raw material in above-mentioned steps
In parts by mass, including：10~25 parts of gelatin, 1.5~5 parts of polyvinyl acetate, 2~2.5 parts of hydroxypropyl cellulose, glycerine is common
7~10 parts, 7~20 parts of water, 1.5~2.5 parts of polyoxyethylene, 5~10 parts of pectin.
3. the preparation method of enteric capsulation material according to claim 1, it is characterised in that：Described polyoxyethylated point
Son amount is 3000~8000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611073641.5A CN106667951A (en) | 2016-11-29 | 2016-11-29 | Preparation method of intestine soluble capsule material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611073641.5A CN106667951A (en) | 2016-11-29 | 2016-11-29 | Preparation method of intestine soluble capsule material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106667951A true CN106667951A (en) | 2017-05-17 |
Family
ID=58867000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611073641.5A Pending CN106667951A (en) | 2016-11-29 | 2016-11-29 | Preparation method of intestine soluble capsule material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106667951A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461792A (en) * | 2008-12-30 | 2009-06-24 | 吴国庆 | Gelatine enteric capsule shell material |
| CN103417380A (en) * | 2012-05-22 | 2013-12-04 | 正和制药股份有限公司 | Hard capsule with enteric film coating |
| CN103961332A (en) * | 2014-04-23 | 2014-08-06 | 湖南尔康北山明胶有限公司 | Composition used as replacement of gelatin for preparation of enteric capsule materials and preparation method for composition |
| CN103977412A (en) * | 2014-04-23 | 2014-08-13 | 湖南尔康正阳药用胶囊有限公司 | Enteric-coated capsule material composition |
| CN105263462A (en) * | 2013-03-15 | 2016-01-20 | 博纳生命科学有限公司 | Non-gelatin enteric soft capsules |
| CN106138007A (en) * | 2015-04-10 | 2016-11-23 | 大丰胶囊工业股份有限公司 | The constituent of preparation enteric capsule shells, enteric capsule shells and preparation method |
-
2016
- 2016-11-29 CN CN201611073641.5A patent/CN106667951A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461792A (en) * | 2008-12-30 | 2009-06-24 | 吴国庆 | Gelatine enteric capsule shell material |
| CN103417380A (en) * | 2012-05-22 | 2013-12-04 | 正和制药股份有限公司 | Hard capsule with enteric film coating |
| CN105263462A (en) * | 2013-03-15 | 2016-01-20 | 博纳生命科学有限公司 | Non-gelatin enteric soft capsules |
| CN103961332A (en) * | 2014-04-23 | 2014-08-06 | 湖南尔康北山明胶有限公司 | Composition used as replacement of gelatin for preparation of enteric capsule materials and preparation method for composition |
| CN103977412A (en) * | 2014-04-23 | 2014-08-13 | 湖南尔康正阳药用胶囊有限公司 | Enteric-coated capsule material composition |
| CN106138007A (en) * | 2015-04-10 | 2016-11-23 | 大丰胶囊工业股份有限公司 | The constituent of preparation enteric capsule shells, enteric capsule shells and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 周建平等: "《药剂学》", 31 March 2007, 东南大学出版社 * |
| 骆涛等: "聚丙烯酸树脂肠溶胶囊壳的制备", 《中国现代应用药学杂志》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170517 |