CN106632825A - Coloring material, coloring film as well as preparation method thereof, and eye lens - Google Patents
Coloring material, coloring film as well as preparation method thereof, and eye lens Download PDFInfo
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- CN106632825A CN106632825A CN201510728096.8A CN201510728096A CN106632825A CN 106632825 A CN106632825 A CN 106632825A CN 201510728096 A CN201510728096 A CN 201510728096A CN 106632825 A CN106632825 A CN 106632825A
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- coloring film
- microcapsules
- coloured material
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Abstract
A preparation method of a coloring film comprises the following steps: providing a plurality of microcapsules coated with hydrogen peroxide solution; mixing a hydrophilic monomer, a cross-linking agent and an initiating agent to obtain a mixture; mixing the microcapsules with the mixture, adding pigment and solvent, mixing uniformly, and forming a coloring material; coating a mold with the coloring materials, carrying out heating or UV-irradiation, enabling the hydrophilic monomer, the cross-linking agent and the initiating agent to have a polymerization reaction, and forming the coloring film. The invention further provides the coloring film prepared with the preparation method, a coloring material for preparing the coloring film, and an eye lens capable of supplying oxygen.
Description
Technical field
The present invention relates to a kind of preparation method of coloring film, the coloring prepared by the preparation method
Film, the coloured material for preparing the coloring film and the eye lens with the coloring film.
Background technology
In recent years, as the quantity of myopia population is more and more, contact lenses because its is portable,
Characteristic attractive in appearance and be widely used.Wherein, coloured contact lenses (U.S. pupil) are even more wide
Favored.However, when in use, often because of oxygen transmission rate, high being easily caused does not make contact lenses
The iris of user supplies hypoxgia, and then causes the eye class disease such as blood-shoot-eye illness.
The content of the invention
In view of this, it is necessary to provide it is a kind of can oxygen supply coloring film preparation method.
Separately, there is a need to a kind of coloring film prepared by above-mentioned preparation method is provided, preparing should
Coloured material used by coloring film and the eye lens with the coloring film.
A kind of preparation method of coloring film, it is comprised the following steps：Some being coated with is provided
The microcapsules of hydrogen peroxide solution；Hydrophilic monomer, crosslinking agent and initiator are mixed to get mixed
Compound；The microcapsules and mixture are mixed, and add pigment and solvent to be well mixed with
Form a coloured material；And by above-mentioned coloured material coat on mould and heated or
Ultraviolet light, makes the hydrophilic monomer, initiator and crosslinking agent that polymerisation to occur,
To form the coloring film.
A kind of coloured material, including being coated with the microcapsules of hydrogenperoxide steam generator, pigment, molten
Agent and the mixture mixed by hydrophilic monomer, crosslinking agent and initiator.
A kind of coloring film, by coloured material as above in heating or ultraviolet light,
There is polymerisation and be obtained in the hydrophilic monomer, crosslinking agent and initiator.
A kind of eye lens, including a hydrogel or silicone-hydrogel matrix and one be formed at it is described
Coloring film on hydrogel or the surface of silicone-hydrogel matrix one, the coloring film is coated with
The microcapsules of hydrogenperoxide steam generator.
A kind of eye lens, including a hydrogel or silicone-hydrogel matrix, the eye lens
Also be coated with the microcapsules of hydrogenperoxide steam generator, the microcapsules be scattered in hydrogel or
In silicone-hydrogel matrix.
Coloring film prepared by above-mentioned preparation method, it is contained within being coated with micro- glue of hydrogen peroxide
Capsule, when the microcapsules for being coated with hydrogen peroxide are applied in eye lens, this was coated with
The wall material of the microcapsules of hydrogen oxide can slowly decompose so as to discharge in the presence of eye discharge
Hydrogen peroxide, the hydrogen peroxide being released decomposes obtain oxygen under light illumination, and the oxygen is passed through
The hydrogel or silicone-hydrogel matrix are the continued eye oxygen supply of user, and then avoid eye
Eyeball using eye lens anoxic because producing eye class disease.
Specific embodiment
Better embodiment of the present invention provides the preparation of a coloring film being applied in eye lens
Method, it is comprised the following steps：
Step S1, there is provided one is coated with the microcapsules of hydrogenperoxide steam generator.The hydrogen peroxide
The mass concentration of hydrogen peroxide is 0.5%～8% in solution.
The wall material of the microcapsules may be selected from natural macromolecular material, semi-synthetic macromolecular material
And one or more in synthesis macromolecular material.Generally, the molecular weight of macromolecular material exists
More than 10000.The natural macromolecular material may be selected from gelatin, chitin, starch, Ah
Draw in primary glue, shellac, lac, dextrin, wax, rosin, sodium alginate and zein
Plant or several.The semi-synthetic macromolecular material may be selected from carboxymethylcellulose calcium, Methyl cellulose
One or more in element and ethyl cellulose.It is described to synthesize the optional autohemagglutination breast of macromolecular material
Acid-co-glycolic acid (PLGA), PLA (PLA) and polyglycolic acid (PGA)
In one or more.
The microcapsules for being coated with hydrogenperoxide steam generator can by Simple coacervation, complex coacervation,
Solvent-nonsolvent method, intra-liquid desiccation method, interface polycondensation, radiation cross-linking process, spray drying
A kind of shape in method, spraying coagulation, suspension coating method, porous centrifugal process and pan coating method
Into it is prior art, and this is not repeated.The hydrogenperoxide steam generator can be molten for hydrogen peroxide
The liquid aqueous solution.
Step S2, hydrophilic monomer, crosslinking agent and initiator is well mixed and obtains a mixing
Thing.In present embodiment, mass percent of the hydrophilic monomer in the mixture
For 63%～85%.Mass percent of the crosslinking agent in the mixture is 5%～34%.
Mass percent of the initiator in the mixture is 3%～10%.
The hydrophilic monomer can be using methacrylic compound, acyclic compound etc. often
Advise the hydrophilic monomer for preparing eye lens gelinite, such as hydroxyethyl methacrylate
(HEMA), methyl methacrylate (MMA), dimethyl silicone polymer, 3- methyl
Acrylic acid propyl group three (trimethoxy silicon), NVP (NVP), methyl
Glycidyl acrylate and N, N- DMAA and methyl acrylate (MA).
The crosslinking agent can adopt GDMA (EGDMA), three hydroxyl first
Base propane trimethyl acrylic ester (TMPTMA) etc. is conventionally used for preparing the friendship of eye lens
Connection agent, the initiator (can be changed using azodiisobutyronitrile (AIBN), Irgacure-1173
Work industry standard number) etc. be conventionally used for preparing the initiator of eye lens.
Step S3, the microcapsules for being coated with hydrogenperoxide steam generator and mixture are mixed,
And add pigment and solvent to be well mixed to form a coloured material.The pigment can be using U.S.
The FD＆C pigments of Food and Drug Admistraton of state (FDA) certification, its species can be according to reality
Needs are selected, and such as FD＆C Sunset Yellow FCFs, FD＆C yellow 6, FD＆C are red
No. 3, FD＆C is red No. 40, FD＆C it is blue No. 1 and FD＆C it is blue No. 2 etc. in
It is at least one.The solvent can be conventionally used for preparing eye lens using toluene, methyl alcohol etc.
One or more of solvent.In the present embodiment, the hydrogenperoxide steam generator of being coated with
Mass percent of the microcapsules in the coloured material is 0.01%～7%.The mixture
Mass percent in the coloured material is 31%～74.99%.The pigment is described
Mass percent in coloured material is 20%～41%.The solvent is in the coloured material
Mass percent be 5%～21%.
Step S4, above-mentioned coloured material is coated on the die inwall of mould and heated
Or ultraviolet light, make the hydrophilic monomer, initiator and crosslinking agent that polymerisation to occur,
So as to obtain the coloring film.In the present embodiment, the thickness of the coloring film is
1 μm～45 μm.The heating or ultraviolet light time are 10s～3min.
Due to containing microcapsules in the coloring film, in the microcapsules hydrogen peroxide is coated with
Solution.The wall material of the microcapsules can slowly decompose so as to release in the presence of eye discharge
Hydrogen oxide is let slip, the hydrogen peroxide being released decomposes under illumination condition and obtains oxygen.Wherein,
There can be corruption to eyes when the mass concentration of hydrogenperoxide steam generator is more than 8% in the microcapsules
Corrosion；And the mass concentration of hydrogenperoxide steam generator be less than 0.5% when its oxygen-supplying amount it is too low.
The present invention is specifically described below.
Embodiment 1
By 65% methacrylic compound, 25% GDMA and
10% Irgacure-1173 is mixed to get mixture.Hydrogen peroxide is coated with by 0.05%
The microcapsules of solution, 23% FD＆C bluenesss 1,19% toluene and 57.95% institute
State mixture and be mixed to get coloured material.The mass concentration of the hydrogenperoxide steam generator is
0.5%.The wall material of the microcapsules is chitin.The coloured material is coated on mould
And under ultraviolet light irradiation 30s obtains coloring film.
Embodiment 2
By 67.5% hydroxyethyl methacrylate, 28% GDMA
And 4.5% Irgacure-1173 is mixed to get mixture.Hydrogen peroxide is coated with by 5%
The microcapsules of solution, 10.8% FD＆C redness No. 40,15.4% FD＆C bluenesss 1
Number, 21% methyl alcohol and 45.8% mixture be mixed to get coloured material.The mistake
The mass concentration of hydrogen peroxide solution is 0.8%.The wall material of the microcapsules is polylactic acid-glycolic base
Acetate multipolymer.30s is coated on mould and irradiated under ultraviolet light to the coloured material
Obtain coloring film.
Embodiment of the present invention also provides the coloured material for preparing above-mentioned coloring film, its bag
Include and be coated with the microcapsules of hydrogen peroxide, pigment, solvent and by hydrophilic monomer, crosslinking
The mixture that agent and initiator are mixed.Wherein, in the present embodiment, the cladding
There is mass percent of the microcapsules of hydrogenperoxide steam generator in the coloured material to be
0.01%～7%.Mass percent of the pigment in the coloured material is 20%～41%.
Mass percent of the solvent in the coloured material is 5%～21%.The mixture
Mass percent in the coloured material is 31%～74.99%.The hydrophilic monomer
Mass percent in the mixture is 63%～85%.The crosslinking agent is in the mixing
Mass percent in thing is 5%～34%.Quality of the initiator in the mixture
Percentage is 3%～10%.Parent in heating or ultraviolet light, in the coloured material
There is polymerisation in aqueous monomers, initiator and crosslinking agent, so as to obtain the coloring film.
Embodiment of the present invention also provides a kind of coloring film, and it is by the parent in above-mentioned coloured material
Aqueous monomers, initiator and crosslinking agent are heated or ultraviolet light occurs polymerisation and is obtained.
The coloring film is coated with the microcapsules of hydrogenperoxide steam generator.In the present embodiment,
The thickness of the coloring film is 1 μm～45 μm.
Embodiment of the present invention also provides a kind of eye lens, and it includes a hydrogel or silicon water
Gel-in-matrix and one be incorporated into hydrogel or the surface of silicone-hydrogel matrix one on a coloring film.
In the present embodiment, the coloring film can be obtained according to the preparation method of above-mentioned coloring film,
The raw material of hydrogel or silicone-hydrogel matrix is then prepared toward addition in die, ultraviolet lighting is treated
Penetrate to be formed after hydrogel or silicone-hydrogel matrix so that the coloring film is incorporated into the water-setting
The surface of glue or silicone-hydrogel matrix.In other embodiments, can be by directly colouring
Material coats the surface of the hydrogel or silicone-hydrogel matrix, is then heated or purple
Outer light irradiation is forming the coloring film.When using the eye lens, the coloring film
In be coated with hydrogen peroxide the wall material of microcapsules can slowly divide in the presence of eye discharge
So as to discharge hydrogen peroxide, the hydrogen peroxide being released decomposes and obtains oxygen solution under illumination condition
Gas.Because hydrogel or silicone-hydrogel matrix generally have oxygen permeability, the oxygen may pass through institute
The continued eye oxygen supply of hydrogel or silicone-hydrogel matrix for user is stated, and then avoids eyes
Because producing eye class disease using eye lens anoxic.
It is appreciated that the microcapsules for being coated with hydrogen peroxide can also be mixed in the water
Obtaining eye lens in gel or silicone-hydrogel matrix.
In addition, for the person of ordinary skill of the art, can be with skill of the invention
Art design make other it is various it is corresponding change with deformation, and it is all these change and deform all
The protection domain of the claims in the present invention should be belonged to.
Claims (13)
1. a kind of preparation method of coloring film, it is comprised the following steps：
Some microcapsules for being coated with hydrogenperoxide steam generator are provided；
Hydrophilic monomer, crosslinking agent and initiator are mixed to get into mixture；
The microcapsules and mixture are mixed, and adds pigment and solvent to be well mixed with shape
Into a coloured material；And
Above-mentioned coloured material is coated on mould and heated or ultraviolet light, institute is made
State hydrophilic monomer, initiator and crosslinking agent and polymerisation occurs, to form the coloring film.
2. the preparation method of coloring film as claimed in claim 1, it is characterised in that described
Being coated with mass percent of the microcapsules of hydrogenperoxide steam generator in the coloured material is
0.01%～7%, mass percent of the mixture in the coloured material be
31%～74.99%, mass percent of the pigment in the coloured material be
20%～41%, mass percent of the solvent in the coloured material is 5%～21%.
3. the preparation method of coloring film as claimed in claim 1, it is characterised in that described
The wall material of microcapsules is selected from natural macromolecular material, semi-synthetic macromolecular material and synthesis high score
At least one in sub- material.
4. the preparation method of coloring film as claimed in claim 3, it is characterised in that described
Natural macromolecular material selected from gelatin, chitin, starch, Arabic gum, shellac, lac,
At least one in dextrin, wax, rosin, sodium alginate and zein, the semi-synthetic height
Molecular material is selected from least in carboxymethylcellulose calcium, methylcellulose and ethyl cellulose
Kind, the synthesis macromolecular material is selected from Poly(D,L-lactide-co-glycolide, PLA and gathers
At least one in glycolic.
5. a kind of coloured material, it is characterised in that the coloured material is coated with peroxide
Change the microcapsules of hydrogen solution, pigment, solvent and by hydrophilic monomer, crosslinking agent and initiator
The mixture for mixing.
6. coloured material as claimed in claim 5, it is characterised in that described to be coated with
Mass percent of the microcapsules of hydrogen peroxide solution in the coloured material is 0.01%～7%,
Mass percent of the mixture in the coloured material is 31%～74.99%, described
Mass percent of the pigment in the coloured material is 20%～41%, and the solvent is described
Mass percent in coloured material is 5%～21%.
7. coloured material as claimed in claim 5, it is characterised in that the microcapsules
Wall material is in natural macromolecular material, semi-synthetic macromolecular material and synthesis macromolecular material
At least one.
8. coloured material as claimed in claim 7, it is characterised in that the natural polymer
Sub- material selected from gelatin, chitin, starch, Arabic gum, shellac, lac, dextrin,
At least one in wax, rosin, sodium alginate and zein, the semi-synthetic macromolecule material
At least one of the material in carboxymethylcellulose calcium, methylcellulose and ethyl cellulose, institute
State synthesis macromolecular material and be selected from Poly(D,L-lactide-co-glycolide, PLA and polyglycolic acid
In at least one.
9. a kind of coloring film, it is characterised in that by as described in claim 5-8 any one
Coloured material in heating or ultraviolet light, the hydrophilic monomer, crosslinking agent and draw
Send out agent generation polymerisation to be obtained.
10. coloring film as claimed in claim 9, it is characterised in that the coloring film
Thickness is 1 μm～45 μm.
11. a kind of eye lens, including a hydrogel or silicone-hydrogel matrix and one be formed at
Coloring film on the hydrogel or the surface of silicone-hydrogel matrix one, it is characterised in that described
Coloring film is coated with the microcapsules of hydrogenperoxide steam generator.
12. eye lens as claimed in claim 11, it is characterised in that the coloring film
Thickness be 1 μm～45 μm.
A kind of 13. eye lens, including a hydrogel or silicone-hydrogel matrix, its feature exists
In the eye lens are also coated with the microcapsules of hydrogenperoxide steam generator, micro- glue
Capsule is scattered in hydrogel or silicone-hydrogel matrix.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510728096.8A CN106632825A (en) | 2015-10-30 | 2015-10-30 | Coloring material, coloring film as well as preparation method thereof, and eye lens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510728096.8A CN106632825A (en) | 2015-10-30 | 2015-10-30 | Coloring material, coloring film as well as preparation method thereof, and eye lens |
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| Publication Number | Publication Date |
|---|---|
| CN106632825A true CN106632825A (en) | 2017-05-10 |
Family
ID=58809381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510728096.8A Pending CN106632825A (en) | 2015-10-30 | 2015-10-30 | Coloring material, coloring film as well as preparation method thereof, and eye lens |
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Citations (5)
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|---|---|---|---|---|
| US5853520A (en) * | 1996-02-22 | 1998-12-29 | Loctite Corporation | Preapplied silicone threadlocker and sealant |
| US20060142512A1 (en) * | 2004-09-07 | 2006-06-29 | Pojman John A | Free-radical frontal polymerization with microencapsulated monomers and initiators |
| CN102382237A (en) * | 2011-08-12 | 2012-03-21 | 北京自然美光学有限公司 | Radiation-proof light-filtering contact lens and production method thereof |
| CN103458684A (en) * | 2011-01-14 | 2013-12-18 | 巴斯夫欧洲公司 | Poly(meth)acrylate based microcapsules comprising pheromone |
| CN103614084A (en) * | 2013-10-28 | 2014-03-05 | 北京天山新材料技术股份有限公司 | High temperature resistant pre-coating type anaerobic adhesive and preparation method thereof |
-
2015
- 2015-10-30 CN CN201510728096.8A patent/CN106632825A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5853520A (en) * | 1996-02-22 | 1998-12-29 | Loctite Corporation | Preapplied silicone threadlocker and sealant |
| US20060142512A1 (en) * | 2004-09-07 | 2006-06-29 | Pojman John A | Free-radical frontal polymerization with microencapsulated monomers and initiators |
| CN103458684A (en) * | 2011-01-14 | 2013-12-18 | 巴斯夫欧洲公司 | Poly(meth)acrylate based microcapsules comprising pheromone |
| CN102382237A (en) * | 2011-08-12 | 2012-03-21 | 北京自然美光学有限公司 | Radiation-proof light-filtering contact lens and production method thereof |
| CN103614084A (en) * | 2013-10-28 | 2014-03-05 | 北京天山新材料技术股份有限公司 | High temperature resistant pre-coating type anaerobic adhesive and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| MALLEPALLY, RR等: "Hydrogen peroxide filled poly(methyl methacrylate) microcapsules: Potential oxygen delivery materials", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》 * |
| MCFARLAND, B等: "Free-radical frontal polymerization with a microencapsulated initiator: Characterization of microcapsules and their effect on pot life, front velocity, and mechanical properties", 《MACROMOLECULES》 * |
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