CN106632170B - A kind of method for crystallising of vitamine C sodium - Google Patents
A kind of method for crystallising of vitamine C sodium Download PDFInfo
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- CN106632170B CN106632170B CN201611205385.0A CN201611205385A CN106632170B CN 106632170 B CN106632170 B CN 106632170B CN 201611205385 A CN201611205385 A CN 201611205385A CN 106632170 B CN106632170 B CN 106632170B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
The invention discloses a kind of method for crystallising of vitamine C sodium, the method coupled using crystallisation by cooling and dilution crystallization prepares the big vitamine C sodium crystal product of purity is high, granularity by regulating and controlling crystallization condition.Particular technique step are as follows: be added to the water vitamin C and sodium bicarbonate, it is heated to 50-60 DEG C of progress neutralization reaction, vitamine C sodium crystal seed is added after the filtering of organic filter film in reaction residual liquor, after growing the grain 1-1.5h, 20-30 DEG C of cooling carries out one section of cooling down crystallization, then heat up 20-30 DEG C and be added methanol carry out one section of heating dilution crystallization, two sections of cooling down crystallizations, two sections of heating dilution crystallizations, three sections of cooling down crystallizations are carried out again, it is then centrifuged for separating, vitamine C sodium crystal cake is washed, vacuum drying, obtains vitamine C sodium crystal product.This method for crystallising high income, obtained vitamine C sodium crystal product purity is high, homogeneous grain diameter, the main granularity of crystal are big.
Description
Technical field
The present invention relates to chemical process technologies, more particularly, to a kind of method for crystallising of vitamine C sodium.
Background technique
Vitamin C is also known as L-AA, medically plays an important role, and is to maintain one kind of human health can not
The substance lacked is the catalyst of living cells redox reaction, participates in a variety of metabolism in body, has promotion is a variety of in vivo to swash
The physiological action of element synthesis.Scurvy can occur for the C that is deficient in vitamin in human body, can cause death when serious.Vitamin C is both medicine
Object is nutritional agents again, is widely used in foods and cosmetics industry in recent years.With the continuous improvement of our people's living standard
And increase vitamin C the increase of human body resistivity, the awareness for extending the service life, demand of the vitamin C in China
It is expected that growth by a relatively large margin will be had.However, vitamin C is weakly acidic, can not safe vein injection, and esophagus, stomach
There is the oral difficulty of the patient of disease, this faintly acid limits ascorbic application.Therefore, vitamin C product salt becomes mouthfeel
Not sour and energy replenishing vitamins C ideal formulation, is paid close attention to by people.
Vitamine C sodium also known as L-AA sodium are a kind of nonacid readily soluble vitamin C products.With supplement dimension life
The dual function of the absorption of plain C and enhancing calcium, opposite vitamin C performance are more stable.It is used as vitamin C enriching substance in medicine,
With replenishing vitamins C insufficiency of intake；It is used as antioxidant in the production of food and some beverages, can prevents food and beverage from becoming
It is color, spoiled, vitamine C sodium be widely used in ham, sausage, the fresh-keeping fixation of cake and moon cake it is mould proof in；Vitamine C sodium is added
In cosmetics, wrinkle resistant, anti-aging, the effect of whitening can produce.
Currently, there are two types of the main preparation methods of vitamine C sodium, the first be prepared in two-step fermentation it is ascorbic
In the process, vitamine C sodium is synthesized in the form of intermediate, be for second using vitamin C finished product as raw material, it is neutralized anti-
Answer, crystallize and etc. vitamine C sodium is prepared.In the first preparation method, esterification reaction temperature is higher, due to vitamin
C sodium has thermal sensitivity, and high temperature is very big to the destruction of its quality, so that vitamine C sodium solution system is in bronzing, has seriously affected dimension
The color of raw element C sodium, and catalyst is made using the concentrated sulfuric acid, sodium sulphate byproduct can be generated and be entrained in vitamine C sodium product, it should
The vitamine C sodium product color that method obtains is poor, purity is low；Second method is low with respect to first method preparation temperature, production
Vitamine C sodium color and quality be improved, but crystallization process is there are still many problems, the dimension obtained using crystallisation by cooling
Raw element C sodium yield is low, and small using the main granularity of crystal that dilution crystallization obtains, and particle is uneven, and impurity content is high.Therefore, existing
There is the method for crystallising for being badly in need of a kind of vitamine C sodium.
Summary of the invention
To solve the above problems, the present invention provides a kind of method for crystallising of vitamine C sodium, using crystallisation by cooling and dissolved
The method for crystallizing coupling, by regulating and controlling crystallization condition, prepared sizes are uniform, vitamine C sodium crystal product with high purity.
A kind of method for crystallising of vitamine C sodium according to the present invention, technical step include:
S1, neutralization reaction
Vitamin C and sodium bicarbonate are added to the water, are heated to 50~60 DEG C, is stirred, progress neutralization reaction 30~
40min obtains reaction residual liquor, and reaction residual liquor is filtered by 0.22 μm of organic filter film, obtains reaction clarification
Liquid.Wherein:
The mass ratio of vitamin C and water is 1:0.75~1.5；
The mass ratio of vitamin C and sodium bicarbonate is 1:0.65~0.95；
Neutralization reaction endpoint pH is 4.5~6.5；
Filtration temperature is 50~60 DEG C.
S2, constant temperature growing the grain
Vitamine C sodium crystal seed is added into the reaction clarified solution that S1 neutralization reaction is obtained by filtration, obtains crystal seed suspension, it is permanent
Warm 1~1.5h of growing the grain obtains growing the grain and completes liquid.Wherein:
The ascorbic mass ratio being added in vitamine C sodium crystal seed and S1 neutralization reaction is 1:800~900；
The granularity of vitamine C sodium crystal seed is 170~200 mesh；
Growing the grain temperature is 50~60 DEG C.
S3, cooling-dissolved coupling crystallization
The step is crystallized by one section of cooling down, one section of heating dilution crystallization, two sections of cooling downs crystallize, two sections of heatings are molten
Analysis crystallization and three sections of cooling down crystallization compositions.
S3-1, one section of cooling down crystallization
The growing the grain that S2 constant temperature growing the grain obtains is completed liquid at the uniform velocity to cool down 20~30 DEG C, it is brilliant to obtain one section of cooling down crystallization
Slurry, one section of cooling down crystallization time are 1.5~2.5h.
S3-2, one section of heating dilution crystallization
One section of cooling down crystallization magma that mono- section of cooling down of S3-1 crystallizes at the uniform velocity is heated up 20~30 DEG C, simultaneously
Methanol is at the uniform velocity added into system, obtains one section of heating dilution crystallization magma, one heating dilution crystallization time is 3~4h, institute
The ascorbic mass ratio being added in the methanol of addition and S1 neutralization reaction is 0.4~0.75:1.
S3-3, two sections of cooling down crystallizations
One section of heating dilution crystallization magma that mono- section of S3-2 heating dilution crystallization obtains at the uniform velocity is cooled down 20~30 DEG C, is obtained
Two sections of cooling downs crystallize magma, and two sections of cooling down crystallization times are 2~3h.
S3-4, two sections of heating dilution crystallizations
Two sections of cooling downs crystallization magma that bis- sections of cooling downs of S3-3 crystallize at the uniform velocity is heated up 20~30 DEG C, simultaneously
Methanol is at the uniform velocity added into system, obtains two sections of heating dilution crystallization magmas, two heating dilution crystallization times are 2.5~
3.5h, the ascorbic mass ratio being added in the methanol and S1 being added are 0.82~1.6:1.
S3-5, three sections of cooling down crystallizations
Two sections of heating dilution crystallization magmas that bis- sections of S3-4 heating dilution crystallizations obtain at the uniform velocity are cooled to 5~10 DEG C, are obtained
Magma is crystallized to three sections of cooling downs, three sections of cooling down crystallization times are 1~2h.
S4, centrifuge separation
Three sections of cooling downs crystallization magma centrifuge separation that tri- sections of cooling downs of S3-5 are crystallized, obtains vitamin C
Sodium crystal filter cake and filtrate.
S5, washing drying
Washing lotion is prepared, vitamine C sodium crystal cake obtained in S4 centrifuge separation is washed, vitamine C sodium is obtained
Vitamine C sodium crystal slurries are centrifugally separating to obtain the wet product of vitamine C sodium crystal and washing mother liquor, will obtained by crystal slurries
The wet product of vitamine C sodium crystal carry out 5~6h of vacuum drying, obtain vitamine C sodium crystal product.Wherein:
Washing lotion is prepared by water and methanol, and wherein the mass ratio of water and methanol is 1:1.65~2；
Preparing in the water and S1 neutralization reaction of washing lotion with the mass ratio of water is 1:4~6；
Vacuum drying vacuum degree is -0.08~-0.1MPa, and temperature is 50~65 DEG C.
Beneficial effects of the present invention:
1, it is combined, is effectively controlled in system supersaturated by three sections of cooling down crystallizations and two sections of heating dilution crystallizations
Degree: since dissolved agent influences greatly, to heat up during dissolved, to slow down dissolved mistake on the solubility of vitamine C sodium
Degree of supersaturation abruptly increase in journey, maintains the degree of supersaturation in system in lower range, avoids caused by high degree of supersaturation
The phenomenon that a large amount of fine grains are precipitated, promote vitamine C sodium crystal stablizes growth, the vitamine C sodium crystal product granularity crystallized out
Greatly, homogeneous grain diameter, purity is high.
2, the method for crystallising coupled using dilution crystallization and crystallisation by cooling, it is low both to have avoided single cooling crystallization method yield
The shortcomings that, and single dilution crystallization product granularity unevenness is overcome, the small disadvantage of granularity effectively improves vitamine C sodium
The yield and quality of crystal product.
3, by the addition of crystal seed, growth basic point is provided for the growth of vitamine C sodium crystal, is conducive to vitamine C sodium
The homoepitaxial of crystal.
4, using vacuum drying, vitamine C sodium crystal product is avoided with air contact metamorphism, to ensure that product at high temperature
Purity.
Detailed description of the invention
Fig. 1 is a kind of flow diagram of the method for crystallising of vitamine C sodium.
Description of symbols in figure:
S1, neutralization reaction S2, constant temperature growing the grain
S3, cooling-dissolved coupling crystallization S4, centrifuge separation
S5, washing drying
Specific embodiment
By embodiment, technical scheme is described further.
Embodiment one
Neutralization reaction (S1): 300mL distilled water is added into reactor, then takes 300g vitamin C and 255g sodium bicarbonate
It is added in reactor, is heated to 50 DEG C, stirring carries out neutralization reaction 30min, and the endpoint pH for controlling neutralization reaction is 4.5, obtains
To reaction residual liquor, reaction residual liquor is filtered with 0.22 μm of organic filter film, filtration temperature is 50 DEG C, is reacted
Clarified solution；
Constant temperature growing the grain (S2): being added the vitamine C sodium crystal seed 0.35g of 200 mesh in Xiang Fanying clarified solution, obtains crystal seed suspension
Liquid, by crystal seed suspension at 50 DEG C growing the grain 1.5h, obtain growing the grain complete liquid；
Cooling-dissolved coupling crystallization (S3): growing the grain completion liquid is at the uniform velocity cooled to 25 DEG C, temperature fall time 2h, cooling knot
Crystalline substance obtains one section of cooling down crystallization magma；One section of cooling down crystallization magma is at the uniform velocity being warming up to 50 DEG C, while to system
246mL methanol is inside at the uniform velocity added, heating-up time 3.5h obtains one section of heating dilution crystallization magma；By one section of heating dissolved knot
Jingjing slurry is at the uniform velocity cooled to 25 DEG C, temperature fall time 2.5h, and crystallisation by cooling obtains two sections of cooling down crystallization magmas；Two sections are dropped
Warm crystallisation by cooling magma is at the uniform velocity warming up to 50 DEG C, while 455mL methanol being at the uniform velocity added into system, and heating-up time 3h is obtained
Two sections of heating dilution crystallization magmas；Two sections of heating dilution crystallization magmas are at the uniform velocity cooled to 5 DEG C, temperature fall time 1.5h, cooling
Crystallization obtains three sections of cooling down crystallization magmas；
It is centrifugated (S4): by three sections of cooling down crystallization magma centrifuge separations, obtaining vitamine C sodium crystal cake and filter
Liquid；
It washs dry (S5): taking 50mL distilled water and 117mL methanol to mix, preparation obtains washing lotion, to vitamine C sodium crystal
Filter cake is washed, and the wet product of vitamine C sodium crystal is centrifugally separating to obtain, by the wet product of vitamine C sodium crystal vacuum degree be-
0.08MPa, temperature obtain vitamine C sodium crystal product 330g, after measured to carry out vacuum drying 5h under 50 DEG C of drying condition
The content of vitamine C sodium is 99.5%.The yield of the present embodiment is 97.5%, and the average particle size of vitamine C sodium crystal is 265 μ
M, the coefficient of variation 40%.
Embodiment two
Neutralization reaction (S1): 360mL distilled water is added into reactor, then takes 300g vitamin C and 270g sodium bicarbonate
It is added in reactor, is heated to 50 DEG C, stirring carries out neutralization reaction 40min, and the endpoint pH for controlling neutralization reaction is 5, obtains
Reaction residual liquor is filtered by reaction residual liquor with 0.22 μm of organic filter film, and filtration temperature is 50 DEG C, obtains reacting clear
Clear liquid；
Constant temperature growing the grain (S2): being added the vitamine C sodium crystal seed 0.4g of 180 mesh in Xiang Fanying clarified solution, obtains crystal seed suspension
Liquid, by crystal seed suspension at 50 DEG C growing the grain 1h, obtain growing the grain complete liquid；
Cooling-dissolved coupling crystallization (S3): growing the grain completion liquid is at the uniform velocity cooled to 25 DEG C, temperature fall time 2.5h, cooling
Crystallization obtains one section of cooling down crystallization magma；One section of cooling down crystallization magma is at the uniform velocity being warming up to 50 DEG C, while to body
265mL methanol is at the uniform velocity added in system, heating-up time 3h obtains one section of heating dilution crystallization magma；By one section of heating dissolved knot
Jingjing slurry is at the uniform velocity cooled to 25 DEG C, temperature fall time 2.5h, and crystallisation by cooling obtains two sections of cooling down crystallization magmas；Two sections are dropped
Warm crystallisation by cooling magma is at the uniform velocity warming up to 50 DEG C, while 569mL methanol being at the uniform velocity added into system, and heating-up time 3.5h is obtained
To two sections of heating dilution crystallization magmas；Two sections of heating dilution crystallization magmas are at the uniform velocity cooled to 10 DEG C, temperature fall time 2h, cooling
Crystallization obtains three sections of cooling down crystallization magmas；
It is centrifugated (S4): by three sections of cooling down crystallization magma centrifuge separations, obtaining vitamine C sodium crystal cake and filter
Liquid；
It washs dry (S5): taking 60mL distilled water and 139mL methanol to mix, preparation obtains washing lotion, to vitamine C sodium crystal
Filter cake is washed, and the wet product of vitamine C sodium crystal is centrifugally separating to obtain, by the wet product of vitamine C sodium crystal vacuum degree be-
0.09MPa, temperature obtain vitamine C sodium crystal product 332g, through surveying to carry out vacuum drying 5.5h under 50 DEG C of drying condition
The content for determining vitamine C sodium is 99.7%.The yield of the present embodiment is 98.1%, and the average particle size of vitamine C sodium crystal is 325
μm, the coefficient of variation 45%.
Embodiment three
Neutralization reaction (S1): 270mL distilled water is added into reactor, then takes 300g vitamin C and 240g sodium bicarbonate
It is added in reactor, is heated to 55 DEG C, stirring carries out neutralization reaction 35min, and the endpoint pH for controlling neutralization reaction is 5.5, obtains
To reaction residual liquor, reaction residual liquor is filtered with 0.22 μm of organic filter film, filtration temperature is 55 DEG C, is reacted
Clarified solution；
Constant temperature growing the grain (S2): being added the vitamine C sodium crystal seed 0.43g of 190 mesh in Xiang Fanying clarified solution, obtains crystal seed suspension
Liquid, by crystal seed suspension at 55 DEG C growing the grain 1h, obtain growing the grain complete liquid；
Cooling-dissolved coupling crystallization (S3): growing the grain completion liquid is at the uniform velocity cooled to 25 DEG C, temperature fall time 2.5h, cooling
Crystallization obtains one section of cooling down crystallization magma；One section of cooling down crystallization magma is at the uniform velocity being warming up to 55 DEG C, while to body
190mL methanol is at the uniform velocity added in system, heating-up time 3h obtains one section of heating dilution crystallization magma；By one section of heating dissolved knot
Jingjing slurry is at the uniform velocity cooled to 25 DEG C, temperature fall time 2.5h, and crystallisation by cooling obtains two sections of cooling down crystallization magmas；Two sections are dropped
Warm crystallisation by cooling magma is at the uniform velocity warming up to 55 DEG C, while 380mL methanol being at the uniform velocity added into system, and heating-up time 3.5h is obtained
To two sections of heating dilution crystallization magmas；Two sections of heating dilution crystallization magmas are at the uniform velocity cooled to 5 DEG C, temperature fall time 2h, cooling
Crystallization obtains three sections of cooling down crystallization magmas；
It is centrifugated (S4): by three sections of cooling down crystallization magma centrifuge separations, obtaining vitamine C sodium crystal cake and filter
Liquid；
It washs dry (S5): taking 50mL distilled water and 105mL methanol to mix, preparation obtains washing lotion, to vitamine C sodium crystal
Filter cake is washed, and the wet product of vitamine C sodium crystal is centrifugally separating to obtain, by the wet product of vitamine C sodium crystal vacuum degree be-
0.08MPa, temperature obtain vitamine C sodium crystal product 332g, after measured to carry out vacuum drying 6h under 55 DEG C of drying condition
The content of vitamine C sodium is 99.4%.The yield of the present embodiment is 97.8%, and the average particle size of vitamine C sodium crystal is 316 μ
M, the coefficient of variation 35%.
Claims (7)
1. a kind of method for crystallising of vitamine C sodium, which is characterized in that technical step includes: neutralization reaction (S1), constant temperature growing the grain
(S2), cooling-dissolved coupling crystallization (S3), centrifuge separation (S4), washing are dry (S5)；
The neutralization reaction (S1): vitamin C and sodium bicarbonate are added to the water, and are heated to 50~60 DEG C, and stirring is neutralized
30~40min is reacted, reaction residual liquor is obtained, reaction residual liquor is filtered by 0.22 μm of organic filter film, is obtained
React clarified solution；
The mass ratio of vitamin C and water is 1:0.75~1.5, the matter of vitamin C and sodium bicarbonate in the neutralization reaction (S1)
Amount is than being 1:0.65~0.95, and neutralization reaction endpoint pH is 4.5~6.5, and filtration temperature is 50~60 DEG C；
The constant temperature growing the grain (S2): being added vitamine C sodium crystal seed in the reaction clarified solution obtained to neutralization reaction (S1), for dimension life
The growth of plain C sodium crystal provides growth basic point, obtains crystal seed suspension, and crystal seed suspension 1~1.5h of growing the grain makes brilliant in system
Kind is stablized and is evenly distributed, and obtains growing the grain and completes liquid；
Vitamine C sodium crystal seed and neutralization reaction (S1) middle ascorbic mass ratio being added are 1 in the constant temperature growing the grain (S2):
800~900, the granularity of vitamine C sodium crystal seed is 170~200 mesh, and growing the grain temperature is 50~60 DEG C；
The cooling-dissolved coupling crystallization (S3): (S3-1), one section of heating dilution crystallization (S3- are crystallized including one section of cooling down
2), two sections of cooling down crystallizations (S3-3), two sections of heating dilution crystallizations (S3-4) and three sections of cooling down crystallizations (S3-5)；
One section of cooling down crystallizes (S3-1): the growing the grain that constant temperature growing the grain (S2) obtains being completed liquid and at the uniform velocity cools down 20~30
DEG C, obtain one section of cooling down crystallization magma；
One section of heating dilution crystallization (S3-2): the one section of cooling down crystallization obtained to one section of cooling down crystallization (S3-1)
Methanol is at the uniform velocity added in magma, at the uniform velocity heats up 20~30 DEG C simultaneously during methanol is added, obtains one section of heating dilution crystallization
Magma；
Two sections of cooling downs crystallize (S3-3): one section of heating dilution crystallization that one section of heating dilution crystallization (S3-2) is obtained
Magma at the uniform velocity cools down 20~30 DEG C, obtains two sections of cooling down crystallization magmas；
Two sections of heatings dilution crystallization (S3-4): the two sections of cooling downs crystallization obtained to two sections of cooling down crystallizations (S3-3)
Methanol is at the uniform velocity added in magma, at the uniform velocity heats up 20~30 DEG C simultaneously during methanol is added, obtains two sections of heating dilution crystallizations
Magma；
Three sections of cooling downs crystallize (S3-5): two sections of heating dilution crystallizations that two sections of heatings dilution crystallization (S3-4) are obtained
Magma is at the uniform velocity cooled to 5~10 DEG C, obtains three sections of cooling down crystallization magmas；
The centrifuge separation (S4): three sections of cooling downs crystallization magma centrifugation point that three sections of cooling down crystallizations (S3-5) are obtained
From obtaining vitamine C sodium crystal cake and filtrate；
The washing is dry (S5): washing lotion is prepared, the vitamine C sodium crystal cake obtained to centrifuge separation (S4) washs,
Vitamine C sodium crystal slurries are obtained, vitamine C sodium crystal slurries are centrifugally separating to obtain the wet product of vitamine C sodium crystal and are washed
Mother liquor is washed, the obtained wet product of vitamine C sodium crystal is subjected to vacuum drying 5-6h, obtains vitamine C sodium crystal product.
2. a kind of method for crystallising of vitamine C sodium according to claim 1, which is characterized in that one section of cooling down
Crystallizing one section of cooling down crystallization time in (S3-1) is 1.5~2.5h.
3. a kind of method for crystallising of vitamine C sodium according to claim 1, which is characterized in that one section of heating dissolved
To crystallize one heating dilution crystallization time in (S3-2) be 3~4h, the methanol being added and is added in neutralization reaction (S1)
Ascorbic mass ratio is 0.4~0.75:1.
4. a kind of method for crystallising of vitamine C sodium according to claim 1, which is characterized in that two sections of cooling downs
Crystallizing two sections of cooling down crystallization times in (S3-3) is 2~3h.
5. a kind of method for crystallising of vitamine C sodium according to claim 1, which is characterized in that two sections of heatings dissolved
Crystallizing two heating dilution crystallization times in (S3-4) is 2.5~3.5h, the methanol being added and neutralization reaction (S1) middle addition
Ascorbic mass ratio be 0.82~1.6:1.
6. a kind of method for crystallising of vitamine C sodium according to claim 1, which is characterized in that three sections of cooling downs
Crystallizing three sections of cooling down crystallization times in (S3-5) is 1~2h.
7. a kind of method for crystallising of vitamine C sodium according to claim 1, it is characterised in that: the washing is dry (S5)
Middle washing lotion is prepared by water and methanol, and wherein the mass ratio of water and methanol is 1:1.65~2；Prepare water and the neutralization reaction of washing lotion
It (S1) with the mass ratio of water is 1:4~6 in；Vacuum drying vacuum degree is -0.08~-0.1MPa, and temperature is 50~65 DEG C.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101899029A (en) * | 2010-07-09 | 2010-12-01 | 宜兴市江山生物科技有限公司 | Preparation method of vitamin C sodium salt |
| CN104557822A (en) * | 2015-01-19 | 2015-04-29 | 精晶药业股份有限公司 | Refinement method of vitamin C sodium salt |
-
2016
- 2016-12-23 CN CN201611205385.0A patent/CN106632170B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101899029A (en) * | 2010-07-09 | 2010-12-01 | 宜兴市江山生物科技有限公司 | Preparation method of vitamin C sodium salt |
| CN104557822A (en) * | 2015-01-19 | 2015-04-29 | 精晶药业股份有限公司 | Refinement method of vitamin C sodium salt |
Non-Patent Citations (2)
| Title |
|---|
| 维生素C钠盐的合成研究;支世涛 等，;《科技风》;20150930(第17期);第125-126页 |
| 维生素C钠结晶粒度的生产控制;周俊俊 等，;《河南化工》;20120228;第29卷(第1、2期);第9页左栏倒数第1段和表4 |
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