CN106632034A - Production process of decoquinate - Google Patents
Production process of decoquinate Download PDFInfo
- Publication number
- CN106632034A CN106632034A CN201510879918.2A CN201510879918A CN106632034A CN 106632034 A CN106632034 A CN 106632034A CN 201510879918 A CN201510879918 A CN 201510879918A CN 106632034 A CN106632034 A CN 106632034A
- Authority
- CN
- China
- Prior art keywords
- decoquinate
- product
- raw material
- crystal
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Decoquinate is an important chemical raw material, and a production process of decoquinate is as follows: a decoquinate raw material medicine crude product is added into a dissolving kettle, and methanol is added by a metering pump; at the same time, temperature is raised to about 40 DEG C, and the decoquinate raw material medicine is mixed and dissolved for about 5 hours; after complete dissolving, refrigerated water is covered for cooling, the temperature is reduced to about 5 DEG C, and the product is crystallized and precipitated; the product is placed in a filter for carrying out centrifugal filtering, and the crystal is obtained and dried. Mother liquor is sent to a rectifying tower for recovery and reusage. After drying, the crystal is crushed, filtered and mixed, and after packaging, the decoquinate product is obtained.
Description
A kind of deccox production technology
Molecular formula：C24H35NO5
Molecular weight：417.55
Structural formula
Product characteristics：This product is off-white color or Light yellow crystals powder.Odorless.Water, ethanol are practically insoluble in, chloroform, ether is slightly soluble in.
Main application：Deccox is a kind of very effective quinolones livestock and poultry anticoccidial drug, and it mainly suppresses sporocyst, mid-term stage to kill early stage schizont and play a role by the stage in the early stage.
Description of the process
Decanoyl ester raw materials drug crude product is added in dissolution kettle, with measuring pump methyl alcohol is added, while 40 DEG C or so are warming up to,
Decanoyl ester raw materials drug mixed dissolution about 5h, is lowered the temperature until completely dissolved with jacket refrigerating water, is down to 5 DEG C or so, and product crystallization is separated out, and placing into filter carries out centrifugal filtration, is obtained crystal and is gone drying.Mother liquor delivers to rectifying column recovery.Crystal after drying is packaged to be deccox product after crushing, sieving, mix.
Description of the drawings：
Fig. 1 is mass balance type.
Claims (2)
1. a kind of deccox production technology.
2. the present invention relates to raw materials for production composition and proportioning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510879918.2A CN106632034A (en) | 2015-12-06 | 2015-12-06 | Production process of decoquinate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510879918.2A CN106632034A (en) | 2015-12-06 | 2015-12-06 | Production process of decoquinate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106632034A true CN106632034A (en) | 2017-05-10 |
Family
ID=58851191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510879918.2A Pending CN106632034A (en) | 2015-12-06 | 2015-12-06 | Production process of decoquinate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106632034A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3665005A (en) * | 1969-12-22 | 1972-05-23 | Morton Norwich Products Inc | Process for preparing 4-hydroxy-6,7-substituted-3-carboalkoxyquinolines |
| CN101012195A (en) * | 2007-02-15 | 2007-08-08 | 常熟市欧亚吉生物医药研究所 | Method of preparing 4-hydroxy-6-decyloxy-7-ethoxy-3-quinoline carboxylic acid ethyl ester |
| CN102766094A (en) * | 2012-08-15 | 2012-11-07 | 青岛康地恩药业股份有限公司 | Preparation method of novel anticoccidial drug decoquinate |
-
2015
- 2015-12-06 CN CN201510879918.2A patent/CN106632034A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3665005A (en) * | 1969-12-22 | 1972-05-23 | Morton Norwich Products Inc | Process for preparing 4-hydroxy-6,7-substituted-3-carboalkoxyquinolines |
| CN101012195A (en) * | 2007-02-15 | 2007-08-08 | 常熟市欧亚吉生物医药研究所 | Method of preparing 4-hydroxy-6-decyloxy-7-ethoxy-3-quinoline carboxylic acid ethyl ester |
| CN102766094A (en) * | 2012-08-15 | 2012-11-07 | 青岛康地恩药业股份有限公司 | Preparation method of novel anticoccidial drug decoquinate |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109134315A (en) | A kind of preparation method of carbasalate calcium and carbasalate calcium prepared by this method | |
| CN103601735B (en) | A kind of method of mosictin of purifying | |
| CN104059007A (en) | Method for extracting lutein ester from marigold flowers | |
| CN106431969B (en) | A kind of method for preparing 2- methyl -4- formaldoxime yl benzoic acid methyl esters | |
| CN105274625A (en) | Spherical NTO (3-nitro-1,2,4-triazol-5-one) crystal with high crystalline density and preparation method | |
| CN104356114A (en) | Preparation method of esomeprazole magnesium trihydrate | |
| CN102351929A (en) | Preparation method of high-purity breviscapine active pharmaceutical ingredient | |
| WO2023019839A1 (en) | Preparation and post-treatment method for 5-aminolevulinate | |
| CN104910135A (en) | Preparation method of new crystal form of dexrabeprazole sodium | |
| CN106632034A (en) | Production process of decoquinate | |
| CN103012300A (en) | Novel method for preparing valsartan | |
| CN103922925B (en) | A kind of production technique of Fenofibric Acid | |
| CN100584845C (en) | Method for preparing (+)-(S-)-clopidogrel hydrosulfate high melting point crystal I | |
| CN103896956A (en) | Method for extracting sesamin from sesame seed husks | |
| CN102167717B (en) | Method for extracting cholesterol from animal brain dry powder with ultrasonic waves | |
| CN102746244B (en) | Refining method of oteracil potassium | |
| CN106632008A (en) | Clopidol production process | |
| CN103172696A (en) | Preparation method of perindopril arginine salt of gamma-crystal form | |
| CN108863765B (en) | Preparation method of loxoprofen sodium crystal | |
| CN106831613A (en) | A kind of quinocetone production technology | |
| CN104230739A (en) | Process for producing N,N',N''-tricyclohexyl-1,3,5-benzamide by using trimesic acid | |
| CN104610145A (en) | Separation method for cisatracurium besilate intermediate R-tetrahydropapaverine-N-acetyl-L-leucine salt | |
| CN104151192A (en) | Improved method of preparation technology of mildronate intermediate 3-(2,2,2-trimethylhydrazine) methyl acrylate methyl sulfate | |
| CN103539733A (en) | Preparation method of isoniazid para-aminosalicylate | |
| CN112028838B (en) | Preparation method of 2-ethoxy-5-fluorouracil impurity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170510 |