CN106622413A - Multi-nozzle module based on 3D (three-dimensional) printing and device and technique for large-scale production of particles - Google Patents
Multi-nozzle module based on 3D (three-dimensional) printing and device and technique for large-scale production of particles Download PDFInfo
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- CN106622413A CN106622413A CN201611232616.7A CN201611232616A CN106622413A CN 106622413 A CN106622413 A CN 106622413A CN 201611232616 A CN201611232616 A CN 201611232616A CN 106622413 A CN106622413 A CN 106622413A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0463—Hydrodynamic forces, venturi nozzles
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- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
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Abstract
The invention discloses a technical method for large-scale production of particles by a multi-nozzle module based on a 3D (three-dimensional) printing technique and application of the technical method. The technical method is characterized in that a single nozzle is of a coaxial annular gap air blowing structure, the middle part is provided with a fluid channel, and the coaxial annular gap is an air channel; on the basis of a two-phase flow cutting principle, liquid-phase liquid is cut by air, and liquid droplet particles are produced; by controlling air and liquid outlet pressures and flow rates, the liquid droplets with different particle sizes can be obtained; the number of nozzles can be designed according to the requirement of droplet output, and liquid and air are uniformly distributed by a distributor, so as to obtain higher droplet production efficiency. The technical method has the advantages that the preparation of 3D printing nozzle modules is simple, the material cost is low, and other complicated mechanical processing methods are not required; the prepared particles are free from the pollution by poisonous matters, such as a continuous phase and surfactants; the technical method is especially suitable for preparing high-viscosity solution and suspension droplets containing insoluble particles, is widely applied to the fields of medical care, petroleum, biology, environment protection and the like, and is suitable for large-scale industrial production.
Description
Technical field
The present invention relates to micro-fluidic chip prepares microparticle technical field, more particularly, to a kind of many sprays based on 3D printing
Mouth module and its high-volume particle production technology.
Background technology
Feature micro particulate materials are all many-sided equal in bioengineering, catalytic reaction, chemisorbed and pharmaceutical field etc.
There is important application.Preferably spheric granules needs more uniform particle diameter distribution, stable chemical performance to endanger environment, biology etc.
Little, particle preparation link is required simply fast, is easily controlled grain diameter, with low cost, to be also easy to amplify volume production.But
In traditional preparation method, such as film dispersion, mechanical agitation, static mixing, colloid mill and ultrasonic disperse etc., although can be effectively
Produced on a large scale, but typically can only obtain spheric granules, the homogeneity of resulting polymers scantling can with process
Control property is difficult to be guaranteed.Therefore the focus that the unified microparticle of size uniform is current research how is prepared.
Microreactor or the new technology such as micro-fluidic are nowadays to realize main platform prepared by feature micro particulate materials.Micro- chi
Under degree, microreactor or microfluidic device small volume, safety, heat and mass efficiency high so that production efficiency is greatly improved.Utilize
The microparticle size of this technology production is uniform, high precision and controllable, can according to demand prepare the function of different-shape
Grain, while being convenient to large-scale integrated in industrial production.
Using microreactor or microflow control technique prepare microparticle premise is that prepare it is accurate in size micro-fluidic
Particle manufacture chip, and then ensure to prepare microlayer model of uniform size.At present the machining manufacture of micro-fluidic chip is main
There are silicon/polymer surfaces micro Process, soft print, impressing, injection moulding, laser ablation, PMMA pressure sinterings, LIGA technologies, etching skill
Art, 3D printing combine PDMS pouring techniques etc., and these methods are provided to process accurate in size fluid channel, after convenience
The continuous particle that uniform particle sizes are prepared using microfluid method etc..The microlayer model size prepared using microfluid method is homogeneous, and yield is high, but
It also has many shortcomings：
(1) shearing needed for micro-fluidic is mutually usually the poisonous oils such as normal octane, atoleine, in addition it is also necessary to add SP80
Deng surfactant, prepared drop can also be mixed with these noxious materials, therefore in medical treatment, food, field of biological pharmacy
And do not apply to.
(2) velocity ratio of micro-fluidic middle continuous phase and dispersion phase is usually 6～10 times, micro- when dispersed phase viscosity is larger
Drop is difficult to be molded, though the velocity ratio to 20 times also differs surely into particle, therefore in the selection of particle material
Limitation.
(3) microfluidic method can only add some reagents that can be dissolved in dispersion phase solution, for some solid particles hold
Fluid channel blocking is easily caused, is not suitable for suspension and is prepared particle.
(4) microfluidic method needs extra increase to shear phase, therefore additionally needs increase syringe pump, high cost, operating process
Control is more difficult to, disturbing factor is more.
The content of the invention
For defect of the prior art, it is an object of the invention to provide a kind of multiinjector mould based on 3D printing technique
Block high-volume particle production technology.
Technical scheme is as follows：
A kind of multiinjector module based on 3D printing, it is characterised in that the nozzle module is sprayed by multiple independent single channels
Mouth is integrated, and each independent single-pass nozzle is connected respectively with liquid phase distributor 9 and vapor distributor 2, and liquid phase distributor 9 connects always to enter
Liquid mouth 8, vapor distributor 2 connects total air inlet 1, whole module 3D printing one-shot forming.
According to the multiinjector module based on 3D printing of the present invention, the separate single channel nozzle arranges infusion channel
4, its one end is connected with the liquid phase distributor 9, other end connection liquid outlet 7, and liquid is by infusion channel 4 from liquid phase distributor
9 inputs, Jing intermediate flow channels are oozed from liquid outlet 7；The separate single channel nozzle arranges gas distribution channel 3, its one end and the gas
Phase partitioning device 2 connects, and other end Jing coaxial rings clearance flows road 5 is connected with gas outlet 6, and gas is distributed by gas distribution channel 3 from gas phase
Device 2 is input into, and Jing coaxial rings clearance flows road 5 sprays from gas outlet 6.At liquid outlet 7, gas produces ring to the droplet particles for generating
Cutting, the droplet particles of generation of blowing off.
According to the multiinjector module based on 3D printing of the present invention, separate single channel nozzle is blown using annular space and is tied
Structure, internal layer leads to liquid, and outer layer ventilation, whole nozzle module ensures as far as possible fluid distribution using the design structure of circular symmetric
Uniformly.Middle liquid phase runner exit is higher by annular space runner 0.5mm.
According to the multiinjector module based on 3D printing of the present invention, further, the internal diameter of liquid outlet 7 may be selected 0.1
～0.5mm, the optional 0.3～2mm of internal diameter of infusion channel, gas outlet may be selected 0.2～0.5mm with the czermak space of liquid outlet, defeated
Optional 0.5～the 3mm of internal diameter of gas passage.
According to the multiinjector module based on 3D printing of the present invention, further, inlet runner in liquid phase distributor 9
Slightly above each entrance of infusion channel 4.Distance only has 0.5mm between each infusion channel entrance 4, and liquid phase distribution is reduced as far as possible
Device diameter, increases distributing uniformity.
According to the multiinjector module based on 3D printing of the present invention, further, the minimum wall thickness (MINI W.) 0.5mm of module.Section
About 3D printing raw material photosensitive resin, while reducing printing difficulty.
The present invention also provides a kind of multiinjector module high-volume particle production apparatus based on 3D printing, and described device is by sky
Press, constant pressure pump, flowmeter, multiinjector module, syringe pump, pipeline composition, air compressor machine produces gas, Jing constant pressure pumps as source of the gas
The pressure of stable setting is reached, Jing flowmeters read flow registration, eventually enter into nozzle module and prepare drop.
The present invention also provides a kind of described multiinjector module high-volume particle production technology based on 3D printing technique, should
With the above-mentioned multiinjector module high-volume particle production apparatus based on 3D printing, air compressor machine setting exit pressure levels 0.4Mpa, perseverance
Press pump 0～0.11Mpa of pressure.
According to the multiinjector module high-volume particle production technology based on 3D printing technique of the present invention, nozzle module
Integrated by multiple separate single channel nozzles, each nozzle connects respectively with the vapor distributor 2 of liquid phase distributor 9, liquid, gas distributor
Connect total inlet 8, total air inlet 1, whole module 3D printing one-shot forming；In single-nozzle liquid by infusion channel 4 from
Liquid phase distributor 9 is input into, and Jing intermediate flow channels are oozed from liquid outlet 7；Gas is input into by gas distribution channel 3 from vapor distributor 2, Jing
Coaxial rings clearance flow road 5 sprays from gas outlet 6；At liquid outlet 7, gas produces ring cutting to the droplet particles for generating, and blows off
The droplet particles of generation；Single-nozzle adopts annular space blowing structure, internal layer to lead to liquid, and outer layer ventilation, whole nozzle module adopts ring
The symmetrical design structure of shape, ensures as far as possible the uniform of fluid distribution；Middle liquid phase runner exit is higher by annular space runner 0.3mm；
Inlet runner is slightly above each entrance of infusion channel 4 in liquid phase distributor 9；Distance between each infusion channel entrance 4
0.5mm；The minimum wall thickness (MINI W.) 0.5mm of module；The internal diameter of liquid outlet 7 may be selected 0.1～0.5mm, the internal diameter optional 0.3 of infusion channel
～2mm, gas outlet may be selected 0.2～0.5mm, the optional 0.5～3mm of internal diameter of gas distribution channel with the czermak space of liquid outlet.
Multiinjector module high-volume particle production technology based on 3D printing technique of the present invention, comprises the following steps：
(1) single two phase flow nozzle arrangements are designed using computer-aided three-dimensional mapping software；
(2) a module is drawn so as to while integrate including multiple nozzles；
(3) step section is carried out to three-dimensional many nozzle structure modules using 3D printing pre-processing software；
(4) delivery nozzle entity is printed using 3D printer；
(5) the composition batch particle manufacture system such as shower nozzle, flowmeter, constant pressure pump, measuring pump is connected by pipeline.
The invention discloses a kind of multiinjector module based on 3D printing technique produce in enormous quantities the technical method of particle and
Its application；Single injector is coaxial annular space blowing structure, and centre is flow channel for liquids, and coaxial annular space is gas flow, based on two phase flow
Incision principle, using air liquid phase fluid is cut, and produces droplet particles.By the control to air-liquid body outlet pressure and flow velocity,
The drop of different-grain diameter can be obtained.Nozzle quantity can be designed according to drop throughput requirements, and liquid, gas are realized uniform by distributor
Distribution, obtains high drop production efficiency.The concrete grammar for realizing the technology is：1) computer aided design software design two-phase
Flow nozzle structure；2) 3D printer prints delivery nozzle entity；3) groups such as shower nozzle, flowmeter, constant pressure pump, air pump are connected by pipeline
Into particle manufacture system, the drop that gas-liquid velocity ratio prepares required particle diameter is controlled.3D printing nozzle module prepares letter in the present invention
Single, the cost of material is low, it is not necessary to other complicated machining process.Function is prepared compared to other microfluidic chip technologies
The method of grain, the prepared particle of the present invention is not by the pollution of the toxicants such as continuous phase, surfactant.It is particularly suited for high viscosity
The preparation of solution, the drop of suspension containing insoluble granule, can be widely used for the fields such as medical treatment, oil, biology, environmental protection, be adapted to work
Sparetime university's large-scale production
Detailed description of the invention
A kind of multiinjector module high-volume particle production technology based on 3D printing technique, comprises the following steps：
Step (1)：Single two phase flow nozzle arrangements are designed using computer-aided three-dimensional mapping software；
Step (2)：Draw a module so as to while integrate including multiple nozzles；
Step (3)：Step section is carried out to three-dimensional many nozzle structure modules using 3D printing pre-processing software；
Step (4)：Delivery nozzle entity is printed using 3D printer；
Step (5)：The composition batch particle manufacture system such as shower nozzle, flowmeter, constant pressure pump, measuring pump is connected by pipeline.
Preferably, described 3D printer is stereolithography (SLA) printer.
Preferably, the material of described many micro-pipe two phase flow nozzle modules is the opaque resins such as pic100.
Preferably, in step (1), single two-phase flow nozzle nozzle has double-decker, and internal layer leads to liquid, outer layer ventilation.Two
A diameter of 0.1～the 0.5mm of liquid outlet of phase flow nozzle.The gas outlet annular space gap of two-phase flow nozzle is 0.2～0.5mm.Two-phase
The liquid outlet capillary length of flow nozzle is 3～10mm.
Preferably, in step (1), the gas flow symmetrical shape of two-phase flow nozzle, to ensure what all directions sprayed
Gas flow is uniform, so as to microlayer model can vertically fall.
Preferably, in step (2), nozzle be uniformly distributed with same circumference.
Preferably, in step (2), the minimum range between each nozzle is 2mm, and each several part minimum wall thickness (MINI W.) is 1mm, is being protected
The use of raw material is reduced while card structural strength.
Preferably, in step (2), a hollow cylinder is needed between gas phase redistributor and liquid phase redistributor
Support, increases structural strength.
Preferably, in step (2), inlet is slightly above wherein each infusion channel entrance, liquid phase in liquid phase redistributor
Into after module, first reach certain volume and separately flow into each runner again, so as to ensure that the uniform flow of each runner liquid phase.
Preferably, constant pressure pump and spinner flowmeter are connected between air compressor machine and shower nozzle.
The microparticle diameters that the present invention is prepared are 0.4～2mm, can adjust gas speed and pressure according to solution viscosity, optional
Liquid phase is substantially unrestricted, is also applied for some suspensions containing pressed powder.
In the present invention, gaseous pressure is about 0.02～0.1MPa, and gas phase flow rate is about 800～2000L/h, can also be according to molten
Fluid viscosity is suitably adjusted.
In the present invention, liquid phase flow is about 100～800 μ L/min.
Compared with prior art, the invention has the advantages that：
Multiinjector module of the present invention based on 3D printing technique, preparation process is easy, lower cost for material, it is not necessary to PDMS
Pour, it is not necessary to other complicated machining process, therefore time-consuming and processing cost.Can be complicated with preparation structure
Runner, flow channel shape and precision it is controllable, be suitable for industrial-scale manufacture.
Multiinjector module high-volume particle production technology of the present invention based on 3D printing technique, compared to microflow control technique and
Traditional handicraft, using two-phase flow nozzle, viscosity influence is not received in the selection of liquid phase.Shearing mutually uses air, and gas speed adjustable extent is big,
Environment-protecting asepsis, with low cost, easily manipulation, can be used for the industries such as medical treatment, biology, pharmacy, food, applied widely.
The present invention is integrated with multiple nozzles based on the multiinjector module of 3D printing technique and quantity is adjustable, also holds between module
Easily superposition is amplified, and significantly increases speed of production.Multiple modules work simultaneously, and production efficiency is high, and yield is big, with good
Application prospect.
Multiinjector module manufacturing process simple and fast of the present invention based on 3D printing technique, prints by painting three-dimensional drawing
Shaping, speed of production is fast, uses manpower and material resources sparingly.And additional pipe joint is not needed, all structures are all one-shot formings, can root
Factually border line size directly prints corresponding joints.
Nozzle flow channel outlet diameter 0.5mm of the present invention or so, length about 5mm, suitable current desktop level DLP,
SLA printers are printed.The longer microchannel chip of direct 3D printing factory length is compared, fluid channel is more difficult in print procedure
Blocking, substantially reduces product rejection quantity.
In particle production technology of the present invention, spinner flowmeter and constant pressure pump are connected between air compressor machine and nozzle, easily
Control nozzle air inlet pressure and flow, stable so as to ensure jet expansion gas speed, final control microparticle particle diameter distribution is equal
It is even.
Description of the drawings
Fig. 1 is the sectional view that the present invention includes liquid phase entrance section；
Fig. 2 is the uniform redistributor sectional view of gas phase of the present invention；
Fig. 3 is overall appearance schematic diagram of the present invention；
Fig. 4 is high-volume particle production technology device flow chart of the present invention；
Fig. 5 is that the Channels module of the present embodiment 1 batch prepares calcium alginate, calcium carbonate granule grain size distribution, institute
Pressure is selected between 0Mpa～0.09Mpa；
Fig. 6 is that the carbonic acid calcisphere row particle that the nozzle module of the present embodiment one is prepared under 0.05MPa is cold through cryogenic vacuum
Freeze dried SEM photograph, particle diameter is 0.75mm；
Wherein：The total air inlets of 1-, 2- vapor distributors, 3- gas distribution channels, 4- infusion channels, 5- coaxial rings clearance flow road 6- go out
Gas port, 7- liquid outlets, the total inlets of 8-, 9- liquid phase distributors, 10- hollow supports, 11- syringe pumps, 12- nozzle modules, 13- magnetic
Power agitator, 14- flowmeters, 15- constant pressure pumps, 16- air compressor machines.
Specific embodiment
With reference to specific embodiments and the drawings, the present invention is described in detail.Following examples will be helpful to this area
Technical staff further understand the present invention, but the invention is not limited in any way.It should be pointed out that to the general of this area
For logical technical staff, without departing from the inventive concept of the premise, some changes and improvements can also be made.These are belonged to
Protection scope of the present invention.
Fig. 1 is the sectional view of the present invention, and mainly comprising multiple two-phase flow nozzles, it is by two outlets, i.e. liquid phase liquid outlet 7
Constitute with gas phase gas outlet 6.Constant pressure pump discharge is connected with total air inlet 1 with 3mm plastic rigid pipes, pump discharge and total feed liquor is injected
Mouth 8 is connected using 3mm conventional hoses, and gas enters to the uniform redistributor 2 of gas phase and even in liquid phase by entrance respectively with liquid
Redistributor 9, respective flow channel is entered Jing after evenly distributing.By adjusting transfusion pump discharge and air compressor machine flow so that
Liquid is split by gas, obtains satisfactory microlayer model.
A kind of multiinjector module based on 3D printing, the nozzle module is integrated by multiple separate single channel nozzles, each
Independent single-pass nozzle is connected respectively with liquid phase distributor 9 and vapor distributor 2, and liquid phase distributor 9 connects total inlet 8, gas phase
Distributor 2 connects total air inlet 1, whole module 3D printing one-shot forming.The separate single channel nozzle arranges infusion channel 4,
Its one end is connected with the liquid phase distributor 9, other end connection liquid outlet 7, and liquid is by infusion channel 4 from liquid phase distributor 9
Input, Jing intermediate flow channels are oozed from liquid outlet 7；The separate single channel nozzle arranges gas distribution channel 3, its one end and the gas phase
Distributor 2 connects, and other end Jing coaxial rings clearance flows road 5 is connected with gas outlet 6, and gas is by gas distribution channel 3 from vapor distributor 2
Input, Jing coaxial rings clearance flows road 5 sprays from gas outlet 6.At liquid outlet 7, gas produces ring and cuts to the droplet particles for generating
Cut, the droplet particles of generation of blowing off.
Embodiment 1
The present invention relates to a kind of multiinjector module high-volume particle production technology based on 3D printing technique, methods described bag
Include following steps：Step (1), using the single two phase flow nozzle arrangements of SOLIDWORKS Software for Design, wherein liquid-phase outlet diameter
For 0.5mm, length is 9.2mm, and wall thickness is 1.5mm；
Step (2), designs a module, as shown in figure 1, and making its integration many using computer-aided three-dimensional mapping software
Individual nozzle, module minimum wall thickness (MINI W.) be 0.5mm, infusion channel diameter 2mm, gas distribution channel diameter 3mm, nozzle quantity 13；
Step (3), cuts off module redundance, mitigates overall weight, saves raw material and module weight.
Step (4), using B9Creator printers corresponding entity is printed.
Step (5), by the module for printing be placed in alcohol clean, it is ensured that pipeline do not block and under ultraviolet light irradiation after
Solidification, makes whole part be fully cured shaping.
Step (6), the 13 runner multiinjector modules that printing is completed connect according to Fig. 4 flow processs order, check that interface is airtight
Property, 5% calcium chloride solution is placed below nozzle as reception phase.
Step (7), configures 2% sodium alginate soln 50ml in 50 DEG C of waters bath with thermostatic control, and adds 1.5g calcium carbonate powders, stirs
Mix and be formed uniformly the larger suspension of viscosity, in being added to syringe pump.The sodium alginate microlayer model of generation, is coated with alumina powder
End, the reaction solidification in calcium chloride solution generates calcium alginate solid particle microballoon.
Step (8), control jet expansion enters apart from calcium chloride liquid level 4cm, setting injection pump discharge 5.2mL/min, gas
Mouth pressure is respectively various working many experiments between 0Mpa～0.09Mpa, prepares the carbonic acid containing solid particle of different-grain diameter
Calcium calcium alginate microsphere.The particle diameter distribution of finished product spherical particles is as shown in figure 5, (a) 0.090MPa (b) 0.080MPa (c)
0.070MPa(d)0.060MPa(e)0.055MPa(f)0.050MPa(g)0.045MPa(h)0.040MPa(i)0.035MPa(j)
0.030MPa (k) 0.025MPa (l) 0.015MPa (m) 0MPa, can adjust pressure according to the actual requirements, expected so as to obtain
Solid particle.
Claims (10)
1. a kind of multiinjector module based on 3D printing, it is characterised in that the nozzle module is by multiple separate single channel nozzles
Integrated, each independent single-pass nozzle is connected respectively with liquid phase distributor (9) and vapor distributor (2), liquid phase distributor (9) connection
Total inlet (8), vapor distributor (2) connects total air inlet (1), whole module 3D printing one-shot forming.
2. the multiinjector module based on 3D printing according to claim 1, it is characterised in that the separate single channel nozzle
Infusion channel (4) is set, and its one end is connected with the liquid phase distributor (9), other end connection liquid outlet (7), liquid is by defeated
Liquid passage (4) is input into from liquid phase distributor (9), and Jing intermediate flow channels are oozed from liquid outlet (7)；The separate single channel nozzle is arranged
Gas distribution channel (3), its one end is connected with the vapor distributor (2), other end Jing coaxial rings clearance flows road (5) and gas outlet (6)
Connection, gas is input into by gas distribution channel (3) from vapor distributor (2), and Jing coaxial rings clearance flows road (5) spray from gas outlet (6),
At liquid outlet (7) place, gas produces ring cutting, the droplet particles of generation of blowing off to the droplet particles for generating.
3. the multiinjector module based on 3D printing according to claim 2, it is characterised in that separate single channel nozzle is adopted
Annular space blowing structure, internal layer leads to liquid, and outer layer ventilation, whole nozzle module is ensured as far as possible using the design structure of circular symmetric
Fluid distribution it is uniform.
4. the multiinjector module based on 3D printing according to claim 2, it is characterised in that the internal diameter of liquid outlet (7) can
0.1～0.5mm, the optional 0.3～2mm of internal diameter of infusion channel (4), gas outlet is selected to may be selected 0.2 with the czermak space of liquid outlet
～0.5mm, the optional 0.5～3mm of internal diameter of gas distribution channel.
5. the multiinjector module based on 3D printing according to claim 1, it is characterised in that liquid phase distributor enters in (9)
Liquid mouth runner is slightly above each infusion channel (4) entrance.
6. the multiinjector module based on 3D printing according to claim 1, it is characterised in that the minimum wall thickness (MINI W.) of module
0.5mm。
7. multiinjector module high-volume particle production apparatus based on 3D printing according to claim 1, it is characterised in that
Described device is produced by air compressor machine, constant pressure pump, flowmeter, multiinjector module, syringe pump, pipeline composition, air compressor machine as source of the gas
Gas, Jing constant pressure pumps reach the pressure of stable setting, and Jing flowmeters read flow registration, eventually enter into nozzle module preparation solution
Drop.
8. the multiinjector module high-volume particle production technology based on 3D printing technique according to claim 1, its feature
It is, using the multiinjector module high-volume particle production apparatus described in claim 7 based on 3D printing, air compressor machine setting outlet
Pressure value 0.4Mpa, constant pressure 0～0.11Mpa of pump pressure.
9. the multiinjector module high-volume particle production technology based on 3D printing technique according to claim 8, its feature
Be that nozzle module is integrated by multiple separate single channel nozzles, each nozzle respectively with liquid phase distributor (9) vapor distributor
(2) connect, liquid, gas distributor connect total inlet (8), total air inlet (1), whole module 3D printing one-shot forming；Single spray
Liquid is input into by infusion channel (4) from liquid phase distributor (9) in mouth, and Jing intermediate flow channels are oozed from liquid outlet (7)；Gas passes through
Gas distribution channel (3) is input into from vapor distributor (2), and Jing coaxial rings clearance flows road (5) spray from liquid outlet (7)；In liquid outlet (7)
Place, gas produces ring cutting, the droplet particles of generation of blowing off to the droplet particles for generating；Single-nozzle is blown using annular space and is tied
Structure, internal layer leads to liquid, and outer layer ventilation, whole nozzle module adopts the design structure of circular symmetric；Middle liquid outlet is higher by gas outlet
(6) runner 0.3mm；Inlet runner is slightly above each infusion channel (4) entrance in liquid phase distributor (9)；Each infusion channel
(4) apart from 0.5mm between entrance；The minimum wall thickness (MINI W.) 0.5mm of module；The internal diameter of liquid outlet (7) may be selected 0.1～0.5mm, transfusion
Optional 0.3～the 2mm of internal diameter of passage, gas outlet may be selected 0.2～0.5mm, the internal diameter of gas distribution channel with the czermak space of liquid outlet
Optional 0.5～3mm.
10. the multiinjector module high-volume particle production technology of 3D printing technique is based on described in a kind of claim 1, including it is following
Step：
(1) single two phase flow nozzle arrangements are designed using computer-aided three-dimensional mapping software；
(2) a module is drawn so as to while integrate including multiple nozzles；
(3) step section is carried out to three-dimensional many nozzle structure modules using 3D printing pre-processing software；
(4) delivery nozzle entity is printed using 3D printer；
(5) the composition batch particle manufacture system such as shower nozzle, flowmeter, constant pressure pump, measuring pump is connected by pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232616.7A CN106622413A (en) | 2016-12-28 | 2016-12-28 | Multi-nozzle module based on 3D (three-dimensional) printing and device and technique for large-scale production of particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232616.7A CN106622413A (en) | 2016-12-28 | 2016-12-28 | Multi-nozzle module based on 3D (three-dimensional) printing and device and technique for large-scale production of particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106622413A true CN106622413A (en) | 2017-05-10 |
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| CN201611232616.7A Pending CN106622413A (en) | 2016-12-28 | 2016-12-28 | Multi-nozzle module based on 3D (three-dimensional) printing and device and technique for large-scale production of particles |
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| US20220161323A1 (en) * | 2020-11-26 | 2022-05-26 | S.A.S 3Dceram-Sinto | Machine for manufacturing green parts from ceramic or metallic material |
| US11364674B2 (en) | 2017-05-16 | 2022-06-21 | Triastek, Inc. | 3D printing device and method |
| US11458684B2 (en) | 2020-07-30 | 2022-10-04 | Triastek, Inc. | High-throughput and high-precision pharmaceutical additive manufacturing system |
| CN115260574A (en) * | 2022-08-05 | 2022-11-01 | 石河子大学 | Preparation method of super-macroporous resin particles |
| US11612569B2 (en) | 2018-01-09 | 2023-03-28 | Triastek, Inc. | Precision pharmaceutical 3D printing device |
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| CN109435474A (en) * | 2018-09-11 | 2019-03-08 | 华中科技大学 | A kind of multiinjector joint EFI print spray head with multi-electrode ring electric field controls function |
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| US11383439B1 (en) | 2019-08-20 | 2022-07-12 | Triastek, Inc. | High-throughput and high-precision pharmaceutical additive manufacturing system |
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| WO2021031824A1 (en) * | 2019-08-20 | 2021-02-25 | Triastek, Inc. | High-throughput and high-preciscion pharmaceutical additive manufacturing system |
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| US20220161323A1 (en) * | 2020-11-26 | 2022-05-26 | S.A.S 3Dceram-Sinto | Machine for manufacturing green parts from ceramic or metallic material |
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| CN115260574A (en) * | 2022-08-05 | 2022-11-01 | 石河子大学 | Preparation method of super-macroporous resin particles |
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