CN106621048A - Low-power deep brain stimulator (DBS) hardware circuit - Google Patents
Low-power deep brain stimulator (DBS) hardware circuit Download PDFInfo
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- CN106621048A CN106621048A CN201510735493.8A CN201510735493A CN106621048A CN 106621048 A CN106621048 A CN 106621048A CN 201510735493 A CN201510735493 A CN 201510735493A CN 106621048 A CN106621048 A CN 106621048A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
- A61N1/37276—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data characterised by means for reducing power consumption during telemetry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
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- Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Electrotherapy Devices (AREA)
Abstract
Disclosed is a low-power deep brain stimulator (DBS) hardware circuit. A deep brain stimulator (DBS) is composed of a main control circuit, a low-frequency wake-up circuit, a RF communication circuit, a low-pass filter circuit and a voltage control constant current source circuit. The circuit design uses low-power short-range RF communication technology and low-frequency wake-up technology. The low-power short-range RF communication technology is used for data transmission of DBS in vitro and in vivo systems; and the low-frequency wake-up technology is used for achieving the wake-up of the systems at any time and reducing power consumption. The circuit is compact in structure, stable in operation, and fast in response.
Description
Technical field
The present invention relates to a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit, it is adaptable to biological field.
Background technology
For a long time, lesions located in deep brain therapy is at aspects such as treatment control parkinson disease, insane pain, mental sickness achieved with greater advance, because the therapy has the advantages that, few intercurrent disease minimum to tissue cell insult, external controllable are adjusted, the therapy also result in the extensive concern of medical circle in the applied research of other medical domains.
In order to support experimentation of the DBS operations in relevant medical domain treatment, the performance quality of lesions located in deep brain device (DBS) that experimental result, or even the life security for jeopardizing experimental subject will be directly affected.Under strong clinical practice and basic research demand, a set of volume of research design is small, low in energy consumption, reliability is high and inexpensive lesions located in deep brain system is also particularly important.
Traditional DBS hardware systems are imbedded at internal pulse generator and the part of external controller three composition by the electrode positioned at brain stimulation area.Its operation principle is by planting people's stimulating electrode and internal pulse generator, by external controller different stimulus parameters being adjusted, certain pulsewidth, frequency, the bioelectric stimulation of time are carried out to intracerebral specific region come to reach activation or barrier effect.According to the needs of medical application, a kind of lesions located in deep brain device of low-power consumption is designed necessary.
The content of the invention
The present invention provides a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit, and the circuit design is using low-power consumption short range radio frequency communications technology and low frequency wake-up technology.Low-power consumption short range radio frequency communications technology is used for the data transfer of external system in DBS bodies；Low frequency wake-up technology is used to realize that any time of system to wake up, and reduces power consumption.Circuit structure is compact, and working stability, response speed is fast.
The technical solution adopted in the present invention is：
The lesions located in deep brain device (DBS) is made up of governor circuit, low frequency wake-up circuit, radio frequency communications circuitry, low-pass filter circuit, controlled constant-current source circuit.
The low frequency wake-up receiver module is responsible for the wake-up of microprocessor sleeping state, notifies that microprocessor has in vitro read-write to require；Radio-frequency communication module is responsible for receiving the working status parameter of the control signal of external controller and the internal stimulator of return；There is the boost pulse that module produces under control of the microprocessor frequency, pulsewidth, intensity variable in stimulus signal.Radio-frequency communication module is received after external control command parameter, notifies that microprocessor generates pulse control signal according to the order for receiving, and stimulus signal occurs module and produces boost pulse, completed by electrode. to cerebral tissue stimulation therapy.
In the governor circuit, 2401CS, 2401CE, 24OIMI, 240lMO, 24O1SCK, 240lRQ are and nRF24L01 communications part of interface, for receiving vitro program controlled parameter or sending internal stimulus parameter for external inquiry；WRST, DATA, WAKE are and ATA5283 communication interfaces, for wake-up during internal single-chip microcomputer dormancy, so that user can wake up single-chip microcomputer any time, to change internal stimulus parameter；IP is electric current degree of convergence PWM output control pin, and TP is boost pulse frequency, pulse-width controlled pin；MISO, MOSI, SCK, RESET are ISP download program interfaces, it is contemplated that the requirement of circuit miniaturization, download interface has carried out miniaturized design.Power supply is powered and is provided by lithium manganese button cell CR2450, and 32768 external crystal oscillators are used as asynchronous real-time clock, and for timing wake-up single-chip microcomputer boost pulse is opened and closed. and system clock adopts the RC agitators of 1MHZ in piece.
In the low frequency wake-up circuit, the LF low frequencies shunt-resonant circuit that LZ and CZ is constituted receives the energy of external controller transmitting.As long as resonance potential is more than 1mV, ATA5283 triggers the interrupt INT 0 of single-chip microcomputer by N_WAKEUP.After single-chip microcomputer wakes up, data are read by DATA.When data receiver is finished, single-chip microcomputer exports high level to the RESET feet of ATA5283, returns it to standby pattern of intercepting and continues to intercept wake operation.The serial data that single-chip microcomputer is received by analysis, to control internal RF transmit-receive circuit transmitting and to receive.Meanwhile, the external devices needed for ATA5283 are quite few, are conducive to the integrated level of raising system, reduce circuit volume.
The DBS radio frequency communications circuitries are adopted:The short-distance wireless rf chip nRF24L01 of Nordic companies production.The chip is by SPI interface and microcontroller communication.Realize the running parameter configuration and data transmission of nRF24 L01.Meanwhile, nRF24L01 supports to be communicated between point-to-multipoint, knows without complicated communication protocols, and peripheral components are few.Additionally, there is nRF24L01 relatively low operating current to consume electric current with static, system power dissipation is greatly reduced.
The exponent number of the low pass filter selects 2 ranks, circuit design to select Sallen-Key structures.Sallen-Key topological structure is applied to high precision, the limit occasion relatively low to Q-value, while also having the less advantage of element demand.Low-pass filter circuit selects TLV2404, and the GBP of the amplifier is 5.5kHz, and conversion speed is 2.5V/ms, can meet design requirement.
The controlled constant-current source circuit, the D/A outputs that PWM based on single chip computer AT mega48 is controlled have completed the control of voltage amplitude, then the voltage-controlled current constant control scheme of double operational is adopted, in order to ensure that current voltage-controlled constant-current circuit is operated in linear zone, output constant current, then require resistance R4=R3=100K, R6=R7=100K, R8=1K.
The invention has the beneficial effects as follows：This circuit can realize that any time of system wakes up, and reduce power consumption, and circuit structure is compact, and working stability, response speed is fast.
Description of the drawings
With reference to the accompanying drawings and examples the present invention is further described.
Fig. 1 is the governor circuit of the present invention.
Fig. 2 is the low frequency wake-up circuit of the present invention.
Fig. 3 is the radio frequency communications circuitry of the present invention.
Fig. 4 is the low-pass filter circuit of the present invention.
Fig. 5 is the controlled constant-current source circuit of the present invention.
Specific embodiment
With reference to the accompanying drawings and examples the invention will be further described.
Such as Fig. 1, in governor circuit, 2401CS, 2401CE, 24OIMI, 240lMO, 24O1SCK, 240lRQ are and nRF24L01 communications part of interface, for receiving vitro program controlled parameter or sending internal stimulus parameter for external inquiry;WRST, DATA, WAKE are and ATA5283 communication interfaces, for wake-up during internal single-chip microcomputer dormancy, so that user can wake up single-chip microcomputer any time, to change internal stimulus parameter；IP is electric current degree of convergence PWM output control pin, and TP is boost pulse frequency, pulse-width controlled pin；MISO, MOSI, SCK, RESET are ISP download program interfaces, it is contemplated that the requirement of circuit miniaturization, download interface has carried out miniaturized design.Power supply is powered and is provided by lithium manganese button cell CR2450, and 32768 external crystal oscillators are used as asynchronous real-time clock, and for timing wake-up single-chip microcomputer boost pulse is opened and closed. and system clock adopts the RC agitators of 1MHZ in piece.
Such as Fig. 2, in low frequency wake-up circuit, the LF low frequencies shunt-resonant circuit that LZ and CZ is constituted receives the energy of external controller transmitting.As long as resonance potential is more than 1mV, ATA5283 triggers the interrupt INT 0 of single-chip microcomputer by N_WAKEUP.After single-chip microcomputer wakes up, data are read by DATA.When data receiver is finished, single-chip microcomputer exports high level to the RESET feet of ATA5283, returns it to standby pattern of intercepting and continues to intercept wake operation.The serial data that single-chip microcomputer is received by analysis, to control internal RF transmit-receive circuit transmitting and to receive.Meanwhile, the external devices needed for ATA5283 are quite few, are conducive to the integrated level of raising system, reduce circuit volume.
Such as Fig. 3, the employing of DBS radio frequency communications circuitries:The short-distance wireless rf chip nRF24L01 of Nordic companies production.The chip is by SPI interface and microcontroller communication.Realize the running parameter configuration and data transmission of nRF24 L01.Meanwhile, nRF24L01 supports to be communicated between point-to-multipoint, knows without complicated communication protocols, and peripheral components are few.Additionally, there is nRF24L01 relatively low operating current to consume electric current with static, system power dissipation is greatly reduced.
As Fig. 4, the exponent number of low pass filter select 2 ranks, circuit design is from Sallen-Key structures.Sallen-Key topological structure is applied to high precision, the limit occasion relatively low to Q-value, while also having the less advantage of element demand.Low-pass filter circuit selects TLV2404, and the GBP of the amplifier is 5.5kHz, and conversion speed is 2.5V/ms, can meet design requirement.
Such as Fig. 5, controlled constant-current source circuit, the D/A outputs that PWM based on single chip computer AT mega48 is controlled have completed the control of voltage amplitude, then the voltage-controlled current constant control scheme of double operational is adopted, in order to ensure that current voltage-controlled constant-current circuit is operated in linear zone, output constant current then requires resistance R4=R3=100K, R6=R7=100K, R8=1K.
Claims (10)
1. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit, is characterized in that：Described lesions located in deep brain device is using low-power consumption short range radio frequency communications technology and low frequency wake-up technology.
2. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：The lesions located in deep brain device (DBS) is made up of governor circuit, low frequency wake-up circuit, radio frequency communications circuitry, low-pass filter circuit, controlled constant-current source circuit.
3. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：Described low frequency wake-up receiver module is responsible for the wake-up of microprocessor sleeping state, notifies that microprocessor has in vitro read-write to require, radio-frequency communication module is responsible for receiving the control signal of external controller and the working status parameter for returning internal stimulator.
4. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：In described governor circuit, 2401CS, 2401CE, 24OIMI, 240lMO, 24O1SCK, 240lRQ are and nRF24L01 communications part of interface, for receiving vitro program controlled parameter or sending internal stimulus parameter for external inquiry.
5. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：In the governor circuit, power supply is powered and is provided by lithium manganese button cell CR2450, and 32768 external crystal oscillators are used as asynchronous real-time clock, and for timing wake-up single-chip microcomputer boost pulse is opened and closed, and system clock adopts the RC agitators of 1MHZ in piece.
6. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：In the low frequency wake-up circuit, the LF low frequencies shunt-resonant circuit that LZ and CZ is constituted receives the energy of external controller transmitting, as long as resonance potential is more than 1mV, ATA5283 triggers the interrupt INT 0 of single-chip microcomputer by N_WAKEUP.
7. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：In the low frequency wake-up circuit, the serial data that single-chip microcomputer is received by analysis, to control internal RF transmit-receive circuit transmitting and to receive.
8. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：The DBS radio frequency communications circuitries are adopted:The short-distance wireless rf chip nRF24L01 of Nordic companies production, the chip is by SPI interface and microcontroller communication.
9. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：The exponent number of the low pass filter selects 2 ranks, circuit design to select Sallen-Key structures.
10. a kind of low-power consumption lesions located in deep brain device (DBS) hardware circuit according to claim 1, is characterized in that：The controlled constant-current source circuit, the D/A outputs that the PWM based on single chip computer AT mega48 is controlled have completed the control of voltage amplitude, then using the voltage-controlled current constant control scheme of double operational.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510735493.8A CN106621048A (en) | 2015-11-03 | 2015-11-03 | Low-power deep brain stimulator (DBS) hardware circuit |
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| CN201510735493.8A CN106621048A (en) | 2015-11-03 | 2015-11-03 | Low-power deep brain stimulator (DBS) hardware circuit |
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| CN106621048A true CN106621048A (en) | 2017-05-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115671549A (en) * | 2022-11-09 | 2023-02-03 | 杭州神络医疗科技有限公司 | Low-power-consumption electrical stimulation method and device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115671549A (en) * | 2022-11-09 | 2023-02-03 | 杭州神络医疗科技有限公司 | Low-power-consumption electrical stimulation method and device |
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Application publication date: 20170510 |
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