CN106621028A - Electrode lead - Google Patents
Electrode lead Download PDFInfo
- Publication number
- CN106621028A CN106621028A CN201611148027.0A CN201611148027A CN106621028A CN 106621028 A CN106621028 A CN 106621028A CN 201611148027 A CN201611148027 A CN 201611148027A CN 106621028 A CN106621028 A CN 106621028A
- Authority
- CN
- China
- Prior art keywords
- electrode
- main body
- body tube
- mating part
- protuberance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000013011 mating Effects 0.000 claims description 41
- 239000003292 glue Substances 0.000 claims description 7
- 230000000638 stimulation Effects 0.000 abstract description 30
- 230000000694 effects Effects 0.000 abstract description 8
- 210000004556 brain Anatomy 0.000 description 9
- 210000005036 nerve Anatomy 0.000 description 6
- 238000002513 implantation Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 238000005424 photoluminescence Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003822 epoxy resin Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- -1 corronil line Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 201000006517 essential tremor Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000001186 vagus nerve Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
Abstract
The present invention provides an electrode lead. The lead comprises a main body tube and an electrode installed on the main body tube. The electrode comprises a matching portion matched with the main body tube, the electrode also comprises a projection portion connected with the matching portion, and the projection portion protrudes from the outer surface of the main body tube. The electrode of the electrode lead has a projection portion protruding from the main body tube and can improve the effective contact area of the electrode and a target stimulation position compared to a traditional flat and straight electrode to allow the electrode to fully contact the relatively rough organizational interface, increase the effectiveness of the stimulation, reduce the side effect caused by unnecessary big stimulation, improve the energy use efficiency of a pulse generator connected with the electrode wire and increase the service life of a battery of the pulse generator.
Description
Technical field
The present invention relates to a kind of electrode cable, especially a kind of electrode having used in source intervention and implantation field are led
Line, is such as used for the Neural stimulation electrodes wire that deep brain stimulates.
Background technology
Nerve electric stimulation has important effect in maladjusted nervous system treatment and neurotrosis rehabilitation.Implantable nerve
Electric stimulation by the implant electrode at such as kinesitherapy nerve, sensorineural specific nerve in human body, by discharging high frequency
Electro photoluminescence, so as to stimulate specific nerve, reaches the shape body for making human body functional recovery to normal operation.At present, it is implanted into
Formula stimulation system mainly includes implanted brain electro photoluminescence（DBS）, the stimulation of implanted cortex（CNS）, implanted ridge
Marrow electric stimulation（SCS）, implanted vagus nerve electric stimulation（VNS）Deng.
Implanted brain electro photoluminescence（DBS）And other be related to it is more and more to the relevant operation of brain implant electrode wire
For treat Parkinson, myodystony, essential tremor, epilepsy, obesity, depression, motion control obstacle and other make
The weak disease of people.In these operations, electrode or other medicine equipments are positioned over the specified target position of brain, Jin Erda
To preferably therapeutic effect.But during actual operation, it is desirable to so that target electrode or medicine equipment can be good at reaching
There is certain uncertainty with the target location that reclines.
In prior art, when the electrode implantation patient's brain core cumularsharolith in implanted brain electric stimulation is put, even if doctor
Raw surgical errors are zero, subside due to there is nuclear magnetic resonance deviation, drift electrode, brain, surgical head rest etc. it is various it is uncertain because
Element so that electrode can not be contacted well well with target stimulation site, and traditional electrode is straight electrodes, should
Electrode outer surface is substantially concordant with main body tube outer surface, as shown in figure 1, due to the goal stimulus position contacted with electrode cable L
Put S and there are certain irregularities, stimulated using traditional straight electrodes, can there is certain probability and straight electrodes occur
Not sufficient enough situation is contacted between target stimulation site S, electric signal is passed in straight electrodes overhead positions
To non-targeted stimulatory function groups such as tissue fluid so that stimulation energy produces certain loss, at this time doctor is expected to control to reach
Therapeutic effect, may increase stimulation energy, and this can increase the side effect of stimulation, and increase stimulation energy, can cause and electrode
The energy ezpenditure of the impulse generator of wire connection is relatively excessive, so as to reduce the battery of impulse generator.
The content of the invention
It is an object of the invention to provide a kind of electrode cable, the electrode cable can lift electrode and target stimulation site
Effective contact area, so as to subtract side effect while improving treatment validity, while extending the pulse that is connected with electrode cable
The battery of generator.
For achieving the above object, the present invention provides a kind of electrode cable, including main body tube and installed in the main body
Electrode on pipe, the electrode includes the mating part connected with the main body tube, and the electrode also includes connecting with the mating part
The protuberance for connecing, the protuberance protrudes from the outer surface of the main body tube.
Used as the further improvement of an embodiment of the present invention, the mating part includes keeping at a certain distance away the first of setting
Mating part and the second mating part, the protuberance is arranged between first mating part and second mating part.
Used as the further improvement of an embodiment of the present invention, the mating part is identical with the protuberance thickness.
Used as the further improvement of an embodiment of the present invention, medium position of the protuberance from the mating part is outside
Extend.
Used as the further improvement of an embodiment of the present invention, the protuberance and the mating part are integrally formed.
Used as the further improvement of an embodiment of the present invention, the height of the protuberance is 0.2 to 0.5mm.
Used as the further improvement of an embodiment of the present invention, the part that the protuberance is connected with the mating part has
The circular arc external surface of indent.
As the further improvement of an embodiment of the present invention, smooth glue is provided between the mating part and the main body tube
Water.
Used as the further improvement of an embodiment of the present invention, in a tubular form, the external diameter of the electrode is more than institute to the electrode
State the external diameter of main body tube.
As the further improvement of an embodiment of the present invention, it is provided with the tube wall of the main body tube along the main body tube
The cylindrical chamber that lengthwise bearing of trend extends.
Compared with prior art, the beneficial effects of the present invention is：The electrode of the electrode cable of the present invention also includes and matches somebody with somebody
The protuberance of socket part connection, protuberance protrudes from the outer surface of main body tube so that electrode has the protrusion knot for protruding from main body tube
Structure, so as to relative to traditional straight electrodes, the effective contact area of electrode and target stimulation site can be lifted so that electrode
Relatively uneven organizational interface can be more fully contacted, so as to increased the validity of stimulation, unnecessary big stimulation is reduced
The side effect for bringing, and the capacity usage ratio of the impulse generator being connected with electrode cable can be lifted, extend pulse generation
The battery of device.
Description of the drawings
Fig. 1 is the schematic diagram that the electrode cable of prior art and target, contact are contacted；
Fig. 2 is the partial sectional view of the electrode cable that first embodiment of the invention is provided；
Fig. 3 is the amplification profile along A-A directions of the electrode cable shown in Fig. 2；
Fig. 4 is electrode cable that another embodiment of the invention the is provided profile similar with Fig. 3；
Fig. 5 is the cross-sectional view of the main body tube of the electrode cable that a further embodiment of the present invention is provided；
Fig. 6 is the schematic diagram that the electrode cable of embodiment of the present invention and target, contact are contacted.
Specific embodiment
Describe the present invention below with reference to specific embodiment shown in the drawings.But these embodiments are simultaneously
The present invention is not limited, structure that one of ordinary skill in the art is made according to these embodiments, method or functionally
Conversion is all contained in protection scope of the present invention.
Fig. 2 is referred to, the electrode cable 100 that embodiment of the present invention is provided includes main body tube 20, is arranged on main body tube 20
The connecting wire 80 of the end 30 of one end, the electrode 50 on main body tube 20 and electrode 50 connection.
When electrode cable 100 is used, electrode cable 100 is positioned in sick body tissue, connecting wire 80 and pulse generation
Device（It is not shown）Connect and receive the signal of impulse generator and electronic stimulation is carried out to sick body tissue.
In present embodiment, main body tube 20 is cylindrical, and the external diameter of main body tube 20 is in 1 ~ 3mm, preferably 1.17mm.This reality
In applying mode, main body tube 20 is made up of the preferable macromolecular material of biocompatibility, is preferably made up of polyurethane material.
In present embodiment, end 30 be ball bumps, diameter is between 1 ~ 2mm, it is preferred that end 30 it is a diameter of
0.97mm.End 30 is sticked on main body tube 20 by binding agent, such as silica gel.In present embodiment, the material of end 30 can be with
For the preferable medical material of biocompatibility, preferably silica gel or the relatively low epoxy resin glue of hardness, thus, end 30
Inherently can be connected directly between on main body tube 20.
In present embodiment, electrode 50 includes the mating part 52 connected with main body tube 20, and electrode 50 is pacified by mating part 52
It is mounted on main body tube 20.
In present embodiment, in a tubular form, electrode 50 is set on the outer surface of main body tube 20 electrode 50.The length of electrode 50 exists
1 ~ 3mm, preferably 1.5mm.In present embodiment, the external diameter of mating part 52 is 0.8 ~ 1.5mm, preferably 1.0mm.
Preferably, smooth glue 90 is provided between mating part 52 and main body tube 20.Smooth glue 90 be biocompatibility compared with
Good medical glue, preferably epoxy resin glue, between it is primarily served the purpose of between enclosed electrode 50 and main body tube 20
Gap, while can be to smoothing at the step of electrode 50, in order to avoid scratching and hindering occur in use in electrode cable 100
Hinder motion etc..
Electrode 50 also includes the protuberance 53 being connected with mating part 52, and protuberance 53 protrudes from the outer surface of main body tube 20.
Because electrode has the protuberance for protruding from main body tube so that electrode cable is relative to traditional straight electrodes, energy
Enough lift the effective contact area of electrode and target stimulation site so that electrode can more be fully contacted relatively uneven tissue circle
Face, so as to increased the validity of stimulation, reduces the side effect that unnecessary big stimulation may bring, and can be lifted with
The capacity usage ratio of the connected impulse generator of electrode cable, increases the battery of impulse generator.
In present embodiment, in a tubular form, the external diameter of electrode 50 is more than the external diameter of main body tube 20 to electrode 50, especially protuberance
, more than the external diameter of main body tube 20, electrode 50 is in boss ring-type, compound with regular structure for 53 external diameter.
In present embodiment, the external diameter of protuberance 53 is 1 ~ 3mm, preferably 1.27mm.The height of protuberance 53 is 0.2
To 1.5mm, preferably 0.2 to 0.5mm.
Incorporated by reference to Fig. 2 and Fig. 3, it is preferred that the part that protuberance 53 is connected with mating part 52 has the circular arc appearance of indent
Face 56.The excessive R angles of the circular arc are 0.1 ~ 0.5mm, preferably 0.3mm.
Preferably, protuberance 53 and mating part 52 are integrally formed, so as to structure is reliable and easy to process.
In present embodiment, electrode 50 is the preferable metal material of biocompatibility, such as 316L stainless steels, titanium alloy, platinum
Iridium alloy etc. is made, preferably platinumiridio, and its composition accounting is 9:1.
Fig. 3 is referred to, in present embodiment, mating part 52 includes keeping at a certain distance away first mating part 58 and the of setting
Two mating parts 59, protuberance 53 is arranged between the first mating part 58 and the second mating part 59.Preferably, in present embodiment,
Mating part 52 is identical with the thickness of protuberance 53.I.e. whole electrode 50 has identical wall thickness.
Fig. 4 is referred to, in another embodiment of the present invention, the overall lengthwise in mating part 52 of electrode 50 extends, protrusion
Portion 53 stretches out from the medium position of mating part 52.It should be noted that medium position of the protuberance from mating part 52 is outside
Extension is not required for the center that protuberance 53 is fully located at mating part 52, can be equipped with appropriate skew relative to centre bit
Turning back to Fig. 2, in present embodiment, connecting wire 80 is connected and through opening on the tube wall 22 of main body tube 20 with electrode 50
Hole（It is not shown）So that connecting wire 80 is partially housed in the center cavity 24 of main body tube 20, rationally using main body tube 20
Space, topology layout is reasonable.
Preferably, connecting wire 80 is by making to putting preferable metal material, such as corronil line, copper cash, platinumiridio
Line etc., preferably platinumiridio line, its composition accounting is 9:1.Connecting wire 80 can be with laser with the connected mode of electrode 50
Weldering, soldering etc., preferably Laser Welding.
Incorporated by reference to Fig. 2 and Fig. 5, in another embodiment, have along the vertical of main body tube 20 in the tube wall 22 of main body tube 20
The cylindrical chamber 26 that long bearing of trend extends.Connecting wire can be partially housed in cylindrical chamber 26.Under normal circumstances, connection is led
The quantity of line 80 is identical with the quantity of electrode 50, when the quantity of electrode 50 is more than or equal to two, needs to arrange more than or equal to two
The connecting wire 80 of root, usual main body tube 20 only has a center cavity 24, when all of connecting wire 80 is contained in master
During the center cavity 24 of body cavity, insulating properties cannot ensure.Therefore, in present embodiment, connecting wire 80 is partially housed in main body
After the cylindrical chamber 26 arranged on the tube wall 22 of pipe 20, it is ensured that each connecting line is not in contact with each other so as to ensure insulation effect, enters
And ensure that electrode cable 100 is reliably used.
Fig. 6 is referred to, the electrode 50 of the electrode cable 100 of the present invention has the protuberance 53 for protruding from main body tube 20, makes
Electrode cable 100 of the invention is obtained relative to traditional straight electrodes, electrode 50 can be lifted effective with target stimulation site S
Contact area so that electrode 50 can more be fully contacted relatively uneven organizational interface, so as to increased the validity of stimulation, drop
The side effect that low unnecessary big stimulation may bring, and the impulse generator being connected with electrode cable 100 can be lifted
Capacity usage ratio, extend impulse generator battery.
Directly application is deep brain Neural stimulation electrodes wire to the present invention, but one skilled in the art will appreciate that the present invention
Electrode cable not limited to this, other it is active intervention and implantation field used in electrode cables, such as use in intervention field
In the electrophysiologicalcatheter catheter for the treatment of arrhythmia cordis and refractory hypertension etc.；In the pacemaker and nerve stimulator in implantation field
Neural stimulation electrodes wire stimulated Deng portion's depth etc., the distinctive boss electrode structure is equally applicable.
In present embodiment, the quantity of electrode is multiple, it will be understood by those skilled in the art that the quantity of electrode can be with root
Arbitrarily arrange according to needs.In present embodiment, the electrode on same electrode cable preferably adopts identical structure, art technology
Personnel be appreciated that the electrode on same electrode cable using different structures also can, it is all using identical with present embodiment or
Similar scheme is encompassed by protection scope of the present invention.
It should be understood that, although this specification is been described by according to embodiment, but not each embodiment only includes one
Individual independent technical scheme, this narrating mode of specification is only that for clarity those skilled in the art will should say
Bright book as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, forming those skilled in the art can
With the other embodiment for understanding.
The a series of detailed description of those listed above is only for the feasibility embodiment of the present invention specifically
Bright, they simultaneously are not used to limit the scope of the invention, all equivalent implementations made without departing from skill spirit of the present invention
Or change should be included within the scope of the present invention.
Claims (10)
1. a kind of electrode cable, including main body tube and the electrode on the main body tube, the electrode includes and the master
The mating part that body pipe is connected, it is characterised in that：The electrode also includes the protuberance being connected with the mating part, the protuberance
Protrude from the outer surface of the main body tube.
2. electrode cable according to claim 1, it is characterised in that：The mating part includes the setting that keeps at a certain distance away
First mating part and the second mating part, the protuberance is arranged between first mating part and second mating part.
3. electrode cable according to claim 2, it is characterised in that：The mating part is identical with the protuberance thickness.
4. electrode cable according to claim 1, it is characterised in that：Medium position of the protuberance from the mating part
Stretch out.
5. electrode cable according to claim 1, it is characterised in that：The protuberance and the mating part are integrally formed.
6. electrode cable according to claim 1, it is characterised in that：The height of the protuberance is 0.2 to 0.5mm.
7. electrode cable according to claim 1, it is characterised in that：The part that the protuberance is connected with the mating part
Circular arc external surface with indent.
8. electrode cable according to claim 1, it is characterised in that：It is provided with flat between the mating part and the main body tube
Sliding glue.
9. electrode cable according to claim 1, it is characterised in that：In a tubular form, the external diameter of the electrode is big for the electrode
In the external diameter of the main body tube.
10. electrode cable according to claim 1, it is characterised in that：It is provided with the tube wall of the main body tube along the master
The cylindrical chamber that the lengthwise bearing of trend of body pipe extends.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611148027.0A CN106621028A (en) | 2016-12-13 | 2016-12-13 | Electrode lead |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611148027.0A CN106621028A (en) | 2016-12-13 | 2016-12-13 | Electrode lead |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106621028A true CN106621028A (en) | 2017-05-10 |
Family
ID=58825866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611148027.0A Pending CN106621028A (en) | 2016-12-13 | 2016-12-13 | Electrode lead |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106621028A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606781A (en) * | 2015-01-19 | 2015-05-13 | 清华大学 | MRI-compatible split implantable medical device |
| CN206700514U (en) * | 2016-12-13 | 2017-12-05 | 苏州景昱医疗器械有限公司 | Electrode cable |
-
2016
- 2016-12-13 CN CN201611148027.0A patent/CN106621028A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606781A (en) * | 2015-01-19 | 2015-05-13 | 清华大学 | MRI-compatible split implantable medical device |
| CN206700514U (en) * | 2016-12-13 | 2017-12-05 | 苏州景昱医疗器械有限公司 | Electrode cable |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11064898B2 (en) | System and method for using impedance to determine proximity and orientation of segmented electrodes | |
| US9775996B2 (en) | Electrical treatment of alzheimer's disease | |
| US9656074B2 (en) | Nerve stimulator system | |
| US9283394B2 (en) | Implantable microstimulators and methods for unidirectional propagation of action potentials | |
| US7899539B2 (en) | Cavernous nerve stimulation via unidirectional propagation of action potentials | |
| US9409028B2 (en) | Implantable microstimulators with programmable multielectrode configuration and uses thereof | |
| US7292890B2 (en) | Vagus nerve stimulation via unidirectional propagation of action potentials | |
| US9604058B2 (en) | Method for achieving low-back spinal cord stimulation without significant side-effects | |
| AU2006315285B2 (en) | Implantable stimulator configured to be implanted within a patient in a pre-determined orientation | |
| JP5627595B2 (en) | Implantable nerve stimulation device with reduced pocket stimulation | |
| US20120016448A1 (en) | Energy efficient high frequency nerve blocking technique | |
| US8706240B2 (en) | Method for direct modulation of the spinothalamic tract | |
| CN206700514U (en) | Electrode cable | |
| US8914120B2 (en) | Method for treating depression by indirectly stimulating raphe nuclei | |
| Stieglitz et al. | Neural Implants in Clinical Practice: Interfacing neurons for neuro-modulatin, limb control, and to restore vision–Part I | |
| CN106621028A (en) | Electrode lead | |
| WO2004000416A1 (en) | Implantable microstimulators for unidirectional propagation of action potentials |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: Building C16, biological nano Park, 218 Xinghu street, Suzhou Industrial Park, Jiangsu Province Applicant after: Jingyu Medical Technology (Suzhou) Co.,Ltd. Address before: 215123 C16, biological nano Park, 218 Xinghu street, Suzhou Industrial Park, Jiangsu Province Applicant before: SCENERAY Co.,Ltd. |
|
| CB02 | Change of applicant information |