CN106619574A - Microporous film controlled-release coating minodronic acid pellet and preparation method thereof - Google Patents
Microporous film controlled-release coating minodronic acid pellet and preparation method thereof Download PDFInfo
- Publication number
- CN106619574A CN106619574A CN201710000270.6A CN201710000270A CN106619574A CN 106619574 A CN106619574 A CN 106619574A CN 201710000270 A CN201710000270 A CN 201710000270A CN 106619574 A CN106619574 A CN 106619574A
- Authority
- CN
- China
- Prior art keywords
- minodronic acid
- controlled release
- micropill
- release coating
- microporous barrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a microporous film controlled-release coating minodronic acid pellet and a preparation method thereof. The microporous film controlled-release coating minodronic acid pellet sequentially comprises a pill-containing core and a controlled-release coating layer from interior to exterior, wherein the pill-containing core comprises 1 to 20% of main material and 80 to 99% of auxiliary materials; the main material is minodronic acid, and the auxiliary materials comprise one or several of microcrystalline cellulose, starch, lactose, dextrin, sodium carboxymethyl starch and sodium carboxymethylcellulose; the controlled-release coating layer comprises 80 to 85% of polymer, 3 to 5% of dissolvable or falling pore-foaming agent, 0.3 to 0.5% of plasticizer, and 10 to 15% of anti-sticking agent, and the polymer is insoluble in gastrointestinal tracts. The microporous film controlled-release coating minodronic acid pellet has the advantages that the bitter taste is coated, the effective ingredient is dissolved out, the plasma-drug concentration is constant and efficient for a long time, and the defect of discharging of drug along with excrement before complete releasing is overcome.
Description
Technical field
The present invention relates to animal drug formulation art, micro- more particularly, to a kind of microporous barrier controlled release coat minodronic acid
Ball and preparation method thereof.
Background technology
It is the nitrogenous virtue of the third generation that minodronic acid (Minodronic acid) is a kind of nitrogenous bisphosphonate
Heterocyclic ring di-phosphonic acid salt, can be used to treat osteoporosis.This product is by Japanese ONO Pharmaceutical Co., Ltd. and Japan
Astellas Pharmaceutical Co., Ltd joint development, submitted to Japanese health ministry in July, 2006 and applies, on January 21st, 2009
It is approved listing first, trade name is respectively Recalbon (little wild medicine) and Bonoteo (Astellas pharmacy).This product is used
In the treatment of osteoporosis, by suppressing farnesyl pyrophosphate (FPP) synthase activity in osteoclast, suppress osteoclast
Bone information, reduce bone conversion, play the osteoporotic effect of preventing and treating.The tablet of 1mg, 1 day 1 time, 1 time 1.The medicine
Comparative advantages show：Compare with diphosphonate clinically conventional at present, it suppresses the activity of bone information strong, is English card phosphine
2 times of acid disodium, 10 times of the sodium of alendronic acid, 100 times of Pamidronate Disodium, and side effect of digestive tract incidence is more existing
Some bisphosphonate class of drugs are few.The product cost is low, and profit is high.Can be used as a line kind of enterprise's focal selection exploitation.【Specially
Profit and protection】In August in 1989 9 days in Japanese publication, the Patent expiry on the 9th of August in 2009 does not have the compound patent of the product
The possibility of application administrative protection, and will expire within 11st in Augusts in 2009 in China's application compounds process for production thereof patent, open
Send out this product and there are no Intellectual Property Rights Issues.
The content of the invention
The present invention is in order to solve defect and deficiency present in above-mentioned prior art, there is provided one kind not only can be wrapped must live
Bitter taste, and molten draw active ingredient, it is ensured that blood concentration is constant long-acting, it is to avoid medicine is not before discharging completely just with excrement
Just microporous barrier controlled release coat minodronic acid micropill for the defect discharged and preparation method thereof.
Technical scheme：A kind of microporous barrier controlled release coat minodronic acid micropill, includes successively from inside to outside pastille
Capsule core and controlled release coating layer,
Described pellet core presses 1-20% by major ingredient and auxiliary material：80-99% ratio composition, the major ingredient be minodronic acid, institute
Auxiliary material is stated including the one kind or several in microcrystalline cellulose, starch, lactose, dextrin, sodium carboxymethyl starch, sodium carboxymethylcellulose
Kind；
The controlled release coating layer is by undissolved polymer in the gastrointestinal tract, the pore-foaming agent that can dissolve or come off, plasticizer and resists
80-85% is pressed in glutinous agent：3-5%：0.3-0.5%：The ratio composition of 10-15%.
Preferably, the polymer undissolved in the gastrointestinal tract is by polymethacrylate resin, methyl methacrylate
With one or more compositions in butyl acrylate copolymer, the Eudragit NE 30D of commercialization；
The dissolvable or tear-away pore-foaming agent is by one or more groups in PEG, PVP, HPMC, lactose, talcum powder
Into；
The plasticizer is made up of one or two in triethyl citrate, phthalic acid methyl esters；
The antitackiness agent is made up of one or two in talcum powder, magnesium stearate.
Preferably, described pellet core is by 10% minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 65% lactose
Composition, the controlled release coating layer is by Eudragit NE 30D aqueous dispersion 20kg, PVP1kg, talcum powder 3kg, lemon triethylenetetraminehexaacetic acid
Ester 0.1kg is constituted.
Preferably, described pellet core is by 15% minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 60% lactose
Composition, the controlled release coating layer is by Eudragit NE 30D aqueous dispersion 60kg, PVP3kg, talcum powder 9kg, lemon triethylenetetraminehexaacetic acid
Ester 0.3kg is constituted.
Preferably, described pellet core is by 20% minodronic acid, 10% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 65% starch
Composition, the controlled release coating layer is by Eudragit NE 30D aqueous dispersion 20kg, PVP1kg, talcum powder 3kg, lemon triethylenetetraminehexaacetic acid
Ester 0.1kg is constituted.
Preferably, described pellet core by 5% phosphoric acid minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 70%
Starch is constituted, and the controlled release coating layer is by Eudragit NE 30D aqueous dispersion 60kg, PVP3kg, talcum powder 9kg, citric acid
Triethyl 0.3kg is constituted.
A kind of preparation method of microporous barrier controlled release coat minodronic acid micropill, comprises the steps：
1）Prepare pellet core：Take 5-20% major ingredients, 70%-90% to put in mixer and be well mixed, plus appropriate 5% hydroxypropyl methylcellulose
Plain sodium solution as adhesive make softwood, softwood Jing 0.6-0.8mm screen clothes extrusion, it is round as a ball, then Jing fluidized dryings, are contained
Pill core；
2）Prepare the coating liquid of two kinds of coating weight gains：By undissolved polymer in the gastrointestinal tract, the cause that can dissolve or come off
Hole agent, plasticizer and antitackiness agent press 80-85%：3-5%：0.3-0.5%：The ratio of 10-15% prepares coating liquid A and coating liquid
B,
3）It is coated：Weigh 100kg pellet cores to put in fluid bed, under fluidized state, sprayed into by spray gun respectively above-mentioned
Coating liquid A or coating liquid B, coating heats up to dry to moisture after terminating and obtains final product micropill A and micropill B less than 10%；
4）By in micropill A and micropill B input V-Mixers, mix 8 minutes, obtain finished product.
The present invention makes medicine in the given time automatically by pre- constant speed by controlling the constituent of coating membrane and capsule core
Degree release, blood concentration is in the long period constant preparation maintained in Valid concentration.It has the following advantages：Effectively cover
The bitter taste of minodronic acid, makes the spice addition be easily reached the therapeutic dose of 400ppm and not affect animal feed intake at all；Can
With the high temperature granulating process of resistance to complete feed；After oral, immediate release section includes that stomach and small intestine are quick in alimentary canal front section
Release, slowbreak part is discharged in a long time by predetermined speed, long so as to totally play rapid-action, constant duration of efficacy
Purpose.Whole active ingredients all discharge complete in 8-12 hours, it is to avoid medicine quilt before absorbing without release completely
Drain.
Sum it up, not only wrapping, bitter taste must be lived, and molten draw active ingredient, it is ensured that blood concentration is constant long-acting, keeps away
The defect that medicine is just discharged before not discharging completely with excrement is exempted from.
Specific embodiment
With reference to embodiment, the present invention is further detailed explanation, but is not the limit to the scope of the present invention
System.
Embodiment one
Prepare pellet core：Take 10% minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 65% lactose and put mixed in mixer
Close uniform, plus appropriate 5% HPMC sodium solution makes softwood as adhesive, softwood Jing 0.6-0.8mm screen clothes are squeezed
Go out, it is round as a ball, then Jing fluidized dryings, obtain pellet core.
Prepare the micropill of different coating weight gains：
Coating weight gain A prescriptions：Eudragit NE 30D aqueous dispersion 20kg, PVP1kg, talcum powder 3kg, triethyl citrate
0.1kg。
Coating weight gain B prescriptions：Eudragit NE 30D aqueous dispersion 60kg, PVP3kg, talcum powder 9kg.
Weigh 100kg pellet cores to put in fluid bed, under fluidized state, above-mentioned coating prescription A or B are sprayed into by spray gun
Liquid.Coating parameter：Blower fan frequency 30,25 DEG C of temperature of charge, hydrojet speed 0.5kg/min.Coating heats up drying extremely after terminating
Moisture obtains final product semi-finished product less than 10%.
It is total mixed：By in two kinds of micropill input V-Mixers of above-mentioned coating weight gain A, B, mix 8 minutes, obtain finished product.
Embodiment two
Prepare pellet core：Take 15% minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 60% lactose and put mixed in mixer
Close uniform, plus appropriate 5% HPMC sodium solution makes softwood as adhesive, softwood Jing 0.6-0.8mm screen clothes are squeezed
Go out, it is round as a ball, then Jing fluidized dryings, obtain pellet core.
Prepare the micropill of different coating weight gains：
Coating weight gain A prescriptions：Eudragit NE 30D aqueous dispersion 20kg, HPMC1kg, talcum powder 3kg, triethyl citrate
0.1kg。
Coating weight gain B prescriptions：Eudragit NE 30D aqueous dispersion 60kg, HPMC3kg, talcum powder 9kg, citric acid three
Ethyl ester 0.3kg.
Weigh 100kg pellet cores to put in fluid bed, under fluidized state, above-mentioned coating prescription A or B are sprayed into by spray gun
Liquid.Coating parameter：Blower fan frequency 35,28 DEG C of temperature of charge, hydrojet speed 0.4kg/min.Coating heats up drying extremely after terminating
Moisture obtains final product semi-finished product less than 10%.
It is total mixed：By in two kinds of micropill input V-Mixers of above-mentioned coating weight gain A, B, mix 8 minutes, obtain finished product.
Embodiment three
Prepare pellet core：Take 20% minodronic acid, 10% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 65% starch and put mixed in mixer
Close uniform, plus appropriate 5% HPMC sodium solution makes softwood as adhesive, softwood Jing 0.6-0.8mm screen clothes are squeezed
Go out, it is round as a ball, then Jing fluidized dryings, obtain pellet core.
Prepare the micropill of different coating weight gains：
Coating weight gain A prescriptions：Eudragit NE 30D aqueous dispersion 20kg, HPMC 1kg, titanium dioxide 1kg, magnesium stearate
2kg, triethyl citrate 0.1kg.
Coating weight gain B prescriptions：Eudragit NE 30D aqueous dispersion 60kg, HPMC 3kg, titanium dioxide 3kg, stearic acid
Magnesium 6kg, triethyl citrate 0.3kg.
Weigh 100kg pellet cores to put in fluid bed, under fluidized state, above-mentioned coating prescription A or B are sprayed into by spray gun
Liquid.Coating parameter：Blower fan frequency 35,30 DEG C of temperature of charge, hydrojet speed 0.6kg/min.Coating heats up drying extremely after terminating
Moisture obtains final product semi-finished product less than 10%.
It is total mixed：By in two kinds of micropill input V-Mixers of above-mentioned coating weight gain A, B, mix 8 minutes, obtain finished product.
Example IV
Prepare pellet core：Take 5% phosphoric acid minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 70% starch and put mixer
In be well mixed, plus appropriate 5% HPMC sodium solution as adhesive make softwood, softwood Jing 0.6-0.8mm screen clothes
Extrusion, it is round as a ball, then Jing fluidized dryings, obtain pellet core.
Prepare the micropill of different coating weight gains：
Coating weight gain A prescriptions：Eudragit NE 30D aqueous dispersion 18kg, HPMC1kg, titanium dioxide 1kg, magnesium stearate
2kg, triethyl citrate 0.1kg.
Coating weight gain B prescriptions：Eudragit NE 30D aqueous dispersion 55kg, HPMC3kg, titanium dioxide 3kg, stearic acid
Magnesium 6kg, triethyl citrate 0.2kg.
Weigh 100kg pellet cores to put in fluid bed, under fluidized state, above-mentioned coating prescription A or B are sprayed into by spray gun
Liquid.Coating parameter：Blower fan frequency 36,30 DEG C of temperature of charge, hydrojet speed 0.6kg/min.Coating heats up drying extremely after terminating
Moisture obtains final product semi-finished product less than 10%.
It is total mixed：By in two kinds of micropill input V-Mixers of above-mentioned coating weight gain A, B, mix 8 minutes, obtain finished product.
Claims (8)
1. a kind of microporous barrier controlled release coat minodronic acid micropill, includes successively from inside to outside pellet core and controlled release coating layer, its
It is characterised by：
Described pellet core presses 1-20% by major ingredient and auxiliary material：80-99% ratio composition, the major ingredient be minodronic acid, institute
Auxiliary material is stated including the one kind or several in microcrystalline cellulose, starch, lactose, dextrin, sodium carboxymethyl starch, sodium carboxymethylcellulose
Kind；
The controlled release coating layer is by undissolved polymer in the gastrointestinal tract, the pore-foaming agent that can dissolve or come off, plasticizer and resists
80-85% is pressed in glutinous agent：3-5%：0.3-0.5%：The ratio composition of 10-15%.
2. a kind of microporous barrier controlled release coat minodronic acid micropill according to claim 1, it is characterised in that：It is described in stomach and intestine
Undissolved polymer is by polymethacrylate resin, methyl methacrylate and butyl acrylate copolymer, commercialization in road
Eudragit NE 30D in one or more composition；
The dissolvable or tear-away pore-foaming agent is by one or more groups in PEG, PVP, HPMC, lactose, talcum powder
Into；
The plasticizer is made up of one or two in triethyl citrate, phthalic acid methyl esters；
The antitackiness agent is made up of one or two in talcum powder, magnesium stearate.
3. a kind of microporous barrier controlled release coat minodronic acid micropill according to claim 2, it is characterised in that：Described pastille
Capsule core is made up of 10% minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 65% lactose, the controlled release coating layer by
Eudragit NE 30D aqueous dispersion 20kg, PVP1kg, talcum powder 3kg, triethyl citrate 0.1kg compositions.
4. a kind of microporous barrier controlled release coat minodronic acid micropill according to claim 2, it is characterised in that：Described pastille
Capsule core is made up of 15% minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 60% lactose, the controlled release coating layer by
Eudragit NE 30D aqueous dispersion 60kg, PVP3kg, talcum powder 9kg, triethyl citrate 0.3kg compositions.
5. a kind of microporous barrier controlled release coat minodronic acid micropill according to claim 2, it is characterised in that：Described pastille
Capsule core is made up of 20% minodronic acid, 10% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 65% starch, the controlled release coating layer by
Eudragit NE 30D aqueous dispersion 20kg, PVP1kg, talcum powder 3kg, triethyl citrate 0.1kg compositions.
6. a kind of microporous barrier controlled release coat minodronic acid micropill according to claim 2, it is characterised in that：Described pastille
Capsule core is made up of 5% phosphoric acid minodronic acid, 20% microcrystalline cellulose, 5% carboxyrnethyl starch sodium, 70% starch, the controlled release coating layer by
Eudragit NE 30D aqueous dispersion 60kg, PVP3kg, talcum powder 9kg, triethyl citrate 0.3kg compositions.
7. the preparation method of a kind of microporous barrier controlled release coat minodronic acid micropill according to claim 2, it is characterised in that：
It comprises the steps：
1）Prepare pellet core：Take 1-20% major ingredients, 80%-99% to put in mixer and be well mixed, plus appropriate 5% hydroxypropyl methylcellulose
Plain sodium solution as adhesive make softwood, softwood Jing 0.6-0.8mm screen clothes extrusion, it is round as a ball, then Jing fluidized dryings, are contained
Pill core；
2）Prepare the coating liquid of two kinds of coating weight gains：By undissolved polymer in the gastrointestinal tract, the cause that can dissolve or come off
Hole agent, plasticizer and antitackiness agent press 80-85%：3-5%：0.3-0.5%：The ratio of 10-15% prepares coating liquid A and coating liquid
B,
3）It is coated：Weigh 100kg pellet cores to put in fluid bed, under fluidized state, sprayed into by spray gun respectively above-mentioned
Coating liquid A or coating liquid B, coating heats up to dry to moisture after terminating and obtains final product micropill A and micropill B less than 10%；
4）By in micropill A and micropill B input V-Mixers, mix 8 minutes, obtain finished product.
8. the preparation method of a kind of microporous barrier controlled release coat minodronic acid micropill according to claim 7, it is characterised in that：
The step 3）In coating parameter：Blower fan frequency 30,25 DEG C of temperature of charge, hydrojet speed 0.5kg/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710000270.6A CN106619574A (en) | 2017-01-02 | 2017-01-02 | Microporous film controlled-release coating minodronic acid pellet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710000270.6A CN106619574A (en) | 2017-01-02 | 2017-01-02 | Microporous film controlled-release coating minodronic acid pellet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106619574A true CN106619574A (en) | 2017-05-10 |
Family
ID=58838675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710000270.6A Pending CN106619574A (en) | 2017-01-02 | 2017-01-02 | Microporous film controlled-release coating minodronic acid pellet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619574A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078323A (en) * | 2009-12-01 | 2011-06-01 | 严洁 | Minodronate-containing pharmaceutical composition |
| CN105919980A (en) * | 2016-07-07 | 2016-09-07 | 杭州爱力迈动物药业有限公司 | Micro-porous membrane release-controlling coating tilmicosin pellet and preparation method thereof |
-
2017
- 2017-01-02 CN CN201710000270.6A patent/CN106619574A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078323A (en) * | 2009-12-01 | 2011-06-01 | 严洁 | Minodronate-containing pharmaceutical composition |
| CN105919980A (en) * | 2016-07-07 | 2016-09-07 | 杭州爱力迈动物药业有限公司 | Micro-porous membrane release-controlling coating tilmicosin pellet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2019268052B2 (en) | Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose | |
| AU2017210571B2 (en) | A delayed release drug formulation | |
| CN102525990B (en) | Ilaprazole enteric-coated tablets and preparation method thereof | |
| CN101596163B (en) | Paracetamol, caffeine and aspirin pellet preparation and preparation method thereof | |
| CN105919980B (en) | A kind of microporous barrier controlled release coat Tilmicosin pellet and preparation method thereof | |
| CN105142726A (en) | Enteric coated multiparticulate composition with proteinaceous subcoat | |
| CN102579384B (en) | Allopurinol slow-release micro pill tablet and preparation method thereof | |
| JP2015506337A (en) | New formulation | |
| CN104922090B (en) | Mesalazine enteric sustained-release pellet | |
| CN102552256A (en) | Ilaprazole enteric capsule and preparation method thereof | |
| CN104997748A (en) | Nifedipine slow-release tablet for treating hypertensive emergency and preparation technology thereof | |
| CN103127026B (en) | Omeprazole enteric capsule and prepared method thereof | |
| CN103230593A (en) | Medicine composition used for treating gastrointestinal diseases | |
| CN102552190A (en) | Ilaprazole enteric coated tablet and preparation method thereof | |
| CN106619574A (en) | Microporous film controlled-release coating minodronic acid pellet and preparation method thereof | |
| CN106692109A (en) | Microporous membrane-coated controlled-release diacerein pellet and preparation method thereof | |
| CN203677566U (en) | Double-layer tablet for treating helicobacter pylori | |
| IL235283A (en) | Delayed release drug formulation | |
| CN102397262B (en) | Amoxicillin sustained release solid medicinal composition and preparation method thereof | |
| CN106822048A (en) | A kind of microporous barrier controlled release coat Apremilast micropill and preparation method thereof | |
| CN106606496A (en) | Naproxen and esomeprazole magnesium compound enteric coated tablets and preparation method thereof | |
| CN106822047A (en) | A kind of microporous barrier controlled release coat Desloratadine micropill and preparation method thereof | |
| CN105816436A (en) | Pantoprazole enteric-coated pellets, pantoprazole enteric-coated controlled-release tablets and preparing method thereof | |
| CN102552214A (en) | Ilaprazole enteric capsule and preparation method thereof | |
| CN106822046A (en) | Net micropills of a kind of microporous barrier controlled release coat En Gelie and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170510 |